Entero Therapeutics (ENTO) 10-Q 14 Aug 23 2023 Q2 Quarterly report Financial data

Document And Entity Information

Document And Entity Information - shares	6 Months Ended
	Jun. 30, 2023	Aug. 10, 2023
Document And Entity Information
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Jun. 30, 2023
Document Transition Report	false
Entity File Number	001-37853
Entity Registrant Name	First Wave BioPharma, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	46-4993860
Entity Address, Address Line One	777 Yamato Road, Suite 502
Entity Address, City or Town	Boca Raton
Entity Address, State or Province	FL
Entity Address, Postal Zip Code	33431
City Area Code	561
Local Phone Number	589-7020
Title of 12(b) Security	Common stock, par value $0.0001 per share
Trading Symbol	FWBI
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		7,152,204
Entity Central Index Key	0001604191
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2023
Document Fiscal Period Focus	Q2
Amendment Flag	false

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets - USD ($)	Jun. 30, 2023	Dec. 31, 2022
Current Assets:
Cash and cash equivalents	$ 1,236,054	$ 1,362,910
Other receivables		93,014
Prepaid expenses	1,117,737	1,956,831
Total Current Assets	2,353,791	3,412,755
Property, equipment, and leasehold improvements, net	29,202	43,839
Other Assets:
Restricted cash	21,519	21,513
Goodwill	1,684,182	1,684,182
Operating lease right-of-use assets	227,927	259,261
Deposits	11,250	18,149
Total other assets	1,944,878	1,983,105
Total Assets	4,327,871	5,439,699
Current Liabilities:
Accounts payable	1,591,195	720,040
Accrued expenses	479,862	320,176
Accrued dividend payable	943,243	761,488
Note payable	153,478	603,494
Operating lease liabilities	63,564	66,151
Other current liabilities	29,907	12,138
Total Current Liabilities	3,261,249	2,483,487
Non-current operating lease liabilities	184,662	214,060
Total Liabilities	3,445,911	2,697,547
Stockholders' Equity:
Common Stock - Par value $0.0001 per share; 50,000,000 shares authorized; 4,208,995 and 995,003 shares issued and outstanding at June 30, 2023 and December 31, 2022, respectively	421	100
Additional paid-in capital	177,675,113	171,275,741
Accumulated deficit	(176,793,574)	(168,533,689)
Total Stockholders' Equity	881,960	2,742,152
Total Liabilities and Stockholders' Equity	4,327,871	5,439,699
Series B Preferred Stock
Stockholders' Equity:
Preferred stock
Series C Preferred Stock
Stockholders' Equity:
Preferred stock
Series D Preferred Stock
Stockholders' Equity:
Preferred stock
Series E Preferred Stock
Stockholders' Equity:
Preferred stock
Series F Preferred Stock
Stockholders' Equity:
Preferred stock

Condensed Consolidated Balanc_2

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Jun. 30, 2023	Dec. 31, 2022	Jun. 30, 2022
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock, shares authorized (in shares)	50,000,000	50,000,000
Common stock, shares issued (in shares)	4,208,995	995,003	995,003
Common stock, shares outstanding (in shares)	4,208,995	995,003
Preferred stock, par value (in dollars per share)	$ 0.0001
Preferred stock, shares designated (in shares)	10,000,000
Series B Preferred Stock
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares designated (in shares)	5,194.81	5,194.81
Preferred stock, shares issued (in shares)	545.94	550.17
Preferred stock, shares outstanding (in shares)	545.94	550.17
Series C Preferred Stock
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares designated (in shares)	75,000	75,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Series D Preferred Stock
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares designated (in shares)	150	150
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Series E Preferred Stock
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares designated (in shares)	150	150
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0
Series F Preferred Stock
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares designated (in shares)	7,000	7,000
Preferred stock, shares issued (in shares)	0	0
Preferred stock, shares outstanding (in shares)	0	0

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Operating expenses:
Research and development expenses	$ 1,353,095	$ 2,906,896	$ 2,714,778	$ 7,883,413
General and administrative expenses	2,828,549	2,498,957	5,529,291	6,904,512
Total operating expenses	4,181,644	5,405,853	8,244,069	14,787,925
Loss from operations	(4,181,644)	(5,405,853)	(8,244,069)	(14,787,925)
Other (expenses) income:
Interest expense	(5,178)	(3,218)	(14,165)	(8,823)
Interest income	205	926	2,078	1,065
Other expense	(2,615)		(3,729)	(239,301)
Total other expenses	(7,588)	(2,292)	(15,816)	(247,059)
Net loss	(4,189,232)	(5,408,145)	(8,259,885)	(15,034,984)
Other comprehensive loss:
Foreign currency translation adjustment		(136,946)		(195,351)
Total comprehensive loss	(4,189,232)	(5,545,091)	(8,259,885)	(15,230,335)
Net loss	(4,189,232)	(5,408,145)	(8,259,885)	(15,034,984)
Deemed dividend on warrant modifications		(47,300)		(47,300)
Preferred stock dividends	(94,324)	(97,125)	(181,755)	(187,917)
Net loss applicable to common shareholders	$ (4,283,556)	$ (5,552,570)	$ (8,441,640)	$ (15,270,201)
Basic weighted average shares outstanding	2,270,922	103,844	2,725,755	89,015
Diluted weighted average shares outstanding	2,270,922	103,844	2,725,755	89,015
Loss per share - basic	$ (1.89)	$ (53.47)	$ (3.10)	$ (171.55)
Loss per share -diluted	$ (1.89)	$ (53.47)	$ (171.55)	$ (3.10)

Condensed Consolidated Statem_2

Condensed Consolidated Statements of Changes in Stockholders' Equity (Deficit) - USD ($)	Convertible preferred stock Series B Convertible Preferred Stock	Common Stock	Additional Paid-in Capital	Accumulated Deficit	Accumulated Other Comprehensive Loss	Total
Balance at the beginning at Dec. 31, 2021		$ 7	$ 147,306,625	$ (153,904,047)	$ (1,224,135)	$ (7,821,550)
Balance at the beginning (in shares) at Dec. 31, 2021	662	70,742
Issuance of common stock, pre-funded warrants and warrants in Private placement and registered direct offering, net of issuance costs (in shares)		7,857
Issuance of common stock, pre-funded warrants and warrants in Private placement and registered direct offering, net of issuance costs		$ 1	7,972,090			7,972,091
Exercise of pre-funded warrants into common stock (in shares)		23,086
Exercise of pre-funded warrants into common stock		$ 2	48,480			48,482
Deemed dividend of Series B preferred stock			(187,917)			(187,917)
Issuance of common stock at-the-market for cash, net of offering costs (in shares)		5,070
Issuance of common stock at-the-market for cash, net of offering costs		$ 1	317,230			317,231
Warrant modification			47,300			47,300
Deemed dividend on warrant modifications			(47,300)			(47,300)
Conversion of Series B preferred shares into common stock (in shares)	(31)	910
Common Stock issued to consultants			118,999			118,999
Common stock and warrants issued to consultants (in shares)		429
Stock-based compensation			593,136			593,136
Foreign currency translation adjustment					(195,351)	(195,351)
Net loss				(15,034,984)		(15,034,984)
Balance at the end at Jun. 30, 2022		$ 11	156,168,643	(168,939,031)	(1,419,486)	(14,189,863)
Balance at the end (in shares) at Jun. 30, 2022	631	108,094
Balance at the beginning at Dec. 31, 2021		$ 7	147,306,625	(153,904,047)	(1,224,135)	(7,821,550)
Balance at the beginning (in shares) at Dec. 31, 2021	662	70,742
Balance at the end at Dec. 31, 2022		$ 100	171,275,741	(168,533,689)		2,742,152
Balance at the end (in shares) at Dec. 31, 2022	550	995,003
Balance at the beginning at Mar. 31, 2022		$ 10	155,573,631	(163,530,886)	(1,282,540)	(9,239,785)
Balance at the beginning (in shares) at Mar. 31, 2022	645	102,613
Deemed dividend of Series B preferred stock			(97,125)			(97,125)
Issuance of common stock at-the-market for cash, net of offering costs (in shares)		5,070
Issuance of common stock at-the-market for cash, net of offering costs		$ 1	317,230			317,231
Warrant modification			47,300			47,300
Deemed dividend on warrant modifications			(47,300)			(47,300)
Conversion of Series B preferred shares into common stock (in shares)	(14)	411
Stock-based compensation			374,907			374,907
Foreign currency translation adjustment					(136,946)	(136,946)
Net loss				(5,408,145)		(5,408,145)
Balance at the end at Jun. 30, 2022		$ 11	156,168,643	(168,939,031)	$ (1,419,486)	(14,189,863)
Balance at the end (in shares) at Jun. 30, 2022	631	108,094
Balance at the beginning at Dec. 31, 2022		$ 100	171,275,741	(168,533,689)		2,742,152
Balance at the beginning (in shares) at Dec. 31, 2022	550	995,003
Issuance of common stock, pre-funded warrants and warrants in Private placement and registered direct offering, net of issuance costs (in shares)		128,000
Issuance of common stock, pre-funded warrants and warrants in Private placement and registered direct offering, net of issuance costs		$ 13	3,690,960			3,690,973
Issuance of Common Stock in connection with the exercise of warrants in the June 2023 Inducement Offering, net of offering costs (in shares)		1,724,332
Issuance of Common Stock in connection with the exercise of warrants in the June 2023 Inducement Offering, net of offering costs		$ 173	2,238,892			2,239,065
Exercise of pre-funded warrants into common stock (in shares)		1,324,493
Exercise of pre-funded warrants into common stock		$ 131	259			390
Issuance of Common Stock from RSU vest (in shares)		40,064
Issuance of Common Stock from RSU vest		$ (4)	4
Deemed dividend of Series B preferred stock			(181,755)			(181,755)
Conversion of Series B preferred shares into common stock (in shares)	(4)	70
Effect of cancelled shares from the 1-for-7 reverse stock split (in shares)		(2,967)
Stock-based compensation			651,020			651,020
Net loss				(8,259,885)		(8,259,885)
Balance at the end at Jun. 30, 2023		$ 421	177,675,113	(176,793,574)		881,960
Balance at the end (in shares) at Jun. 30, 2023	546	4,208,995
Balance at the beginning at Mar. 31, 2023		$ 155	175,316,783	(172,604,342)		2,712,596
Balance at the beginning (in shares) at Mar. 31, 2023	546	1,549,581
Issuance of common stock, pre-funded warrants and warrants in Private placement and registered direct offering, net of issuance costs			(78,938)			(78,938)
Issuance of Common Stock in connection with the exercise of warrants in the June 2023 Inducement Offering, net of offering costs (in shares)		1,724,332
Issuance of Common Stock in connection with the exercise of warrants in the June 2023 Inducement Offering, net of offering costs		$ 173	2,238,892			2,239,065
Exercise of pre-funded warrants into common stock (in shares)		895,018
Exercise of pre-funded warrants into common stock		$ 89				89
Issuance of Common Stock from RSU vest (in shares)		40,064
Issuance of Common Stock from RSU vest		$ (4)	4
Deemed dividend of Series B preferred stock			(94,324)			(94,324)
Stock-based compensation			292,704			292,704
Net loss				(4,189,232)		(4,189,232)
Balance at the end at Jun. 30, 2023		$ 421	$ 177,675,113	$ (176,793,574)		$ 881,960
Balance at the end (in shares) at Jun. 30, 2023	546	4,208,995

