| Cover | Aug. 25, 2022 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Aug. 25, 2022 |
| Current Fiscal Year End Date | --12-31 |
| Entity File Number | 001-37853 |
| Entity Registrant Name | First Wave BioPharma, Inc. |
| Entity Central Index Key | 0001604191 |
| Entity Tax Identification Number | 46-4993860 |
| Entity Incorporation, State or Country Code | DE |
| Entity Address, Address Line One | 777 Yamato Road |
| Entity Address, Address Line Two | Suite 502 |
| Entity Address, City or Town | Boca Raton |
| Entity Address, State or Province | FL |
| Entity Address, Postal Zip Code | 33431 |
| City Area Code | 561 |
| Local Phone Number | 589-7020 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, par value $0.0001 per share |
| Trading Symbol | FWBI |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | false |
