Summit Therapeutics (SMMT) 10-K 9 Mar 23 2022 FY Annual report Financial data

Cover

Cover - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2022	Mar. 07, 2023	Jun. 30, 2022
Cover [Abstract]
Document Type	10-K
Document Annual Report	true
Document Period End Date	Dec. 31, 2022
Current Fiscal Year End Date	--12-31
Document Transition Report	false
Entity File Number	001-36866
Entity Registrant Name	Summit Therapeutics Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	37-1979717
Entity Address, Address Line One	2882 Sand Hill Road, Suite 106
Entity Address, City or Town	Menlo Park,
Entity Address, State or Province	CA
Entity Address, Postal Zip Code	94025
City Area Code	650
Local Phone Number	460-8308
Title of 12(b) Security	Common Stock, par value $0.01 per share
Trading Symbol	SMMT
Security Exchange Name	NASDAQ
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
ICFR Auditor Attestation Flag	false
Entity Shell Company	false
Entity Public Float			$ 25.7
Entity Common Stock, Shares Outstanding		697,685,365
Documents Incorporated by Reference	Portions of the registrant’s definitive Proxy Statement to be filed with the Securities and Exchange Commission within 120 days after registrant’s fiscal year ended December 31, 2022 are incorporated by reference into Part III of this report.
Amendment Flag	false
Entity Central Index Key	0001599298
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	FY

Audit Information

Audit Information	12 Months Ended
	Dec. 31, 2022
Audit Information [Abstract]
Auditor Firm ID	238
Auditor Name	PricewaterhouseCoopers LLP
Auditor Location	Boston, Massachusetts

Consolidated Balance Sheets

Consolidated Balance Sheets - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Current assets:
Cash and cash equivalents	$ 348,607	$ 71,791
Restricted cash	300,000	0
Accounts receivable	349	1,464
Prepaid expenses	1,504	7,161
Other current assets	486	1,201
Research and development tax credit receivable	5,766	15,695
Total current assets	656,712	97,312
Non-current assets:
Property and equipment, net	906	694
Right-of-use assets	4,175	2,790
Goodwill	1,798	2,009
Intangible assets, net	0	10,399
Other assets	577	170
Total assets	664,168	113,374
Current liabilities:
Accounts payable	355	4,374
Accrued liabilities	10,664	7,197
Accrued compensation	5,641	4,125
Lease liabilities	1,690	1,091
Deferred revenue and other income	0	7,939
Other current liabilities	662	897
Promissory note payable to related parties	19,770	0
Total current liabilities	38,782	25,623
Non-current liabilities
Lease liabilities, net of current portion	2,763	1,691
Other non-current liabilities	1,429	2,776
Promissory notes payable to related parties	494,540	0
Total liabilities	537,514	30,090
Commitments and contingencies (Note 21)
Stockholders' equity:
Preferred stock, $0.01 par value, 20,000,000 shares authorized; none issued and outstanding at December 31, 2022 and 2021, respectively	0	0
Common stock, $0.01 par value: 350,000,000 shares authorized; 211,091,425 and 98,039,540 shares issued and outstanding at December 31, 2022 and 2021, respectively	2,110	980
Additional paid-in capital	504,767	384,049
Accumulated other comprehensive loss	(1,893)	(2,197)
Accumulated deficit	(378,330)	(299,548)
Total stockholders' equity	126,654	83,284
Total liabilities and stockholders' equity	$ 664,168	$ 113,374

Consolidated Balance Sheets (Pa

Consolidated Balance Sheets (Parenthetical) - $ / shares	Dec. 31, 2022	Dec. 31, 2021
Statement of Financial Position [Abstract]
Preferred stock par value (in dollars per share)	$ 0.01	$ 0.01
Preferred stock, shares authorized (in shares)	20,000,000	20,000,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Common stock par value (in dollars per share)	$ 0.01	$ 0.01
Common stock, shares authorized (in shares)	350,000,000	350,000,000
Common stock, shares issued (in shares)	211,091,425	98,039,540
Common stock, shares outstanding (in shares)	211,091,425	98,039,540

Consolidated Statements of Oper

Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Statement And Statement Of Comprehensive Income [Abstract]
Revenue	$ 705	$ 1,809
Operating expenses:
Research and development	51,999	85,352
General and administrative	26,743	23,611
Impairment of intangible assets	8,468	0
Total operating expenses	87,210	108,963
Other operating income	14,416	20,968
Operating loss	(72,089)	(86,186)
Other expense, net	(6,693)	(2,416)
Loss before income tax	(78,782)	(88,602)
Net loss	$ (78,782)	$ (88,602)
Net loss per share:
Basic (in dollars per share)	$ (0.41)	$ (0.67)
Diluted (in dollars per share)	$ (0.41)	$ (0.67)
Weighted average common shares outstanding:
Basic (in shares)	193,336,063	131,714,225
Diluted (in shares)	193,336,063	131,714,225
Other comprehensive income (loss):
Foreign currency translation adjustments	$ 304	$ 1,597
Comprehensive loss	$ (78,478)	$ (87,005)

Consolidated Statements of Stoc

Consolidated Statements of Stockholders' Equity - USD ($) $ in Thousands	Total	Common Stock	Additional Paid-In Capital	Accumulated Other Comprehensive Loss	Total Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2020		82,575,064
Beginning balance at Dec. 31, 2020	$ 79,453	$ 826	$ 293,367	$ (3,794)	$ (210,946)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Rights offering of common stock, net of offering costs (in shares)		14,312,976
Rights offering of common stock, net of offering costs	74,841	$ 143	74,698
Issuance of common stock under stock purchase plans and exercise of stock options (in shares)		1,151,500
Issuance of common stock under stock purchase plans and exercise of stock options	3,088	$ 11	3,077
Stock-based compensation	12,804		12,804
Imputed interest expense on promissory notes payable to related parties	103		103
Foreign currency translation adjustment	1,597			1,597
Net loss	$ (88,602)				(88,602)
Ending balance (in shares) at Dec. 31, 2021	98,039,540	98,039,540
Ending balance at Dec. 31, 2021	$ 83,284	$ 980	384,049	(2,197)	(299,548)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Rights offering of common stock, net of offering costs (in shares)		103,092,783
Rights offering of common stock, net of offering costs	99,889	$ 1,031	98,858
Issuance of common stock in lieu of interest to related parties (in shares)		9,720,291
Issuance of common stock in lieu of interest to related parties	7,594	$ 97	7,497
Issuance of common stock under stock purchase plans and exercise of stock options (in shares)		238,811
Issuance of common stock under stock purchase plans and exercise of stock options	399	$ 2	397
Stock-based compensation	11,948		11,948
Imputed interest expense on promissory notes payable to related parties	2,018		2,018
Foreign currency translation adjustment	304			304
Net loss	$ (78,782)				(78,782)
Ending balance (in shares) at Dec. 31, 2022	211,091,425	211,091,425
Ending balance at Dec. 31, 2022	$ 126,654	$ 2,110	$ 504,767	$ (1,893)	$ (378,330)

Consolidated Statements of St_2

Consolidated Statements of Stockholders' Equity (Parenthetical) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Statement of Stockholders' Equity [Abstract]
Offering cots	$ 111	$ 159

Consolidated Statements of Cash

Consolidated Statements of Cash Flows - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Cash flows used in operating activities:
Net loss	$ (78,782,000)	$ (88,602,000)
Adjustments to reconcile net loss to net cash used in operating activities:
Gain on remeasurement of liabilities	(1,265,000)	0
Non-cash interest expense	4,303,000	196,000
Unrealized foreign exchange loss	2,614,000	326,000
Amortization of operating right-of-use assets	1,251,000	1,108,000
Depreciation	349,000	330,000
Amortization of intangible assets	914,000	1,017,000
Impairment of intangible assets	8,468,000	0
Stock-based compensation	11,948,000	12,804,000
Other adjustments	2,000	301,000
Changes in operating assets and liabilities:
Accounts receivable	975,000	(1,138,000)
Prepaid expenses	5,107,000	2,345,000
Other current and long-term assets	215,000	104,000
Research and development tax credit receivable	8,437,000	(6,015,000)
Deferred revenue and other income	(7,278,000)	(813,000)
Accounts payable	(4,132,000)	(1,711,000)
Accrued liabilities	4,782,000	5,075,000
Accrued compensation	1,609,000	3,154,000
Operating lease liabilities	(1,099,000)	(1,068,000)
Net cash used in operating activities	(41,582,000)	(72,587,000)
Cash flows used in investing activities:
Purchase of property and equipment	(624,000)	(306,000)
Net cash used in investing activities	(624,000)	(306,000)
Cash flows provided by financing activities:
Proceeds from the issuance of common stock	100,000,000	75,000,000
Transaction costs from the issuance of common stock	(111,000)	(118,000)
Proceeds from related party promissory notes	545,000,000	110,000,000
Re-payment of related party promissory notes	(25,000,000)	(110,000,000)
Payments of related party promissory notes issuance costs	(44,000)	(54,000)
Proceeds from exercise of share options	399,000	3,088,000
Net cash provided by financing activities	620,244,000	77,916,000
Effect of exchange rates on cash and restricted cash	(1,222,000)	351,000
Increase in cash, cash equivalents and restricted cash	576,816,000	5,374,000
Cash at beginning of period	71,791,000	66,417,000
Cash, cash equivalents and restricted cash at end of period	648,607,000	71,791,000
Supplemental Disclosure of Cash Flow Information
Cash paid for interest on related party promissory note	434,000	85,000
Debt issuance costs in accrued expenses	31,000	0
Transaction costs included in accrued expenses	0	41,000
Deferred transaction costs included in other non-current assets	425,000	0
Leased assets obtained in exchange for operating lease liabilities	$ 2,860,000	$ 3,389,000

Nature of Business and Operatio

Nature of Business and Operations and Recent Events	12 Months Ended
	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Nature of Business and Operations and Recent Events	Nature of Business and Operations and Recent Events Nature of Business and Operations The Company is a biopharmaceutical company focused on the discovery, development, and commercialization of patient-, physician-, caregiver- and societal-friendly medicinal therapies intended to improve quality of life, increase potential duration of life, and resolve serious unmet medical needs. The Company's pipeline of product candidates is designed with the goal to become the patient-friendly, new-era standard-of-care medicines. Recent Events On September 28, 2022, the Company determined that it would seek partners or a divestiture of ridinilazole, the Company's lead product candidate for treating patients suffering from Clostridioides difficile infection, also known as C. difficile infection, or CDI, as the path forward for the clinical development of the asset. As a result of this determination, the Company discontinued its only active study for ridinilazole, a pediatric clinical trial evaluating ridinilazole for treating adolescent patients with CDI. The Company is currently involved in activities related to closeout of ridinilazole clinical trials. On December 5, 2022, the Company entered into a Collaboration and License Agreement (the “License Agreement”) with Akeso, Inc. and its affiliates (“Akeso”) pursuant to which we are partnering with Akeso to in-license its breakthrough bispecific antibody, ivonescimab. Ivonescimab, known as AK112 in China and Australia, and also as SMT112 in the United States, Canada, Europe, and Japan, is a novel, potential first-in-class bispecific antibody intending to combine the power of immunotherapy via a blockade of PD-1 with the anti-angiogenesis benefits of an anti-VEGF into a single molecule. Ivonescimab was engineered to bring two well established oncology targeted mechanisms together. Through the License Agreement, the Company obtained the rights to develop and commercialize SMT112 in the United States, Canada, Europe, and Japan. In exchange for these rights, an upfront payment of $500,000 is payable to Akeso, $300,000 of which was payable within the later of 15 days after execution of the License Agreement or upon the earliest date on which the parties have actual knowledge that all applicable waiting periods under the Hart-Scott-Rodino Antitrust Improvements Act of 1976 and any comparable extension periods with respect to the transactions contemplated by the License Agreement have expired or been terminated (the “Antitrust Clearance Date”) and $200,000 of which is payable within the later of (i) 90 days after execution of the License Agreement or (ii) the Antitrust Clearance Date. In connection with the first payment, up to 16 million shares of Company common stock may be issued in lieu of cash at Akeso’s election (the “Share Transfer”), with the value of such shares based on the ten (10) day volume-weighted average price for the five five On December 6, 2022, the Company entered into a Note Purchase Agreement (the "Note Purchase Agreement"), with Mr. Duggan and Dr. Zanganeh, pursuant to which the Company agreed to sell to each of Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the aggregate amount of $520,000. For further details see Note 17. On January 6, 2023, the Company held a Special Meeting of Stockholders (the “Shareholder Special Meeting”), whereby the following matters were submitted to a vote of the Company’s stockholders: (i) an amendment to the Company’s Restated Certificate of Incorporation, dated September 18, 2020, as amended on July 27, 2022 (the “Restated Certificate”), to increase the number of authorized shares of common stock by 650,000,000 (from 350,000,000 to 1,000,000,000); and (ii) an amendment to the Restated Certificate to effect, as needed, a reverse stock split of all of the outstanding shares of the Company’s common stock at a ratio in the range of 1-for-5 to 1-for-10. Each of the matters submitted to a vote of the Company’s stockholders at the Special Meeting was approved by the requisite vote of the Company’s stockholders in accordance with the recommendation of the Company’s Board of Directors. The final decision of whether to proceed with the amendments may be determined by the Company's Board of Directors, in its discretion, at any time prior to January 6, 2024. On January 19, 2023, the Company filed Amendment No. 2 to the Restated Certificate of Incorporation (the “Amendment No. 2”) with the Secretary of State of the State of Delaware to increase the number of authorized shares of its common stock by 650,000,000 (from 350,000,000 to 1,000,000,000), which became effective on such date. On February 7, 2023, the Company commenced its previously announced rights offering ("Rights Offering"). On March 1, 2023, the Company closed the Rights Offering, which was fully subscribed. The Company received aggregate gross proceeds from the Rights Offering of $500,000 from the sale of 476,190,471 shares of our common stock at a price per share of $1.05. Issuance costs associated with the Rights Offering were approximately $500. In connection with the closing of the Rights Offering, $400,000 of the unsecured promissory notes, issued by us to Mr. Duggan, matured and became due and the Company repaid the principal amount and all outstanding accrued interest thereunder using a portion of the proceeds from this Rights Offering. On February 15, 2023, $20,000 of the unsecured promissory notes, issued by us to Dr. Zanganeh, matured and the Company repaid the outstanding principal balance.

Basis of Presentation and Use o

Basis of Presentation and Use of Estimates	12 Months Ended
	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Basis of Presentation and Use of Estimates	Basis of Presentation and Use of Estimates The consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States ("U.S. GAAP") and pursuant to the rules and regulations of the U.S. Securities and Exchange Commission. Any reference in these notes to applicable guidance is meant to refer to authoritative U.S. GAAP as found in the Accounting Standards Codification (“ASC”) and as amended by Accounting Standards Updates (“ASU”) of the Financial Accounting Standards Board (“FASB”). The preparation of these financial statements requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. On an on-going basis, management evaluates its estimates and judgments, including those related to revenue recognition, accrued research and development expenses, stock-based compensation, intangible assets, goodwill, other long-lived assets and income taxes. Management bases its estimates and judgments on historical experience and on various other factors that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions. The progression of the COVID-19 pandemic continues to evolve and its enduring impact on the Company's business remains uncertain. Management believes the estimates and assumptions underlying its financial statements are reasonable and supportable based on the information available as of December 31, 2022, however, the extent to which the COVID-19 pandemic impacts the Company's financial results beyond December 31, 2022 will depend on future developments that are highly uncertain and cannot be predicted at this time.

Liquidity and Capital Resources

Liquidity and Capital Resources	12 Months Ended
	Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Liquidity and Capital Resources	Liquidity and Capital Resources During the year ended December 31, 2022, the Company incurred a net loss of $78,782 and cash flows used in operating activities was $41,582. As of December 31, 2022, the Company had an accumulated deficit of $378,330, cash and cash equivalents of $348,607, restricted cash of $300,000, research and development tax credit receivable of $5,766 and accounts receivable of $349. The Company expects to continue to generate operating losses for the foreseeable future. Based on the Company's existing cash, cash equivalents and U.K. research and development tax credits, after considering the payments made to Akeso in January and March 2023 totaling $474,900, the net proceeds of $499,500 from the Rights Offering that closed on March 1, 2023, and repayments of the promissory notes payable to related parties in February and March 2023 totaling $420,000, the Company has the ability to fund its operating costs and working capital needs for its planned clinical trials for ivonescimab for a period of at least twelve months from the date of issuance of these consolidated financial statements. Until the Company can generate substantial revenue and achieve profitability, the Company will need to raise additional capital to fund its ongoing operations and capital needs. The Company continues to evaluate options to further finance its operating cash needs for its product candidates through a combination of some, or all, of the following: equity and debt offerings, collaborations, strategic alliances, grants and clinical trial support from government entities, philanthropic, non-government and not-for-profit organizations, and marketing, distribution or licensing arrangements. While the Company believes that funds would be available in this manner before 2024, there is no assurance, however, that additional financing will be available when needed or that management of the Company will be able to obtain financing on terms acceptable to the Company. If the Company is unable to obtain funding when required in the future, the Company could be required to delay, reduce, or eliminate research and development programs, product portfolio expansion, or future commercialization efforts, which could adversely affect its business prospects. The accompanying consolidated financial statements are prepared assuming the Company will continue as a going concern, which contemplates the realization of assets and satisfaction of liabilities in the normal course of the business. The consolidated financial statements do not include any adjustments relating to the recoverability and classification of recorded asset amounts or the amounts and classifications of liabilities that might result from the outcome of this uncertainty.