Condensed Consolidated Statem_3

Condensed Consolidated Statements of Changes in Stockholders' Equity (Deficit) (Parenthetical) - shares			6 Months Ended
	Jan. 18, 2023	Aug. 26, 2022	Jun. 30, 2022
Condensed Consolidated Statements of Changes in Stockholders' Equity (Deficit)
Reverse stock splits (in shares)	7	30	1

Condensed Consolidated Statem_4

Condensed Consolidated Statements of Cash Flows - USD ($)	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Cash flows from operating activities:
Net loss	$ (8,259,885)	$ (15,034,984)
Adjustments to reconcile net loss to net cash used in operating activities:
Depreciation	14,637	14,635
Change in right-of-use assets	31,334	46,693
Stock-based compensation	651,020	593,136
Common Stock granted to consultants		118,999
Changes in assets and liabilities:
Other receivables	93,014	(70,429)
Prepaid expenses	839,094	612,607
Lease liabilities	(31,985)	(78,228)
Deposits	6,899	9,686
Accounts payable	871,155	1,258,632
Accrued expenses	159,686	32,982
Other liabilities	17,769	(1,410)
Net cash used in operating activities	(5,607,262)	(12,497,681)
Cash flows from financing activities:
Proceeds from issuance of Common Stock, pre-funded warrants and warrants, net of offering costs	3,690,973	8,289,322
Proceeds from exercise of warrants, net of issuance costs	2,239,455	48,482
Payment made related to acquisition		(2,414,955)
Repayments of note payable	(450,016)	(479,327)
Net cash provided by financing activities	5,480,412	5,443,522
Net decrease in cash	(126,850)	(7,054,159)
Effect of exchange rate changes on cash		(39,516)
Cash and restricted cash, beginning balance	1,384,423	8,248,684
Cash and restricted cash, ending balance	1,257,573	1,155,009
Supplemental disclosures of cash flow information:
Cash paid for interest	14,165	8,823
Non-cash investing and financing activities:
Deemed dividend on warrant modifications		(47,300)
Accrued dividends on preferred stock	$ (181,755)	$ (187,917)

The Company and Basis of Presen

The Company and Basis of Presentation	6 Months Ended
	Jun. 30, 2023
The Company and Basis of Presentation
The Company and Basis of Presentation	Note 1 - The Company and Basis of Presentation The Company First Wave BioPharma, Inc. (“ First Wave FWB GI The Company is currently focused on developing its pipeline of gut-restricted GI clinical drug candidates, including the biologic adrulipase (formerly MS1819), a recombinant lipase enzyme designed to enable the digestion of fats and other nutrients, and niclosamide, an oral small molecule with anti-viral and anti-inflammatory properties. The Company’s adrulipase programs are focused on the development of an oral, non-systemic, biologic capsule for the treatment of exocrine pancreatic insufficiency (“ EPI CF CP The Company is developing its product candidates for a host of GI diseases where there are significant unmet clinical needs and limited therapeutic options, resulting in painful, life threatening and discomforting consequences for patients. Since its inception, the Company has devoted substantially all its efforts to research and development, business development, and raising capital, and has financed its operations through issuance of Common Stock, convertible preferred stock, convertible debt, and other debt/equity instruments. Risks and Uncertainties The Company is subject to risks and uncertainties common to early-stage companies in the biotechnology industry, including, but not limited to, development and regulatory success, development by competitors of new technological innovations, dependence on key personnel, protection of proprietary technology, compliance with government regulations, and ability to secure additional capital to fund clinical trials and operations. In February 2022, the Russian Federation and Belarus commenced a military action with the country of Ukraine. As a result of this action, various nations, including the United States, have instituted economic sanctions against the Russian Federation and Belarus. Further, the impact of this action and related sanctions on the world economy are not determinable as of the date of these financial statements and the specific impact on the Company’s financial condition, results of operations, and cash flows is also not determinable as of the date of these financial statements. In addition, the Company is subject to other challenges and risks specific to its business, its ability to maintain compliance with the continued listing requirements of The Nasdaq Capital Market and its ability to execute on its strategy, as well as risks and uncertainties common to companies in the biotechnology and pharmaceutical industries with development and commercial operations, including, without limitation, risks and uncertainties associated with: obtaining regulatory approval of its drug candidates; delays or problems in the manufacture and supply of its drug candidates; loss of single source suppliers or failure to comply with manufacturing regulations; identifying, acquiring or in-licensing additional products or drug candidates; pharmaceutical product development and the inherent uncertainty of clinical success; the challenges of protecting and enhancing our intellectual property rights; and complying with applicable regulatory requirements. Principles of Consolidation The accompanying unaudited interim condensed consolidated financial statements have been prepared in accordance with generally accepted accounting principles in the United States of America (“ GAAP In our opinion, the accompanying unaudited interim condensed consolidated financial statements include all adjustments, consisting of normal recurring adjustments, which are necessary to present fairly our financial position, results of operations, and cash flows. The consolidated balance sheet at December 31, 2022, has been derived from audited financial statements of that date. The unaudited interim condensed consolidated results of operations are not necessarily indicative of the results that may occur for the full fiscal year. Certain information and footnote disclosure normally included in financial statements prepared in accordance with GAAP have been omitted pursuant to instructions, rules, and regulations prescribed by the SEC. The Company believes that the disclosures provided herein are adequate to make the information presented not misleading when these unaudited interim condensed consolidated financial statements are read in conjunction with the audited financial statements and notes previously distributed in our Annual Report Form 10-K for the year ended December 31, 2022, filed with the SEC on March 20, 2023. Going Concern Uncertainty The accompanying unaudited interim condensed consolidated financial statements have been prepared as if the Company will continue as a going concern. The Company has incurred significant operating losses and negative cash flows from operations since inception. On June 30, 2023, the Company had cash and cash equivalents of approximately $1.2 million, an accumulated deficit of approximately $176.8 million and a working capital deficiency of approximately $0.9 million. Subsequent to June 30, 2023 through August 14, 2023, the Company has raised aggregate gross proceeds of approximately $2.1 million from the July 2023 Offering. The Company has incurred recurring losses, has experienced recurring negative operating cash flows, and requires significant cash resources to execute its business plans. The Company anticipates having sufficient cash to fund planned operations through September 2023, however, the acceleration or reduction of cash outflows by Company management can significantly impact the timing for the need to raise additional capital to complete development of its products. Historically, the Company’s major sources of cash have been comprised of proceeds from various public and private offerings of its capital stock. The Company is dependent on obtaining additional working capital funding from the sale of equity and/or debt securities in order to continue to execute its development plans and continue operations. Without adequate working capital, the Company may not be able to meet its obligations and continue as a going concern. These conditions raise substantial doubt about the Company’s ability to continue as a going concern one year from the date these financial statements are issued. The financial statements do not include any adjustments that might result from the outcome of this uncertainty.

Significant Accounting Policies

Significant Accounting Policies and Recent Accounting Pronouncements	6 Months Ended
	Jun. 30, 2023
Significant Accounting Policies and Recent Accounting Pronouncements
Significant Accounting Policies and Recent Accounting Pronouncements	Note 2 - Significant Accounting Policies and Recent Accounting Pronouncements Use of Estimates The accompanying unaudited condensed consolidated financial statements are prepared in conformity with GAAP and include certain estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements (including goodwill), and the reported amounts of revenue and expense during the reporting period, including contingencies. Accordingly, actual results may differ from those estimates. Reverse Stock Split On January 18, 2023, the Company effected a reverse stock split, whereby every seven shares of the Company’s issued and outstanding Common Stock was converted automatically into one issued and outstanding share of Common Stock, but without any change in the number of authorized shares of Common Stock and the par value per share. All share and per share amounts have been retroactively restated to reflect the reverse stock splits referenced above. Cash and Cash Equivalents and Restricted Cash The Company considers all highly liquid investments with maturities of three months or less from the date of purchase to be cash equivalents. All cash and cash equivalent balances were highly liquid at June 30, 2023 and December 31, 2022. As of June 30, 2023 and December 31, 2022, the Company has classified approximately $0.02 million as restricted cash. Concentrations of Credit Risk Financial instruments that potentially expose the Company to concentrations of credit risk consist of cash. The Company primarily maintains its cash balances with financial institutions in federally insured accounts in the U.S. The Company may from time to time have cash in banks in excess of FDIC insurance limits. At June 30, 2023 the Company had approximately $1.2 million in one account in the U.S. which was in excess of these limits. The Company has not experienced any losses to date resulting from this practice. The Company mitigates its risk by maintaining the majority of its cash and equivalents with high quality financial institutions. Fair Value Measurements The Company follows Accounting Standards Codification (“ ASC ( ASC 820 As a basis for considering such assumptions, a three-tier fair value hierarchy has been established, which prioritizes the inputs used in measuring fair value as follows: Level 1: Observable inputs such as quoted prices (unadjusted) in active markets for identical assets or liabilities; Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly; and Level 3: Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions, which reflect those that a market participant would use. In certain cases, the inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, an instrument’s level within the fair value hierarchy is based on the lowest level of input that is significant to the overall fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires judgment and considers factors specific to the financial instrument. The Company recognizes transfers between levels as if the transfers occurred on the last day of the reporting period. Foreign Currency Translation For foreign subsidiaries with operations denominated in a foreign currency, assets and liabilities were translated to U.S. dollars, which is the functional currency, at period end exchange rates. Income and expense items were translated at average rates of exchange prevailing during the periods presented. Gains and losses from translation adjustments were accumulated in a separate component of stockholders’ equity up until the dissolution of AzurRx SAS in October 2022, at which time cumulative translation adjustments were recognized as a loss for the year ended December 31, 2022. Goodwill Goodwill represents the excess of the purchase price of the acquired business over the fair value of amounts assigned to assets acquired and liabilities assumed. Goodwill and other intangible assets with indefinite useful lives are reviewed for impairment annually or more frequently if events or circumstances indicate impairment may be present. Any excess in carrying value over the estimated fair value is charged to results of operations. The Company has not recognized any impairment charges through June 30, 2023 related to goodwill. Impairment of Long-Lived Assets The Company periodically evaluates its long-lived assets for potential impairment in accordance with ASC Topic 360, Property, Plant and Equipment ( ASC 360 Leases The Company determines if an arrangement is a lease at inception. Operating leases are included in right-of-use (“ ROU Research and Development Research and development costs are charged to operations when incurred and are included in operating expense, except for goodwill related to patents. Research and development costs consist principally of compensation of employees and consultants that perform the Company’s research activities, payments to third parties for preclinical and non-clinical activities, expenses with clinical research organizations (“ CROs CDMOs CMC Research and Development – The Company records intellectual property in asset acquisitions that have not reached technological feasibility and which have no alternative future use, as an expense at the acquisition date. On September 13, 2021, the Company entered into an agreement with FWB for the acquisition of intellectual property and patents for the worldwide, exclusive right to develop, manufacture, and commercialize proprietary formulations of niclosamide for the fields of treating ICI-AC and COVID-19 in humans, which was accounted for as an asset acquisition (see Note 4). Stock-Based Compensation The Company’s board of directors (the “ Board 2014 Plan 2020 Plan ASC 718 For awards with performance conditions that affect their vesting, such as the occurrence of certain transactions or the achievement of certain operating or financial milestones, recognition of fair value of the award occurs when vesting becomes probable. The Company estimates the grant date fair value of stock option awards using the Black-Scholes option-pricing model. The use of the Black-Scholes option-pricing model requires management to make assumptions with respect to the expected term of the option, the expected volatility of the Common Stock consistent with the expected life of the option, risk-free interest rates and expected dividend yields of the Common Stock. Recent Accounting Pronouncements In August 2020, the Financial Accounting Standards Board (the “ FASB ASU 2020-06 SEC In June 2016, the FASB issued accounting pronouncement ASU 2016-13 – Measurement of Credit Losses on Financial Statements (“ ASU 2016-13 In June 2022, the FASB issued ASU 2022-03 - Fair Value Measurement, or Topic 820: Fair Value Measurement of Equity Securities Subject to Contractual Sale Restrictions (“ ASU 2022-03 The Company has evaluated other recently issued accounting pronouncements and has concluded that the impact of recently issued standards that are not yet effective will not have a material impact on the Company’s financial position or results of operations upon adoption.