Summary of Significant Accounti

Summary of Significant Accounting Policies	12 Months Ended
	Dec. 31, 2022
Accounting Policies [Abstract]
Summary of Significant Accounting Policies	Summary of Significant Accounting Policies The significant accounting policies adopted by the Company in the preparation of these consolidated financial statements are set out below. These policies have been consistently applied to all the years presented, unless otherwise stated. Principles of Consolidation The accompanying consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) and pursuant to the rules and regulations of the U.S. Securities and Exchange Commission. The consolidated financial statements reflect the accounts of Summit Therapeutics Inc. and its wholly owned subsidiaries. Intercompany balances and transactions are eliminated in consolidation. Foreign Currency Translation The financial statements of the Company’s subsidiaries with functional currencies other than the United States ("U.S.") dollar are translated into U.S. dollars using period-end exchange rates for assets and liabilities, historical exchange rates for stockholders’ equity and weighted average exchange rates for operating results. Translation gains and losses are included in accumulated other comprehensive (loss) income in shareholders’ equity. Foreign currency transaction gains and losses are included in other expense, net in the results of operations. The Company recorded realized and unrealized foreign currency transaction losses of $4,109 and $2,135 for the years ended December 31, 2022 and 2021, respectively, which is included in other expense, net in the statements of operations and comprehensive loss. Revenue Recognition The Company accounts for revenue using ASC 606. This standard applies to all contracts with customers, except for contracts that are within the scope of other standards. The Company enters into out-licensing agreements within the scope of ASC 606 under which it licenses certain rights to its product candidates to third parties. Such agreements may include the transfer of intellectual property rights in the form of licenses, transfer of technological know-how, delivery of drug substances, research and development services, and participation on certain committees with the counterparty. Payments made by the customers may include one or more of the following: non-refundable, up-front license fees; development, regulatory, and commercial milestone payments; payments for manufacturing supply services the Company provides through its contract manufacturers; and royalties on net sales of licensed products if they are successfully approved and commercialized. Each of these payments may result in license, collaboration, or other revenue, except revenue from royalties on net sales of licensed products, which would be classified as royalty revenue. In determining the appropriate amount of revenue to be recognized as the Company fulfills its obligations under each of its out-licensing agreements, the following steps are performed: (i) identification of the promised goods or services in the contract; (ii) determination of whether the promised goods or services are performance obligations including whether they are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraint on variable consideration; (iv) allocation of the transaction price to the performance obligations; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation. At contract inception, once the contract is determined to be within the scope of ASC 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations and assesses whether each promised good or service is distinct. Revenue is then recognized in respect of the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. As part of the accounting for these arrangements, the Company must use significant judgment to determine: (a) the performance obligations based on the determination under step (ii) above; (b) the transaction price under step (iii) above; and (c) the standalone selling price for each performance obligation identified in the contract for the allocation of transaction price in step (iv) above. The Company also uses judgment to determine whether milestone payments or other variable consideration, except for royalties and sales-based milestones, should be included in the transaction price, as described below. The transaction price is allocated to each performance obligation based on the relative standalone selling price of each performance obligation in the contract, and the Company recognizes revenue based on those amounts when, or as, the performance obligations under the contract are satisfied. Exclusive Licenses If the license to the Company’s intellectual property is determined to be distinct from the other promises or performance obligations identified in the arrangement, the Company recognizes revenue from nonrefundable, upfront fees allocated to the license when the license is transferred to the customer and the customer is able to use and benefit from the license. In assessing whether a promise or performance obligation is distinct from the other promises, the Company considers factors such as the research, development, manufacturing and commercialization capabilities of the collaboration partner and the availability of the associated expertise in the general marketplace. In addition, the Company considers whether the collaboration partner can benefit from a promise for its intended purpose without the receipt of the remaining promises, whether the value of the promise is dependent on the unsatisfied promises, whether there are other vendors that could provide the remaining promises, and whether it is separately identifiable from the remaining promises. For licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of progress and related revenue recognition. The measure of progress, and the resulting periods over which revenue should be recognized, are subject to estimates by management and may change over the course of the research, development and licensing arrangement. Such a change could have a material impact on the amount of revenue the Company records in future periods. Under the Company’s existing license and collaboration agreements, the Company has concluded that the transfer of control to the customer occurs over the time period that the research and development services are to be provided by the Company, and this output method is, in management’s judgment, the best measure of progress towards satisfying the performance obligation. Milestone Payments At the inception of each arrangement that includes potential research, development or regulatory milestone payments, the Company evaluates whether the milestones are considered likely to be met and estimates the amount to be considered for inclusion in the transaction price using the most-likely-amount method. If it is probable that a significant reversal in the amount of cumulative revenue recognized would not occur, the associated milestone payment value is included in the transaction price. For milestone payments due upon events that are not within the control of the Company or the licensee, such as regulatory approvals, the Company is not able to assert that it is likely that the regulatory approval will be granted and that it is probable that a significant reversal in the amount of cumulative revenue recognized will not occur until those approvals are received. In making this assessment, the Company evaluates factors such as the scientific, clinical, regulatory, commercial and other risks that must be overcome to achieve the particular milestone. There is considerable judgment involved in determining whether it is probable that a significant reversal in the amount of cumulative revenue recognized would not occur. At the end of each subsequent reporting period, the Company reevaluates the probability of achievement of all milestones subject to constraint and, if necessary, adjusts its estimate of the overall transaction price of the arrangement. Any such adjustments are recorded on a cumulative catch-up basis, which would affect the amounts of revenue and earnings in the period of adjustment. Royalties For arrangements that include sales-based royalties, including milestone payments due upon first commercial sales or based on a level of sales, that are the result of a customer-vendor relationship and for which the license is deemed to be the predominant item to which the royalties relate, the Company recognizes revenue at the later of (i) the occurrence of the related sales or (ii) the date upon which the performance obligation to which some or all of the royalty has been allocated has been satisfied or partially satisfied. To date, the Company has not recognized any royalty revenue from any of its licensing arrangements. Other Operating Income The Company generates income from government contracts that reimburse the Company for certain allowable costs for funded projects. For contracts with government agencies where the funding arrangement is considered central to the Company’s ongoing operations, the Company classifies the recognized funding received as other operating income. Income from government grants is recognized as the qualifying expenses related to the contracts are incurred, provided that there is reasonable assurance of recoverability. If the government agency approves the project proposed by the Company, the government agency funds the project upon receipt of the support for the costs incurred up to the contract limit. Income recognized upon incurring qualifying expenses in advance of billing is recorded as unbilled receivable, a component of other current assets, in the consolidated balance sheet. Grant income is not recognized as deductions of research and development costs because the Company acts as the principal in conducting the research and development activities and these contracts are central to its ongoing operations. The funds received through these means are held as deferred income in the consolidated balance sheets and are released to the consolidated statement of operations and comprehensive loss, classified as other operating income, as the underlying expenditure is incurred and to the extent the conditions of the grant are met. The related costs incurred by the Company are included in research and development expense in the Company’s consolidated statements of operations and comprehensive loss. The Company benefits from two U.K. research and development ("R&D") tax credit cash rebate regimes: Small and Medium Enterprise ("SME") Program and the Research and Development Expenditure Credit ("RDEC") Program. Each reporting period, management evaluates which tax relief programs the Company is expected to be eligible for and records as other operating income the portion of the expense that it expects to qualify under the programs, that it plans to submit a claim for, and it has reasonable assurance that the amount will ultimately be realized. Based on criteria established by HM Revenue and Customs (“HMRC”), management of the Company expects a proportion of expenditures being undertaken in relation to its pipeline research, clinical trials management and manufacturing development activities to be eligible for the research and development tax relief programs for the year ended December 31, 2022 . Qualifying expenditures largely comprise of employment costs for research staff, consumables, a proportion of relevant, permitted sub-contract costs and certain internal overhead costs incurred as part of research projects for which the Company does not receive commercial or other funding income. Credits related to the SME and RDEC Programs are recorded as other operating income in the consolidated statements of operations and other comprehensive (loss)/income. Under both schemes, the Company receives cash rebate payments of up to 33.3% of eligible research and development expenditures and these payments are not dependent on the Company’s pre-tax net income levels. The Company has qualified under the more favorable SME regime for the year ended December 31, 2021 and expects to qualify under the SME regime for the year ending December 31, 2022. Net Loss Per Share Basic net loss per share is computed by dividing the net loss by the weighted-average number of common shares outstanding for the period. Diluted net loss per share is computed by dividing the diluted net loss by the weighted-average number of common shares outstanding for the period, including potentially dilutive common shares. The dilutive effect of share options and warrants are determined under the treasury stock method using the average market price for the period. In addition, the assumed proceeds under the treasury stock method include the average unrecognized compensation expense of stock options and warrants that are in-the-money. Business Combinations Business combinations are accounted for under the acquisition method. Acquired assets and assumed liabilities are measured at their fair values at the acquisition date. The excess of the consideration transferred over the net fair value of assets acquired and liabilities assumed is recorded as goodwill. The accounting for an acquisition involves a considerable amount of judgement and estimation. Cost, income, market or a combination of approaches may be used to establish the fair value of consideration exchanged, assets acquired, and liabilities assumed, depending on the nature of those items. The valuation approach is determined in accordance with generally accepted valuation methods. Key areas of estimation and judgment may include the selection of valuation approaches, cost of capital, market characteristics, cost structure, impacts of synergies, and estimates of terminal value, among other factors. While the Company uses estimates and assumptions as part of the purchase price allocation process to estimate the value of assets acquired and liabilities assumed, estimates are inherently uncertain and subject to refinement. During the measurement period, which maybe up to one year from the acquisition date, the Company may record adjustments to the assets acquired and liabilities assumed, with a corresponding offset to goodwill, to the extent that adjustments are identified to the preliminary purchase price allocation. Upon conclusion of the measurement period, or final determination of the value of the assets acquired and liabilities assumed, whichever comes first, any subsequent adjustments are recorded to results of operations. Results of operations related to business combinations are included prospectively beginning with the date of acquisition and transaction costs related to business combinations are recorded within general and administrative expenses. Goodwill Goodwill represents the excess of the consideration transferred over the fair value of net assets acquired. Goodwill is assigned to reporting units at the time of acquisition or when there is a change in the reporting structure and bases that allocation on which reporting units will benefit from the acquired assets and liabilities. Reporting units are defined as operating segments or one level below an operating segment, referred to as a component. Typically acquisitions related to a single reporting unit do not require the allocation of goodwill to multiple reporting units. If the products obtained in an acquisition are assigned to multiple reporting units, the goodwill is distributed to the respective reporting units as part of the purchase price allocation process. The Company assesses goodwill for impairment on an annual basis or more frequently when events and circumstances occur indicating that the recorded goodwill may be impaired. The Company regularly monitors current business conditions and other factors including, but not limited to, adverse industry or economic trends and lower projections of profitability that may impact future operating results. The process of evaluating the potential impairment of goodwill requires significant judgment. In performing the Company’s annual goodwill impairment test, the Company is permitted to first assess qualitative factors to determine whether it is more likely than not that the fair value of the Company’s reporting unit is less than its carrying amount, including goodwill. In performing the qualitative assessment, the Company considers certain events and circumstances specific to the reporting unit and to the entity as a whole, such as macroeconomic conditions, industry and market considerations, overall financial performance and cost factors when evaluating whether it is more likely than not that the fair value of the reporting unit is less than its carrying amount. The Company is also permitted to bypass the qualitative assessment and proceed directly to the quantitative test. If the Company chooses to undertake the qualitative assessment and concludes that it is more likely than not that the fair value of the reporting unit is less than its carrying amount, the Company would then proceed to the quantitative impairment test. In the quantitative assessment, the Company compares the fair value of the reporting unit to its carrying amount, which includes goodwill. If the fair value exceeds the carrying value, no impairment loss exists. If the fair value is less than the carrying amount, a goodwill impairment loss is measured and recorded. The Company performed its annual impairment assessment of goodwill in the fourth quarter of 2022 by performing a qualitative analysis for its single identified reporting unit for goodwill and determined that it is more likely than not that the fair value of the reporting unit exceeded its carrying amount. Intangible Assets Intangible assets are estimated by management based on the fair value of assets acquired. These include acquired technology, licenses, an option over non-financial assets and a research and development discovery platform ("Discuva Platform"). Intangible assets are amortized from one Our intangible assets are recorded at fair value at the time of their acquisition, assigned an estimated useful life, and amortized primarily on a straight-line basis over their estimated useful lives or over the period of the relevant agreement for an option over non-financial assets. Intangible assets are stated in our consolidated balance sheets net of accumulated amortization and impairments, if applicable. The Company evaluates the recoverability of its intangible and long-lived assets whenever events and changes in circumstances indicate that the carrying amount of an asset or asset group may not be fully recoverable. If events and circumstances indicate that the carrying amount may not fully be recoverable, the carrying values of the asset or asset group are evaluated in relation to their operating performance and future undiscounted cash flows of the underlying business. If the future undiscounted cash flows are less than their carrying value, impairment exists. The impairment is measured as the difference between the carrying value and the fair value of the underlying asset or asset group. Fair values are based on estimates of market prices and assumptions concerning the amount and timing of estimated future cash flows and assumed discount rates, reflecting varying degrees of perceived risk. Amortization of intangible assets is included as part of the research and development expense line shown on the face of the consolidated statement of operations and comprehensive loss. As of December 31, 2022 and 2021, intangible assets were $0 and $10,399, respectively. The carrying value of $10,399 as of December 31, 2021 related to the Discuva Platform has been impaired in full during the year end December 31, 2022. Property and Equipment Property and equipment are stated at cost less accumulated depreciation. Cost comprises the purchase price plus any incidental costs of acquisition and commissioning. Depreciation is calculated based on cost, less residual value, in equal annual installments over the estimated useful lives of the assets. The residual value, if significant, is reassessed annually. Leasehold improvements Over the shorter of the asset's useful life or the remaining lease term Laboratory equipment 2 - 10 years Office and IT equipment 3 - 5 years Depreciation is recognized as part of the general and administrative and research and development expense lines shown on the face of the consolidated statement of operations and comprehensive loss depending on the nature of the underlying assets. Expenditures for repairs and maintenance are expensed as incurred. Upon retirement or sale, the cost of assets disposed of and the related accumulated depreciation are removed from the accounts and any resulting gain or loss is included in loss from operations. Leases The Company has operating leases for real estate. The Company does not have any finance leases. Under ASC 842, a contract is or contains a lease when the lessee has the right to control the use of an identified asset. The Company determines if an arrangement is a lease at inception of the contract, which is the date on which the terms of the contract are agreed to and the agreement creates enforceable rights and obligations. The lease term used to calculate the lease liability include options to extend or terminate the lease when it is reasonably certain that the option will be exercised. At the lease commencement date, the Company measures and recognizes a lease liability and a right-of-use asset in the financial statements. Lease liabilities are recognized based on the present value of the future lease payments over the lease term at commencement date. The right-of use asset is measured by taking the present value of future lease payments, plus any incremental direct costs incurred, less any lease incentives received. As most of the Company's leases do not provide an implicit rate, the Company uses an estimated incremental borrowing rate based on the lease term and the economic environment of the lease at the lease commencement date, which is then utilized to determine the present value of future lease payments. Lease expense for minimum lease payments are recognized on a straight-line basis over the lease term, with variable lease payments recognized in the periods in which they are incurred. The Company has existing lease agreements with lease and non-lease components, has elected to account for the lease and non-lease components as a single lease component, and has allocated all of the contract consideration to the lease component only. Leases with an initial lease term of 12 months or less are not recorded on the balance sheet. The Company recognizes lease expense for its short-term leases on a straight-line basis over the lease term. Research and Development Costs Research and development costs are expensed as incurred. Research and development expenses consist of costs incurred to discover, research and develop product candidates, including personnel expenses, stock-based compensation expense, allocated facility-related and depreciation expenses, third-party license fees and external costs of outside vendors engaged to conduct preclinical and clinical development activities and clinical trials as well as to manufacture clinical trial materials. Non - refundable prepayments for goods or services that will be used or rendered for future research and development activities are recorded as prepaid expenses. Such amounts are recognized as an expense as the goods are delivered or the related services are performed, or until it is no longer expected that the goods will be delivered, or the services rendered. Milestone and other payments made to third-parties with respect to in-process research and development, in accordance with the Company’s license, acquisition and other similar agreements are expensed when determined to be probable and estimable. The Company has entered into various research and development contracts with other companies. These agreements are generally cancellable, and related payments are recorded as research and development expenses as incurred. The Company records accruals for estimated ongoing research and development costs or prepaid expenses where the payments made exceeds the estimated costs. When evaluating the adequacy of these balances, the Company analyzes progress of the studies, including the estimated costs to complete each study or activity, the estimation of the current stage of completion and the invoices received, as well as predetermined milestones which are not reflective of the current stage of development for prepaid expenses. Actual results could differ from the Company’s estimates. In all cases, the full cost of each study or activity is expensed by the time the final report or where applicable, product, has been received. The Company’s historical estimates have not been materially different from the actual costs. Stock-Based Compensation The Company measures and recognizes compensation expense for all stock option and restricted stock unit awards based on the estimated fair value of the award on the grant date. The Company uses the Black-Scholes option pricing model to estimate the fair value of stock option awards. Additionally, the Company uses a Monte Carlo simulation model to calculate the estimated fair value on the date of grant related to awards with market-based service conditions. The fair value is recognized as expense, over the requisite service period, which is generally the vesting period of the respective award, on a straight-line basis for each separately vesting portion of the award when the only condition to vesting is continued service. If vesting is subject to a market or performance condition, recognition is based on the derived service period of the award. Expense for awards with performance conditions is estimated and adjusted on a quarterly basis based upon the assessment of the probability that the performance condition will be met. Use of the Black-Scholes option-pricing model requires management to apply judgment under highly subjective assumptions. These assumptions include: • Expected term—The expected term of stock options represents the weighted-average period the stock options are expected to be outstanding. The Company uses the simplified method for estimating the expected term as provided by the Securities and Exchange Commission. The simplified method calculates the expected term as the average of the time-to-vesting and the contractual life of the options. • Expected volatility—The expected volatility is calculated based on historical volatility of the Company's share price. • Risk-free interest rate—The risk-free rate assumption is based on the U.S. Treasury instruments, the terms of which were consistent with the expected term of the Company’s stock options. • Expected dividend—The expected dividend assumption is based on the Company’s history and expectation of dividend payouts. The Company has not paid and does not intend to pay dividends. The Company estimates expected forfeitures at the time of grant instead of accounting for forfeitures as they occur. Stock option and restricted stock unit awards have been granted at fair value to non-employees in connection with research and consulting services provided to the Company. Equity awards generally vest over terms of 3 or 4 years. The Company classifies stock-based compensation expense in the consolidated statements of operations in the same manner in which the award recipient’s payroll costs are classified. Income Taxes The Company is primarily subject to corporation taxes in the U.S. and the U.K.. The calculation of the Company’s tax provision involves the application of both U.S. and U.K. tax law and requires judgment and estimates. The provision for income taxes is determined using the asset and liability approach. Tax laws may require items to be included in tax filings at different times than the items are reflected in the financial statements. A current asset or liability is recognized for the estimated taxes receivable or payable for the current year. Deferred taxes represent the future tax consequences expected to occur when the reported amounts of assets and liabilities are recovered or paid. Deferred taxes are initially recognized at enacted tax rates in force at the time of initial recognition and are subsequently adjusted for any enacted changes in tax rates and tax laws. Subsequent changes to deferred taxes originally recognized in equity are recognized in income. Valuation allowances are recorded to reduce deferred tax assets when it is more likely than not that a tax benefit will not be realized. The Company has recorded a full valuation allowance against the deferred tax assets in excess of its deferred tax liabilities, as the deferred tax liability represents future reversals of existing taxable temporary differences. The Company records interest and penalties related to income tax matters as part of income tax expense. The Company accounts for uncertainty in income taxes by applying a two-step process to determine the amount of tax benefit to be recognized. First, the tax position must be evaluated to determine the likelihood that it will be sustained upon external examination by the taxing authorities. If the tax position is deemed more-likely-than-not to be sustained, the tax position is then assessed as the amount of benefit to recognize in the consolidated financial statements. The amount of benefits that may be used is the largest amount that has a greater than 50% likelihood of being realized upon ultimate settlement. The provision for income taxes includes the effects of any resulting tax reserves, or unrecognized tax benefits, that are considered appropriate, as well as the related net interest and penalties. At December 31, 2022 and 2021, the Company had no uncertain tax positions. Concentration of Credit Risk and of Significant Supplier Financial instruments that potentially expose the Company to concentrations of credit risk consist primarily of short-term cash deposits and accounts and other receivables. The Company's cash is comprised of short-term cash deposits at a variety of financial institutions with strong credit ratings in amounts that may exceed federally insured limits and has not experienced any losses on such accounts. Cash balances maintained during the year have been principally held with reputable U.K.-based and U.S.-based banks. The Company does not believe it is exposed to any unusual credit risk beyond the normal credit risk associated with commercial banking relationships. The Company maintains deposits in accredited financial institutions in excess of federally insured limits. The Company deposits its cash in financial institutions that it believes have high credit quality and has not experienced any losses on such accounts and does not believe it is exposed to any unusual credit risk beyond the normal credit risk associated with commercial banking relationships. The credit risk with respect to customers and funding bodies is limited as the Company has only a small number of these arrangements. The Company relies, and expects to continue to rely, on a number of vendors to conduct its clinical trials and preclinical studies, manufacture drug product and supply clinical trial and preclinical study materials for its development programs. These programs could be adversely affected by a significant interruption in these services or the availability of materials. Fair Value Measurements In accordance with the provisions of fair value accounting, a fair value measurement assumes that the transaction to sell an asset or transfer a liability occurs in the principal market for the asset or liability or, in the absence of a principal market, the most advantageous market for the asset or liability and defines fair value based on the exit price model. The fair value measurement guidance establishes a fair value hierarchy, which requires an entity to maximize the use of observable inputs and minimize the use of unobservab

Recently Issued or Adopted Acco

Recently Issued or Adopted Accounting Pronouncements	12 Months Ended
	Dec. 31, 2022
Accounting Changes and Error Corrections [Abstract]
Recently Issued or Adopted Accounting Pronouncements	Recently Issued or Adopted Accounting Pronouncements In November 2021, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") No. 2021-10, " Government Assistance (Topic 832)". This ASU increases the transparency of government assistance including the disclosure of (1) the types of assistance, (2) an entity's accounting for the assistance, and (3) the effect of the assistance on an entity's financial statements as diversity currently exists in the recognition, measurement, presentation and disclosure of government assistance received by business entities because of the lack of specific authoritative guidance in U.S. GAAP. This ASU is effective for annual periods, and interim periods within those fiscal years, beginning after December 15, 2021. Early application of this ASU is permitted. The Company applied the amendments of this ASU to its disclosures during the fourth quarter of 2021 and the application of this ASU did not have a material impact on its financial position, results of operations or cash flows. In October 2021, the FASB issued ASU No. 2021-08, "Business Combinations (Topic 805): Accounting for Contract Assets and Contract Liabilities from Contracts with Customers". This ASU improves the accounting for acquired revenue contracts with customers in a business combination by addressing diversity in practice and inconsistency relating to: 1) recognition of an acquired contract liability and 2) payment terms and their effect on subsequent revenue recognized by the acquirer. The amendments in this ASU require acquiring entities to apply Topic 606 to recognize and measure contract assets and contract liabilities in a business combination, whereas current U.S. GAAP requires that the acquirer measure such assets and liabilities at fair value on the acquisition date. This ASU is effective for annual periods, and interim periods within those fiscal years, beginning after December 15, 2022. The Company will apply this ASU on a prospective basis for business combinations once this ASU is effective and at that time, will be able to determine the potential impact on its financial position, results of operations or cash flows. In May 2021, the FASB issued AS No. 2021-04, "Earnings Per Share (Topic 260), Debt - Modifications and Extinguishments (Subtopic 470-50), Compensation - Stock Compensation (Topic 718), and Derivatives and Hedging Contracts in Entity's Own Equity (Subtopic 815-40) - Issuer's Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options". This ASU provides clarification and reduces diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options (such as warrants) that remain equity classified after modification or exchange. This ASU is effective for annual periods, and interim periods within those fiscal years, beginning after December 15, 2021. The Company will apply this ASU on a prospective basis for any modifications or exchanges once this ASU is effective and at that time, will be able to determine the potential impact on its financial position, results of operations or cash flows. In December 2019, the FASB issued ASU No. 2019-12, "Income Taxes (Topic 740)". This ASU simplifies the accounting for income taxes by removing certain exceptions to the general principles in Topic 740. The amendments also improve consistent application and simplify U.S. GAAP for other areas of Topic 740 by clarifying and amending existing guidance. This ASU is effective for annual periods, and interim periods within those fiscal years, beginning after December 15, 2020. The Company adopted this ASU during the first quarter of 2021 and the adoption of this ASU did not have a material impact on its financial position, results of operations or cash flows.

Segment Reporting

Segment Reporting	12 Months Ended
	Dec. 31, 2022
Segment Reporting [Abstract]
Segment Reporting	Segment Reporting The Company's chief operating decision makers (the "CODM function"), which are the Company's Co-CEOs, Mr. Duggan and Dr. Zanganeh, utilize consolidated financial information to make decisions about allocating resources and assessing performance for the entire Company. The CODM function approves of key operating and strategic decisions, including key decisions in clinical development and clinical operating activities, entering into significant contracts, such as revenue contracts and collaboration agreements and approves the Company's consolidated operating budget. The CODM function views the Company's operations and manages its business as a single reportable operating segment. The Company's single operating segment covers the Company’s research and development activities, primarily comprising of oncology product research activities (including ivonescimab), antibiotic pipeline research activities, and CDI program activities. As the Company operates in one operating segment, all required financial segment information can be found in the consolidated financial statements. The Company operates in two geographic regions: the U.K. and the U.S. The following table summarizes the Company's long-lived assets, which include the Company's property and equipment, net and right-of-use assets by geography: Year Ended December 31, 2022 Year Ended December 31, 2021 United Kingdom $ 2,517 $ 2,762 United States (1) 2,564 722 $ 5,081 $ 3,484 (1) The increase of long-lived assets in the United States is primarily attributed to additional right-of-use assets recorded related to the Company's first and second amendments to its sublease agreement during the period for its Menlo Park, California, U.S. location. For details of revenue from external customers by geography refer to Note 7.

Revenue

Revenue	12 Months Ended
	Dec. 31, 2022
Revenue from Contract with Customer [Abstract]
Revenue	Revenue The following table summarizes revenue by category: Year Ended December 31, 2022 Year Ended December 31, 2021 Licensing agreements $ 705 $ 1,809 Revenue recognized consists of amounts received from the Company's license and commercialization agreement with Eurofarma Laboratórios S.A. The following table summarizes revenue by geography: Year Ended December 31, 2022 Year Ended December 31, 2021 Latin America $ 705 $ 1,809 The analysis of revenue by geography has been identified on the basis of the geographical location of each collaboration partner. The following table summarizes the deferred revenue relating to Eurofarma Laboratórios S.A. and deferred other income relating to BARDA (as defined in Note 8): 2022 2021 Beginning deferred revenue and other income, January 1 (1) $ 7,939 $ 8,939 Additions 1,397 5,443 Amount of deferred revenue and other income recognized in the statement of operations (8,790) (6,438) Foreign currency adjustment (546) (5) Ending deferred revenue and other income, December 31 (2) $ — $ 7,939 __________ (1) Beginning deferred revenue and other income as of January 1, 2022 and 2021 included $7,939 of current and $0 of long-term deferred revenue and other income, and $8,370 of current and $569 of long-term deferred revenue and other income, respectively. (2) Ending deferred revenue and other income as of December 31, 2022 and 2021 included $0 of current and $0 of long-term deferred revenue and other income, and $7,939 of current and $0 of long-term deferred revenue and other income, respectively. As of January 1, 2022, deferred revenue and other income is compromised of $756 and $7,183 relating to Eurofarma and BARDA, respectively. As of December 31, 2022, deferred revenue was $0. Refer to Note 8 below for further details regarding other income recognized under the BARDA contract. Eurofarma Laboratórios S.A. On December 21, 2017, Summit announced it had entered into an exclusive license and commercialization agreement with Eurofarma Laboratórios S.A. ("Eurofarma"), pursuant to which the Company granted Eurofarma the exclusive right to commercialize ridinilazole in specified countries in South America, Central America and the Caribbean. The Company has retained commercialization rights in the rest of the world. Under the terms of the license and commercialization agreement with Eurofarma, the Company received an upfront payment of $2,500 in December 2017. In February 2020, the Company reached the first enrollment milestone and earned $1,000. In September 2021, the Company reached the second enrollment milestone and earned $1,250. The terms of the contract have been assessed under ASC 606 and currently only the upfront payment and the first two enrollment milestone payments are included in the transaction price. These payments were initially reported as deferred revenue in the balance sheet and were recognized as revenue ratably over the performance period. Revenue recognized during the years ended December 31, 2022 and 2021 related to the upfront payment and the first two enrollment milestones earned in accordance with the Company's revenue recognition policy. The revenue was recognized ratably over the determined performance period to reflect the transfer of control to the customer occurring over the time period that the research and development services were provided by the Company. This output method is, in management’s judgment, the best measure of progress towards satisfying the performance obligation. As of December 31, 2022 and 2021, the current contract liability relating to the Eurofarma contract was $0 and $756, respectively, and was recorded in current deferred revenue in the consolidated balance sheet. As of December 31, 2022, the Company has recognized $4,678 of cumulative income since inception.

Other Operating Income

Other Operating Income	12 Months Ended
	Dec. 31, 2022
Other Income and Expenses [Abstract]
Other Operating Income	Other Operating Income The following table sets forth the components of other operating income by category: Year Ended December 31, 2022 Year Ended December 31, 2021 Other operating income by category: Funding income from BARDA (as defined below) $ 8,085 $ 4,604 Research and development tax credits 4,523 15,206 Grant income from CARB-X (as defined below) 1,808 1,158 $ 14,416 $ 20,968 BARDA (as defined below) In September 2017, the Company was awarded a funding contract from the Biomedical Advanced Research and Development Authority ("BARDA"), part of the Office of the Assistant Secretary for Preparedness and Response at the United States Department of Health and Human Services, in support of the Company's Ri-CoDIFy clinical trials and clinical development of of ridinilazole. The awarded contract was originally worth up to $62,000. In June 2019 and again in January 2020, BARDA increased the value of the contract such that it is now worth up to $72,500 and brought the total amount of committed funding to $62,400. The remaining federal government funding is dependent on BARDA in its sole discretion exercising the final independent option work segment, upon the achievement by the Company of certain agreed-upon milestones for ridinilazole. This option work segment was never exercised by BARDA. The contract ran through April 2022 and was extended through December 2022 as a no cost contract, solely to close out open activities. As of December 31, 2022, based on translation of historical foreign currency amounts in the period of recognition, the Company has recognized $59,203 of cumulative income since contract inception. As a result of the Company's decision, on September 28, 2022, to not pursue further internal clinical development of ridinilazole and seek partners or a divestiture related to ridinilazole as a path forward for the clinical development of the asset, the Company recorded expenses for the remaining clinical trial costs associated with the close out activities of ridinilazole and recognized the remainder of the deferred income that had been received from BARDA prior to the expenses being recognized during the third quarter of 2022. Research and development credits Income from tax credits, consist of R&D tax credits received in the U.K. The Company benefits from two U.K. research and development tax credit cash rebate regimes: Small and Medium Enterprise Program ("SME, Program") and the Research and Development Expenditure Credit Program ("RDEC Program"). Qualifying expenditures largely comprise of employment costs for research staff, consumables, a proportion of relevant, permitted sub-contract costs and certain internal overhead costs incurred as part of research projects for which the Company does not receive income. Tax credits related to the SME Program and RDEC Program are recorded as other operating income in the consolidated statements of operations and other comprehensive loss. Under both schemes, the Company receives cash payments that are not dependent on the Company’s pre-tax net income levels. Based on criteria established by His Majesty’s Revenue and Customs ("HMRC"), a portion of expenditures being carried out in relation to the Company's pipeline research and development, clinical trials management and third-party manufacturing development activities are eligible for the SME regime and the Company expects such elements of research and development expenditure incurred in its UK entities will also continue to be eligible for the SME regime for future periods. As of December 31, 2022 and 2021, the current research and development tax credit receivable was $5,766 and $15,695, respectively. CARB-X (as defined below) In May 2021, the Company announced the selection of a new preclinical candidate, SMT-738, from the DDS-04 series for development in the fight against multi-drug resistant infections, specifically Carbapenem-resistant Enterobacteriaceae ("CRE") infections. Simultaneously, the Company announced it had received an award from the Trustees of Boston University under the Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator program ("CARB-X") to progress this candidate through preclinical development and Phase Ia clinical trials. The award commits initial funding of up to $4,100, with the possibility of up to another $3,700 based on the achievement of future milestones. As of December 31, 2022, based on translation of historical foreign currency amounts in the period that the amounts were recognized, the Company has recognized $2,875 of cumulative income since contract inception. During the quarter ended September 30, 2022, CARB-X announced changes to its funding arrangements and terms and conditions. As a result, the current arrangement concluded as of June 30, 2022, however the Company has the ability to recognize reimbursements for any milestone payments related to work incurred subsequent to this date in accordance with this agreement.

Other Expense, net

Other Expense, net	12 Months Ended
	Dec. 31, 2022
Other Income and Expenses [Abstract]
Other Expense, net	Other Expense, net The following table sets forth the components of other (expense) income: Year Ended December 31, 2022 Year Ended December 31, 2021 Foreign currency loss $ (4,109) $ (2,135) Interest expense on promissory notes payable to related parties (4,401) (242) Investment income 1,513 — Other income (expense), net 304 (39) Other Expense, net $ (6,693) $ (2,416) For the year ended December 31, 2022, other expense, net primarily consisted of unfavorable changes in foreign currency, loan interest expense incurred related to the $520,000 and $25,000 promissory notes, as described in Note 17, partially offset by investment income related to our money market funds and investments in highly liquid U.S. treasury securities, which are classified as cash equivalents as of December 31, 2022.

Income Tax

Income Tax	12 Months Ended
	Dec. 31, 2022
Income Tax Disclosure [Abstract]
Income Tax	Income Tax The components of the Company's loss before income taxes are as follows: Year Ended December 31, 2022 Year Ended December 31, 2021 United Kingdom $ (46,868) $ (72,244) United States (31,914) (16,358) Loss before income taxes $ (78,782) $ (88,602) The Company has not recognized a current or deferred provision for federal, state or non-United States income taxes in either of the years ending December 31, 2022 or December 31, 2021. Deferred taxes are recognized for temporary differences between the basis of assets and liabilities for financial statement and income tax purposes. The major components of deferred tax assets and liabilities are as follows: Year Ended December 31, 2022 Year Ended December 31, 2021 Deferred tax assets: Net operating loss carryforward $ 52,948 $ 49,422 Research and development credit carryforward 1,723 941 Stock-based compensation 3,879 2,560 Section 174 Research and Development Capitalization 3,553 — Other 2,139 1,477 Total deferred tax assets 64,242 54,400 Deferred tax liabilities: Intangible asset — (2,600) Other (226) (54) Total deferred tax liabilities (226) (2,654) Net deferred tax assets before valuation allowance 64,016 51,746 Valuation allowance (64,016) (51,746) Deferred tax, net $ — $ — For the year ended December 31, 2022 and 2021, the Company recorded a deferred tax asset of $64,242 and $54,400 respectively. The Company has evaluated the positive and negative evidence bearing upon its ability to realize its deferred tax assets, which are comprised primarily of net operating loss carryforwards and excess tax benefits related to stock-based compensation. Management has considered the Company’s history of cumulative net losses in the United States ("U.S.") and the United Kingdom ("U.K."), estimated future taxable income, as well as prudent and feasible tax planning strategies, and has concluded that it is more likely than not that the Company will not realize the benefits of its U.S. federal and state deferred tax assets and U.K. deferred tax assets. Accordingly, a full valuation allowance has been established against these net deferred tax assets as of December 31, 2022 and 2021, respectively. The Company reevaluates the positive and negative evidence at each reporting period. The Company’s valuation allowance increased during 2021 by $12,270 primarily due to the generation of net operating loss and stock-based compensation. As of December 31, 2022 and 2021, the Company had U.S. Federal gross operating loss carryforwards of approximately $11,620 and $4,921, respectively, which may be available to offset future income tax liabilities. The 2017 Tax Cuts and Jobs Act (“ TCJA”) will generally allow losses incurred after 2017 to be carried over indefinitely, but will generally limit the net operating loss deduction to the lesser of the net operating loss carryover or 80% of a corporation’s taxable income (subject to Section 382 of the Internal Revenue Code of 1986, as amended). In addition, the Company has approximately $7,278 in U.S. State gross loss carryforwards which expire through various dates through 2036 and as of December 31, 2022, the Company had an estimated U.S. federal research and development tax credit carryforwards of $1,723 which may be available to offset future tax liabilities, and each begin to expire in 2041. The Company also had approximately $199,091 in U.K. gross loss carryforwards available to use against future taxable profits on a year-by-year basis (a potential deferred tax asset of $49,773). To the extent that U.K. taxable profits exceed £5,000 in each year, the loss available to utilize against profits in excess of £5,000 will be restricted to 50%. The U.K. loss carryforwards do not lapse and therefore, the full amount will be relieved over time provided there are sufficient profits against which the losses can be utilized. Utilization of the U.S. net operating loss carryforwards and research and development tax credit carryforwards may be subject to a substantial annual limitation under Section 382 of the Internal Revenue Code of 1986 due to ownership changes that have occurred previously or that could occur in the future. These ownership changes may limit the amount of carryforwards that can be utilized annually to offset future taxable income. In general, an ownership change, as defined by Section 382, results from transactions increasing the ownership of certain shareholders or public groups in the stock of a corporation by more than 50% over a three-year period. The Company has not completed a study to assess whether a change of ownership has occurred, or whether there have been multiple ownership changes since its formation. Any limitation may result in the loss of a portion of the net operating loss carryforwards or research and development tax credit carryforwards before utilization. U.K. tax losses are subject to additional restrictions where there is a change in ownership in the business and certain other conditions are met. An ownership change of a UK tax resident company would occur where (directly or indirectly) a single person acquires more than half of the ordinary share capital of a company, or two or more persons each acquire a holding of at least 5% of the ordinary share capital of a company and these holdings together amount to more than half the ordinary share capital of a company. Where a change in ownership has occurred, and within three years prior to that change in ownership and five years afterwards, there is a major change in the nature and conduct of trade of that company or the trade of that business becomes small or negligible, any losses carried forward will be extinguished from the point of the change in ownership. In addition, losses accrued subsequent to April 1, 2017 will be extinguished on a change of ownership when there is a major change in the nature or conduct of a company’s business, or where there is a major change in the scale of that business, or a company ceases to carry on a particular trade or business. The Company has not completed a study to assess whether a change of ownership has occurred since its formation, or whether there has been a major change in the Company's business that would restrict the U.K. tax losses. Any limitation may result in the loss of a portion of the net operating loss carryforwards before utilization. The 2017 Tax Cuts and Jobs Act (“TCJA”) created a requirement that US corporations include in income earnings of certain controlled foreign corporations (“CFC”) under the global intangible low taxed income (“GILTI”) regime. Pursuant to the FASB Staff Q&A, Topic 740 No.5. Accounting for Global Intangible Low-taxed Income, the Company is allowed to make an accounting policy election to either recognize deferred taxes for temporary basis differences expected to reverse as GILTI in future years or to provide for the tax expense related to GILTI in the year the tax is incurred as period expense only. The Company has elected to account for GILTI in the year the tax is incurred and include the current tax impact of GILTI in the effective tax rate. Given the Company's loss position in the U.S. and the valuation allowance recorded against its U.S. net deferred tax assets, these provisions have not had a material impact on the Company's consolidated financial statements. IRC Section 174 generally permitted taxpayers that incurred research expenses to deduct them in the current year. For tax years beginning before January 1, 2022, taxpayers were able to make an election with respect to research and experimental (“R&E”) expenditures incurred in connection with a trade or business to either currently deduct or defer and amortize such expenditures. The TCJA amended this provision to require that R&E expenditures be capitalized and amortized, but delayed the effective date of this amendment, which applies to tax years beginning January 1, 2022 or later. As such, the changes to IRC Section 174 pursuant to the TCJA are currently applicable to the Company for the 2022 tax year. R&E expenditures attributable to U.S. based research must be amortized over a period of five years and R&E expenditures attributable to research conducted outside of the U.S. must be amortized over a period of 15 years. As such, the Company is capitalizing $14,830 R&E expenditures with a net adjustment of $13,347 to account for the capitalization and amortization of R&D expenses incurred in the U.S. On March 27, 2020, the United States enacted the Coronavirus Aid, Relief, and Economic Security Act (“CARES Act”). The Cares Act includes provisions relating to refundable payroll tax credits, deferment of the employer portion of certain payroll taxes, net operating loss carryback periods, alternative minimum tax credit refunds, modifications to the net interest deduction limitations, and technical corrections to tax depreciation methods for qualified improvement property. The CARES Act also established a Paycheck Protection Program whereby certain small businesses are eligible for a loan to fund payroll expenses, rent, and related costs. The Company considered the provisions under the CARES Act and elected not to take advantage of the provisions of the CARES Act as the effect of such provisions was not expected to have a material impact on the Company’s results of operations, cash flows, and consolidated financial statements. During 2021, the U.K. Government announced that from April 1, 2023, the corporation tax rate would increase to 25%. This new law was enacted on June 10, 2021. The overall effect of the change was an increase in net deferred tax assets by $9,311 and an increase in valuation allowance by an equal amount for the year ended December 31, 2021. No changes to this rate have been made during 2022. A reconciliation of the Company's effective tax rate to the U.S. federal statutory rate is as follows: Year Ended December 31, 2022 Year Ended December 31, 2021 U.S. federal income tax statutory rate 21.0 % 21.0 % Change in valuation allowance (16.8) (10.5) Non-deductible expenses — (0.4) Refundable research and development tax credit (3.6) (8.3) Effect of foreign operations taxed at various rates 2.1 0.5 Stock-based compensation (2.2) (1.6) Other (0.5) (0.7) — % — % In the U.K., the Company is entitled to a research and development tax relief for small and medium-sized enterprises which allows the Company an enhanced deduction rate of 230% on qualifying research and development expenditure (the tax relief). If the Company incurs tax losses, it is entitled to surrender the lesser of unrelieved tax loss sustained and the tax relief. As the realization of the tax relief does not depend on generation of future taxable income or the Company's ongoing tax status or tax position, the Company does not consider the tax relief as an element of income tax accounting under ASC 740. For the year ended December 31, 2022 and 2021, the Company recognized research and development tax relief of $4,523 and $15,206 respectively, which is included in other operating income in the consolidated statements of operations and other comprehensive loss. It is the intention of the Company to reinvest the earnings of its non-U.S. subsidiaries in those operations and not to repatriate the earnings to the U.S. Accordingly, the Company does not provide for deferred taxes on differences between financial reporting and tax basis in its investments in foreign subsidiaries as they are considered permanent in duration or are not expected to reverse in the foreseeable future. The Company does not have any uncertain tax positions as of December 31, 2022. In the U.K., tax returns for the year ended December 31, 2021 remains subject to examination by HMRC. In the U.S., the Company files income tax returns in various states. In the U.S., tax years from 2019 remain subject to examination by the U.S. Internal Revenue Service and state tax authorities. The Company is not currently under examination by the Internal Revenue Service or any other jurisdiction for years 2019 through present. To the extent the Company has tax attribute carryforwards, the tax years in which the attribute was generated may be adjusted upon examination by the Internal Revenue Service or state tax authorities to the extent utilized in a future period. The Company’s policy is to recognize interest and penalties related to uncertain tax positions as part of its income tax provision. As of December 31, 2022, and 2021, the Company has recorded no liability for unrecognized tax benefits, interest, or penalties related to federal, state or foreign income tax matters.

Loss per Share

Loss per Share	12 Months Ended
	Dec. 31, 2022
Earnings Per Share [Abstract]
Loss per Share	Loss per Share The following table sets forth the computation of basic and diluted net loss per share: Year Ended December 31, 2022 Year Ended December 31, 2021 Net loss $ (78,782) $ (88,602) Basic weighted average number of shares of common stock outstanding 193,336,063 131,714,225 Diluted weighted average number of shares of common stock outstanding 193,336,063 131,714,225 Basic net loss per share $ (0.41) $ (0.67) Diluted net loss per share $ (0.41) $ (0.67) Basic net loss per share is computed by dividing the net loss by the weighted-average number of common shares outstanding for the period. Diluted net loss per share is computed by dividing the diluted net loss by the weighted-average number of common shares outstanding for the period, including potentially dilutive common shares. Since the Company was in a loss position for all periods presented, basic net loss per share is the same as diluted net loss per share for all periods, as the inclusion of all potential common share equivalents outstanding would have been anti-dilutive. Because the Rights Offering exercise price of $1.05 per share was less than the closing price of $1.82 per share on March 1, 2023, the expiration of the Rights Offering (further detailed in Note 23), the Company has retroactively adjusted earnings per share and weighted average number of shares outstanding for the bonus element for all periods presented. The following potentially dilutive securities were excluded from the computation of the diluted net loss per share of common stock for the periods presented because their effect would have been anti-dilutive: 2022 2021 Options to purchase common stock 19,476,359 13,797,556 Warrants 5,821,137 5,821,137 Shares expected to be purchased under employee stock purchase plan 229,475 202,045 25,526,971 19,820,738

Goodwill and Intangible Assets

Goodwill and Intangible Assets	12 Months Ended
	Dec. 31, 2022
Goodwill and Intangible Assets Disclosure [Abstract]
Goodwill and Intangible Assets	Goodwill and Intangible Assets Goodwill The Company’s annual evaluation for impairment of goodwill consists of one reporting unit. In accordance with the Company’s policy, the Company completed its annual evaluation for impairment in the fourth quarter of 2022 using the qualitative assessment. No impairment charge was recognized for the year ended December 31, 2022 and there have been no cumulative goodwill impairment charges recognized to date. As of December 31, 2022 and 2021, goodwill was $1,798 and $2,009, respectively. Changes year over year are the result of foreign currency movements. Intangible Assets Components of the Company's acquired intangible assets are comprised of the following: December 31, 2022 Gross Accumulated amortization and impairment charges Net Utrophin program acquired $ 4,015 $ (4,015) $ — Discuva platform acquired 12,900 (12,900) — Option over non-financial asset 816 (816) — Other intangibles 133 (133) — $ 17,864 $ (17,864) $ — December 31, 2021 Gross Accumulated amortization and impairment charges Net Utrophin program acquired $ 4,487 $ (4,487) $ — Discuva platform acquired 14,416 (4,017) 10,399 Option over non-financial asset 912 (912) — Other intangibles 148 (148) — $ 19,963 $ (9,564) $ 10,399 In December 2017, we expanded our activities in the field of infectious diseases with the acquisition of Discuva Limited, a privately held United Kingdom-based company. Through this acquisition, we obtained a bacterial genetics platform and a suite of software-based technologies (collectively termed our “Discuva Platform”), which facilitates the discovery and development of new mechanism antibiotics. In conjunction with the significant change in the Company’s strategy and shift in focus to the therapeutic area of oncology, the Company determined that it will cease further investment in the Discuva Platform and evaluate further options for the use of the Discuva Platform. Management have concluded that this indicated the carrying amount of the acquired Discuva Platform intangible asset may not be recoverable and hence performed an assessment using a probability-weighted approach to determine the undiscounted cash flows of the asset, which indicated that an impairment exists. Based on the assessment to compare the fair value of the asset to its carrying amount, an impairment charge of $8.5 million was recognized during the year ended December 31, 2022, representing the aggregate carrying value of the intangible asset. This impairment charge is presented as impairment of intangible assets

Cash Equivalents and Fair Value

Cash Equivalents and Fair Value Measurements	12 Months Ended
	Dec. 31, 2022
Fair Value Disclosures [Abstract]
Cash Equivalents and Fair Value Measurements	Cash Equivalents and Fair Value Measurements The following tables set forth the fair value of the Company's financial assets measured at fair value on a recurring basis and indicates the level within the fair value hierarchy utilized to determine such values: Fair Value Measurements as of December 31, 2022 using: Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 60,783 $ — $ — $ 60,783 U.S. Government treasury bills $ — $ 225,730 $ — $ 225,730 Total financial assets $ 60,783 $ 225,730 $ — $ 286,513 The table above does not include cash at December 31, 2022 of $62,094. There were no cash equivalents held by the Company as of December 31, 2021. Cash at December 31, 2021 was $71,791. The Company's financial instruments include cash and cash equivalents and restricted cash. Cash consists of non-interest-bearing deposits denominated in the U.S. dollar, British pound and Euro, while cash equivalents consists of interest-bearing money market fund deposits denominated in the U.S. dollar and U.S. treasury bills, and restricted cash consists of interest-bearing deposits denominated in the U.S. dollar. The Company believes that the carrying amounts of prepaid expenses, other current assets, accounts payable, and accrued expenses approximates their fair values due to the short-term nature of those instruments. The carrying value of the Company’s promissory notes approximates its fair value due to the recent issuance of the notes in December 2022 when compared to market interest rates (which represents a Level 2 measurement).

Property and Equipment

Property and Equipment	12 Months Ended
	Dec. 31, 2022
Property, Plant and Equipment [Abstract]
Property and Equipment	Property and Equipment Property and equipment consisted of the following: December 31, 2022 December 31, 2021 Laboratory equipment $ 505 $ 546 Furniture and fixtures, office equipment and software 889 819 Leasehold improvements 809 365 Property and equipment, gross 2,203 1,730 Less: accumulated depreciation 1,297 1,036 Property and equipment, net $ 906 $ 694 Depreciation expense for the years ended December 31, 2022 and 2021 was $349 and $330, respectively.

Research and Development Prepai

Research and Development Prepaid Expenses and Accrued Liabilities	12 Months Ended
	Dec. 31, 2022
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Research and Development Prepaid Expenses and Accrued Liabilities	Research and Development Prepaid Expenses and Accrued LiabilitiesIncluded within prepaid expenses at December 31, 2022 and 2021 is $442 and $6,138, respectively, of prepayments relating to research and development expenditures. Included within accrued liabilities at December 31, 2022 and 2021 is $8,911 and $5,226, respectively, relating to research and development expenditures.These amounts are determined based on the estimated costs to complete each study or activity, the estimation of the current stage of completion and the invoices received, as well as predetermined milestones which are not reflective of the current stage of development for prepaid expenses. However, prepaid expenses decrease and accrued liabilities increase as the activities progress, and if actual costs incurred exceed the prepaid expense, an accrual will be recorded for the liability. The key sensitivity is the estimated current stage of completion of each study or activity, which is based on information received from the supplier and the Company's operational knowledge of the work completed under those contracts.

Leases

Leases	12 Months Ended
	Dec. 31, 2022
Leases [Abstract]
Leases	Leases The Company has operating leases for real estate. The Company does not have any finance leases. During the year ended December 31, 2022, the Company recorded $2,860 of additional right-of-use assets of which $2,755 related to the first and second amendments to its sublease agreement during the period for its Menlo Park, California, United States location and $105 which related to a remeasurement of the right of use asset and lease liability following a contractual rent review resulting in an increase in rent payments during the period for its Oxfordshire, United Kingdom location. The carrying value of the right-of-use assets as of December 31, 2022 and 2021 is $4,175 and $2,790 , respectively. The elements of lease expense were as follows: Lease Cost: Year Ended December 31, 2022 Year Ended December 31, 2021 Fixed lease costs $ 1,384 $ 785 Variable lease costs 137 164 Short-term lease (1) 31 278 Total lease cost $ 1,552 $ 1,227 (1) Short-term lease costs relate to the Company's Cambridge, Massachusetts, United States office lease which the Company exited during fiscal year 2022. The weighted average discount rate and the weighted average remaining lease term were 5.7% and 3.4 years, respectively, as of December 31, 2022. The weighted average discount rate and the weighted average remaining lease term were 2.5% and 3.9 years, respectively, as of December 31, 2021. The Company made cash payments related to lease liabilities of $1,092 and $1,041 for the years ending December 31, 2022 and 2021 respectively. Future lease payments under non-cancelable leases as of December 31, 2022 are detailed as follows: Year Ending December 31, 2023 $ 1,474 2024 1,502 2025 1,533 2026 381 Total lease payments 4,890 Less: imputed interest 437 Total operating lease liabilities $ 4,453 Total operating lease liabilities balance sheet presentation: Current lease liabilities $ 1,690 Non-current lease liabilities 2,763 $ 4,453