Fair Value Disclosures

Fair Value Disclosures	6 Months Ended
	Jun. 30, 2023
Fair Value Disclosures
Fair Value Disclosures	Note 3 - Fair Value Disclosures Fair value is the price that would be received from the sale of an asset or paid to transfer a liability assuming an orderly transaction in the most advantageous market at the measurement date. U.S. GAAP establishes a hierarchical disclosure framework that prioritizes and ranks the level of observability of inputs used in measuring fair value. ​ The fair value of the Company’s financial instruments are as follows: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Fair Value Measured at Reporting Date ​ ​ ​ ​ ​ ​ ​ ​ Using ​ ​ ​ ​ ​ Carrying ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Amount Level 1 Level 2 Level 3 Fair Value June 30, 2023 (unaudited): ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Money market funds ​ $ 11,925 ​ $ 11,925 ​ $ — ​ $ — ​ $ 11,925 Note payable ​ 153,478 ​ — ​ 153,478 ​ — ​ 153,478 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ December 31, 2022: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Money market funds ​ ​ 509,890 ​ ​ 509,890 ​ ​ — ​ ​ — ​ ​ 509,890 Note payable ​ $ 603,494 ​ $ — ​ $ 603,494 ​ $ — ​ $ 603,494 ​ At June 30, 2023 and December 31, 2022, the Company had no other assets or liabilities that are subject to fair value methodology and estimation in accordance with U.S. GAAP.

Asset Acquisition

Asset Acquisition	6 Months Ended
	Jun. 30, 2023
Asset Acquisition
Asset Acquisition	Note 4 – Asset Acquisition The Asset Acquisition During the six months ended June 30, 2022, the Company paid an aggregate of $2.4 million in cash towards the purchase price of FWB in accordance with the terms of an Agreement and Plan of Merger dated as of September 13, 2021 (the “ Merger Agreement November 2021 Settlement Agreement On May 19, 2022, Fortis Advisors LLC, the hired representative (in such capacity, the “ Representative FWB Action July 2022 Term Sheet Second Payment Payments In the July 2022 Term Sheet, the Representative agreed to stay the FWB Action for a period of 90 days and to eliminate the Company’s obligation to pay a portion of any offering proceeds to the Representative. In addition, the Company’s obligation to use commercially reasonable efforts to develop niclosamide will be deferred for a period of 24 months from the date of the July 2022 Term Sheet. Effective upon the Second Payment, the Representative dismissed the FWB Action with prejudice and extinguished the remaining fixed payment obligations owed to the former FWB shareholders. On November 30, 2022, the Company entered into a formal settlement agreement with the Representative on substantially the same terms as the July 2022 Term Sheet (the “ November 2022 Settlement Agreement ​ Accounting Treatment Under the July 2022 Term Sheet, the $1.5 million in cash due and paid on July 29, 2022, as well as the Second Payment due and paid in September 2022, were recorded as a reduction to current liabilities for the three months ended September 30, 2022. Effective upon the Second Payment, the approximately $10.1 million of remaining fixed payment obligations previously owed to the former FWB shareholders was settled. The third payment obligation of $2.0 million due and paid by November 30, 2022 was recorded as research and development expense in the three months ended December 31, 2022. The remaining unachieved potential milestone payments and revenue share are not yet considered probable, therefore have not been accrued as of June 30, 2023. Depending on the status of development at the time a contingent payment is recognized, the Company may determine that the payment should be expensed as research and development or be capitalized as an intangible asset. This determination will be based on the facts and circumstances that exist at the time a contingent payment is recognized.

Property, Equipment and Leaseho

Property, Equipment and Leasehold Improvements	6 Months Ended
	Jun. 30, 2023
Property, Equipment and Leasehold Improvements
Property, Equipment and Leasehold Improvements	Note 5 – Property, Equipment and Leasehold Improvements Property, equipment, and leasehold improvements consisted of the following: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ June 30, ​ ​ ​ ​ 2023 December 31, ​ ​ (unaudited) ​ 2022 Computer equipment and software ​ $ 11,540 ​ $ 11,540 Office equipment ​ 48,278 ​ 48,278 Leasehold improvements ​ 28,000 ​ 28,000 Total property, plant, and equipment ​ 87,818 ​ 87,818 Less accumulated depreciation ​ (58,616) ​ (43,979) Property, plant and equipment, net ​ $ 29,202 ​ $ 43,839 ​ Depreciation expense for the three months ended June 30, 2023 and 2022 was approximately $7,300 and $7,300, respectively, and for the six months ended June 30, 2023 and 2022 was approximately $14,600 and $14,600, respectively.

Goodwill

Goodwill	6 Months Ended
	Jun. 30, 2023
Goodwill
Goodwill	Note 6 –Goodwill Goodwill is as follows: ​ ​ ​ ​ ​ ​ Goodwill Balance on January 1, 2022 ​ $ 1,911,705 Foreign currency translation ​ (227,523) Balance on December 31, 2022 ​ 1,684,182 Foreign currency translation ​ — Balance on June 30, 2023 (unaudited) ​ $ 1,684,182 ​

Accrued Expenses

Accrued Expenses	6 Months Ended
	Jun. 30, 2023
Accrued Expenses
Accrued Expenses	Note 7 - Accrued Expenses Accrued expenses consisted of the following: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ June 30, ​ ​ ​ ​ 2023 December 31, ​ ​ (unaudited) ​ 2022 Clinical trials ​ $ 301,226 ​ $ 5,340 Professional fees ​ ​ 178,636 ​ ​ 309,867 Consulting fees ​ ​ — ​ ​ 4,969 Total accrued expenses ​ $ 479,862 ​ $ 320,176 ​

Note Payable

Note Payable	6 Months Ended
	Jun. 30, 2023
Note Payable
Note Payable	Note 8 – Note Payable Directors and Officer ’ s Liability Insurance On November 30, 2022, the Company entered into 9-month