Promissory Notes Payable to Rel

Promissory Notes Payable to Related Parties	12 Months Ended
	Dec. 31, 2022
Related Party Transactions [Abstract]
Promissory Notes Payable to Related Parties	Promissory Notes Payable to Related Parties Non-current and current debt consisted of the following: Current notes Non-current notes December 31, 2022 December 31, 2021 December 31, 2022 December 31, 2021 Principal amounts $ 20,000 $ — $ 500,000 — Debt discount (230) — (5,460) $ — Total promissory notes payable to related parties $ 19,770 $ — $ 494,540 $ — March 2022 Promissory Note On March 10, 2022, Mr. Duggan, entered into a Note Purchase Agreement (the “March 2022 Note”), pursuant to which he loaned the Company $25,000 in exchange for the issuance by the Company of an unsecured promissory note in the amount of $25,000. The March 2022 Note accrued interest at a rate per annum equal to the prime rate as reported in the Wall Street Journal . The March 2022 Note, including all accrued interest, became due upon the earlier of (i) the consummation of a registered public offering with net proceeds of no less than $25,000 or (ii) 18 months from the date of issuance of the March 2022 Note. Debt issuance costs associated with the March 2022 Note were immaterial and expensed as incurred. The March 2022 Note of $25,000, plus accrued interest of $434 has been repaid to Mr. Duggan on August 10, 2022 in connection with the completion of the rights offering with aggregate gross proceeds of $100,000. The Company incurred interest expense of $1,296 for the year ended December 31, 2022, which included amortized imputed interest of $861 for the year ended December 31, 2022. December 2022 Promissory Notes On December 6, 2022, the Company entered into a Note Purchase Agreement (the "Note Purchase Agreement"), with Mr. Duggan and Dr. Zanganeh, pursuant to which the Company agreed to sell to each of Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the aggregate amount of $520,000. Pursuant to the Note Purchase Agreement, the Company issued to Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the amount of $400,000 (the "Duggan February Note") and $20,000 (the "Zanganeh Note"), respectively, which would mature and become due on February 15, 2023 and an unsecured promissory note to Mr. Duggan in the amount of $100,000 (the “Duggan September Note” and together with the Duggan February Note and the Zanganeh Note, the “December 2022 Notes”), which will mature and become due on September 15, 2023. The maturity dates of the December 2022 Notes could be extended one or more times at the Company’s election, but in no event to a date later than September 6, 2024. In addition, if the Company shall consummate a public offering, then upon the later to occur of (i) five On January 19, 2023, the Company provided notice to extend the term of the Duggan February Note and Duggan September Note to a maturity date of September 6, 2024. Furthermore, on January 19, 2023, the Company and Mr. Duggan rectified the Duggan February Note and Duggan September Note in order to correctly reflect the parties’ intent that the Company may only prepay (i) the Duggan February Note following the completion of a public rights offering to be conducted by Summit in the approximate amount of $500,000 (the “Rights Offering”), or a similar capital raise, in an amount equal to the lesser of (x) the net proceeds of the Rights Offering or such capital raise or (y) the full amount outstanding of the Duggan February Note, and (ii) Duggan September Note following the completion of a capital raising transaction subsequent to the Rights Offering in an amount equal to the lesser of (i) the net proceeds of such capital raise or (ii) the full amount outstanding of the Duggan September Note. Following the issuance of the two new Promissory Notes (the “Duggan Promissory Notes”), the Duggan February Note and Duggan September Note were marked as “cancelled” on their face and replaced in their entirety by the Duggan Promissory Notes (together with the Zanganeh Note, the "Notes"). The Notes accrue interest at an initial rate of 7.5%. All interest on the Notes shall be paid on the date of signing for the period through February 15, 2023. Such prepaid interest shall be paid in a number of shares of the Company’s common stock, par value $0.01 (“Common Stock”) equal to the dollar amount of such prepaid interest, divided by $0.7913 (the consolidated closing bid price immediately preceding the time the Company entered into the Note Purchase Agreement, plus $0.01), which was 9,720,291 shares. For all applicable periods following the February 15, 2023, interest shall accrue on the outstanding principal balance of the Notes at the US prime interest rate, as reported in the Wall Street Journal, plus 50 basis points, as adjusted monthly, for three months immediately following February 15, 2023, and thereafter at the US prime rate plus 300 basis points, as adjusted monthly. Debt issuance costs associated with the Notes were $44 and we capitalized as part of the carrying value of the promissory notes payable to related parties. The Company incurred interest expense of $3,105 for the year ended December 31, 2022, which included amortized imputed interest of $395. Imputed interest is calculated as the difference between the expected interest payable and the deemed market rate of interest and is recorded as a debt discount at inception of the note payable with a credit to additional paid-in capital for notes payable to related parties. The debt discount is amortized to interest expense using an effective interest rate method. The effective interest rate of the Duggan February Note and Zanganeh Note was 8.7% and the effective interest rate of the Duggan September Note was 8.8%. The Company incurred interest expense of $244 for the year ended December 31, 2021, which included amortized imputed interest $159 for the year ended December 31, 2021, respectively, related to the March 24, 2021 Note Purchase Agreement with Mr. Duggan, for $55,000 which was subsequently rescinded and replaced by a second note on April 20, 2021, of the same amount, and paid in full in May 2021, as described further in Note 22. As of December 31, 2022, and reflecting the Company's election to extend the term of the Duggan February Note and the Duggan September Note, the estimated future principal payments due were as follows: Year Ending December 31, 2023 $ 20,000 2024 500,000 $ 520,000 On February 15, 2023, the $20,000 Zanganeh Note matured and the Company repaid the outstanding principal balance. In connection with the closing of the rights offering, the $400,000 Duggan Promissory Note matured and became due, and the Company repaid all principal and accrued interest thereunder using a portion of the proceeds from this rights offering. March 24, 2021 Note Purchase Agreement On March 24, 2021, Mr. Duggan, the Company's Executive Chairman and Chief Executive Officer and primary stockholder, entered into a Note Purchase Agreement (the “Initial Purchase Agreement”) pursuant to which he loaned the Company $55,000 in exchange for the issuance by the Company of an unsecured promissory note (the “Initial Note”) in the amount of $55,000. The Initial Note was to accrue interest at a rate per annum equal to 150% of the applicable 10 Year United States Treasury rate, as adjusted monthly. The rate was initially estimated to be approximately 2.4%. The terms of the Initial Note were that it would mature and become due upon the earlier of (i) the consummation of a registered public offering with net proceeds of no less than $55,000, or (ii) 13 months from the date of issuance of the Initial Note. On April 20, 2021, the Company determined, with Mr. Duggan’s agreement, to rescind both the Initial Purchase Agreement and the Initial Note issued thereunder, and repaid the principal amount of the Initial Note in full, without interest or penalty. April 20, 2021 Note Purchase Agreement On April 20, 2021, subsequent to the repayment of the Initial Note, Mr. Duggan entered into a second Note Purchase Agreement (the “Second Purchase Agreement”) pursuant to which he loaned the Company $55,000 in exchange for the issuance by the Company of an unsecured promissory note (the “Second Note”) in the amount of $55,000. The Second Note accrued interest at a rate per annum equal to 150% of the applicable 10 Year United States Treasury rate, as adjusted monthly (initially estimated to be approximately 2.4%). The Company was permitted to prepay any portion of the Second Note at its option without penalty. May 12, 2021 Rights Offering ("2021 Rights Offering") On May 12, 2021, the Company closed its 2021 Rights Offering, which was fully subscribed. Aggregate gross proceeds from the 2021 Rights Offering were $75,000 from the sale of 14,312,976 shares of the Company's common stock, of which 11,365,921 shares were purchased by Mr. Duggan and 389,977 shares were purchased by Dr. Zanganeh, at price of $5.24 per share. In connection with the closing of the 2021 Rights Offering, the Second Note, issued by the Company to Mr. Duggan, matured and became due and was repaid using a portion of the proceeds from the 2021 Rights Offering. March 26, 2021 Sublease Agreement with Maky Zanganeh and Associates, Inc. On March 26, 2021, the Company entered into a sublease with Maky Zanganeh and Associates, Inc. ("MZA") consisting of 4,500 square feet of office space at 2882 Sand Hill Road, Menlo Park, California (the “Sublease”). Dr. Zanganeh, the Company's Co-Chief Executive Officer and President, is the sole owner of MZA. The sublease ran until September 2022. The rent payable under the terms of the sublease was equivalent to the proportionate share of the rent payable by MZA to the third-party landlord, based on the square footage of office space sublet by the Company, and no mark-up has been applied. During the years ended December 31, 2022 and 2021, payments of $544 and $556, were made pursuant to the sublease. July 25, 2022 First Amendment to Sublease Agreement with Maky Zanganeh and Associates, Inc. On July 25, 2022 the Company entered into a first amendment, dated July 19, 2022, to its existing sublease agreement with MZA, described above. The existing sublease term, which was set to expire on September 30, 2022, was extended for a period of thirty-nine months from October 1, 2022 through December 31, 2025. The rent payable under the terms of the sublease is equivalent to the proportionate share of the net payable by MZA to the third-party landlord, based on the square footage of office space sublet by the Company, and no mark-up has been applied. July 29, 2022 Second Amendment to Sublease Agreement with Maky Zanganeh and Associates, Inc. On July 29, 2022, the Company entered into a second amendment, dated August 1, 2022, to its existing sublease agreement with MZA, described above. The second amendment was effective as of August 1, 2022 and expires on December 31, 2025. The second amendment includes an additional 1,277 square feet (the "Expansion Premises") of office space at 2882 Sand Hill Road, Menlo Park, California. The rent payable under the terms of the sublease is equivalent to the proportionate share of the net payable by MZA to the third-party landlord, based on the square footage of office space sublet by the Company, and no mark-up has been applied. During the year ended December 31, 2022 payments of $54, were made pursuant to the secondment amendment to the sublease. March 10, 2022 Note Purchase Agreement On March 10, 2022, the Company entered into a Note Purchase Agreement (the "March 2022 Note"), with Mr. Duggan, pursuant to which Mr. Duggan loaned the Company $25,000 in exchange for the issuance by the Company of an unsecured promissory note in the amount of $25,000. The March 2022 Note accrued interest at a rate per annum equal to the prime rate as reported in the Wall Street Journal , which was 3.25% as of the effective date and 4.75% as of June 30, 2022. The March 2022 Note, including accrued interest, became due upon the earlier of (i) the consummation of a registered public offering with net proceeds of no less than $25,000 or (ii) 18 months from the date of issuance of the March 2022 Note, and was repaid on August 10, 2022. 2022 Rights Offering ("2022 Rights Offering") In August 2022, the Company announced the closing and final results of its previously announced rights offering. The 2022 Rights Offering commenced on July 18, 2022, and the associated subscription rights expired on August 8, 2022. Aggregate gross proceeds received from the rights offering were $100,000 from the sale of 103,092,783 shares of common stock. Mr. Duggan and Dr. Zanganeh fully subscribed to their respective basic subscription rights and oversubscribed, at a price of $0.97 per share. Issuance costs were $111. In connection with the closing of the 2022 Rights Offering, the March 2022 Note matured and became due, and the Company repaid all principal and accrued interest thereunder using a portion of the proceeds from the 2022 Rights Offering on August 10, 2022. December 6, 2022 Note Purchase Agreement On December 6, 2022, the Company entered into a Note Purchase Agreement (the "Note Purchase Agreement"), with Mr. Duggan and Dr. Zanganeh, pursuant to which the Company agreed to sell to each of Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the aggregate amount of $520,000. Pursuant to the Note Purchase Agreement, the Company issued to Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the amount of $400,000 (the "Duggan February Note") and $20,000 (the "Zanganeh Note"), respectively, which would mature and become due on February 15, 2023 and an unsecured promissory note to Mr. Duggan in the amount of $100,000 (the “Duggan September Note” and together with the Duggan February Note and the Zanganeh Note, the “December 2022 Notes”), which will mature and become due on September 15, 2023. The maturity dates of the December 2022 Notes could be extended one or more times at the Company’s election, but in no event to a date later than September 6, 2024. In addition, if the Company shall consummate a public offering, then upon the later to occur of (i) five On January 19, 2023, the Company provided notice to extend the term of the Duggan February Note and Duggan September Note to a maturity date of September 6, 2024. Furthermore, on January 19, 2023, the Company and Mr. Duggan rectified the Duggan February Note and Duggan September Note in order to correctly reflect the parties’ intent that the Company may only prepay (i) the Duggan February Note following the completion of a public rights offering to be conducted by Summit in the approximate amount of $500,000 (the “Rights Offering”), or a similar capital raise, in an amount equal to the lesser of (x) the net proceeds of the Rights Offering or such capital raise or (y) the full amount outstanding of the Duggan February Note, and (ii) Duggan September Note following the completion of a capital raising transaction subsequent to the Rights Offering in an amount equal to the lesser of (i) the net proceeds of such capital raise or (ii) the full amount outstanding of the Duggan September Note. Following the issuance of the two new Promissory Notes (the “Duggan Promissory Notes”), the Duggan February Note and Duggan September Note were marked as “cancelled” on their face and replaced in their entirety by the Duggan Promissory Notes (together with the Zanganeh Note, the "Notes"). The Notes accrue interest at an initial rate of 7.5%. All interest on the Notes shall be paid on the date of signing for the period through February 15, 2023. Such prepaid interest shall be paid in a number of shares of the Company’s common stock, par value $0.01 (“Common Stock”) equal to the dollar amount of such prepaid interest, divided by $0.7913 (the consolidated closing bid price immediately preceding the time the Company entered into the Note Purchase Agreement, plus $0.01), which was 9,720,291 shares. For all applicable periods following the February 15, 2023, interest shall accrue on the outstanding principal balance of the Notes at the United States prime interest rate, as reported in the Wall Street Journal, plus 50 basis points, as adjusted monthly, for three months immediately following February 15, 2023, and thereafter at the United States prime rate plus 300 basis points, as adjusted monthly.

Other Non-Current Liabilities

Other Non-Current Liabilities	12 Months Ended
	Dec. 31, 2022
Payables and Accruals [Abstract]
Other Non-Current Liabilities	Other Non-Current Liabilities Included within other non-current liabilities at December 31, 2022 and 2021 is $1,209 and $2,531, respectively, relating to assumed contingent liabilities. As part of the acquisition of Discuva Limited in December 2017, the Company assumed certain contingent liabilities as certain employees, former employees and former directors of Discuva Limited are eligible for payments from Discuva Limited based on specified development and clinical milestones related to proprietary product candidates developed under the Discuva Platform. The timing of these potential payments is uncertain. In conjunction with the significant change in the Company’s strategy and shift in focus to the therapeutic area of oncology, the Company determined that it will cease further investment in the Discuva platform and evaluate further options for the use of the Discuva Platform. As a result, management has revised the estimated presented value of these payments and remeasured the contingent liabilities. This resulted in recording a gain on remeasurement of liabilities of $1,265 during the year ended December 31, 2022, which is included net as part of the research and development expenses in the consolidated statement of operations and comprehensive loss. There were no remeasurement losses or gains recognized during the year ended December 31, 2021.

Stockholders' Equity

Stockholders' Equity	12 Months Ended
	Dec. 31, 2022
Equity [Abstract]
Stockholders' Equity	Stockholders' Equity Common Stock In August 2022, the Company announced the closing of its 2022 rights offering ("2022 Rights Offering). The rights offering commenced on July 18, 2022, and the associated subscription rights expired on August 8, 2022. The 2022 Rights Offering received aggregate gross proceeds of $100,000 from the sale of 103,092,783 shares of common stock. Mr. Duggan and Dr. Zanganeh fully subscribed to their respective basic subscription rights and oversubscribed, at a price per share of $0.97. Offering costs of $111 were incurred. On May 12, 2021, the Company closed its rights offering ("2021 Rights Offering"), which was fully subscribed and received aggregate gross proceeds of $75,000 from the sale of 14,312,976 shares of common stock to existing investors at a price per share of $5.24. Offering costs of $159 were incurred. Warrants As part of the private placement on December 24, 2019, the participating investors were granted warrants with the right to subscribe for 5,261,350 shares of common stock at an exercise price of $1.58, exercisable any time in the period commencing on the date falling six months following December 24, 2019 and ending on the tenth anniversary of admission. Each warrant entitles the warrant holder to subscribe in cash for one share. Shares of common stock allotted pursuant to the exercise of the warrant will rank in full for all dividends and other distributions with a record date after the exercise date with the shares of common stock in issue at that date. The Company has the option to require the warrant holder to exercise some or all of the outstanding warrants after the third anniversary date if the ten-day volume weighted average price of the shares of common stock as reported on Nasdaq represents a premium of at least 50 percent to the exercise price. The warrants are classified within stockholders’ equity as they are indexed to the Company's shares of common stock and require settlement in its shares of common stock with no provision for any cash settlement. Also, as part of the private placement on December 24, 2019, certain consultants were granted warrants with the right to subscribe for 3,358,732 shares of common stock in exchange for certain services. The warrants have an exercise price of $1.44 and vest quarterly over three years. If the consulting agreement terminated prior to three years after the date of the grant, all unvested warrants will be deemed cancelled. On June 30, 2020, the consulting agreement was terminated and 2,798,945 warrants cancelled immediately. The remaining 559,787 of outstanding warrants are held by Dr. Zanganeh and Dr. Elaine Stracker. Warrants granted over shares of common stock to consultants in exchange of certain services are similar to stock-based compensation (see Note 20). The Company had 5,821,137 total warrants outstanding as of December 31, 2022 and 2021, respectively, and an intrinsic value of $15,640 as of December 31, 2022 and $6,559 as of December 31, 2021. Dividends

Stock-Based Compensation

Stock-Based Compensation	12 Months Ended
	Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]
Stock-Based Compensation	Stock-Based Compensation 2016 Long Term Incentive Plan Upon the effectiveness of the 2020 Stock Incentive Plan, no additional grants will be made under the 2016 Long Term Incentive Plan, (the "2016 Plan") and any outstanding awards continue with their original terms. 2020 Stock Award Plan In September 2020, the Company’s Board of Directors approved the 2020 Stock Incentive Plan (the “2020 Plan”), which became effective on September 21, 2020. The 2020 plan provides for the grant of incentive stock options, non-qualified stock options, stock appreciation rights, restricted stock, restricted stock units and other stock-based awards. A total of 8,000,000 shares of common stock were initially reserved for issuance under the 2020 Plan. Additionally, up to 5,000,000 shares of common stock, including RSUs can be added to the 2020 Plan for future issuance from options that expire, lapse or are terminated from the 2016 Plan or any other predecessor plans. The number of shares of common stock that may be issued under the 2020 Plan will automatically increase on each January 1, beginning in 2021 and continuing for each fiscal year until, and including, the fiscal year ending December 31, 2030, equal to the lesser of (i) 6,400,000 shares of common stock, (ii) 4% of the common shares outstanding on the final day of the immediately preceding calendar year and (iii) an amount as determined by the Company’s Board of Directors. On July 27, 2022, the Company held a Special Meeting of Stockholders (the "Special Meeting") whereby the following matters were submitted to a vote of the Company's stockholders at the Special Meeting and the Board of Directors resolved the following: (i) an amendment to the Company's Restated Certificate of Incorporation, dated September 18, 2020, to increase the number of authorized shares of common stock by 100,000,000 (from 250,000,000 to 350,000,000); and (ii) an amendment to the Summit Therapeutics Inc. 2020 Stock Incentive Plan (the "Plan") to increase the number of shares of the Company's common stock issuable under the Plan by 8,000,000 shares. As of December 31, 2022, there are 5,879,768 shares available to be issued under the 2020 Plan. 2020 Employee Stock Purchase Plan The 2020 Employee Stock Purchase Plan (the "2020 ESPP") was adopted by the Board of Directors and approved by the Company's shareholders on July 17, 2020 and approved by the predecessor company shareholders on August 19, 2020 and is qualified under Section 423 of the Internal Revenue Code. The 2020 ESPP initially authorized the issuance of up to 1,000,000 shares of common stock to participating employees. The number of common shares that may be issued under the 2020 ESPP automatically increases on each fiscal year commencing January 1, 2021 and continuing for each fiscal year until, and including the fiscal year commencing on, January 1, 2030 equal to the lesser of (i) 1,600,000 shares of common stock, (ii) 1% of the common shares outstanding on such date and (iii) an amount as determined by the Company’s Board of Directors. As of December 31, 2022, there were 2,628,893 shares available to be issued under the 2020 ESPP. The first offering period of the 2020 ESPP plan consisted of seven months, commencing on August 2, 2021 and completed on February 28, 2022. The second offering period commenced on March 1, 2022 and was completed on August 31, 2022. Offering periods thereafter will be six months in duration and will commence immediately proceeding the end of the previous offering period, unless otherwise determined by the Board of Directors or Compensation Committee. Under the 2020 ESPP, eligible employees can purchase shares of common stock through payroll deductions of up to 15% of their compensation received during the plan period or such shorter period during which deductions from payroll are made, up to a defined maximum amount. The option price is determined based on the lesser of the closing price of common stock on (i) the first business day of the plan period or (ii) the exercise date, or shall be based solely on the closing price of the common stock on the exercise date; provided that such option price shall be at least 85% of the applicable closing price. In the absence of a determination by the Board of Directors or the Compensation Committee, the option price is 85% of the lesser of the closing price of the common stock on (i) the first business day of the plan period or (ii) the exercise date. The closing price is the (a) the closing price (for the primary trading session) on the Nasdaq Global Select Market or (b) the average of the closing bid and asked prices in the over-the-counter-market, whichever is applicable, as published in the Wall Street Journal or another source selected by the Board or the Committee. During the fiscal year ended December 31, 2022, 176,857 shares were issued under the 2020 ESPP. As the first offering period of the 2020 ESPP plan completed during the fiscal year ended December 31, 2022, no shares were issued under the 2020 ESPP during the fiscal year ended December 31, 2021. Stock Option Valuation The Company estimates the fair value of stock options granted to employees and directors using the Black-Scholes valuation model. Stock options granted under the 2016 and 2020 Plans generally vest over three The assumptions used in the Company's valuation are summarized as follows, presented on a weighted average basis: Year Ended December 31, 2022 Year Ended December 31, 2021 Risk-free interest rate 3.11 % 1.05 % Expected term (in years) 5.9 5.7 Expected volatility 91.2 % 74.5 % Expected annual dividends per share — % — % The following table summarizes the Company's stock option activity for the year ended December 31, 2022: Number of share options Weighted average exercise price Weighted average remaining contractual term Aggregate intrinsic value Outstanding as of December 31, 2021 13,797,556 $ 5.55 8.6 years $ 712 Granted 9,837,797 1.31 Forfeited (4,097,040) 4.89 Exercised (61,954) 2.04 Outstanding as of December 31, 2022 19,476,359 $ 3.55 8.8 years $ 29,657 Outstanding as of December 31, 2022 - vested and expected to vest 13,110,654 4.49 8.5 years $ 11,799 Exercisable at December 31, 2022 3,895,109 $ 4.91 8.0 years $ 1,652 During the year ended December 31, 2022, the Compensation Committee of the Company's Board of Directors and management approved 6,984,000 option grants to its executives and certain employees of the Company which will vest based upon certain market-based and revenue performance conditions. The weighted-average grant-date fair value of stock options granted during the years ended December 31, 2022 and 2021 was $0.87 and $3.50, per share, respectively. The aggregate intrinsic value of stock options exercised during the years ended December 31, 2022 and December 31, 2021 was $142 and $3,744, respectively. The aggregate intrinsic value of stock options is calculated as the difference between the exercise price of the stock options and the fair value of the Company’s common stock for those stock options that had exercise prices lower than the fair value of the Company’s common stock. As of December 31, 2022, total unrecognized compensation cost related to unvested stock option grants was approximately $12,274. This amount is expected to be recognized over a weighted average period of approximately 1.8 years. This excludes unvested market-based and performance stock options outstanding that were deemed not probable of vesting as of December 31, 2022, constituting 6,764,000 shares with unrecognized stock-based compensation expense of $4,655, for which the timing of recognition will be determined once the conditions for achievement become probable. In September 2021, the Compensation Committee of the Board of Directors approved a modification to the Company's outstanding performance-based stock option awards for active employees which removed the performance-based vesting criteria from these awards. Following this modification, the option awards are subject only to previously existing time-based vesting conditions. The Company accounted for this change as a modification in accordance with the requirements of Accounting Standards Codification Topic 718. As a result, 9,250,000 options, related to twenty-five employees, that were previously authorized that had not achieved a grant date became granted on September 24, 2021 relating to the modification. The Company is recognizing the newly assessed measurement date fair value of the awards as compensation expense over the remaining vesting period. Warrants The fair value of warrants is estimated on the date of grant using the Black-Scholes valuation methodology. Expected volatilities are based on historical share price performance, weighted to exclude periods of unusually high volatility. The Company assumed the warrants to be exercised immediately on vesting. The risk-free rate is equal to the prevailing U.K. Gilts rate at grant date that most closely matches the expected term of the grant, as the warrants were issued when the Company was domiciled in the U.K.. Expected dividend yield is zero, and consistent with the Board of Directors’ view that the Company’s business model is to generate value through capital growth rather than the payment of dividends. Each warrant entitles the warrant holder to subscribe in cash for one share. Shares of common stock allotted pursuant to the exercise of the warrant will rank in full for all dividends and other distributions with a record date after the exercise date with the shares of common stock in issue at that date. As of December 31, 2022, 5,821,137 warrants were granted, of which 559,787 warrants were granted to consultants and 5,261,350 warrants were granted to investors. All warrants are considered vested at December 31, 2022, have a weighted-average exercise price of $1.56, an aggregate intrinsic value of $15,640, and a weighted average remaining contractual life of 3.5 years. At December 31, 2022, there was no unrecognized compensation expense related to warrants. Stock-Based Compensation Stock‑based compensation expense related to stock options is recorded within the consolidated statements of operations and comprehensive loss as follows: Year Ended December 31, 2022 Year Ended December 31, 2021 Research and development $ 4,303 $ 5,909 General and administrative 7,645 6,895 Total stock-based compensation $ 11,948 $ 12,804

Commitments and Contingencies

Commitments and Contingencies	12 Months Ended
	Dec. 31, 2022
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies	Commitments and Contingencies Fixed asset purchase commitments At December 31, 2022 and 2021, the Company had no capital commitments. Lease commitments Refer to Note 16 for a discussion of the Company's lease commitments. Debt commitments Refer to Note 17 for discussion of promissory notes payable to related parties. Other commitments The Company enters into contracts in the normal course of business with various third parties for clinical trials, preclinical research studies and testing, manufacturing and other services and products for operating purposes. Most contracts provide for termination upon notice, and therefore are cancellable contracts. As of December 31, 2022, total contractual commitments, excluding leases commitments and debt commitments, are estimated to be approximately $11,510 and the majority of these commitments are due within one year. The Company has certain commitments under its agreements with the Akeso, Wellcome Trust, the University College London and certain employees, former employees and former directors of Discuva, pursuant to which it will be required to pay royalties or make milestone payments. The License Agreement with Akeso also contains certain manufacturing and purchase commitments. As of December 31, 2022, the Company is unable to estimate the amount, timing or likelihood of achieving the milestones, making future product sales or assessing estimated forecasts for manufacturing and supplied materials which these contingent payment obligations relate to. Indemnifications The Company's certificate of incorporation provides that it will indemnify the directors and officers to the fullest extent permitted by Delaware law. In addition, the Company has entered into indemnification agreements with all of the directors and executive officers. These indemnification agreements may require the Company, among other things, to indemnify each such director or executive officer for some expenses, including attorneys’ fees, judgments, fines, and settlement amounts incurred by him or her in any action or proceeding arising out of his or her service as one of the Company's directors or executive officers. The Company believes the fair value for these indemnification obligations is minimal. Accordingly, the Company has not recognized any liabilities relating to these obligations as of December 31, 2022. Legal Proceedings The Company is not currently subject to any material legal proceedings.