Capital Stock

Capital Stock	6 Months Ended
	Jun. 30, 2023
Capital Stock
Capital Stock	Note 9 – Common Stock and Preferred Stock The Company’s amended and restated certificate of incorporation, as amended to date, (the “ Charter On January 18, 2023, the Company effected a reverse stock split, whereby every seven shares of the Company’s issued and outstanding Common Stock was converted automatically into one issued and outstanding share of Common Stock, but without any change in the number of authorized shares of Common Stock and the par value per share. On August 26, 2022, the Company effected a reverse stock split, whereby every thirty shares of the Company’s issued and outstanding Common Stock was converted automatically into one issued and outstanding share of Common Stock, but without any change in the number of authorized shares of Common Stock and the par value per share. All share and per share amounts have been retroactively restated to reflect the reverse stock splits referenced above. The Company had 4,208,995 and 995,003 shares of its Common Stock issued outstanding The Company had approximately 545.94 and 550.17 shares of Series B preferred stock issued outstanding The Company had 0 shares of Series C, Series D, Series E and Series F preferred stock issued and outstanding on June 30, 2023 and December 31, 2022. Most Favored Nations Exchange Right and Waiver Agreements In the event the Company effects any issuance by the Company or any of its subsidiaries of Common Stock or Common Stock equivalents for cash consideration, or a combination of units thereof (a “ Subsequent Financing Exchange Amount Series B Exchange Right Between February 1, 2022 and February 7, 2022, the Company entered into waiver agreements (the “ Waiver ​ During the six months ended June 30, 2022, the Company entered into Waivers with holders of approximately $2.88 million of stated value of Series B Preferred Stock. The Company also entered into Waivers with Company insiders holding approximately $0.047 million of stated value of Series B Preferred Stock for which the Company did not pay a waiver fee. The cash waivers paid of approximately $0.233 million were recorded as other expense on the Company’s condensed consolidated statements of operations for the six months ended June 30, 2022. Effective May 12, 2022, the holders of 81.3% of the outstanding shares of the Series B Preferred Stock (the “ Consenting Holders Permanent Waiver Record Holders Pursuant to the terms of a Waiver Agreement entered into by the Company and the Consenting Holders (the “ Waiver Agreement Series B Warrants Exercise Price Reduction From inception through June 30, 2023, (i) holders of approximately 1,839.76 shares of Series B Preferred Stock with an aggregate Exchange Amount of approximately $14.4 million had previously elected to exercise their Series B Exchange Rights into Series C Preferred Stock, convertible into an aggregate of 9,058 shares of Common Stock (which conversion the Company has elected to make in full), and additional warrants exercisable for up to an aggregate of 9,058 shares of Common Stock, (ii) holders of approximately 99.200 shares of Series B Preferred Stock with an aggregate Exchange Amount of approximately $880,000 had previously elected to exercise their Series B Exchange Rights into 1,552 shares of Common Stock with no warrants, and (iii) holders of approximately 30.91 shares of Series B Preferred Stock with an aggregate Exchange Amount of approximately $265,000 had previously elected to exercise their Series B Exchange Rights into 909 shares of Common Stock, and additional Series C Warrants exercisable for up to an aggregate of 909 shares of Common Stock. At The Market Agreement with H.C. Wainwright On May 26, 2021, the Company entered into an At The Market Offering Agreement (the “ ATM Agreement Wainwright June 2023 Inducement Offering On June 13, 2023, the Company entered into warrant exercise inducement offer letters with certain holders (the “ Holders Existing Warrants Inducement Warrants Inducement Warrant Shares June 2023 Inducement Offering Roth March 2023 Private Placement On March 15, 2023, the Company completed a private placement offering (the “ March 2023 Offering March 2023 Pre-Funded Warrants March 2023 Warrants The Company received gross proceeds of approximately $4.0 million less placement agent’s fees and other offering expenses of approximately $300,000. March 2022 Registered Direct Offering On March 2, 2022, the Company completed a registered direct offering (the “ March 2022 Offering March 2022 Pre-Funded Warrants March 2022 Warrants March 2022 Placement Agent Warrants The Company received gross proceeds of approximately $9.0 million less placement agent’s fees and other offering expenses of approximately $1.0 million. Common Stock Issuances Issuances for the Three Months Ended June 30, 2023 During the three months ended June 30, 2023, the Company issued 1,724,332 shares of Common Stock upon the exercise of an aggregate of 1,724,332 investor warrants for which the Company received net proceeds of approximately $2.2 million (See Note 10). During the three months ended June 30, 2023, the Company issued an aggregate of 895,018 shares of Common Stock upon the conversion of pre-funded warrants issued at a par value of $0.0001. During the three months ended June 30, 2023, the Company issued an aggregate of 40,064 shares of Common Stock upon the vesting of restricted stock units (“ RSUs Issuances for the Six Months Ended June 30, 2023 During the six months ended June 30, 2023, the Company issued 128,000 shares of Common Stock under the March 2023 Offering for which the Company received net proceeds of approximately $3.7 million. During the six months ended June 30, 2023, the Company issued 1,724,332 shares of Common Stock upon the exercise of an aggregate of 1,724,332 investor warrants for which the Company received net proceeds of approximately $2.2 million (See Note 10). During the six months ended June 30, 2023, the Company issued an aggregate of 1,324,493 shares of Common Stock upon the conversion of pre-funded warrants issued at a par value of $0.0001 (See Note 10). During the six months ended June 30, 2023, the Company issued an aggregate of 70 shares of Common Stock upon the exchange of an aggregate of 4.23 shares of Series B Preferred Stock with a stated value of approximately $32,600 plus accrued dividends of approximately $6,200. During the six months ended June 30, 2023, the Company issued an aggregate of 40,064 shares of Common Stock upon the vesting of RSUs (See Note 11). During the six months ended June 30, 2023, the Company cancelled an aggregate of 2,967 shares of Common Stock in connection with the 1-for-7 reverse stock split on January 18, 2023. Issuances for the Three Months Ended June 30, 2022 During the three months ended June 30, 2022, the Company issued and sold an aggregate of 5,070 shares of Common Stock under the ATM Agreement for which the Company received net proceeds of approximately $317,000. During the three months ended June 30, 2022, the Company issued an aggregate of 411 shares of Common Stock and accompanying warrants (the “ Exchange Warrants Issuances for the Six Months Ended June 30, 2022 During the six months ended June 30, 2022, the Company issued 7,857 shares of Common Stock under the March 2022 Offering for which the Company received net proceeds of approximately $8.0 million. During the six months ended June 30, 2022, the Company issued and sold an aggregate of 5,070 shares of Common Stock under the ATM Agreement for which the Company received net proceeds of approximately $317,000. During the six months ended June 30, 2022, the Company issued an aggregate of 23,086 shares of Common Stock upon the conversion of pre-funded warrants issued at a par value of $0.01 (See Note 10). During the six months ended June 30, 2022, the Company issued an aggregate of 910 shares of Common Stock and accompanying Exchange Warrants upon the exchange of an aggregate of 30.92 shares of Series B Preferred Stock with a stated value of approximately $238,000 plus accrued dividends of approximately $27,000. The Exchange Warrants have an exercise price of $264.60 per share and will be exercisable for five years from the issuance date. During the six months ended June 30, 2022, the Company issued an aggregate of 429 shares of its Common Stock to consultants with a grant date fair value of approximately $119,000 for investor relations services provided, which was recorded as stock-based compensation and included as part of general and administrative expenses.

Warrants

Warrants	6 Months Ended
	Jun. 30, 2023
Warrants
Warrants	Note 10 – Warrant activity for the six months ended June 30, 2023 and 2022 was as follows: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ​ Weighted ​ ​ ​ ​ Average ​ Average ​ ​ Number of ​ Exercise Price ​ Remaining ​ Warrants Per Share Term in Years Outstanding and exercisable on January 1, 2023 2,179,798 ​ $ 19.16 5.50 Issued 6,389,718 ​ 1.79 4.85 Expired (116) ​ 773.79 — Exercised (3,048,825) ​ 0.65 4.94 Warrants outstanding and exercisable on June 30, 2023 5,520,575 ​ ​ 7.85 4.86 ​ ​ ​ ​ ​ ​ ​ ​ Warrants outstanding and exercisable on January 1, 2022 26,089 ​ $ 1,992.90 3.95 Issued 56,795 ​ 161.70 4.67 Expired (564) ​ 7,755.30 — Exercised (23,087) ​ 2.10 4.67 Warrants outstanding and exercisable on June 30, 2022 59,233 ​ $ 732.90 4.18 ​ The outstanding warrants expire from 2024 through 2028. During the six months ended June 30, 2023, the Company issued warrants and pre-funded warrants to purchase 2,941,054 shares of the Company’s Common Stock in connection with the March 2023 Offering. During the six months ended June 30, 2023, the Company issued warrants to purchase 3,448,664 shares of the Company’s Common Stock in connection with the June 2023 Inducement Offering (See Note 9). During the six months ended June 30, 2023, an investor exercised pre-funded warrants to purchase 1,324,493 shares of the Company’s Common Stock in connection with previous offerings. During the six months ended June 30, 2023, an investor exercised warrants to purchase 1,724,332 shares of the Company’s Common Stock in connection with previous offerings as a result of the June 2023 Inducement Offering (see Note 9). During the six months ended June 30, 2022, the Company issued warrants, pre-funded warrants, and placement agent warrants to purchase 55,883 shares of the Company’s Common Stock in connection with the March 2022 Offering, as well as Series C warrants to purchase 499 shares of the Company’s Common Stock in connection with a Series B Preferred Stock exchange (See Note 9). During the six months ended June 30, 2022, an investor exercised pre-funded warrants to purchase 23,087 shares of the Company’s Common Stock in connection with previous offerings. In connection with the March 2022 Offering, the Company entered into a warrant amendment agreement with an investor pursuant to which the Company agreed to amend the investor’s existing warrants to purchase up to 5,080 shares of Common Stock at an exercise price of $1,680.00 per share issued in January 2021 and warrants to purchase up to 1,872 shares of Common Stock at an exercise price of $2,541.00 per share issued in March 2021 (the “ March Existing Warrants