Related Party Transactions

Related Party Transactions	12 Months Ended
	Dec. 31, 2022
Related Party Transactions [Abstract]
Related Party Transactions	Promissory Notes Payable to Related Parties Non-current and current debt consisted of the following: Current notes Non-current notes December 31, 2022 December 31, 2021 December 31, 2022 December 31, 2021 Principal amounts $ 20,000 $ — $ 500,000 — Debt discount (230) — (5,460) $ — Total promissory notes payable to related parties $ 19,770 $ — $ 494,540 $ — March 2022 Promissory Note On March 10, 2022, Mr. Duggan, entered into a Note Purchase Agreement (the “March 2022 Note”), pursuant to which he loaned the Company $25,000 in exchange for the issuance by the Company of an unsecured promissory note in the amount of $25,000. The March 2022 Note accrued interest at a rate per annum equal to the prime rate as reported in the Wall Street Journal . The March 2022 Note, including all accrued interest, became due upon the earlier of (i) the consummation of a registered public offering with net proceeds of no less than $25,000 or (ii) 18 months from the date of issuance of the March 2022 Note. Debt issuance costs associated with the March 2022 Note were immaterial and expensed as incurred. The March 2022 Note of $25,000, plus accrued interest of $434 has been repaid to Mr. Duggan on August 10, 2022 in connection with the completion of the rights offering with aggregate gross proceeds of $100,000. The Company incurred interest expense of $1,296 for the year ended December 31, 2022, which included amortized imputed interest of $861 for the year ended December 31, 2022. December 2022 Promissory Notes On December 6, 2022, the Company entered into a Note Purchase Agreement (the "Note Purchase Agreement"), with Mr. Duggan and Dr. Zanganeh, pursuant to which the Company agreed to sell to each of Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the aggregate amount of $520,000. Pursuant to the Note Purchase Agreement, the Company issued to Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the amount of $400,000 (the "Duggan February Note") and $20,000 (the "Zanganeh Note"), respectively, which would mature and become due on February 15, 2023 and an unsecured promissory note to Mr. Duggan in the amount of $100,000 (the “Duggan September Note” and together with the Duggan February Note and the Zanganeh Note, the “December 2022 Notes”), which will mature and become due on September 15, 2023. The maturity dates of the December 2022 Notes could be extended one or more times at the Company’s election, but in no event to a date later than September 6, 2024. In addition, if the Company shall consummate a public offering, then upon the later to occur of (i) five On January 19, 2023, the Company provided notice to extend the term of the Duggan February Note and Duggan September Note to a maturity date of September 6, 2024. Furthermore, on January 19, 2023, the Company and Mr. Duggan rectified the Duggan February Note and Duggan September Note in order to correctly reflect the parties’ intent that the Company may only prepay (i) the Duggan February Note following the completion of a public rights offering to be conducted by Summit in the approximate amount of $500,000 (the “Rights Offering”), or a similar capital raise, in an amount equal to the lesser of (x) the net proceeds of the Rights Offering or such capital raise or (y) the full amount outstanding of the Duggan February Note, and (ii) Duggan September Note following the completion of a capital raising transaction subsequent to the Rights Offering in an amount equal to the lesser of (i) the net proceeds of such capital raise or (ii) the full amount outstanding of the Duggan September Note. Following the issuance of the two new Promissory Notes (the “Duggan Promissory Notes”), the Duggan February Note and Duggan September Note were marked as “cancelled” on their face and replaced in their entirety by the Duggan Promissory Notes (together with the Zanganeh Note, the "Notes"). The Notes accrue interest at an initial rate of 7.5%. All interest on the Notes shall be paid on the date of signing for the period through February 15, 2023. Such prepaid interest shall be paid in a number of shares of the Company’s common stock, par value $0.01 (“Common Stock”) equal to the dollar amount of such prepaid interest, divided by $0.7913 (the consolidated closing bid price immediately preceding the time the Company entered into the Note Purchase Agreement, plus $0.01), which was 9,720,291 shares. For all applicable periods following the February 15, 2023, interest shall accrue on the outstanding principal balance of the Notes at the US prime interest rate, as reported in the Wall Street Journal, plus 50 basis points, as adjusted monthly, for three months immediately following February 15, 2023, and thereafter at the US prime rate plus 300 basis points, as adjusted monthly. Debt issuance costs associated with the Notes were $44 and we capitalized as part of the carrying value of the promissory notes payable to related parties. The Company incurred interest expense of $3,105 for the year ended December 31, 2022, which included amortized imputed interest of $395. Imputed interest is calculated as the difference between the expected interest payable and the deemed market rate of interest and is recorded as a debt discount at inception of the note payable with a credit to additional paid-in capital for notes payable to related parties. The debt discount is amortized to interest expense using an effective interest rate method. The effective interest rate of the Duggan February Note and Zanganeh Note was 8.7% and the effective interest rate of the Duggan September Note was 8.8%. The Company incurred interest expense of $244 for the year ended December 31, 2021, which included amortized imputed interest $159 for the year ended December 31, 2021, respectively, related to the March 24, 2021 Note Purchase Agreement with Mr. Duggan, for $55,000 which was subsequently rescinded and replaced by a second note on April 20, 2021, of the same amount, and paid in full in May 2021, as described further in Note 22. As of December 31, 2022, and reflecting the Company's election to extend the term of the Duggan February Note and the Duggan September Note, the estimated future principal payments due were as follows: Year Ending December 31, 2023 $ 20,000 2024 500,000 $ 520,000 On February 15, 2023, the $20,000 Zanganeh Note matured and the Company repaid the outstanding principal balance. In connection with the closing of the rights offering, the $400,000 Duggan Promissory Note matured and became due, and the Company repaid all principal and accrued interest thereunder using a portion of the proceeds from this rights offering. March 24, 2021 Note Purchase Agreement On March 24, 2021, Mr. Duggan, the Company's Executive Chairman and Chief Executive Officer and primary stockholder, entered into a Note Purchase Agreement (the “Initial Purchase Agreement”) pursuant to which he loaned the Company $55,000 in exchange for the issuance by the Company of an unsecured promissory note (the “Initial Note”) in the amount of $55,000. The Initial Note was to accrue interest at a rate per annum equal to 150% of the applicable 10 Year United States Treasury rate, as adjusted monthly. The rate was initially estimated to be approximately 2.4%. The terms of the Initial Note were that it would mature and become due upon the earlier of (i) the consummation of a registered public offering with net proceeds of no less than $55,000, or (ii) 13 months from the date of issuance of the Initial Note. On April 20, 2021, the Company determined, with Mr. Duggan’s agreement, to rescind both the Initial Purchase Agreement and the Initial Note issued thereunder, and repaid the principal amount of the Initial Note in full, without interest or penalty. April 20, 2021 Note Purchase Agreement On April 20, 2021, subsequent to the repayment of the Initial Note, Mr. Duggan entered into a second Note Purchase Agreement (the “Second Purchase Agreement”) pursuant to which he loaned the Company $55,000 in exchange for the issuance by the Company of an unsecured promissory note (the “Second Note”) in the amount of $55,000. The Second Note accrued interest at a rate per annum equal to 150% of the applicable 10 Year United States Treasury rate, as adjusted monthly (initially estimated to be approximately 2.4%). The Company was permitted to prepay any portion of the Second Note at its option without penalty. May 12, 2021 Rights Offering ("2021 Rights Offering") On May 12, 2021, the Company closed its 2021 Rights Offering, which was fully subscribed. Aggregate gross proceeds from the 2021 Rights Offering were $75,000 from the sale of 14,312,976 shares of the Company's common stock, of which 11,365,921 shares were purchased by Mr. Duggan and 389,977 shares were purchased by Dr. Zanganeh, at price of $5.24 per share. In connection with the closing of the 2021 Rights Offering, the Second Note, issued by the Company to Mr. Duggan, matured and became due and was repaid using a portion of the proceeds from the 2021 Rights Offering. March 26, 2021 Sublease Agreement with Maky Zanganeh and Associates, Inc. On March 26, 2021, the Company entered into a sublease with Maky Zanganeh and Associates, Inc. ("MZA") consisting of 4,500 square feet of office space at 2882 Sand Hill Road, Menlo Park, California (the “Sublease”). Dr. Zanganeh, the Company's Co-Chief Executive Officer and President, is the sole owner of MZA. The sublease ran until September 2022. The rent payable under the terms of the sublease was equivalent to the proportionate share of the rent payable by MZA to the third-party landlord, based on the square footage of office space sublet by the Company, and no mark-up has been applied. During the years ended December 31, 2022 and 2021, payments of $544 and $556, were made pursuant to the sublease. July 25, 2022 First Amendment to Sublease Agreement with Maky Zanganeh and Associates, Inc. On July 25, 2022 the Company entered into a first amendment, dated July 19, 2022, to its existing sublease agreement with MZA, described above. The existing sublease term, which was set to expire on September 30, 2022, was extended for a period of thirty-nine months from October 1, 2022 through December 31, 2025. The rent payable under the terms of the sublease is equivalent to the proportionate share of the net payable by MZA to the third-party landlord, based on the square footage of office space sublet by the Company, and no mark-up has been applied. July 29, 2022 Second Amendment to Sublease Agreement with Maky Zanganeh and Associates, Inc. On July 29, 2022, the Company entered into a second amendment, dated August 1, 2022, to its existing sublease agreement with MZA, described above. The second amendment was effective as of August 1, 2022 and expires on December 31, 2025. The second amendment includes an additional 1,277 square feet (the "Expansion Premises") of office space at 2882 Sand Hill Road, Menlo Park, California. The rent payable under the terms of the sublease is equivalent to the proportionate share of the net payable by MZA to the third-party landlord, based on the square footage of office space sublet by the Company, and no mark-up has been applied. During the year ended December 31, 2022 payments of $54, were made pursuant to the secondment amendment to the sublease. March 10, 2022 Note Purchase Agreement On March 10, 2022, the Company entered into a Note Purchase Agreement (the "March 2022 Note"), with Mr. Duggan, pursuant to which Mr. Duggan loaned the Company $25,000 in exchange for the issuance by the Company of an unsecured promissory note in the amount of $25,000. The March 2022 Note accrued interest at a rate per annum equal to the prime rate as reported in the Wall Street Journal , which was 3.25% as of the effective date and 4.75% as of June 30, 2022. The March 2022 Note, including accrued interest, became due upon the earlier of (i) the consummation of a registered public offering with net proceeds of no less than $25,000 or (ii) 18 months from the date of issuance of the March 2022 Note, and was repaid on August 10, 2022. 2022 Rights Offering ("2022 Rights Offering") In August 2022, the Company announced the closing and final results of its previously announced rights offering. The 2022 Rights Offering commenced on July 18, 2022, and the associated subscription rights expired on August 8, 2022. Aggregate gross proceeds received from the rights offering were $100,000 from the sale of 103,092,783 shares of common stock. Mr. Duggan and Dr. Zanganeh fully subscribed to their respective basic subscription rights and oversubscribed, at a price of $0.97 per share. Issuance costs were $111. In connection with the closing of the 2022 Rights Offering, the March 2022 Note matured and became due, and the Company repaid all principal and accrued interest thereunder using a portion of the proceeds from the 2022 Rights Offering on August 10, 2022. December 6, 2022 Note Purchase Agreement On December 6, 2022, the Company entered into a Note Purchase Agreement (the "Note Purchase Agreement"), with Mr. Duggan and Dr. Zanganeh, pursuant to which the Company agreed to sell to each of Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the aggregate amount of $520,000. Pursuant to the Note Purchase Agreement, the Company issued to Mr. Duggan and Dr. Zanganeh unsecured promissory notes in the amount of $400,000 (the "Duggan February Note") and $20,000 (the "Zanganeh Note"), respectively, which would mature and become due on February 15, 2023 and an unsecured promissory note to Mr. Duggan in the amount of $100,000 (the “Duggan September Note” and together with the Duggan February Note and the Zanganeh Note, the “December 2022 Notes”), which will mature and become due on September 15, 2023. The maturity dates of the December 2022 Notes could be extended one or more times at the Company’s election, but in no event to a date later than September 6, 2024. In addition, if the Company shall consummate a public offering, then upon the later to occur of (i) five On January 19, 2023, the Company provided notice to extend the term of the Duggan February Note and Duggan September Note to a maturity date of September 6, 2024. Furthermore, on January 19, 2023, the Company and Mr. Duggan rectified the Duggan February Note and Duggan September Note in order to correctly reflect the parties’ intent that the Company may only prepay (i) the Duggan February Note following the completion of a public rights offering to be conducted by Summit in the approximate amount of $500,000 (the “Rights Offering”), or a similar capital raise, in an amount equal to the lesser of (x) the net proceeds of the Rights Offering or such capital raise or (y) the full amount outstanding of the Duggan February Note, and (ii) Duggan September Note following the completion of a capital raising transaction subsequent to the Rights Offering in an amount equal to the lesser of (i) the net proceeds of such capital raise or (ii) the full amount outstanding of the Duggan September Note. Following the issuance of the two new Promissory Notes (the “Duggan Promissory Notes”), the Duggan February Note and Duggan September Note were marked as “cancelled” on their face and replaced in their entirety by the Duggan Promissory Notes (together with the Zanganeh Note, the "Notes"). The Notes accrue interest at an initial rate of 7.5%. All interest on the Notes shall be paid on the date of signing for the period through February 15, 2023. Such prepaid interest shall be paid in a number of shares of the Company’s common stock, par value $0.01 (“Common Stock”) equal to the dollar amount of such prepaid interest, divided by $0.7913 (the consolidated closing bid price immediately preceding the time the Company entered into the Note Purchase Agreement, plus $0.01), which was 9,720,291 shares. For all applicable periods following the February 15, 2023, interest shall accrue on the outstanding principal balance of the Notes at the United States prime interest rate, as reported in the Wall Street Journal, plus 50 basis points, as adjusted monthly, for three months immediately following February 15, 2023, and thereafter at the United States prime rate plus 300 basis points, as adjusted monthly.

Subsequent Events

Subsequent Events	12 Months Ended
	Dec. 31, 2022
Subsequent Events [Abstract]
Subsequent Events	Subsequent Events Akeso Collaboration and License Agreement On December 5, 2022, the Company entered into the License Agreement with Akeso, which is detailed further in Note 1. The License Agreement closed on January 17, 2023, and both Akeso and Summit entered into the Common Stock Issuance Agreement (“Issuance Agreement”). Pursuant to the License Agreement and Issuance Agreement, Akeso elected to receive 10 million shares of Company common stock in lieu of cash and was paid $274,900 in cash as the initial upfront payment. The remaining $200,000 of the upfront payment was paid on March 6, 2023. As regulatory approval for ivonescimab has not yet been granted, the Company will record in-process research and development expenses in the first quarter of 2023 for the cash payments of $474,900 and for the fair market value of the 10 million shares issued to Akeso. Maturity date extension and rectification of promissory notes issued pursuant to the Note Purchase Agreement As disclosed in Notes 17 and 22, on January 19, 2023, the Company provided notice to extend the term of the Duggan February Note and Duggan September Note to a maturity date of September 6, 2024. Furthermore, on January 19, 2023, the Company and Mr. Duggan rectified the Duggan February Note and Duggan September Note in order to correctly reflect the parties’ intent, see Notes 17 and 22 for further details. 2023 Rights Offering ("Rights Offering") On December 6, 2022, the Company announced a rights offering for its existing shareholders to participate in the purchase of additional shares of its common stock. The Rights Offering commenced on February 7, 2023 and the associated subscription rights expired on March 1, 2023. Aggregate gross proceeds from the Rights Offering were $500,000 from the sale of 476,190,471 shares of the Company's common stock at a price of $1.05 per share. Issuance costs were approximately $500. Repayment of promissory notes On February 15, 2023, the $20,000 Zanganeh Note matured and the Company repaid the outstanding principal balance. In connection with the closing of the Rights Offering, the $400,000 Duggan Promissory Note, which is defined in Note 17, matured and became due, and the Company repaid all principal and accrued interest thereunder using a portion of the proceeds from the Rights Offering.