Equity Incentive Plan

Equity Incentive Plan	6 Months Ended
	Jun. 30, 2023
Equity Incentive Plan
Equity Incentive Plan	Note 11 – Equity Incentive Plan The Company’s Board and stockholders adopted and approved the Amended and Restated 2014 Omnibus Equity Incentive Plan (the “ 2014 Plan 2020 Plan The 2020 Plan allows for the issuance of securities, including stock options to employees, Board members and consultants. The initial number of shares of Common Stock available for issuance under the 2020 Plan was 4,761 shares, which will, on January 1 of each calendar year, unless the Board decides otherwise, automatically increase to equal ten percent (10)% of the total number of shares of Common Stock outstanding on December 31 of the immediately preceding calendar year, calculated on an As Converted Basis. As Converted Shares include all outstanding shares of Common Stock and all shares of Common Stock issuable upon the conversion of outstanding preferred stock, warrants and other convertible securities, but will not include any shares of Common Stock issuable upon the exercise of options and other convertible securities issued pursuant to either the 2014 Plan or the 2020 Plan. The number of shares permitted to be issued as “incentive stock options” (“ ISOs On April 20, 2023, the Company’s board of directors approved an amendment (i) increasing the number of shares of Common Stock available for issuance under the 2020 Plan from 317,480 to 1,167,480 and (ii) increasing the number of shares of our Common Stock otherwise available under the 2020 Plan that may be granted as ISOs to 5,000,000 shares. The board of directors directed that the amendment be submitted to the stockholders of the Company at the Company’s annual meeting of stockholders. On June 22, 2023, the stockholders approved the amendment to the 2020 Plan at the annual meeting of stockholders. As of January 1, 2023, the number of shares of Common Stock available for issuance under the 2020 Plan automatically increased to 317,480 under the 2020 Plan’s evergreen provision. As of June 22, 2023, as a result of approval at the annual shareholders’ meeting, the number of shares of Common Stock available for issuance under the 2020 Plan increased to 1,167,480. As of June 30, 2023, there were an aggregate of 1,024 total shares available (but un-issuable) under the 2014 Plan, of which 732 are issued and outstanding, and 292 shares are reserved subject to issuance of restricted stock and RSUs. As of June 30, 2023, 1,167,480 total shares were authorized under the 2020 Plan, of which 159,384 were issued and outstanding and 1,008,096 shares were available for potential issuances. During the six months ended June 30, 2023 and 2022, stock option activity under the 2014 Plan and 2020 Plan was as follows: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Average ​ Remaining ​ ​ ​ ​ ​ Number ​ Exercise ​ Contract ​ Intrinsic ​ of Shares Price Life (Years) Value Outstanding at January 1, 2023 4,076 ​ $ 958.14 8.22 ​ $ — Granted 5,000 ​ 3.73 9.91 ​ — Forfeited ​ (11) ​ ​ 573.68 ​ — ​ ​ — Expired ​ (109) ​ ​ 4,363.67 ​ — ​ ​ — Outstanding at June 30, 2023 8,956 ​ $ 397.33 8.93 ​ $ — Exercisable at June 30, 2023 5,271 ​ $ 574.49 8.69 ​ $ — ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Outstanding at January 1, 2022 1,941 ​ $ 2,470.99 7.28 ​ $ — Granted 3,219 ​ 291.90 8.08 ​ — Cancelled (202) ​ 278.14 — ​ — Forfeited ​ (475) ​ ​ 852.60 ​ — ​ ​ — Outstanding at June 30, 2022 4,483 ​ $ 1,096.20 8.52 ​ $ — Exercisable at June 30, 2022 2,093 ​ $ 2,226.00 7.59 ​ $ — ​ During the six months ended June 30, 2023 and 2022, the Board approved the grant of options to purchase 5,000 and 3,219 shares of Common Stock, respectively. All option grants were pursuant to the 2020 Plan. In general, options granted under the 2020 Plan vest monthly over a 36 During the six months ended June 30, 2023 and 2022, stock options to purchase 11 and 475 shares of Common Stock, respectively, were forfeited. During the six months ended June 30, 2023, stock options to purchase 109 shares of Common Stock expired. During the six months ended June 30, 2022, stock options to purchase 202 shares of Common Stock were cancelled. For the six months ended June 30, 2023 and 2022, the fair value of each option grant has been estimated on the date of grant using the Black-Scholes option-pricing model with the following weighted-average assumptions: ​ ​ ​ ​ ​ ​ ​ ​ 2023 2022 Contractual term (in years) 6.50 ​ 6.50 ​ Expected Volatility 98.80 % 90.92 % Risk-free interest rate 4.08 % 1.11 % Expected Dividend yield 0 % 0 % ​ Using the Black-Scholes option-pricing model, the estimated weighted average fair value of an option to purchase one share of Common Stock granted during the six months ended June 30, 2023 and 2022 was $3.05 and $258.30, respectively. Restricted Stock and Restricted Stock Units Restricted stock refers to shares of Common Stock subject to vesting based on certain service, performance, and market conditions. Restricted stock units (“ RSUs As of June 30, 2023 and 2022, under the 2014 Plan, the Company had 130 shares of restricted stock outstanding and an aggregate unrecognized restricted Common Stock expense of approximately $388,000, which will be recognized when vesting of certain milestones become probable. During the six months ended June 30, 2023, RSU activity under the 2020 Plan was as follows: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted-Average Weighted-Average ​ ​ Number ​ Grant Date ​ Remaining Recognition ​ of Shares Fair Value Period (Years) Non-vested Outstanding at January 1, 2023 ​ — ​ $ — ​ — Awarded 160,239 ​ 6.20 Vested ​ (77,095) ​ ​ 6.20 ​ ​ Cancelled (9,079) ​ 6.20 Non-vested Outstanding at June 30, 2023 74,065 ​ $ 6.20 0.50 ​ During the six months ended June 30, 2023, the Board approved the grant of 160,239 RSUs. All grants of RSUs were pursuant to the 2020 Plan, vest quarterly over a one-year period and are issued in the following quarter. The total stock-based compensation expense for employees and non-employees is included in the accompanying condensed consolidated statements of operations and as follows: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Three Months Ended June 30, ​ Six Months Ended June 30, ​ 2023 2022 2023 2022 Research and development ​ $ 38,165 ​ $ 24,839 ​ $ 76,245 ​ $ 71,246 General and administrative ​ 254,539 ​ 350,068 ​ 574,775 ​ 521,891 Total stock-based compensation expense ​ $ 292,704 ​ $ 374,907 ​ $ 651,020 ​ $ 593,136 ​ As of June 30, 2023, the Company had unrecognized stock-based compensation expense related to stock options and RSUs of approximately $0.8 million. Approximately $0.6 million of this unrecognized expense will be recognized over the average remaining vesting term of the stock awards of 0.78 years. Approximately $0.2 million of this unrecognized expense will vest upon achieving certain clinical and/or corporate milestones. The Company will recognize the expense related to these milestones when the milestones become probable. As of June 30, 2022, the Company had unrecognized stock-based compensation expense of approximately $1.1 million. Approximately $0.6 million of this unrecognized expense will be recognized over the average remaining vesting term of the stock options of 9.40 years. Approximately $0.5 million of this unrecognized expense will vest upon achieving certain clinical and/or corporate milestones. The Company will recognize the expense related to these milestones when the milestones become probable.

Leases

Leases	6 Months Ended
	Jun. 30, 2023
Leases
Leases	Note 12 – The Company leases its office under an operating lease which is subject to various rent provisions and escalation clauses. The Company is a party to one real property operating lease for the rental of office space. The Company has office space of 3,472 square feet in Boca Raton, Florida that is used for its corporate headquarters with a term through August 31, 2026. The Company previously had office space in Brooklyn, New York on a month-to-month basis, which was terminated in June 2023. The Company was also previously a party to office space in Hayward, California with a term through May 31, 2022, which was not renewed upon its expiration. The Company’s lease expires in 2026. The escalation clause is indeterminable and considered not material and has been excluded from minimum future annual rental payments. Lease expenses were approximately $35,000 and $50,000, respectively, for the three months ended June 30, 2023 and 2022 and $72,000 and $78,000, respectively, for the six months ended June 30, 2023 and 2022. The weighted-average remaining lease term and weighted-average discount rate under operating leases as of June 30, 2023 are: ​ ​ ​ ​ ​ ​ ​ June 30, ​ 2023 Lease term and discount rate ​ Weighted-average remaining lease term (years) 3.2 ​ Weighted-average discount rate 7.00 % ​ Maturities of operating lease liabilities as of June 30, 2023, were as follows: ​ ​ ​ ​ ​ 2023 (remainder of year) ​ $ 42,360 2024 ​ 86,202 2025 ​ 88,788 2026 ​ 60,593 Total lease payments ​ 277,943 Less imputed interest ​ (29,717) Present value of lease liabilities ​ $ 248,226 ​

Net Loss per Common Share

Net Loss per Common Share	6 Months Ended
	Jun. 30, 2023
Net Loss per Common Share
Net Loss per Common Share	Note 13 - Net Loss per Common Share Basic net loss per share is computed by dividing net loss available to Common Stockholders by the weighted average number of common shares outstanding during the period. Diluted earnings per share reflect, in periods in which they have a dilutive effect, the impact of common shares issuable upon exercise of stock options and warrants and conversion of convertible debt that are not deemed to be anti-dilutive. The dilutive effect of the outstanding stock options and warrants is computed using the treasury stock method. All shares of Common Stock that may potentially be issued in the future are as follows: ​ ​ ​ ​ ​ ​ ​ ​ June 30, 2023 ​ June 30, 2022 ​ (unaudited) (unaudited) Common stock warrants 5,520,575 59,233 Stock options 8,956 4,483 RSUs not yet issued ​ 160,239 ​ — Convertible preferred stock (1) 3,157 3,416 Restricted stock not yet issued 162 162 Total shares of Common Stock issuable 5,693,089 67,294 (1) Convertible preferred stock is assumed to be converted at the rate of $1,617.70 per common share, which is the conversion price as of June 30, 2023.

Employee Benefit Plans

Employee Benefit Plans	6 Months Ended
	Jun. 30, 2023
Employee Benefit Plans
Employee Benefit Plans	Note 14 - Employee Benefit Plans 401(k) Plan Since 2015, the Company has sponsored a multiple employer defined contribution benefit plan, which complies with Section 401(k) of the Internal Revenue Code covering substantially all employees of the Company. All employees are eligible to participate in the plan. Employees may contribute from 1% to 100% of their compensation and the Company matches an amount equal to 100% on the first 6% of the employee contribution and may also make discretionary profit-sharing contributions. Employer contributions under this 401(k) plan amounted to approximately $21,000 and $29,000 for the three months ended June 30, 2023 and 2022, respectively, and approximately $47,000 and $76,000 for the six months ended June 30, 2023 and 2022, respectively.

Subsequent Events

Subsequent Events	6 Months Ended
	Jun. 30, 2023
Subsequent Events
Subsequent Events	Note 15 - Subsequent Events The Company evaluated subsequent events and transactions that occurred after the balance sheet date up to the date that the financial statements were available to be issued. The Company did not identify any subsequent events that would have required adjustment or disclosure in the financial statements except for the items noted below. Phase 2 SPAN Trial On July 13, 2023, the Company announced initial topline results from the Phase 2b SPAN clinical trial investigating an enhanced enteric microgranule delivery formulation of adrulipase for the treatment of exocrine pancreatic insufficiency in patients with cystic fibrosis. Initial data from the study indicated that the enhanced adrulipase formulation was safe and well tolerated, as well as demonstrated an improvement over prior formulations of adrulipase. However, the preliminary data also indicated that it is likely that the primary efficacy endpoint was not achieved. The Company is continuing to assess the data and expects to report additional findings on primary and secondary endpoints in the third quarter of 2023. July 2023 Public Offering On July 21, 2023, the Company completed a public offering (the “ July 2023 Offering July 2023 Pre-Funded Warrants July 2023 Warrants The Company received gross proceeds of approximately $2.1 million less placement agent’s fees and other offering expenses of approximately $350,000.

Significant Accounting Polici_2

Significant Accounting Policies and Recent Accounting Pronouncements (Policies)	6 Months Ended
	Jun. 30, 2023
Significant Accounting Policies and Recent Accounting Pronouncements
Use of Estimates	Use of Estimates The accompanying unaudited condensed consolidated financial statements are prepared in conformity with GAAP and include certain estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements (including goodwill), and the reported amounts of revenue and expense during the reporting period, including contingencies. Accordingly, actual results may differ from those estimates.
Reverse Stock Split	Reverse Stock Split On January 18, 2023, the Company effected a reverse stock split, whereby every seven shares of the Company’s issued and outstanding Common Stock was converted automatically into one issued and outstanding share of Common Stock, but without any change in the number of authorized shares of Common Stock and the par value per share. All share and per share amounts have been retroactively restated to reflect the reverse stock splits referenced above.
Cash and Cash Equivalents and Restricted Cash	Cash and Cash Equivalents and Restricted Cash The Company considers all highly liquid investments with maturities of three months or less from the date of purchase to be cash equivalents. All cash and cash equivalent balances were highly liquid at June 30, 2023 and December 31, 2022. As of June 30, 2023 and December 31, 2022, the Company has classified approximately $0.02 million as restricted cash.
Concentrations of Credit Risk	Concentrations of Credit Risk Financial instruments that potentially expose the Company to concentrations of credit risk consist of cash. The Company primarily maintains its cash balances with financial institutions in federally insured accounts in the U.S. The Company may from time to time have cash in banks in excess of FDIC insurance limits. At June 30, 2023 the Company had approximately $1.2 million in one account in the U.S. which was in excess of these limits. The Company has not experienced any losses to date resulting from this practice. The Company mitigates its risk by maintaining the majority of its cash and equivalents with high quality financial institutions.
Fair Value Measurements	Fair Value Measurements The Company follows Accounting Standards Codification (“ ASC ( ASC 820 As a basis for considering such assumptions, a three-tier fair value hierarchy has been established, which prioritizes the inputs used in measuring fair value as follows: Level 1: Observable inputs such as quoted prices (unadjusted) in active markets for identical assets or liabilities; Level 2: Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly; and Level 3: Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions, which reflect those that a market participant would use. In certain cases, the inputs used to measure fair value may fall into different levels of the fair value hierarchy. In such cases, an instrument’s level within the fair value hierarchy is based on the lowest level of input that is significant to the overall fair value measurement. The Company’s assessment of the significance of a particular input to the fair value measurement in its entirety requires judgment and considers factors specific to the financial instrument. The Company recognizes transfers between levels as if the transfers occurred on the last day of the reporting period.
Foreign Currency Translation	Foreign Currency Translation For foreign subsidiaries with operations denominated in a foreign currency, assets and liabilities were translated to U.S. dollars, which is the functional currency, at period end exchange rates. Income and expense items were translated at average rates of exchange prevailing during the periods presented. Gains and losses from translation adjustments were accumulated in a separate component of stockholders’ equity up until the dissolution of AzurRx SAS in October 2022, at which time cumulative translation adjustments were recognized as a loss for the year ended December 31, 2022.
Goodwill	Goodwill Goodwill represents the excess of the purchase price of the acquired business over the fair value of amounts assigned to assets acquired and liabilities assumed. Goodwill and other intangible assets with indefinite useful lives are reviewed for impairment annually or more frequently if events or circumstances indicate impairment may be present. Any excess in carrying value over the estimated fair value is charged to results of operations. The Company has not recognized any impairment charges through June 30, 2023 related to goodwill.
Impairment of Long-Lived Assets	Impairment of Long-Lived Assets The Company periodically evaluates its long-lived assets for potential impairment in accordance with ASC Topic 360, Property, Plant and Equipment ( ASC 360
Leases	Leases The Company determines if an arrangement is a lease at inception. Operating leases are included in right-of-use (“ ROU
Research and Development	Research and Development Research and development costs are charged to operations when incurred and are included in operating expense, except for goodwill related to patents. Research and development costs consist principally of compensation of employees and consultants that perform the Company’s research activities, payments to third parties for preclinical and non-clinical activities, expenses with clinical research organizations (“ CROs CDMOs CMC Research and Development – The Company records intellectual property in asset acquisitions that have not reached technological feasibility and which have no alternative future use, as an expense at the acquisition date. On September 13, 2021, the Company entered into an agreement with FWB for the acquisition of intellectual property and patents for the worldwide, exclusive right to develop, manufacture, and commercialize proprietary formulations of niclosamide for the fields of treating ICI-AC and COVID-19 in humans, which was accounted for as an asset acquisition (see Note 4).
Stock-Based Compensation	Stock-Based Compensation The Company’s board of directors (the “ Board 2014 Plan 2020 Plan ASC 718 For awards with performance conditions that affect their vesting, such as the occurrence of certain transactions or the achievement of certain operating or financial milestones, recognition of fair value of the award occurs when vesting becomes probable. The Company estimates the grant date fair value of stock option awards using the Black-Scholes option-pricing model. The use of the Black-Scholes option-pricing model requires management to make assumptions with respect to the expected term of the option, the expected volatility of the Common Stock consistent with the expected life of the option, risk-free interest rates and expected dividend yields of the Common Stock.
Recent Accounting Pronouncements	Recent Accounting Pronouncements In August 2020, the Financial Accounting Standards Board (the “ FASB ASU 2020-06 SEC In June 2016, the FASB issued accounting pronouncement ASU 2016-13 – Measurement of Credit Losses on Financial Statements (“ ASU 2016-13 In June 2022, the FASB issued ASU 2022-03 - Fair Value Measurement, or Topic 820: Fair Value Measurement of Equity Securities Subject to Contractual Sale Restrictions (“ ASU 2022-03 The Company has evaluated other recently issued accounting pronouncements and has concluded that the impact of recently issued standards that are not yet effective will not have a material impact on the Company’s financial position or results of operations upon adoption.

Fair Value Disclosures (Tables)

Fair Value Disclosures (Tables)	6 Months Ended
	Jun. 30, 2023
Fair Value Disclosures
Schedule of fair value of the Company's financial instruments	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Fair Value Measured at Reporting Date ​ ​ ​ ​ ​ ​ ​ ​ Using ​ ​ ​ ​ ​ Carrying ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Amount Level 1 Level 2 Level 3 Fair Value June 30, 2023 (unaudited): ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Money market funds ​ $ 11,925 ​ $ 11,925 ​ $ — ​ $ — ​ $ 11,925 Note payable ​ 153,478 ​ — ​ 153,478 ​ — ​ 153,478 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ December 31, 2022: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Money market funds ​ ​ 509,890 ​ ​ 509,890 ​ ​ — ​ ​ — ​ ​ 509,890 Note payable ​ $ 603,494 ​ $ — ​ $ 603,494 ​ $ — ​ $ 603,494

Property, Equipment and Lease_2

Property, Equipment and Leasehold Improvements (Tables)	6 Months Ended
	Jun. 30, 2023
Property, Equipment and Leasehold Improvements
Summary of property, equipment and leasehold improvements	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ June 30, ​ ​ ​ ​ 2023 December 31, ​ ​ (unaudited) ​ 2022 Computer equipment and software ​ $ 11,540 ​ $ 11,540 Office equipment ​ 48,278 ​ 48,278 Leasehold improvements ​ 28,000 ​ 28,000 Total property, plant, and equipment ​ 87,818 ​ 87,818 Less accumulated depreciation ​ (58,616) ​ (43,979) Property, plant and equipment, net ​ $ 29,202 ​ $ 43,839

Goodwill (Tables)

Goodwill (Tables)	6 Months Ended
	Jun. 30, 2023
Goodwill
Schedule of goodwill	​ ​ ​ ​ ​ ​ Goodwill Balance on January 1, 2022 ​ $ 1,911,705 Foreign currency translation ​ (227,523) Balance on December 31, 2022 ​ 1,684,182 Foreign currency translation ​ — Balance on June 30, 2023 (unaudited) ​ $ 1,684,182

Accrued Expenses (Tables)

Accrued Expenses (Tables)	6 Months Ended
	Jun. 30, 2023
Accrued Expenses
Schedule of accrued expenses	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ June 30, ​ ​ ​ ​ 2023 December 31, ​ ​ (unaudited) ​ 2022 Clinical trials ​ $ 301,226 ​ $ 5,340 Professional fees ​ ​ 178,636 ​ ​ 309,867 Consulting fees ​ ​ — ​ ​ 4,969 Total accrued expenses ​ $ 479,862 ​ $ 320,176

Warrants (Tables)

Warrants (Tables)	6 Months Ended
	Jun. 30, 2023
Warrants
Schedule of warrant activity	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ​ Weighted ​ ​ ​ ​ Average ​ Average ​ ​ Number of ​ Exercise Price ​ Remaining ​ Warrants Per Share Term in Years Outstanding and exercisable on January 1, 2023 2,179,798 ​ $ 19.16 5.50 Issued 6,389,718 ​ 1.79 4.85 Expired (116) ​ 773.79 — Exercised (3,048,825) ​ 0.65 4.94 Warrants outstanding and exercisable on June 30, 2023 5,520,575 ​ ​ 7.85 4.86 ​ ​ ​ ​ ​ ​ ​ ​ Warrants outstanding and exercisable on January 1, 2022 26,089 ​ $ 1,992.90 3.95 Issued 56,795 ​ 161.70 4.67 Expired (564) ​ 7,755.30 — Exercised (23,087) ​ 2.10 4.67 Warrants outstanding and exercisable on June 30, 2022 59,233 ​ $ 732.90 4.18

Equity Incentive Plan (Tables)

Equity Incentive Plan (Tables)	6 Months Ended
	Jun. 30, 2023
Equity Incentive Plan
Schedule of stock option activity	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Average ​ Remaining ​ ​ ​ ​ ​ Number ​ Exercise ​ Contract ​ Intrinsic ​ of Shares Price Life (Years) Value Outstanding at January 1, 2023 4,076 ​ $ 958.14 8.22 ​ $ — Granted 5,000 ​ 3.73 9.91 ​ — Forfeited ​ (11) ​ ​ 573.68 ​ — ​ ​ — Expired ​ (109) ​ ​ 4,363.67 ​ — ​ ​ — Outstanding at June 30, 2023 8,956 ​ $ 397.33 8.93 ​ $ — Exercisable at June 30, 2023 5,271 ​ $ 574.49 8.69 ​ $ — ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Outstanding at January 1, 2022 1,941 ​ $ 2,470.99 7.28 ​ $ — Granted 3,219 ​ 291.90 8.08 ​ — Cancelled (202) ​ 278.14 — ​ — Forfeited ​ (475) ​ ​ 852.60 ​ — ​ ​ — Outstanding at June 30, 2022 4,483 ​ $ 1,096.20 8.52 ​ $ — Exercisable at June 30, 2022 2,093 ​ $ 2,226.00 7.59 ​ $ —
Schedule of option pricing model with the following weighted-average assumptions	​ ​ ​ ​ ​ ​ ​ ​ 2023 2022 Contractual term (in years) 6.50 ​ 6.50 ​ Expected Volatility 98.80 % 90.92 % Risk-free interest rate 4.08 % 1.11 % Expected Dividend yield 0 % 0 %
Schedule of RSU activity under the 2020 Plan	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted-Average Weighted-Average ​ ​ Number ​ Grant Date ​ Remaining Recognition ​ of Shares Fair Value Period (Years) Non-vested Outstanding at January 1, 2023 ​ — ​ $ — ​ — Awarded 160,239 ​ 6.20 Vested ​ (77,095) ​ ​ 6.20 ​ ​ Cancelled (9,079) ​ 6.20 Non-vested Outstanding at June 30, 2023 74,065 ​ $ 6.20 0.50
Schedule of stock-based compensation expense	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Three Months Ended June 30, ​ Six Months Ended June 30, ​ 2023 2022 2023 2022 Research and development ​ $ 38,165 ​ $ 24,839 ​ $ 76,245 ​ $ 71,246 General and administrative ​ 254,539 ​ 350,068 ​ 574,775 ​ 521,891 Total stock-based compensation expense ​ $ 292,704 ​ $ 374,907 ​ $ 651,020 ​ $ 593,136