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	12 Months Ended
	Dec. 31, 2022
Accounting Policies [Abstract]
Basis of Presentation	The consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States ("U.S. GAAP") and pursuant to the rules and regulations of the U.S. Securities and Exchange Commission.
Use of Estimates	The preparation of these financial statements requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and the disclosure of contingent liabilities at the date of the financial statements and the reported amounts of revenues and expenses during the reporting period. On an on-going basis, management evaluates its estimates and judgments, including those related to revenue recognition, accrued research and development expenses, stock-based compensation, intangible assets, goodwill, other long-lived assets and income taxes. Management bases its estimates and judgments on historical experience and on various other factors that are believed to be reasonable under the circumstances, the results of which form the basis for making judgments about the carrying values of assets and liabilities that are not readily apparent from other sources. Actual results may differ from these estimates under different assumptions or conditions.
Principles of Consolidation	Principles of Consolidation The accompanying consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States of America (“U.S. GAAP”) and pursuant to the rules and regulations of the U.S. Securities and Exchange Commission. The consolidated financial statements reflect the accounts of Summit Therapeutics Inc. and its wholly owned subsidiaries. Intercompany balances and transactions are eliminated in consolidation.
Foreign Currency Translation	Foreign Currency Translation The financial statements of the Company’s subsidiaries with functional currencies other than the United States ("U.S.") dollar are translated into U.S. dollars using period-end exchange rates for assets and liabilities, historical exchange rates for stockholders’ equity and weighted average exchange rates for operating results. Translation gains and losses are included in accumulated other comprehensive (loss) income in shareholders’ equity. Foreign currency transaction gains and losses are included in other expense, net in the results of operations. The Company recorded realized and unrealized foreign currency transaction losses of $4,109 and $2,135 for the years ended December 31, 2022 and 2021, respectively, which is included in other expense, net in the statements of operations and comprehensive loss.
Revenue Recognition	Revenue Recognition The Company accounts for revenue using ASC 606. This standard applies to all contracts with customers, except for contracts that are within the scope of other standards. The Company enters into out-licensing agreements within the scope of ASC 606 under which it licenses certain rights to its product candidates to third parties. Such agreements may include the transfer of intellectual property rights in the form of licenses, transfer of technological know-how, delivery of drug substances, research and development services, and participation on certain committees with the counterparty. Payments made by the customers may include one or more of the following: non-refundable, up-front license fees; development, regulatory, and commercial milestone payments; payments for manufacturing supply services the Company provides through its contract manufacturers; and royalties on net sales of licensed products if they are successfully approved and commercialized. Each of these payments may result in license, collaboration, or other revenue, except revenue from royalties on net sales of licensed products, which would be classified as royalty revenue. In determining the appropriate amount of revenue to be recognized as the Company fulfills its obligations under each of its out-licensing agreements, the following steps are performed: (i) identification of the promised goods or services in the contract; (ii) determination of whether the promised goods or services are performance obligations including whether they are distinct in the context of the contract; (iii) measurement of the transaction price, including the constraint on variable consideration; (iv) allocation of the transaction price to the performance obligations; and (v) recognition of revenue when (or as) the Company satisfies each performance obligation. At contract inception, once the contract is determined to be within the scope of ASC 606, the Company assesses the goods or services promised within each contract and determines those that are performance obligations and assesses whether each promised good or service is distinct. Revenue is then recognized in respect of the amount of the transaction price that is allocated to the respective performance obligation when (or as) the performance obligation is satisfied. As part of the accounting for these arrangements, the Company must use significant judgment to determine: (a) the performance obligations based on the determination under step (ii) above; (b) the transaction price under step (iii) above; and (c) the standalone selling price for each performance obligation identified in the contract for the allocation of transaction price in step (iv) above. The Company also uses judgment to determine whether milestone payments or other variable consideration, except for royalties and sales-based milestones, should be included in the transaction price, as described below. The transaction price is allocated to each performance obligation based on the relative standalone selling price of each performance obligation in the contract, and the Company recognizes revenue based on those amounts when, or as, the performance obligations under the contract are satisfied. Exclusive Licenses If the license to the Company’s intellectual property is determined to be distinct from the other promises or performance obligations identified in the arrangement, the Company recognizes revenue from nonrefundable, upfront fees allocated to the license when the license is transferred to the customer and the customer is able to use and benefit from the license. In assessing whether a promise or performance obligation is distinct from the other promises, the Company considers factors such as the research, development, manufacturing and commercialization capabilities of the collaboration partner and the availability of the associated expertise in the general marketplace. In addition, the Company considers whether the collaboration partner can benefit from a promise for its intended purpose without the receipt of the remaining promises, whether the value of the promise is dependent on the unsatisfied promises, whether there are other vendors that could provide the remaining promises, and whether it is separately identifiable from the remaining promises. For licenses that are combined with other promises, the Company utilizes judgment to assess the nature of the combined performance obligation to determine whether the combined performance obligation is satisfied over time or at a point in time and, if over time, the appropriate method of measuring progress for purposes of recognizing revenue. The Company evaluates the measure of progress each reporting period and, if necessary, adjusts the measure of progress and related revenue recognition. The measure of progress, and the resulting periods over which revenue should be recognized, are subject to estimates by management and may change over the course of the research, development and licensing arrangement. Such a change could have a material impact on the amount of revenue the Company records in future periods. Under the Company’s existing license and collaboration agreements, the Company has concluded that the transfer of control to the customer occurs over the time period that the research and development services are to be provided by the Company, and this output method is, in management’s judgment, the best measure of progress towards satisfying the performance obligation. Milestone Payments At the inception of each arrangement that includes potential research, development or regulatory milestone payments, the Company evaluates whether the milestones are considered likely to be met and estimates the amount to be considered for inclusion in the transaction price using the most-likely-amount method. If it is probable that a significant reversal in the amount of cumulative revenue recognized would not occur, the associated milestone payment value is included in the transaction price. For milestone payments due upon events that are not within the control of the Company or the licensee, such as regulatory approvals, the Company is not able to assert that it is likely that the regulatory approval will be granted and that it is probable that a significant reversal in the amount of cumulative revenue recognized will not occur until those approvals are received. In making this assessment, the Company evaluates factors such as the scientific, clinical, regulatory, commercial and other risks that must be overcome to achieve the particular milestone. There is considerable judgment involved in determining whether it is probable that a significant reversal in the amount of cumulative revenue recognized would not occur. At the end of each subsequent reporting period, the Company reevaluates the probability of achievement of all milestones subject to constraint and, if necessary, adjusts its estimate of the overall transaction price of the arrangement. Any such adjustments are recorded on a cumulative catch-up basis, which would affect the amounts of revenue and earnings in the period of adjustment. Royalties
Other Operating Income	Other Operating Income The Company generates income from government contracts that reimburse the Company for certain allowable costs for funded projects. For contracts with government agencies where the funding arrangement is considered central to the Company’s ongoing operations, the Company classifies the recognized funding received as other operating income. Income from government grants is recognized as the qualifying expenses related to the contracts are incurred, provided that there is reasonable assurance of recoverability. If the government agency approves the project proposed by the Company, the government agency funds the project upon receipt of the support for the costs incurred up to the contract limit. Income recognized upon incurring qualifying expenses in advance of billing is recorded as unbilled receivable, a component of other current assets, in the consolidated balance sheet. Grant income is not recognized as deductions of research and development costs because the Company acts as the principal in conducting the research and development activities and these contracts are central to its ongoing operations. The funds received through these means are held as deferred income in the consolidated balance sheets and are released to the consolidated statement of operations and comprehensive loss, classified as other operating income, as the underlying expenditure is incurred and to the extent the conditions of the grant are met. The related costs incurred by the Company are included in research and development expense in the Company’s consolidated statements of operations and comprehensive loss. The Company benefits from two U.K. research and development ("R&D") tax credit cash rebate regimes: Small and Medium Enterprise ("SME") Program and the Research and Development Expenditure Credit ("RDEC") Program. Each reporting period, management evaluates which tax relief programs the Company is expected to be eligible for and records as other operating income the portion of the expense that it expects to qualify under the programs, that it plans to submit a claim for, and it has reasonable assurance that the amount will ultimately be realized. Based on criteria established by HM Revenue and Customs (“HMRC”), management of the Company expects a proportion of expenditures being undertaken in relation to its pipeline research, clinical trials management and manufacturing development activities to be eligible for the research and development tax relief programs for the year ended December 31, 2022
Net Loss Per Share	Net Loss Per Share Basic net loss per share is computed by dividing the net loss by the weighted-average number of common shares outstanding for the period. Diluted net loss per share is computed by dividing the diluted net loss by the weighted-average number of common shares outstanding for the period, including potentially dilutive common shares. The dilutive effect of share options and warrants are determined under the treasury stock method using the average market price for the period. In addition, the assumed proceeds under the treasury stock method include the average unrecognized compensation expense of stock options and warrants that are in-the-money.
Business Combinations	Business Combinations Business combinations are accounted for under the acquisition method. Acquired assets and assumed liabilities are measured at their fair values at the acquisition date. The excess of the consideration transferred over the net fair value of assets acquired and liabilities assumed is recorded as goodwill. The accounting for an acquisition involves a considerable amount of judgement and estimation. Cost, income, market or a combination of approaches may be used to establish the fair value of consideration exchanged, assets acquired, and liabilities assumed, depending on the nature of those items. The valuation approach is determined in accordance with generally accepted valuation methods. Key areas of estimation and judgment may include the selection of valuation approaches, cost of capital, market characteristics, cost structure, impacts of synergies, and estimates of terminal value, among other factors.
Goodwill	Goodwill Goodwill represents the excess of the consideration transferred over the fair value of net assets acquired. Goodwill is assigned to reporting units at the time of acquisition or when there is a change in the reporting structure and bases that allocation on which reporting units will benefit from the acquired assets and liabilities. Reporting units are defined as operating segments or one level below an operating segment, referred to as a component. Typically acquisitions related to a single reporting unit do not require the allocation of goodwill to multiple reporting units. If the products obtained in an acquisition are assigned to multiple reporting units, the goodwill is distributed to the respective reporting units as part of the purchase price allocation process. The Company assesses goodwill for impairment on an annual basis or more frequently when events and circumstances occur indicating that the recorded goodwill may be impaired. The Company regularly monitors current business conditions and other factors including, but not limited to, adverse industry or economic trends and lower projections of profitability that may impact future operating results. The process of evaluating the potential impairment of goodwill requires significant judgment. In performing the Company’s annual goodwill impairment test, the Company is permitted to first assess qualitative factors to determine whether it is more likely than not that the fair value of the Company’s reporting unit is less than its carrying amount, including goodwill. In performing the qualitative assessment, the Company considers certain events and circumstances specific to the reporting unit and to the entity as a whole, such as macroeconomic conditions, industry and market considerations, overall financial performance and cost factors when evaluating whether it is more likely than not that the fair value of the reporting unit is less than its carrying amount. The Company is also permitted to bypass the qualitative assessment and proceed directly to the quantitative test. If the Company chooses to undertake the qualitative assessment and concludes that it is more likely than not that the fair value of the reporting unit is less than its carrying amount, the Company would then proceed to the quantitative impairment test. In the quantitative assessment, the Company compares the fair value of the reporting unit to its carrying amount, which includes goodwill. If the fair value exceeds the carrying value, no impairment loss exists. If the fair value is less than the carrying amount, a goodwill impairment loss is measured and recorded.
Intangible Assets	Intangible Assets Intangible assets are estimated by management based on the fair value of assets acquired. These include acquired technology, licenses, an option over non-financial assets and a research and development discovery platform ("Discuva Platform"). Intangible assets are amortized from one Our intangible assets are recorded at fair value at the time of their acquisition, assigned an estimated useful life, and amortized primarily on a straight-line basis over their estimated useful lives or over the period of the relevant agreement for an option over non-financial assets. Intangible assets are stated in our consolidated balance sheets net of accumulated amortization and impairments, if applicable. The Company evaluates the recoverability of its intangible and long-lived assets whenever events and changes in circumstances indicate that the carrying amount of an asset or asset group may not be fully recoverable. If events and circumstances indicate that the carrying amount may not fully be recoverable, the carrying values of the asset or asset group are evaluated in relation to their operating performance and future undiscounted cash flows of the underlying business. If the future undiscounted cash flows are less than their carrying value, impairment exists. The impairment is measured as the difference between the carrying value and the fair value of the underlying asset or asset group. Fair values are based on estimates of market prices and assumptions concerning the amount and timing of estimated future cash flows and assumed discount rates, reflecting varying degrees of perceived risk. Amortization of intangible assets is included as part of the research and development expense line shown on the face of the consolidated statement of operations and comprehensive loss.
Property and Equipment	Property and Equipment Property and equipment are stated at cost less accumulated depreciation. Cost comprises the purchase price plus any incidental costs of acquisition and commissioning. Depreciation is calculated based on cost, less residual value, in equal annual installments over the estimated useful lives of the assets. The residual value, if significant, is reassessed annually. Leasehold improvements Over the shorter of the asset's useful life or the remaining lease term Laboratory equipment 2 - 10 years Office and IT equipment 3 - 5 years Depreciation is recognized as part of the general and administrative and research and development expense lines shown on the face of the consolidated statement of operations and comprehensive loss depending on the nature of the underlying assets. Expenditures for repairs and maintenance are expensed as incurred. Upon retirement or sale, the cost of assets disposed of and the related accumulated depreciation are removed from the accounts and any resulting gain or loss is included in loss from operations.
Leases	Leases The Company has operating leases for real estate. The Company does not have any finance leases. Under ASC 842, a contract is or contains a lease when the lessee has the right to control the use of an identified asset. The Company determines if an arrangement is a lease at inception of the contract, which is the date on which the terms of the contract are agreed to and the agreement creates enforceable rights and obligations. The lease term used to calculate the lease liability include options to extend or terminate the lease when it is reasonably certain that the option will be exercised. At the lease commencement date, the Company measures and recognizes a lease liability and a right-of-use asset in the financial statements. Lease liabilities are recognized based on the present value of the future lease payments over the lease term at commencement date. The right-of use asset is measured by taking the present value of future lease payments, plus any incremental direct costs incurred, less any lease incentives received. As most of the Company's leases do not provide an implicit rate, the Company uses an estimated incremental borrowing rate based on the lease term and the economic environment of the lease at the lease commencement date, which is then utilized to determine the present value of future lease payments. Lease expense for minimum lease payments are recognized on a straight-line basis over the lease term, with variable lease payments recognized in the periods in which they are incurred. The Company has existing lease agreements with lease and non-lease components, has elected to account for the lease and non-lease components as a single lease component, and has allocated all of the contract consideration to the lease component only. Leases with an initial lease term of 12 months or less are not recorded on the balance sheet. The Company recognizes lease expense for its short-term leases on a straight-line basis over the lease term.
Research and Development Costs	Research and Development Costs Research and development costs are expensed as incurred. Research and development expenses consist of costs incurred to discover, research and develop product candidates, including personnel expenses, stock-based compensation expense, allocated facility-related and depreciation expenses, third-party license fees and external costs of outside vendors engaged to conduct preclinical and clinical development activities and clinical trials as well as to manufacture clinical trial materials. Non - refundable prepayments for goods or services that will be used or rendered for future research and development activities are recorded as prepaid expenses. Such amounts are recognized as an expense as the goods are delivered or the related services are performed, or until it is no longer expected that the goods will be delivered, or the services rendered. Milestone and other payments made to third-parties with respect to in-process research and development, in accordance with the Company’s license, acquisition and other similar agreements are expensed when determined to be probable and estimable. The Company has entered into various research and development contracts with other companies. These agreements are generally cancellable, and related payments are recorded as research and development expenses as incurred. The Company records accruals for estimated ongoing research and development costs or prepaid expenses where the payments made exceeds the estimated costs. When evaluating the adequacy of these balances, the Company analyzes progress of the studies, including the estimated costs to complete each study or activity, the estimation of the current stage of completion and the invoices received, as well as predetermined milestones which are not reflective of the current stage of development for prepaid expenses. Actual results could differ from the Company’s estimates. In all cases, the full cost of each study or activity is expensed by the time the final report or where applicable, product, has been received. The Company’s historical estimates have not been materially different from the actual costs.
Stock-Based Compensation	Stock-Based Compensation The Company measures and recognizes compensation expense for all stock option and restricted stock unit awards based on the estimated fair value of the award on the grant date. The Company uses the Black-Scholes option pricing model to estimate the fair value of stock option awards. Additionally, the Company uses a Monte Carlo simulation model to calculate the estimated fair value on the date of grant related to awards with market-based service conditions. The fair value is recognized as expense, over the requisite service period, which is generally the vesting period of the respective award, on a straight-line basis for each separately vesting portion of the award when the only condition to vesting is continued service. If vesting is subject to a market or performance condition, recognition is based on the derived service period of the award. Expense for awards with performance conditions is estimated and adjusted on a quarterly basis based upon the assessment of the probability that the performance condition will be met. Use of the Black-Scholes option-pricing model requires management to apply judgment under highly subjective assumptions. These assumptions include: • Expected term—The expected term of stock options represents the weighted-average period the stock options are expected to be outstanding. The Company uses the simplified method for estimating the expected term as provided by the Securities and Exchange Commission. The simplified method calculates the expected term as the average of the time-to-vesting and the contractual life of the options. • Expected volatility—The expected volatility is calculated based on historical volatility of the Company's share price. • Risk-free interest rate—The risk-free rate assumption is based on the U.S. Treasury instruments, the terms of which were consistent with the expected term of the Company’s stock options. • Expected dividend—The expected dividend assumption is based on the Company’s history and expectation of dividend payouts. The Company has not paid and does not intend to pay dividends. The Company estimates expected forfeitures at the time of grant instead of accounting for forfeitures as they occur. Stock option and restricted stock unit awards have been granted at fair value to non-employees in connection with research and consulting services provided to the Company. Equity awards generally vest over terms of 3 or 4 years. The Company classifies stock-based compensation expense in the consolidated statements of operations in the same manner in which the award recipient’s payroll costs are classified.
Income Taxes	Income Taxes The Company is primarily subject to corporation taxes in the U.S. and the U.K.. The calculation of the Company’s tax provision involves the application of both U.S. and U.K. tax law and requires judgment and estimates. The provision for income taxes is determined using the asset and liability approach. Tax laws may require items to be included in tax filings at different times than the items are reflected in the financial statements. A current asset or liability is recognized for the estimated taxes receivable or payable for the current year. Deferred taxes represent the future tax consequences expected to occur when the reported amounts of assets and liabilities are recovered or paid. Deferred taxes are initially recognized at enacted tax rates in force at the time of initial recognition and are subsequently adjusted for any enacted changes in tax rates and tax laws. Subsequent changes to deferred taxes originally recognized in equity are recognized in income. Valuation allowances are recorded to reduce deferred tax assets when it is more likely than not that a tax benefit will not be realized. The Company has recorded a full valuation allowance against the deferred tax assets in excess of its deferred tax liabilities, as the deferred tax liability represents future reversals of existing taxable temporary differences. The Company records interest and penalties related to income tax matters as part of income tax expense.
Concentration of Credit Risk and of Significant Supplier	Concentration of Credit Risk and of Significant Supplier Financial instruments that potentially expose the Company to concentrations of credit risk consist primarily of short-term cash deposits and accounts and other receivables. The Company's cash is comprised of short-term cash deposits at a variety of financial institutions with strong credit ratings in amounts that may exceed federally insured limits and has not experienced any losses on such accounts. Cash balances maintained during the year have been principally held with reputable U.K.-based and U.S.-based banks. The Company does not believe it is exposed to any unusual credit risk beyond the normal credit risk associated with commercial banking relationships. The Company maintains deposits in accredited financial institutions in excess of federally insured limits. The Company deposits its cash in financial institutions that it believes have high credit quality and has not experienced any losses on such accounts and does not believe it is exposed to any unusual credit risk beyond the normal credit risk associated with commercial banking relationships. The credit risk with respect to customers and funding bodies is limited as the Company has only a small number of these arrangements.
Fair Value Measurements	Fair Value Measurements In accordance with the provisions of fair value accounting, a fair value measurement assumes that the transaction to sell an asset or transfer a liability occurs in the principal market for the asset or liability or, in the absence of a principal market, the most advantageous market for the asset or liability and defines fair value based on the exit price model. The fair value measurement guidance establishes a fair value hierarchy, which requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. The guidance describes three levels of inputs that may be used to measure fair value: Level 1 Quoted prices in active markets for identical assets or liabilities as of the reporting date. Active markets are those in which transactions for the asset or liability occur in sufficient frequency and volume to provide pricing information on an ongoing basis. Level 2 Observable inputs other than Level 1 prices, such as quoted prices for similar assets or liabilities; quoted prices in markets that are not active; or other inputs that are observable or can be corroborated by observable market data for substantially the full term of the assets or liabilities. Level 2 assets and liabilities include debt securities with quoted prices that are traded less frequently than exchange-traded instruments or securities or derivative contracts that are valued using a pricing model with inputs that are observable in the market or can be derived principally from or corroborated by observable market data. Level 3 Unobservable inputs that are supported by little or no market activity and that are significant to the fair value of the assets or liabilities. Level 3 assets and liabilities include financial instruments whose value is determined using pricing models, discounted cash flow methodologies, or similar techniques, as well as instruments for which the determination of fair value requires significant management judgment or estimation. In certain cases, the inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, the Company categorizes such assets and liabilities based on the lowest level input that is significant to the fair value measurement in its entirety. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires judgment and considers factors specific to the asset.
Cash and Cash Equivalents	Cash and Cash EquivalentsWe consider only those investments that are highly liquid, readily convertible to cash and that mature within 90 days or less from date of purchase to be cash equivalents, and the related investment income is recognized in net loss.
Restricted Cash	Restricted CashRestricted cash represents amounts which are legally restricted to withdrawal or usage and is presented in the Consolidated Balance Sheet as restricted cash.
Assumed Contingent Liabilities	Assumed Contingent Liabilities As part of the acquisition of Discuva Limited in December 2017, the Company assumed certain contingent liabilities as certain employees, former employees and former directors of Discuva Limited are eligible for payments from Discuva Limited based on specified development and clinical milestones related to proprietary product candidates developed under the Discuva Platform. The timing of these potential payments is uncertain. The fair value of the assumed contingent liability was estimated using the expected value of the payments. The assumed contingent liabilities are subsequently measured at amortized cost using discounted cash flow models which calculate the risk adjusted net present values of estimated potential future cash flows of the payments. The assumed contingent liabilities are remeasured when there is a specific significant event that provides evidence of a significant change in the probability of successful development and clinical milestones being achieved. The models will be updated for changes in the probability of successful development and clinical milestones being achieved and other associated assumptions with the discount factor remaining unchanged within the model. A discount factor of 13% has been used to discount the contingent liabilities back to net present value. This discount factor has been calculated using appropriate measures and rates which could have been obtained in the period that the contingent liabilities were assumed. Accretion of the discount factor and gains or losses upon remeasurement are recognized as part of operating expenses in the consolidated statements of operations and comprehensive loss.
Warrants	Warrants Warrants issued by the Company are recognized and classified as equity when, upon exercise, the Company would issue a fixed amount of its own equity instruments (common stock) in exchange for a fixed amount of cash or another financial asset. Consideration received, net of incremental costs directly attributable to the issue of such new warrants, is shown in equity. Such warrants are not remeasured at fair value in subsequent reporting periods. Warrants issued in which external services are received as consideration for equity instruments of the company should be measured at the fair value of the goods or services received. Only if the fair value of the services cannot be measured reliably would the fair value of the equity instruments granted be used. The fair value for the warrants is calculated using the Black-Scholes formula and recorded in the consolidated statement of operations and comprehensive loss on a straight-line basis over the period of the consulting services. If the services are terminated prior to the end of the consultancy agreement, the warrants cease vesting and any unvested portion of the warrants will lapse immediately.
Recently Issued or Adopted Accounting Pronouncements	Recently Issued or Adopted Accounting Pronouncements In November 2021, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") No. 2021-10, " Government Assistance (Topic 832)". This ASU increases the transparency of government assistance including the disclosure of (1) the types of assistance, (2) an entity's accounting for the assistance, and (3) the effect of the assistance on an entity's financial statements as diversity currently exists in the recognition, measurement, presentation and disclosure of government assistance received by business entities because of the lack of specific authoritative guidance in U.S. GAAP. This ASU is effective for annual periods, and interim periods within those fiscal years, beginning after December 15, 2021. Early application of this ASU is permitted. The Company applied the amendments of this ASU to its disclosures during the fourth quarter of 2021 and the application of this ASU did not have a material impact on its financial position, results of operations or cash flows. In October 2021, the FASB issued ASU No. 2021-08, "Business Combinations (Topic 805): Accounting for Contract Assets and Contract Liabilities from Contracts with Customers". This ASU improves the accounting for acquired revenue contracts with customers in a business combination by addressing diversity in practice and inconsistency relating to: 1) recognition of an acquired contract liability and 2) payment terms and their effect on subsequent revenue recognized by the acquirer. The amendments in this ASU require acquiring entities to apply Topic 606 to recognize and measure contract assets and contract liabilities in a business combination, whereas current U.S. GAAP requires that the acquirer measure such assets and liabilities at fair value on the acquisition date. This ASU is effective for annual periods, and interim periods within those fiscal years, beginning after December 15, 2022. The Company will apply this ASU on a prospective basis for business combinations once this ASU is effective and at that time, will be able to determine the potential impact on its financial position, results of operations or cash flows. In May 2021, the FASB issued AS No. 2021-04, "Earnings Per Share (Topic 260), Debt - Modifications and Extinguishments (Subtopic 470-50), Compensation - Stock Compensation (Topic 718), and Derivatives and Hedging Contracts in Entity's Own Equity (Subtopic 815-40) - Issuer's Accounting for Certain Modifications or Exchanges of Freestanding Equity-Classified Written Call Options". This ASU provides clarification and reduces diversity in an issuer’s accounting for modifications or exchanges of freestanding equity-classified written call options (such as warrants) that remain equity classified after modification or exchange. This ASU is effective for annual periods, and interim periods within those fiscal years, beginning after December 15, 2021. The Company will apply this ASU on a prospective basis for any modifications or exchanges once this ASU is effective and at that time, will be able to determine the potential impact on its financial position, results of operations or cash flows. In December 2019, the FASB issued ASU No. 2019-12, "Income Taxes (Topic 740)". This ASU simplifies the accounting for income taxes by removing certain exceptions to the general principles in Topic 740. The amendments also improve consistent application and simplify U.S. GAAP for other areas of Topic 740 by clarifying and amending existing guidance. This ASU is effective for annual periods, and interim periods within those fiscal years, beginning after December 15, 2020. The Company adopted this ASU during the first quarter of 2021 and the adoption of this ASU did not have a material impact on its financial position, results of operations or cash flows.

Summary of Significant Accoun_3

Summary of Significant Accounting Policies (Tables)	12 Months Ended
	Dec. 31, 2022
Accounting Policies [Abstract]
Schedule of property and equipment useful lives	Depreciation is calculated based on cost, less residual value, in equal annual installments over the estimated useful lives of the assets. The residual value, if significant, is reassessed annually. Leasehold improvements Over the shorter of the asset's useful life or the remaining lease term Laboratory equipment 2 - 10 years Office and IT equipment 3 - 5 years Property and equipment consisted of the following: December 31, 2022 December 31, 2021 Laboratory equipment $ 505 $ 546 Furniture and fixtures, office equipment and software 889 819 Leasehold improvements 809 365 Property and equipment, gross 2,203 1,730 Less: accumulated depreciation 1,297 1,036 Property and equipment, net $ 906 $ 694

Segment Reporting (Tables)

Segment Reporting (Tables)	12 Months Ended
	Dec. 31, 2022
Segment Reporting [Abstract]
Summary of long-lived assets by geography	The following table summarizes the Company's long-lived assets, which include the Company's property and equipment, net and right-of-use assets by geography: Year Ended December 31, 2022 Year Ended December 31, 2021 United Kingdom $ 2,517 $ 2,762 United States (1) 2,564 722 $ 5,081 $ 3,484 (1) The increase of long-lived assets in the United States is primarily attributed to additional right-of-use assets recorded related to the Company's first and second amendments to its sublease agreement during the period for its Menlo Park, California, U.S. location.

Revenue (Tables)

Revenue (Tables)	12 Months Ended
	Dec. 31, 2022
Revenue from Contract with Customer [Abstract]
Summary of revenue by category	The following table summarizes revenue by category: Year Ended December 31, 2022 Year Ended December 31, 2021 Licensing agreements $ 705 $ 1,809
Summary of revenue by geography	The following table summarizes revenue by geography: Year Ended December 31, 2022 Year Ended December 31, 2021 Latin America $ 705 $ 1,809
Summary of deferred revenue and other income	The following table summarizes the deferred revenue relating to Eurofarma Laboratórios S.A. and deferred other income relating to BARDA (as defined in Note 8): 2022 2021 Beginning deferred revenue and other income, January 1 (1) $ 7,939 $ 8,939 Additions 1,397 5,443 Amount of deferred revenue and other income recognized in the statement of operations (8,790) (6,438) Foreign currency adjustment (546) (5) Ending deferred revenue and other income, December 31 (2) $ — $ 7,939 __________ (1) Beginning deferred revenue and other income as of January 1, 2022 and 2021 included $7,939 of current and $0 of long-term deferred revenue and other income, and $8,370 of current and $569 of long-term deferred revenue and other income, respectively. (2) Ending deferred revenue and other income as of December 31, 2022 and 2021 included $0 of current and $0 of long-term deferred revenue and other income, and $7,939 of current and $0 of long-term deferred revenue and other income, respectively.

Other Operating Income (Tables)

Other Operating Income (Tables)	12 Months Ended
	Dec. 31, 2022
Other Income and Expenses [Abstract]
Summary of other operating income by category	The following table sets forth the components of other operating income by category: Year Ended December 31, 2022 Year Ended December 31, 2021 Other operating income by category: Funding income from BARDA (as defined below) $ 8,085 $ 4,604 Research and development tax credits 4,523 15,206 Grant income from CARB-X (as defined below) 1,808 1,158 $ 14,416 $ 20,968

Other Expense, net (Tables)

Other Expense, net (Tables)	12 Months Ended
	Dec. 31, 2022
Other Income and Expenses [Abstract]
Schedule of other (expense) income	The following table sets forth the components of other (expense) income: Year Ended December 31, 2022 Year Ended December 31, 2021 Foreign currency loss $ (4,109) $ (2,135) Interest expense on promissory notes payable to related parties (4,401) (242) Investment income 1,513 — Other income (expense), net 304 (39) Other Expense, net $ (6,693) $ (2,416)

Income Tax (Tables)

Income Tax (Tables)	12 Months Ended
	Dec. 31, 2022
Income Tax Disclosure [Abstract]
Components of loss before income taxes	The components of the Company's loss before income taxes are as follows: Year Ended December 31, 2022 Year Ended December 31, 2021 United Kingdom $ (46,868) $ (72,244) United States (31,914) (16,358) Loss before income taxes $ (78,782) $ (88,602)
Major components of deferred tax assets and liabilities	The major components of deferred tax assets and liabilities are as follows: Year Ended December 31, 2022 Year Ended December 31, 2021 Deferred tax assets: Net operating loss carryforward $ 52,948 $ 49,422 Research and development credit carryforward 1,723 941 Stock-based compensation 3,879 2,560 Section 174 Research and Development Capitalization 3,553 — Other 2,139 1,477 Total deferred tax assets 64,242 54,400 Deferred tax liabilities: Intangible asset — (2,600) Other (226) (54) Total deferred tax liabilities (226) (2,654) Net deferred tax assets before valuation allowance 64,016 51,746 Valuation allowance (64,016) (51,746) Deferred tax, net $ — $ —
Reconciliation of the effective income tax rate to the statutory rate	A reconciliation of the Company's effective tax rate to the U.S. federal statutory rate is as follows: Year Ended December 31, 2022 Year Ended December 31, 2021 U.S. federal income tax statutory rate 21.0 % 21.0 % Change in valuation allowance (16.8) (10.5) Non-deductible expenses — (0.4) Refundable research and development tax credit (3.6) (8.3) Effect of foreign operations taxed at various rates 2.1 0.5 Stock-based compensation (2.2) (1.6) Other (0.5) (0.7) — % — %

Loss per Share (Tables)

Loss per Share (Tables)	12 Months Ended
	Dec. 31, 2022
Earnings Per Share [Abstract]
Schedule of net loss per share	The following table sets forth the computation of basic and diluted net loss per share: Year Ended December 31, 2022 Year Ended December 31, 2021 Net loss $ (78,782) $ (88,602) Basic weighted average number of shares of common stock outstanding 193,336,063 131,714,225 Diluted weighted average number of shares of common stock outstanding 193,336,063 131,714,225 Basic net loss per share $ (0.41) $ (0.67) Diluted net loss per share $ (0.41) $ (0.67)
Schedule of potentially dilutive securities excluded from the computation of loss per share	The following potentially dilutive securities were excluded from the computation of the diluted net loss per share of common stock for the periods presented because their effect would have been anti-dilutive: 2022 2021 Options to purchase common stock 19,476,359 13,797,556 Warrants 5,821,137 5,821,137 Shares expected to be purchased under employee stock purchase plan 229,475 202,045 25,526,971 19,820,738

Goodwill and Intangible Assets

Goodwill and Intangible Assets (Tables)	12 Months Ended
	Dec. 31, 2022
Goodwill and Intangible Assets Disclosure [Abstract]
Schedule of acquired intangible assets	Components of the Company's acquired intangible assets are comprised of the following: December 31, 2022 Gross Accumulated amortization and impairment charges Net Utrophin program acquired $ 4,015 $ (4,015) $ — Discuva platform acquired 12,900 (12,900) — Option over non-financial asset 816 (816) — Other intangibles 133 (133) — $ 17,864 $ (17,864) $ — December 31, 2021 Gross Accumulated amortization and impairment charges Net Utrophin program acquired $ 4,487 $ (4,487) $ — Discuva platform acquired 14,416 (4,017) 10,399 Option over non-financial asset 912 (912) — Other intangibles 148 (148) — $ 19,963 $ (9,564) $ 10,399

Cash Equivalents and Fair Val_2

Cash Equivalents and Fair Value Measurements (Tables)	12 Months Ended
	Dec. 31, 2022
Fair Value Disclosures [Abstract]
Schedule of financial assets measured at fair value on a recurring basis	The following tables set forth the fair value of the Company's financial assets measured at fair value on a recurring basis and indicates the level within the fair value hierarchy utilized to determine such values: Fair Value Measurements as of December 31, 2022 using: Level 1 Level 2 Level 3 Total Cash equivalents: Money market funds $ 60,783 $ — $ — $ 60,783 U.S. Government treasury bills $ — $ 225,730 $ — $ 225,730 Total financial assets $ 60,783 $ 225,730 $ — $ 286,513

Property and Equipment (Tables)

Property and Equipment (Tables)	12 Months Ended
	Dec. 31, 2022
Property, Plant and Equipment [Abstract]
Schedule of property and equipment	Depreciation is calculated based on cost, less residual value, in equal annual installments over the estimated useful lives of the assets. The residual value, if significant, is reassessed annually. Leasehold improvements Over the shorter of the asset's useful life or the remaining lease term Laboratory equipment 2 - 10 years Office and IT equipment 3 - 5 years Property and equipment consisted of the following: December 31, 2022 December 31, 2021 Laboratory equipment $ 505 $ 546 Furniture and fixtures, office equipment and software 889 819 Leasehold improvements 809 365 Property and equipment, gross 2,203 1,730 Less: accumulated depreciation 1,297 1,036 Property and equipment, net $ 906 $ 694

Leases (Tables)

Leases (Tables)	12 Months Ended
	Dec. 31, 2022
Leases [Abstract]
Schedule of lease expense	The elements of lease expense were as follows: Lease Cost: Year Ended December 31, 2022 Year Ended December 31, 2021 Fixed lease costs $ 1,384 $ 785 Variable lease costs 137 164 Short-term lease (1) 31 278 Total lease cost $ 1,552 $ 1,227 (1) Short-term lease costs relate to the Company's Cambridge, Massachusetts, United States office lease which the Company exited during fiscal year 2022.
Schedule of future lease payments	Future lease payments under non-cancelable leases as of December 31, 2022 are detailed as follows: Year Ending December 31, 2023 $ 1,474 2024 1,502 2025 1,533 2026 381 Total lease payments 4,890 Less: imputed interest 437 Total operating lease liabilities $ 4,453 Total operating lease liabilities balance sheet presentation: Current lease liabilities $ 1,690 Non-current lease liabilities 2,763 $ 4,453

Promissory Notes Payable to R_2

Promissory Notes Payable to Related Parties (Tables)	12 Months Ended
	Dec. 31, 2022
Related Party Transactions [Abstract]
Schedule of related party debt	Non-current and current debt consisted of the following: Current notes Non-current notes December 31, 2022 December 31, 2021 December 31, 2022 December 31, 2021 Principal amounts $ 20,000 $ — $ 500,000 — Debt discount (230) — (5,460) $ — Total promissory notes payable to related parties $ 19,770 $ — $ 494,540 $ —
Schedule of estimated future principal payments	As of December 31, 2022, and reflecting the Company's election to extend the term of the Duggan February Note and the Duggan September Note, the estimated future principal payments due were as follows: Year Ending December 31, 2023 $ 20,000 2024 500,000 $ 520,000

Stock Based Compensation (Table

Stock Based Compensation (Tables)	12 Months Ended
	Dec. 31, 2022
Share-Based Payment Arrangement [Abstract]
Schedule of weighted-average assumptions used for stock option awards	The assumptions used in the Company's valuation are summarized as follows, presented on a weighted average basis: Year Ended December 31, 2022 Year Ended December 31, 2021 Risk-free interest rate 3.11 % 1.05 % Expected term (in years) 5.9 5.7 Expected volatility 91.2 % 74.5 % Expected annual dividends per share — % — %
Schedule of stock option activity	The following table summarizes the Company's stock option activity for the year ended December 31, 2022: Number of share options Weighted average exercise price Weighted average remaining contractual term Aggregate intrinsic value Outstanding as of December 31, 2021 13,797,556 $ 5.55 8.6 years $ 712 Granted 9,837,797 1.31 Forfeited (4,097,040) 4.89 Exercised (61,954) 2.04 Outstanding as of December 31, 2022 19,476,359 $ 3.55 8.8 years $ 29,657 Outstanding as of December 31, 2022 - vested and expected to vest 13,110,654 4.49 8.5 years $ 11,799 Exercisable at December 31, 2022 3,895,109 $ 4.91 8.0 years $ 1,652
Schedule of stock-based compensation expense	Stock‑based compensation expense related to stock options is recorded within the consolidated statements of operations and comprehensive loss as follows: Year Ended December 31, 2022 Year Ended December 31, 2021 Research and development $ 4,303 $ 5,909 General and administrative 7,645 6,895 Total stock-based compensation $ 11,948 $ 12,804

Nature of Business and Operat_2

Nature of Business and Operations and Recent Events (Details) $ / shares in Units, $ in Thousands

2 Months Ended

12 Months Ended

Mar. 06, 2023 USD ($)

Mar. 01, 2023 USD ($) $ / shares shares

Feb. 15, 2023 USD ($)

Jan. 19, 2023 shares

Jan. 17, 2023 USD ($) shares

Jan. 06, 2023

Aug. 08, 2022 USD ($) $ / shares shares

Jul. 27, 2022 shares

May 12, 2021 USD ($) $ / shares shares

Mar. 06, 2023 USD ($)

Dec. 31, 2022 USD ($) shares

Dec. 31, 2021 USD ($) shares

Dec. 06, 2022 USD ($)

Jul. 26, 2022 shares

Subsequent Event [Line Items]

Increase in common stock, shares authorized (in shares) | shares

100,000,000

Common stock, shares authorized (in shares) | shares

350,000,000

350,000,000

350,000,000

250,000,000

Gross proceeds from the sale of stock

$ 100,000

$ 75,000

Issuance costs

111

118

Repayment of related party notes payable

$ 25,000

$ 110,000

Rights Offering

Subsequent Event [Line Items]

Gross proceeds from the sale of stock

$ 100,000

$ 75,000

Shares issued (in shares) | shares

103,092,783

14,312,976

Sale of stock price (in dollars per share) | $ / shares

$ 0.97

$ 5.24

Issuance costs

$ 111

$ 159

Chief Executive Officer | Rights Offering

Subsequent Event [Line Items]

Shares issued (in shares) | shares

11,365,921

Sale of stock price (in dollars per share) | $ / shares

$ 5.24

Co-Chief Executive Officer and President | Rights Offering

Subsequent Event [Line Items]

Shares issued (in shares) | shares

389,977

Sale of stock price (in dollars per share) | $ / shares

$ 5.24

Note Purchase Agreement | Chief Executive Officer and Co-Chief Executive Officer and President

Subsequent Event [Line Items]

Notes payable, related parties

$ 520,000

Zanganeh Note | Co-Chief Executive Officer and President

Subsequent Event [Line Items]

Notes payable, related parties

20,000

Duggan February Note | Chief Executive Officer

Subsequent Event [Line Items]

Notes payable, related parties

$ 400,000

Subsequent event

Subsequent Event [Line Items]

Increase in common stock, shares authorized (in shares) | shares

650,000,000

Common stock, shares authorized (in shares) | shares

1,000,000,000

Subsequent event | Minimum

Subsequent Event [Line Items]

Reverse stock split ratio authorized

0.2

Subsequent event | Maximum

Subsequent Event [Line Items]

Reverse stock split ratio authorized

0.1

Subsequent event | Rights Offering

Subsequent Event [Line Items]

Gross proceeds from the sale of stock

$ 500,000

Shares issued (in shares) | shares

476,190,471

Sale of stock price (in dollars per share) | $ / shares

$ 1.05

Issuance costs

$ 500

Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement

Subsequent Event [Line Items]

Collaborative arrangement, upfront payment payable

$ 500,000

Collaborative arrangement, potential upfront and milestone payments

5,000,000

Collaborative arrangement, potential regulatory milestone payments

1,050,000

Collaborative arrangement, potential commercial milestone payments

3,450,000

Cash payment for collaborative arrangement, upfront payment

$ 474,900

Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement, upfront payment one

Subsequent Event [Line Items]

Collaborative arrangement, upfront payment payable

$ 300,000

Collaborative arrangement, upfront payment, minimum payable period

15 days

Collaborative arrangement, option for shares of common stock in lieu of upfront payment | shares

16,000,000

Volume-weighted average price, period

10 days

Volume-weighted average price, period prior to agreement execution

5 days

Volume-weighted average price, period after agreement execution

5 days

Collaborative arrangement, common stock issued in lieu of cash upfront payment (in shares) | shares

10,000,000

Cash payment for collaborative arrangement, upfront payment

$ 274,900

Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement, upfront payment two

Subsequent Event [Line Items]

Collaborative arrangement, upfront payment payable

$ 200,000

Collaborative arrangement, upfront payment, minimum payable period

90 days

Cash payment for collaborative arrangement, upfront payment

$ 200,000

Subsequent event | Zanganeh Note | Co-Chief Executive Officer and President

Subsequent Event [Line Items]

Repayment of related party notes payable

$ 20,000

Subsequent event | Duggan February Note | Chief Executive Officer

Subsequent Event [Line Items]

Repayment of related party notes payable

$ 400,000

Liquidity and Capital Resourc_2

Liquidity and Capital Resources (Details) - USD ($) $ in Thousands		1 Months Ended	2 Months Ended	12 Months Ended
	Mar. 01, 2023	Mar. 01, 2023	Mar. 06, 2023	Dec. 31, 2022	Dec. 31, 2021	Dec. 15, 2022
Subsequent Event [Line Items]
Net loss				$ 78,782	$ 88,602
Net cash used in operating activities				41,582	72,587
Accumulated deficit				378,330	299,548
Cash and cash equivalents				348,607	71,791
Restricted cash				300,000	0	$ 300,000
Research and development tax credit receivable				5,766
Accounts receivable				349	1,464
Repayment of related party notes payable				$ 25,000	$ 110,000
Subsequent event
Subsequent Event [Line Items]
Net proceeds From the sale of stock	$ 499,500
Subsequent event | Duggan February Note and Zanganeh Note | Chief Executive Officer and Co-Chief Executive Officer and President
Subsequent Event [Line Items]
Repayment of related party notes payable		$ 420,000
Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement
Subsequent Event [Line Items]
Cash payment for collaborative arrangement, upfront payment			$ 474,900

Summary of Significant Accoun_4

Summary of Significant Accounting Policies (Details) $ in Thousands, shares in Millions		2 Months Ended	12 Months Ended
	Jan. 17, 2023 USD ($) shares	Mar. 06, 2023 USD ($)	Dec. 31, 2022 USD ($)	Dec. 31, 2021 USD ($)	Dec. 15, 2022 USD ($)
Significant Accounting Policies [Line Items]
Foreign currency transaction losses			$ 4,109	$ 2,135
Research and development maximum cash rebate percentage			33.30%
Intangible assets, net			$ 0	10,399
Restricted cash			$ 300,000	$ 0	$ 300,000
Discount rate
Significant Accounting Policies [Line Items]
Assumed contingent liability, measurement input			0.13
Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement
Significant Accounting Policies [Line Items]
Cash payment for collaborative arrangement, upfront payment		$ 474,900
Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement, upfront payment one
Significant Accounting Policies [Line Items]
Collaborative arrangement, common stock issued in lieu of cash upfront payment (in shares) | shares	10
Cash payment for collaborative arrangement, upfront payment	$ 274,900
Minimum
Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives			1 year
Equity award, vesting period			3 years
Minimum | Laboratory equipment
Significant Accounting Policies [Line Items]
Property and equipment, estimated useful Lives			2 years
Minimum | Office and IT equipment
Significant Accounting Policies [Line Items]
Property and equipment, estimated useful Lives			3 years
Maximum
Significant Accounting Policies [Line Items]
Intangible assets, estimated useful lives			18 years
Equity award, vesting period			4 years
Maximum | Laboratory equipment
Significant Accounting Policies [Line Items]
Property and equipment, estimated useful Lives			10 years
Maximum | Office and IT equipment
Significant Accounting Policies [Line Items]
Property and equipment, estimated useful Lives			5 years

Segment Reporting - Narrative (

Segment Reporting - Narrative (Details)	12 Months Ended
	Dec. 31, 2022 country segment
Segment Reporting [Abstract]
Number of operating segments | segment	1
Number of geographic regions in which the Company operates | country	2

Segment Reporting - Long-lived

Segment Reporting - Long-lived assets by geography (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Revenues from External Customers and Long-Lived Assets [Line Items]
Long-lived assets	$ 5,081	$ 3,484
United Kingdom
Revenues from External Customers and Long-Lived Assets [Line Items]
Long-lived assets	2,517	2,762
United States
Revenues from External Customers and Long-Lived Assets [Line Items]
Long-lived assets	$ 2,564	$ 722

Revenue - Revenue by category (

Revenue - Revenue by category (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Revenue from External Customer [Line Items]
Revenue	$ 705	$ 1,809
Licensing agreements
Revenue from External Customer [Line Items]
Revenue	$ 705	$ 1,809

Revenue - Revenue by geography

Revenue - Revenue by geography (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Disaggregation of Revenue [Line Items]
Revenue	$ 705	$ 1,809
Latin America
Disaggregation of Revenue [Line Items]
Revenue	$ 705	$ 1,809

Revenue - Deferred revenue and

Revenue - Deferred revenue and other income (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2020
Change in Contract with Customer, Asset and Liability [Roll Forward]
Beginning deferred revenue and other income	$ 7,939	$ 8,939
Additions	1,397	5,443
Amount of deferred revenue and other income recognized in the statement of operations	(8,790)	(6,438)
Foreign currency adjustment	(546)	(5)
Ending deferred revenue and other income	0	7,939
Current deferred revenue and other income	0	7,939	$ 8,370
Long-term deferred revenue and other income	$ 0	$ 0	$ 569

Revenue - Narrative (Details)

Revenue - Narrative (Details) $ in Thousands	12 Months Ended		60 Months Ended
	Dec. 31, 2022 USD ($) milestone	Dec. 31, 2021 USD ($)	Dec. 31, 2022 USD ($)	Sep. 30, 2021 USD ($)	Dec. 31, 2020 USD ($)	Feb. 29, 2020 USD ($)	Dec. 31, 2017 USD ($)
Disaggregation of Revenue [Line Items]
Deferred revenue and other income	$ 0	$ 7,939	$ 0		$ 8,939
Current contract liability	0	7,939	0		$ 8,370
Revenue	705	1,809
Licensing agreements
Disaggregation of Revenue [Line Items]
Deferred revenue and other income	0		0
Revenue	$ 705	1,809
Licensing agreements | EuroFarma
Disaggregation of Revenue [Line Items]
Deferred revenue and other income		756					$ 2,500
Deferred revenue, enrollment milestone				$ 1,250		$ 1,000
Number of enrollment milestones included in transaction price | milestone	2
Current contract liability	$ 0	756	0
Revenue			$ 4,678
Licensing agreements | BARDA
Disaggregation of Revenue [Line Items]
Deferred revenue and other income		$ 7,183

Other Operating Income - Other

Other Operating Income - Other operating income by category (Details) - USD ($) $ in Thousands	12 Months Ended		20 Months Ended	64 Months Ended
	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2022	Dec. 31, 2022
Revenue from External Customer [Line Items]
Research and development tax credits	$ 4,523	$ 15,206
Other operating income	14,416	20,968
BARDA
Revenue from External Customer [Line Items]
Funding/Grant income	8,085	4,604		$ 59,203
CARB-X
Revenue from External Customer [Line Items]
Funding/Grant income	$ 1,808	$ 1,158	$ 2,875

Other Operating Income - Narrat

Other Operating Income - Narrative (Details) - USD ($) $ in Thousands	1 Months Ended		12 Months Ended		20 Months Ended	64 Months Ended
	May 31, 2021	Sep. 30, 2017	Dec. 31, 2022	Dec. 31, 2021	Dec. 31, 2022	Dec. 31, 2022
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Current research and development tax credit receivable			$ 5,766	$ 15,695	$ 5,766	$ 5,766
BARDA
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum funding value		$ 62,000	72,500
Total committed funding			62,400
Funding/Grant income			8,085	4,604		$ 59,203
CARB-X
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum funding value	$ 4,100
Funding/Grant income			$ 1,808	$ 1,158	$ 2,875
Funding increase based on achievement of future milestones	$ 3,700

Other Expense, net - Components

Other Expense, net - Components (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Other Income and Expenses [Abstract]
Foreign currency loss	$ (4,109)	$ (2,135)
Interest expense on promissory notes payable to related parties	(4,401)	(242)
Investment income	1,513	0
Other income (expense), net	304	(39)
Other Expense, net	$ (6,693)	$ (2,416)

Other Expense, net - Narrative

Other Expense, net - Narrative (Details) - USD ($) $ in Thousands	Dec. 06, 2022	Mar. 10, 2022	Mar. 24, 2021
Note Purchase Agreement | Chief Executive Officer and Co-Chief Executive Officer and President
Related Party Transaction [Line Items]
Notes payable, related parties	$ 520,000
March 2022 Note | Chief Executive Officer
Related Party Transaction [Line Items]
Notes payable, related parties		$ 25,000
Initial Purchase Agreement | Chief Executive Officer
Related Party Transaction [Line Items]
Notes payable, related parties			$ 55,000

Income Tax - Components of loss

Income Tax - Components of loss before income taxes (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
United Kingdom	$ (46,868)	$ (72,244)
United States	(31,914)	(16,358)
Loss before income tax	$ (78,782)	$ (88,602)

Income Tax - Narrative (Details

Income Tax - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Schedule Of Income Tax [Line Items]
Current provision for federal income taxes	$ 0	$ 0
Current provision for state income taxes		0
Current provision for non-United States income taxes		0
Deferred provision for federal income taxes	0	0
Deferred provision for state income taxes	0	0
Deferred provision for non-United States income taxes	0	0
Deferred tax asset	64,242,000	54,400,000
Increase in valuation allowance	12,270,000
Research and experimental expenditures capitalized	14,830,000
Net adjustment for research and experimental expenditures	13,347,000
Increase in net deferred tax assets due to change in enacted tax rate		9,311,000
Increase in valuation allowance due to change in enacted tax rate		9,311,000
Research and development tax relief	4,523,000	15,206,000
Liability for unrecognized tax benefits	0	0
Liability for interest and penalties	0	0
Research and development tax credit carryforwards
Schedule Of Income Tax [Line Items]
Tax credit carryforward	1,723,000
U.S. Federal
Schedule Of Income Tax [Line Items]
Operating loss carryforwards	11,620,000	$ 4,921,000
U.S. State
Schedule Of Income Tax [Line Items]
Operating loss carryforwards	7,278,000
U.K.
Schedule Of Income Tax [Line Items]
Operating loss carryforwards	199,091,000
Potential deferred tax asset	$ 49,773,000

Income Tax - Major components o

Income Tax - Major components of deferred tax assets and liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred tax assets:
Net operating loss carryforward	$ 52,948	$ 49,422
Research and development credit carryforward	1,723	941
Stock-based compensation	3,879	2,560
Section 174 Research and Development Capitalization	3,553	0
Other	2,139	1,477
Total deferred tax assets	64,242	54,400
Deferred tax liabilities:
Intangible asset	0	(2,600)
Other	(226)	(54)
Total deferred tax liabilities	(226)	(2,654)
Net deferred tax assets before valuation allowance	64,016	51,746
Valuation allowance	(64,016)	(51,746)
Deferred tax, net	$ 0	$ 0

Income Tax - Reconciliation of

Income Tax - Reconciliation of the effective income tax rate to statutory rate (Details)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Tax Disclosure [Abstract]
U.S. federal income tax statutory rate	21%	21%
Change in valuation allowance	(16.80%)	(10.50%)
Non-deductible expenses	0%	(0.40%)
Refundable research and development tax credit	(3.60%)	(8.30%)
Effect of foreign operations taxed at various rates	2.10%	0.50%
Stock-based compensation	(2.20%)	(1.60%)
Other	(0.50%)	(0.70%)
Effective tax rate	0%	0%

Loss per Share - Computation of

Loss per Share - Computation of net loss per share (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Earnings Per Share [Abstract]
Net loss	$ (78,782)	$ (88,602)
Basic weighted average number of shares of common stock outstanding (in shares)	193,336,063	131,714,225
Diluted weighted average number of shares of common stock outstanding (in shares)	193,336,063	131,714,225
Basic net loss per share (in dollars per share)	$ (0.41)	$ (0.67)
Diluted net loss per share (in dollars per share)	$ (0.41)	$ (0.67)

Loss per Share - Narrative (Det

Loss per Share - Narrative (Details) - $ / shares	Mar. 01, 2023	Aug. 08, 2022	May 12, 2021
Subsequent event
Subsidiary, Sale of Stock [Line Items]
Closing share price (in dollars per share)	$ 1.82
Rights Offering
Subsidiary, Sale of Stock [Line Items]
Exercise price (in dollars per share)		$ 0.97	$ 5.24
Rights Offering | Subsequent event
Subsidiary, Sale of Stock [Line Items]
Exercise price (in dollars per share)	$ 1.05

Loss per Share - Potentially di

Loss per Share - Potentially dilutive securities excluded from the computation of loss per share (Details) - shares	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from the computation of diluted loss per share (in shares)	25,526,971	19,820,738
Options to purchase common stock
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from the computation of diluted loss per share (in shares)	19,476,359	13,797,556
Warrants
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from the computation of diluted loss per share (in shares)	5,821,137	5,821,137
Shares expected to be purchased under employee stock purchase plan
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Potentially dilutive securities excluded from the computation of diluted loss per share (in shares)	229,475	202,045

Goodwill and Intangible Asset_2

Goodwill and Intangible Assets - Narrative (Details)	12 Months Ended
	Dec. 31, 2022 USD ($) reporting_unit	Dec. 31, 2021 USD ($)
Goodwill and Intangible Assets Disclosure [Abstract]
Number of reporting units | reporting_unit	1
Goodwill impairment charge	$ 0
Cumulative goodwill impairment charges	0
Goodwill	1,798,000	$ 2,009,000
Amortization expense	$ 914,000	$ 1,017,000
Finite-Lived Intangible Assets [Line Items]
Impairment, Intangible Asset, Finite-Lived, Statement of Income or Comprehensive Income [Extensible Enumeration]	Impairment of intangible assets
Discuva platform | Software
Finite-Lived Intangible Assets [Line Items]
Impairment charge	$ 8,500,000