Leases (Tables)

Leases (Tables)	6 Months Ended
	Jun. 30, 2023
Leases
Schedule of weighted-average remaining lease term and weighted-average discount rate under operating leases	​ ​ ​ ​ ​ ​ ​ June 30, ​ 2023 Lease term and discount rate ​ Weighted-average remaining lease term (years) 3.2 ​ Weighted-average discount rate 7.00 %
Schedule of maturities of operating lease liabilities	Maturities of operating lease liabilities as of June 30, 2023, were as follows: ​ ​ ​ ​ ​ 2023 (remainder of year) ​ $ 42,360 2024 ​ 86,202 2025 ​ 88,788 2026 ​ 60,593 Total lease payments ​ 277,943 Less imputed interest ​ (29,717) Present value of lease liabilities ​ $ 248,226

Net Loss per Common Share (Tabl

Net Loss per Common Share (Tables)	6 Months Ended
	Jun. 30, 2023
Net Loss per Common Share
Schedule of Common Stock that may potentially be issued in the future	​ ​ ​ ​ ​ ​ ​ ​ June 30, 2023 ​ June 30, 2022 ​ (unaudited) (unaudited) Common stock warrants 5,520,575 59,233 Stock options 8,956 4,483 RSUs not yet issued ​ 160,239 ​ — Convertible preferred stock (1) 3,157 3,416 Restricted stock not yet issued 162 162 Total shares of Common Stock issuable 5,693,089 67,294 (1) Convertible preferred stock is assumed to be converted at the rate of $1,617.70 per common share, which is the conversion price as of June 30, 2023.

The Company and Basis of Pres_2

The Company and Basis of Presentation (Details) - USD ($)			1 Months Ended
	Aug. 14, 2023	Jun. 30, 2023	Jul. 31, 2023	Dec. 31, 2022
The Company and Basis of Presentation
Cash and cash equivalents		$ 1,236,054		$ 1,362,910
Accumulated deficit		(176,793,574)		$ (168,533,689)
Working capital deficiency		900,000
July 2023 Purchase Agreement
The Company and Basis of Presentation
Proceeds from issuance of shares	$ 2,100,000	$ 2,100,000	$ 2,100,000

Significant Accounting Polici_3

Significant Accounting Policies and Recent Accounting Pronouncements (Details) - USD ($)			6 Months Ended
	Jan. 18, 2023	Aug. 26, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Significant Accounting Policies and Recent Accounting Pronouncements
Number of shares reduced due to reverse stock split	7	30		1
Restricted cash			$ 20,000		$ 20,000
Cash in US banks in excess of FDIC insurance limits			1,200,000
Asset impairment charges			$ 0

Fair Value Disclosures (Details

Fair Value Disclosures (Details) - USD ($)	Jun. 30, 2023	Dec. 31, 2022
Fair Value Disclosures
Money market funds	$ 1,236,054	$ 1,362,910
Note payable	153,478	603,494
Carrying Amount
Fair Value Disclosures
Note payable	153,478	603,494
Fair Value, Inputs, Level 2
Fair Value Disclosures
Note payable	153,478	603,494
Money Market Funds
Fair Value Disclosures
Money market funds	11,925	509,890
Money Market Funds | Carrying Amount
Fair Value Disclosures
Money market funds	11,925	509,890
Money Market Funds | Fair Value, Inputs, Level 1
Fair Value Disclosures
Money market funds	$ 11,925	$ 509,890

Asset Acquisition (Details)

Asset Acquisition (Details) - USD ($) $ in Millions					1 Months Ended	6 Months Ended
	Nov. 30, 2022	Sep. 29, 2022	Jul. 29, 2022	May 19, 2022	Jul. 31, 2022	Jun. 30, 2023	Jun. 30, 2022
Asset Acquisition
Stock cancelled during period, shares, acquisitions (in shares)						2,967
First Wave Bio Inc
Asset Acquisition
Asset acquisition consideration transferred	$ 2	$ 1	$ 1.5				$ 2.4
Asset acquisition, consideration transferred, contingent consideration				$ 4
Cash consideration					$ 1.5
Asset acquisition, potential milestone payments						$ 10.1
Milestone payment					$ 2

Property, Equipment and Lease_3

Property, Equipment and Leasehold Improvements - Property (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022
Property, Equipment and Leasehold Improvements
Total property, plant, and equipment	$ 87,818		$ 87,818		$ 87,818
Less accumulated depreciation	(58,616)		(58,616)		(43,979)
Property, plant and equipment, net	29,202		29,202		43,839
Depreciation expense	7,300	$ 7,300	14,600	$ 14,600
Computer equipment and software
Property, Equipment and Leasehold Improvements
Total property, plant, and equipment	11,540		11,540		11,540
Office equipment
Property, Equipment and Leasehold Improvements
Total property, plant, and equipment	48,278		48,278		48,278
Leasehold improvements
Property, Equipment and Leasehold Improvements
Total property, plant, and equipment	$ 28,000		$ 28,000		$ 28,000

Goodwill (Details)

Goodwill (Details) - USD ($)	6 Months Ended	12 Months Ended
	Jun. 30, 2023	Dec. 31, 2022
Goodwill
Beginning balance	$ 1,684,182	$ 1,911,705
Foreign currency translation	0	(227,523)
Ending balance	$ 1,684,182	$ 1,684,182

Accrued Expenses (Details)

Accrued Expenses (Details) - USD ($)	Jun. 30, 2023	Dec. 31, 2022
Accrued Expenses
Clinical trials	$ 301,226	$ 5,340
Professional fees	178,636	309,867
Consulting fees		4,969
Total accrued expenses	$ 479,862	$ 320,176

Note Payable (Details)

Note Payable (Details) - USD ($)	Nov. 30, 2022	Jun. 30, 2023	Dec. 31, 2022
Note Payable
Notes payable balance		$ 153,000	$ 603,000
Financing Agreement for Directors and Officer's and Other Liability Insurances
Note Payable
Debt instrument, term	9 months
Debt instrument, face amount	$ 677,000
Debt instrument, interest Rate	6.79%
Debt instrument, periodic payment	$ 77,000

Capital Stock (Details)