Goodwill and Intangible Asset_3

Goodwill and Intangible Assets - Schedule of acquired intangible assets (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Finite-Lived Intangible Assets [Line Items]
Gross	$ 17,864	$ 19,963
Accumulated amortization and impairment charges	(17,864)	(9,564)
Net	0	10,399
Software | Utrophin program
Finite-Lived Intangible Assets [Line Items]
Gross	4,015	4,487
Accumulated amortization and impairment charges	(4,015)	(4,487)
Net	0	0
Software | Discuva platform
Finite-Lived Intangible Assets [Line Items]
Gross	12,900	14,416
Accumulated amortization and impairment charges	(12,900)	(4,017)
Net	0	10,399
Option over non-financial asset
Finite-Lived Intangible Assets [Line Items]
Gross	816	912
Accumulated amortization and impairment charges	(816)	(912)
Net	0	0
Other intangibles
Finite-Lived Intangible Assets [Line Items]
Gross	133	148
Accumulated amortization and impairment charges	(133)	(148)
Net	$ 0	$ 0

Cash Equivalents and Fair Val_3

Cash Equivalents and Fair Value Measurements - Recurring basis (Details) $ in Thousands	Dec. 31, 2022 USD ($)
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total financial assets	$ 286,513
Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	60,783
U.S. Government treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	225,730
Level 1
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total financial assets	60,783
Level 1 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	60,783
Level 1 | U.S. Government treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	0
Level 2
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total financial assets	225,730
Level 2 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	0
Level 2 | U.S. Government treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	225,730
Level 3
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Total financial assets	0
Level 3 | Money market funds
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	0
Level 3 | U.S. Government treasury bills
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items]
Cash equivalents	$ 0

Cash Equivalents and Fair Val_4

Cash Equivalents and Fair Value Measurements - Narrative (Details) - USD ($)	Dec. 31, 2022	Dec. 31, 2021
Fair Value Disclosures [Abstract]
Cash	$ 62,094,000	$ 71,791,000
Cash equivalents		$ 0

Property and Equipment - Compon

Property and Equipment - Components of property and equipment (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 2,203	$ 1,730
Less: accumulated depreciation	1,297	1,036
Property and equipment, net	906	694
Laboratory equipment
Property, Plant and Equipment [Line Items]
Property and equipment, gross	505	546
Furniture and fixtures, office equipment and software
Property, Plant and Equipment [Line Items]
Property and equipment, gross	889	819
Leasehold improvements
Property, Plant and Equipment [Line Items]
Property and equipment, gross	$ 809	$ 365

Property and Equipment - Narrat

Property and Equipment - Narrative (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Property, Plant and Equipment [Abstract]
Depreciation expense	$ 349	$ 330

Research and Development Prep_2

Research and Development Prepaid Expenses and Accrued Liabilities (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Deferred Costs, Capitalized, Prepaid, and Other Assets Disclosure [Abstract]
Prepaid research and development expenditures	$ 442	$ 6,138
Accrued research and development expenditure	$ 8,911	$ 5,226

Leases - Narrative (Details)

Leases - Narrative (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Lessee, Lease, Description [Line Items]
Additional right-of-use assets recorded	$ 2,860	$ 3,389
Right-of-use assets	$ 4,175	$ 2,790
Weighted average discount rate	5.70%	2.50%
Weighted average remaining lease term	3 years 4 months 24 days	3 years 10 months 24 days
Cash payments related to lease liabilities	$ 1,092	$ 1,041
Menlo Park, California, US
Lessee, Lease, Description [Line Items]
Additional right-of-use assets recorded	2,755
Oxfordshire, UK
Lessee, Lease, Description [Line Items]
Additional right-of-use assets recorded	$ 105

Leases - Lease expense (Details

Leases - Lease expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Lease Cost:
Fixed lease costs	$ 1,384	$ 785
Variable lease costs	137	164
Short-term lease	31	278
Total lease cost	$ 1,552	$ 1,227

Leases - Future lease payments

Leases - Future lease payments (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Leases [Abstract]
2023	$ 1,474
2024	1,502
2025	1,533
2026	381
Total lease payments	4,890
Less: imputed interest	437
Total operating lease liabilities	4,453
Total operating lease liabilities balance sheet presentation:
Current lease liabilities	1,690	$ 1,091
Non-current lease liabilities	2,763	$ 1,691
Total operating lease liabilities	$ 4,453

Promissory Notes Payable to R_3

Promissory Notes Payable to Related Parties - Summary of related party debt (Details) - USD ($) $ in Thousands	Dec. 31, 2022	Dec. 31, 2021
Related Party Transaction [Line Items]
Total promissory notes payable to related parties, current	$ 19,770	$ 0
Total promissory notes payable to related parties, noncurrent	494,540	0
Promissory Notes
Related Party Transaction [Line Items]
Principal amounts, current	20,000	0
Debt discount, current	(230)	0
Total promissory notes payable to related parties, current	19,770	0
Principal amounts, noncurrent	500,000	0
Debt discount, noncurrent	(5,460)	0
Total promissory notes payable to related parties, noncurrent	$ 494,540	$ 0

Promissory Notes Payable to R_4

Promissory Notes Payable to Related Parties - Narrative (Details) $ / shares in Units, $ in Thousands

1 Months Ended

12 Months Ended

Mar. 01, 2023 USD ($)

Feb. 15, 2023 USD ($)

Jan. 19, 2023 USD ($) promissory_note

Dec. 06, 2022 USD ($) $ / shares shares

Aug. 10, 2022 USD ($)

Aug. 08, 2022 USD ($)

Jun. 30, 2022

Mar. 10, 2022 USD ($)

May 12, 2021 USD ($)

Mar. 24, 2021 USD ($)

Mar. 01, 2023 USD ($)

Dec. 31, 2022 USD ($) $ / shares

Dec. 31, 2021 USD ($) $ / shares

Related Party Transaction [Line Items]

Proceeds from related party promissory notes

$ 545,000

$ 110,000

Repayment of related party notes payable

25,000

110,000

Gross proceeds from the sale of stock

$ 100,000

$ 75,000

Common stock par value (in dollars per share) | $ / shares

$ 0.01

$ 0.01

$ 0.01

Rights Offering

Related Party Transaction [Line Items]

Gross proceeds from the sale of stock

$ 100,000

$ 75,000

Rights Offering | Subsequent event

Related Party Transaction [Line Items]

Gross proceeds from the sale of stock

$ 500,000

March 2022 Note | Chief Executive Officer

Related Party Transaction [Line Items]

Proceeds from related party promissory notes

$ 25,000

Notes payable, related parties

25,000

Notes payable, maturity triggering event, public offering proceeds threshold

$ 25,000

Notes payable, maximum term

18 months

Repayment of related party notes payable

$ 25,000

Payment of related party interest

$ 434

Interest expense, related party

$ 1,296

Amortized imputed interest

861

Interest rate

4.75%

3.25%

Note Purchase Agreement | Chief Executive Officer and Co-Chief Executive Officer and President

Related Party Transaction [Line Items]

Notes payable, related parties

$ 520,000

Interest expense, related party

3,105

$ 244

Amortized imputed interest

$ 395

$ 159

Period from public offering

5 days

Public offering proceeds threshold percentage

100%

Interest rate

7.50%

Prepaid interest, conversion amount | $ / shares

$ 0.7913

Prepaid interest, conversion amount base | $ / shares

$ 0.01

Common stock issued for prepaid interest (in shares) | shares

9,720,291

Debt issuance costs

$ 44

Note Purchase Agreement | Chief Executive Officer and Co-Chief Executive Officer and President | Prime Rate | Variable rate, three months immediately following February 15, 2023

Related Party Transaction [Line Items]

Interest rate margin

0.50%

Note Purchase Agreement | Chief Executive Officer and Co-Chief Executive Officer and President | Prime Rate | Variable rate, thereafter

Related Party Transaction [Line Items]

Interest rate margin

3%

Duggan Promissory Notes | Chief Executive Officer | Subsequent event

Related Party Transaction [Line Items]

Notes payable, maturity triggering event, public offering proceeds threshold

$ 500,000

New note issuances | promissory_note

2

Duggan September Note | Chief Executive Officer

Related Party Transaction [Line Items]

Notes payable, related parties

$ 100,000

Effective interest rate

8.80%

Duggan February Note | Chief Executive Officer

Related Party Transaction [Line Items]

Notes payable, related parties

400,000

Effective interest rate

8.70%

Duggan February Note | Chief Executive Officer | Subsequent event

Related Party Transaction [Line Items]

Repayment of related party notes payable

$ 400,000

Zanganeh Note | Co-Chief Executive Officer and President

Related Party Transaction [Line Items]

Notes payable, related parties

$ 20,000

Effective interest rate

8.70%

Zanganeh Note | Co-Chief Executive Officer and President | Subsequent event

Related Party Transaction [Line Items]

Repayment of related party notes payable

$ 20,000

Duggan February Note and Zanganeh Note | Chief Executive Officer and Co-Chief Executive Officer and President

Related Party Transaction [Line Items]

Period from public offering

5 days

Public offering proceeds threshold percentage

100%

Duggan February Note and Zanganeh Note | Chief Executive Officer and Co-Chief Executive Officer and President | Subsequent event

Related Party Transaction [Line Items]

Repayment of related party notes payable

$ 420,000

Initial Purchase Agreement | Chief Executive Officer

Related Party Transaction [Line Items]

Proceeds from related party promissory notes

$ 55,000

Notes payable, related parties

55,000

Notes payable, maturity triggering event, public offering proceeds threshold

$ 55,000

Notes payable, maximum term

13 months

Promissory Notes Payable to R_5

Promissory Notes Payable to Related Parties - Estimated future principal payments (Details) - Promissory Notes $ in Thousands	Dec. 31, 2022 USD ($)
Related Party Transaction [Line Items]
2023	$ 20,000
2024	500,000
Notes payable, related parties, gross	$ 520,000

Other Non-Current Liabilities (

Other Non-Current Liabilities (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Payables and Accruals [Abstract]
Assumed contingent liabilities, non-current	$ 1,209,000	$ 2,531,000
Remeasurement gains (losses)	$ 1,265,000	$ 0

Stockholders' Equity (Details)

Stockholders' Equity (Details) - USD ($) $ / shares in Units, $ in Thousands					12 Months Ended
	Aug. 08, 2022	May 12, 2021	Jun. 30, 2020	Dec. 24, 2019	Dec. 31, 2022	Dec. 31, 2021
Subsidiary, Sale of Stock [Line Items]
Gross proceeds from the sale of stock					$ 100,000	$ 75,000
Offering costs					$ 111	$ 118
Number of common stock shares into which each warrant converts (in shares)					1
Warrants outstanding (in shares)					5,821,137	5,821,137
Warrants
Subsidiary, Sale of Stock [Line Items]
Aggregate intrinsic value					$ 15,640	$ 6,559
Consulting Agreement | Affiliated entity
Subsidiary, Sale of Stock [Line Items]
Number of common stock shares into which warrants may be converted (in shares)				3,358,732
Exercise price of warrants (in dollars per share)				$ 1.44
Warrants quarterly vesting period				3 years
Consulting Agreement | Affiliated entity | Warrants
Subsidiary, Sale of Stock [Line Items]
Warrants cancelled (in shares)			2,798,945
Warrants outstanding (in shares)					559,787
Rights Offering
Subsidiary, Sale of Stock [Line Items]
Gross proceeds from the sale of stock	$ 100,000	$ 75,000
Shares issued (in shares)	103,092,783	14,312,976
Sale of stock price (in dollars per share)	$ 0.97	$ 5.24
Offering costs	$ 111	$ 159
Private placement
Subsidiary, Sale of Stock [Line Items]
Number of common stock shares into which warrants may be converted (in shares)				5,261,350
Exercise price of warrants (in dollars per share)				$ 1.58
Number of common stock shares into which each warrant converts (in shares)				1
Minimum volume weighted average common stock price to warrant exercise price, premium, percentage				50%

Stock Based Compensation - Narr

Stock Based Compensation - Narrative (Details)							7 Months Ended	12 Months Ended
	Jan. 19, 2023 shares	Jul. 27, 2022 shares	Mar. 01, 2022	Sep. 24, 2021 employee shares	Sep. 21, 2020 shares	Aug. 19, 2020 shares	Feb. 28, 2022	Dec. 31, 2022 USD ($) $ / shares shares	Dec. 31, 2021 USD ($) $ / shares shares	Jul. 26, 2022 shares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Increase in common stock, shares authorized (in shares)		100,000,000
Common stock, shares authorized (in shares)		350,000,000						350,000,000	350,000,000	250,000,000
Options granted (in shares)				9,250,000				9,837,797
Weighted-average grant date fair value of stock options granted (in dollars per share) | $ / shares								$ 0.87	$ 3.50
Aggregate intrinsic value, options exercised | $								$ 142,000	$ 3,744,000
Number of common stock shares into which each warrant converts (in shares)								1
Subsequent event
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Increase in common stock, shares authorized (in shares)	650,000,000
Common stock, shares authorized (in shares)	1,000,000,000
Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity award, vesting period								3 years
Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity award, vesting period								4 years
ESPP
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares initially reserve for future issuance (in shares)						1,000,000
Potential number of additional shares that can be added to the plan for future issuance (in shares)						1,600,000
Maximum percentage of outstanding shares						1%
Number of shares available for grant (in shares)								2,628,893
Offering period							7 months
Consecutive offering period			6 months
Maximum common stock purchase allowable as a percentage of compensation						15%
Purchase price of common stock as a percentage of closing price						85%
Stock issued (in shares)								176,857	0
ESPP | Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Purchase price of common stock as a percentage of closing price						85%
Stock options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expiration period								10 years
Number of employees affected by modification | employee				25
Expected dividend yield								0%	0%
Stock options | Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity award, vesting period								3 years
Stock options | Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Equity award, vesting period								4 years
Stock options expected to vest
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expense for options | $								$ 12,274,000
Unrecognized compensation expense for options, period of recognition								1 year 9 months 18 days
Market-based and performance stock options
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Options granted (in shares)								6,984,000
Market-based and performance stock options not expected to vest
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Unrecognized compensation expense for options | $								$ 4,655,000
Nonvested options outstanding (in shares)								6,764,000
Warrants
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Expected dividend yield								0%
Outstanding vested awards (in shares)								5,821,137
Aggregate intrinsic value | $								$ 15,640,000
Weighted average exercise price (in dollars per share) | $ / shares								$ 1.56
Weighted average remaining contractual term								3 years 6 months
Unrecognized compensation expense | $								$ 0
Warrants | Consultants
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Outstanding vested awards (in shares)								559,787
Warrants | Investor
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Outstanding vested awards (in shares)								5,261,350
2020 Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of shares initially reserve for future issuance (in shares)					8,000,000
Number of shares that can be added to the plan upon option expiration (in shares)					5,000,000
Potential number of additional shares that can be added to the plan for future issuance (in shares)					6,400,000
Maximum percentage of outstanding shares					4%
Number of shares available for grant (in shares)								5,879,768
2020 Plan | Common Stock
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Additional common stock issuable (in shares)		8,000,000

Stock Based Compensation - Weig

Stock Based Compensation - Weighted-average assumptions used for stock option awards (Details) - Stock options	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Risk-free interest rate	3.11%	1.05%
Expected term (in years)	5 years 10 months 24 days	5 years 8 months 12 days
Expected volatility	91.20%	74.50%
Expected annual dividends per share	0%	0%

Stock Based Compensation - Stoc

Stock Based Compensation - Stock option activity (Details) - USD ($) $ / shares in Units, $ in Thousands		12 Months Ended
	Sep. 24, 2021	Dec. 31, 2022	Dec. 31, 2021
Number of share options
Beginning balance (in shares)		13,797,556
Granted (in shares)	9,250,000	9,837,797
Forfeited (in shares)		(4,097,040)
Exercised (in shares)		(61,954)
Ending balance (in shares)		19,476,359	13,797,556
Weighted average exercise price
Beginning balance (in dollars per share)		$ 5.55
Granted (in dollars per share)		1.31
Forfeited (in dollars per share)		4.89
Exercised (in dollars per share)		2.04
Ending balance (in dollars per share)		$ 3.55	$ 5.55
Stock option activity, additional disclosures
Weighted average remaining contractual term, options outstanding		8 years 9 months 18 days	8 years 7 months 6 days
Aggregate intrinsic value, options outstanding		$ 29,657	$ 712
Number of share options, vested and expected to vest (in shares)		13,110,654
Weighted average exercise price, vested and expected to vest (in dollars per share)		$ 4.49
Weighted average remaining contractual term, vested and expected to vest		8 years 6 months
Aggregate intrinsic value, vested and expected to vest		$ 11,799
Number of share options, exercisable (in shares)		3,895,109
Weighted average exercise price, exercisable (in dollars per share)		$ 4.91
Weighted average remaining contractual term, exercisable		8 years
Aggregate intrinsic value, exercisable		$ 1,652

Stock-Based Compensation - Summ

Stock-Based Compensation - Summary of stock-based compensation expense (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Stock-based compensation	$ 11,948	$ 12,804
Research and development
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Stock-based compensation	4,303	5,909
General and administrative
Share-based Payment Arrangement, Expensed and Capitalized, Amount [Line Items]
Stock-based compensation	$ 7,645	$ 6,895

Commitments and Contingencies (

Commitments and Contingencies (Details) - USD ($)	Dec. 31, 2022	Dec. 31, 2021
Commitments and Contingencies Disclosure [Abstract]
Capital commitments	$ 0	$ 0
Contractual commitments	$ 11,510,000
Period for which the majority of contractual commitments are to be paid	1 year

Related Party Transactions (Det

Related Party Transactions (Details) $ / shares in Units, $ in Thousands

12 Months Ended

Mar. 01, 2023 USD ($) $ / shares shares

Jan. 19, 2023 USD ($) promissory_note

Dec. 06, 2022 USD ($) $ / shares shares

Aug. 08, 2022 USD ($) $ / shares shares

Jun. 30, 2022

Mar. 10, 2022 USD ($)

May 12, 2021 USD ($) $ / shares shares

Apr. 20, 2021 USD ($)

Mar. 24, 2021 USD ($)

Dec. 31, 2022 USD ($) $ / shares

Dec. 31, 2021 USD ($) $ / shares

Jul. 29, 2022 ft²

Jul. 25, 2022

Mar. 26, 2021 ft²

Related Party Transaction [Line Items]

Proceeds from related party promissory notes

$ 545,000

$ 110,000

Gross proceeds from the sale of stock

100,000

75,000

Issuance costs

$ 111

$ 118

Common stock par value (in dollars per share) | $ / shares

$ 0.01

$ 0.01

$ 0.01

Affiliated entity | Sublease agreement

Related Party Transaction [Line Items]

Area of premises subleased | ft²

4,500

Payments to related party

$ 544

$ 556

Affiliated entity | First amendment to sublease

Related Party Transaction [Line Items]

Sublease extension term

39 months

Affiliated entity | Second amendment to sublease

Related Party Transaction [Line Items]

Area of premises subleased | ft²

1,277

Payments to related party

$ 54

Chief Executive Officer and Co-Chief Executive Officer and President | Note Purchase Agreement

Related Party Transaction [Line Items]

Notes payable, related parties

$ 520,000

Interest rate

7.50%

Period from public offering

5 days

Public offering proceeds threshold percentage

100%

Prepaid interest, conversion amount | $ / shares

$ 0.7913

Prepaid interest, conversion amount base | $ / shares

$ 0.01

Common stock issued for prepaid interest (in shares) | shares

9,720,291

Chief Executive Officer and Co-Chief Executive Officer and President | Note Purchase Agreement | Prime Rate | Variable rate, three months immediately following February 15, 2023

Related Party Transaction [Line Items]

Interest rate margin

0.50%

Chief Executive Officer and Co-Chief Executive Officer and President | Note Purchase Agreement | Prime Rate | Variable rate, thereafter

Related Party Transaction [Line Items]

Interest rate margin

3%

Chief Executive Officer | Initial Purchase Agreement

Related Party Transaction [Line Items]

Proceeds from related party promissory notes

$ 55,000

Notes payable, related parties

$ 55,000

Notes payable, estimated interest rate

2.40%

Notes payable, maturity triggering event, public offering proceeds threshold

$ 55,000

Notes payable, maximum term

13 months

Chief Executive Officer | Initial Purchase Agreement | 10 year US Treasury rate

Related Party Transaction [Line Items]

Notes payable, basis spread on variable rate

150%

Chief Executive Officer | Second Purchase Agreement

Related Party Transaction [Line Items]

Proceeds from related party promissory notes

$ 55,000

Notes payable, related parties

$ 55,000

Notes payable, estimated interest rate

2.40%

Chief Executive Officer | Second Purchase Agreement | 10 year US Treasury rate

Related Party Transaction [Line Items]

Notes payable, basis spread on variable rate

150%

Chief Executive Officer | March 2022 Note

Related Party Transaction [Line Items]

Proceeds from related party promissory notes

$ 25,000

Notes payable, related parties

25,000

Notes payable, maturity triggering event, public offering proceeds threshold

$ 25,000

Notes payable, maximum term

18 months

Interest rate

4.75%

3.25%

Chief Executive Officer | Duggan Promissory Notes | Subsequent event

Related Party Transaction [Line Items]

Notes payable, maturity triggering event, public offering proceeds threshold

$ 500,000

New note issuances | promissory_note

2

Chief Executive Officer | Duggan February Note

Related Party Transaction [Line Items]

Notes payable, related parties

$ 400,000

Chief Executive Officer | Duggan September Note

Related Party Transaction [Line Items]

Notes payable, related parties

100,000

Co-Chief Executive Officer and President | Zanganeh Note

Related Party Transaction [Line Items]

Notes payable, related parties

$ 20,000

Rights Offering

Related Party Transaction [Line Items]

Gross proceeds from the sale of stock

$ 100,000

$ 75,000

Shares issued (in shares) | shares

103,092,783

14,312,976

Sale of stock price (in dollars per share) | $ / shares

$ 0.97

$ 5.24

Issuance costs

$ 111

$ 159

Rights Offering | Subsequent event

Related Party Transaction [Line Items]

Gross proceeds from the sale of stock

$ 500,000

Shares issued (in shares) | shares

476,190,471

Sale of stock price (in dollars per share) | $ / shares

$ 1.05

Issuance costs

$ 500

Rights Offering | Chief Executive Officer

Related Party Transaction [Line Items]

Shares issued (in shares) | shares

11,365,921

Sale of stock price (in dollars per share) | $ / shares

$ 5.24

Rights Offering | Co-Chief Executive Officer and President

Related Party Transaction [Line Items]

Shares issued (in shares) | shares

389,977

Sale of stock price (in dollars per share) | $ / shares

$ 5.24

Subsequent Events (Details)

Subsequent Events (Details) - USD ($) $ / shares in Units, $ in Thousands							2 Months Ended	12 Months Ended
	Mar. 06, 2023	Mar. 01, 2023	Feb. 15, 2023	Jan. 17, 2023	Aug. 08, 2022	May 12, 2021	Mar. 06, 2023	Dec. 31, 2022	Dec. 31, 2021
Subsequent Event [Line Items]
Gross proceeds from the sale of stock								$ 100,000	$ 75,000
Issuance costs								111	118
Repayment of related party notes payable								$ 25,000	$ 110,000
Rights Offering
Subsequent Event [Line Items]
Gross proceeds from the sale of stock					$ 100,000	$ 75,000
Shares issued (in shares)					103,092,783	14,312,976
Sale of stock price (in dollars per share)					$ 0.97	$ 5.24
Issuance costs					$ 111	$ 159
Rights Offering | Co-Chief Executive Officer and President
Subsequent Event [Line Items]
Shares issued (in shares)						389,977
Sale of stock price (in dollars per share)						$ 5.24
Rights Offering | Chief Executive Officer
Subsequent Event [Line Items]
Shares issued (in shares)						11,365,921
Sale of stock price (in dollars per share)						$ 5.24
Subsequent event | Zanganeh Note | Co-Chief Executive Officer and President
Subsequent Event [Line Items]
Repayment of related party notes payable			$ 20,000
Subsequent event | Duggan February Note | Chief Executive Officer
Subsequent Event [Line Items]
Repayment of related party notes payable		$ 400,000
Subsequent event | Rights Offering
Subsequent Event [Line Items]
Gross proceeds from the sale of stock		$ 500,000
Shares issued (in shares)		476,190,471
Sale of stock price (in dollars per share)		$ 1.05
Issuance costs		$ 500
Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement
Subsequent Event [Line Items]
Cash payment for collaborative arrangement, upfront payment							$ 474,900
Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement, upfront payment one
Subsequent Event [Line Items]
Collaborative arrangement, common stock issued in lieu of cash upfront payment (in shares)				10,000,000
Cash payment for collaborative arrangement, upfront payment				$ 274,900
Subsequent event | Collaborative arrangement, transaction with party to collaborative arrangement, upfront payment two
Subsequent Event [Line Items]
Cash payment for collaborative arrangement, upfront payment	$ 200,000