Capital Stock (Details)								3 Months Ended		6 Months Ended		12 Months Ended
	Jun. 13, 2023 USD ($) $ / shares shares	Mar. 15, 2023 USD ($) $ / shares shares	Jan. 18, 2023 shares	Aug. 26, 2022 shares	May 12, 2022 $ / shares shares	Mar. 02, 2022 USD ($) $ / shares shares	May 26, 2021 shares	Jun. 30, 2023 USD ($) $ / shares shares	Jun. 30, 2022 USD ($) $ / shares shares	Jun. 30, 2023 USD ($) $ / shares shares	Jun. 30, 2022 USD ($) $ / shares shares	Dec. 31, 2022 USD ($) $ / shares shares	Mar. 31, 2022 $ / shares	Dec. 31, 2021 shares
Common stock, shares authorized (in shares)								50,000,000		50,000,000		50,000,000
Common stock, par or stated value per share (in dollars per share) | $ / shares								$ 0.0001		$ 0.0001		$ 0.0001
Preferred stock, shares designated (in shares)								10,000,000		10,000,000
Preferred stock, par or stated value per share (in dollars per share) | $ / shares								$ 0.0001		$ 0.0001
Common stock, shares, issued, total (in shares)								4,208,995	995,003	4,208,995	995,003	995,003
Warrant exercise price | $ / shares						$ 264.60
Warrants to purchase of stock						1
Purchase of aggregate common stock								5,520,575	59,233	5,520,575	59,233	2,179,798		26,089
Deemed dividend on warrant modifications | $									$ 47,300		$ 47,300	$ (47,000)
Number of shares reduced due to reverse stock split			7	30							1
Common stock, shares, outstanding, ending balance (in shares)								4,208,995		4,208,995		995,003
Proceeds from Issuance of Common Stock | $						$ 8,000,000
Stock issued during period, value, new issues | $									$ 317,231		$ 317,231
Issuance of common stock, pre-funded warrants and warrants in registered direct offering, net of issuance costs (in shares)						7,857
Shares issued, price per share (in dollars per share) | $ / shares						$ 288.75
Warrants and rights outstanding, term (year)						5 years
Reverse stock split ratio										1
Stock Cancelled During Period, Shares, Acquisitions (in shares)										2,967
Common Stock issued to consultants | $											$ 118,999
March 2022 Warrants
Warrants to purchase of stock						30,943
Pre-Funded Warrant
Warrant exercise price | $ / shares						$ 363.30
Warrants to purchase of stock						23,086
Shares issued, price per share (in dollars per share) | $ / shares						$ 290.85
Warrants and rights outstanding, term (year)						5 years
Number of common stock shares called by each warrant (in shares)						1
March 2022 Pre-Funded warrants
Warrants to purchase of stock						1
Waiver
Purchase of aggregate common stock					1,196
Waiver | Common stock warrants
Warrant exercise price | $ / shares					$ 52.50
Series B Preferred Stock Converted into Common Stock
Warrant exercise price | $ / shares									$ 264.60		$ 264.60
Conversion of Stock, Shares Converted (in shares)									13.87		30.92
Warrants and rights outstanding, term (year)									5 years		5 years
Common stock issued upon conversion of preferred stock | $									$ 107,000		$ 238,000
Conversion of Stock, Amount Converted, Accrued Dividends | $									$ 13,000		$ 27,000
Officers and Directors | Waiver
Warrant exercise price | $ / shares					$ 69.174
Consultants
Stock Issued During Period, Shares, Settlement (in shares)											429
Stock Issued During Period, Value, Settlement | $											$ 119,000
Restricted Stock Units
Conversion of stock, shares issued (in shares)								40,064		40,064
Market Agreement | H C Wainwright Co L L C
Stock issued during period, shares, new issues (in shares)											217,036	217,036
Proceeds from Issuance of Common Stock | $												$ 8,000,000
Stock issuance costs | $												$ 309,000
At The Market Offering Agreement
Stock issued during period, shares, new issues (in shares)									5,070		5,070
Stock issued during period, value, new issues | $											$ 317,000
Gross proceeds | $									$ 317,000
At The Market Offering Agreement | Wainwright
Stock Sales Agreement, Commission on Shares Sold, Percentage							3%
Stock Sales Agreement, Number of Shares Authorized (in shares)							8,000,000
July 2022 Private Placement
Gross proceeds | $		$ 4,000,000
Other offering expenses | $		$ 300,000
March 2022 offering
Warrant exercise price | $ / shares													$ 5.901
Stock issued during period, shares, new issues (in shares)											7,857
Shares issued, price per share (in dollars per share) | $ / shares													$ 264.60
Gross proceeds | $											$ 8,000,000
March 2023 offering
Stock issued during period, shares, new issues (in shares)										128,000
Proceeds from Issuance of Common Stock | $										$ 3,700,000
March 2022 Registered Direct Offering
Gross proceeds | $						$ 9,000,000
Other offering expenses | $						$ 1,000,000
Direct offering | Pre-Funded Warrant
Warrants to purchase of stock						1,856
Class of Warrant or Right, Issued, Percentage of Common Stock Issued in Offering						6%
June 2023 Inducement Offering
Warrant exercise price | $ / shares	$ 1.15
Warrants to purchase of stock	1,724,332							3,448,664		3,448,664
Payment For Service Fee | $	$ 150,000
June 2023 Inducement Offering | Existing warrants
Warrant exercise price | $ / shares	$ 0.125
Proceeds from issuance of shares | $	$ 2,400,000
Proceeds from Issuance or Sale of Equity, Total | $	$ 2,400,000
Warrant | June 2023 Inducement Offering
Proceeds from Issuance of Common Stock | $								$ 2,200,000		$ 2,200,000
Class of warrant or right, exercised during period (in shares)								1,724,332		1,724,332
Pre-Funded Warrants
Conversion of stock, shares issued (in shares)								895,018		1,324,493
Stock Issued During Period, Shares, Exercise of Warrants (in shares)											23,086
Par value per warrant | $ / shares								$ 0.0001		$ 0.0001	$ 0.01
Series B Preferred Stock
Preferred stock, shares designated (in shares)								5,194.81		5,194.81		5,194.81
Preferred stock, par or stated value per share (in dollars per share) | $ / shares								$ 0.0001		$ 0.0001		$ 0.0001
Preferred stock, shares issued, total (in shares)								545.94		545.94		550.17
Exchange Amount | $								$ 7,700		$ 7,700
Warrants to purchase of stock									499		499
Preferred stock, shares outstanding (in shares)								545.94		545.94		550.17
Series B Preferred Stock | Waiver
Value of preferred stock agreed to be waived with holders of preferred stock | $									$ 2,880,000		$ 2,880,000
Value of preferred stock agreed to be waived with insiders | $									47,000		47,000
Waiver fee paid | $											233,000
Percentage of outstanding shares					81.30%
Series B Preferred Stock | Series B Preferred Stock Converted into Common Stock
Conversion of Stock, Shares Converted (in shares)										4.23
Common stock issued upon conversion of preferred stock | $										$ 32,600
Conversion of Stock, Amount Converted, Accrued Dividends | $										6,200
Series B Preferred Stock convertible into Series C Preferred Stock
Exchange Amount | $								$ 14,400,000	$ 265,000	$ 14,400,000	$ 265,000
Conversion of Series B preferred shares into common stock (in shares)										9,058
Conversion of Stock, Shares Converted (in shares)										1,839.76
Series B Preferred Stock convertible into Series C Preferred Stock | Investor warrants
Conversion of Series B preferred shares into common stock (in shares)										9,058
Series B Preferred Stock convertible into common stock with no warrants
Exchange Amount | $								$ 880,000		$ 880,000
Conversion of Series B preferred shares into common stock (in shares)										1,552
Conversion of Stock, Shares Converted (in shares)										99.200
Series B Preferred Stock Convertible Into Common Stock With Series C Warrants
Conversion of Series B preferred shares into common stock (in shares)										909
Conversion of Stock, Shares Converted (in shares)										30.91
Series B Preferred Stock Convertible Into Common Stock With Series C Warrants | March 2022 Warrants
Warrants to purchase of stock								909		909
Series C Preferred Stock
Preferred stock, shares designated (in shares)								75,000		75,000		75,000
Preferred stock, par or stated value per share (in dollars per share) | $ / shares								$ 0.0001		$ 0.0001		$ 0.0001
Preferred stock, shares issued, total (in shares)								0		0		0
Preferred stock, shares outstanding (in shares)								0		0		0
Series C Preferred Stock | July 2022 Private Placement
Number of common shares issuable upon conversion		895,018
Series D Preferred Stock
Preferred stock, shares designated (in shares)								150		150		150
Preferred stock, par or stated value per share (in dollars per share) | $ / shares								$ 0.0001		$ 0.0001		$ 0.0001
Preferred stock, shares issued, total (in shares)								0		0		0
Preferred stock, shares outstanding (in shares)								0		0		0
Series D Preferred Stock | July 2022 Private Placement
Convertible preferred stock, shares issued upon conversion (in shares)		3.91
Stock issued during period, shares, new issues (in shares)		128,000
Preferred stock, convertible, conversion price (in dollars per share) | $ / shares		$ 0.0001
Series E Preferred Stock
Preferred stock, shares designated (in shares)								150		150		150
Preferred stock, par or stated value per share (in dollars per share) | $ / shares								$ 0.0001		$ 0.0001		$ 0.0001
Preferred stock, shares issued, total (in shares)								0		0		0
Preferred stock, shares outstanding (in shares)								0		0		0
Series E Preferred Stock | July 2022 Private Placement
Preferred stock, par or stated value per share (in dollars per share) | $ / shares		$ 2,046,036
Number of shares reduced due to reverse stock split		3.66
Series F Preferred Stock
Preferred stock, shares designated (in shares)								7,000		7,000		7,000
Preferred stock, par or stated value per share (in dollars per share) | $ / shares								$ 0.0001		$ 0.0001		$ 0.0001
Preferred stock, shares issued, total (in shares)								0		0		0
Preferred stock, shares outstanding (in shares)								0		0		0
Common Stock
Conversion of stock, shares issued (in shares)									411	70	910
Common Stock | Pre-Funded Warrant
Warrant exercise price | $ / shares						$ 2.10
Common Stock | June 2023 Inducement Offering
Warrants to purchase of stock								1,724,332		1,724,332
Stock Issued During Period, Shares, Exercise of Warrants (in shares)								1,724,332		1,724,332
Maximum | June 2023 Inducement Offering
Warrants to purchase of stock	3,448,664

Warrants (Details)

Warrants (Details) - USD ($) $ / shares in Units, $ in Millions	6 Months Ended		12 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022	Dec. 31, 2021	Jun. 13, 2023	Mar. 31, 2022	Mar. 02, 2022	Mar. 31, 2021	Jan. 31, 2021
Number of Warrants
Outstanding and exercisable, beginning (in shares)	2,179,798	26,089	26,089
Issued (in shares)	6,389,718	56,795
Expired (in shares)	(116)	(564)
Exercised (in shares)	(3,048,825)	(23,087)
Warrants outstanding and exercisable, ending (in shares)	5,520,575	59,233	2,179,798	26,089
Weighted Average Exercise Price Per Share
Outstanding and exercisable, beginning (in dollars per share)	$ 19.16	$ 1,992.90	$ 1,992.90
Issued (in dollars per share)	1.79	161.70
Expired (in dollars per share)	773.79	7,755.30
Exercised (in dollars per share)	0.65	2.10
Warrants outstanding and exercisable, ending (in dollars per share)	$ 7.85	$ 732.90	$ 19.16	$ 1,992.90
Weighted Average Remaining Term in Years
Outstanding and exercisable (in years)	4 years 10 months 9 days	4 years 2 months 4 days	5 years 6 months	3 years 11 months 12 days
Issued (in years)	4 years 10 months 6 days	4 years 8 months 1 day
Exercised (in years)	4 years 11 months 8 days	4 years 8 months 1 day
Warrants to purchase of stock							1
Class of warrant or right, exercise price of warrants or rights (in dollars per share)							$ 264.60
Shares issued, price per share (in dollars per share)							$ 288.75
Series B Preferred Stock
Weighted Average Remaining Term in Years
Warrants to purchase of stock		499
March 2022 offering
Weighted Average Remaining Term in Years
Class of warrant or right, exercise price of warrants or rights (in dollars per share)						$ 5.901
Consideration for purchase of securities						$ 9
Shares issued, price per share (in dollars per share)						$ 264.60
Warrant amendment agreement
Weighted Average Remaining Term in Years
Class of warrant or right, exercise price of warrants or rights (in dollars per share)								$ 2,541	$ 1,680
June 2023 Inducement Offering
Weighted Average Remaining Term in Years
Warrants to purchase of stock	3,448,664				1,724,332
Class of warrant or right, exercise price of warrants or rights (in dollars per share)					$ 1.15
June 2023 Inducement Offering | Common Stock
Weighted Average Remaining Term in Years
Warrants to purchase of stock	1,724,332
Maximum | Warrant amendment agreement
Weighted Average Remaining Term in Years
Warrants to purchase of stock								1,872	5,080
Maximum | June 2023 Inducement Offering
Weighted Average Remaining Term in Years
Warrants to purchase of stock					3,448,664
Warrants, pre-funded warrants, and placement agent warrants
Weighted Average Remaining Term in Years
Warrants to purchase of stock	23,087
Warrants, pre-funded warrants, and placement agent warrants | March 2022 offering
Weighted Average Remaining Term in Years
Warrants to purchase of stock		55,883
Warrants, pre-funded warrants, and placement agent warrants | March 2023 offering
Weighted Average Remaining Term in Years
Warrants to purchase of stock	2,941,054
Warrants, pre-funded warrants, and placement agent warrants | June 2023 Inducement Offering | Common Stock
Weighted Average Remaining Term in Years
Warrants to purchase of stock	1,324,493
Existing warrants | June 2023 Inducement Offering
Weighted Average Remaining Term in Years
Class of warrant or right, exercise price of warrants or rights (in dollars per share)					$ 0.125

Equity Incentive Plan (Details)

Equity Incentive Plan (Details) - USD ($)			6 Months Ended
	Jun. 22, 2023	Sep. 11, 2020	Jun. 30, 2023	Jun. 30, 2022	Apr. 20, 2023	Jan. 01, 2023	Dec. 31, 2022
Equity Incentive Plan
Granted (in shares)			5,000	3,219
Unrecognized stock-based compensation expense			$ 800,000	$ 1,100,000
Remaining Term
Equity Incentive Plan
Unrecognized stock-based compensation expense			$ 600,000	$ 600,000
Average remaining vesting term of the stock options (in years)			9 months 10 days	9 years 4 months 24 days
Clinical, corporate milestones
Equity Incentive Plan
Unrecognized stock-based compensation expense			$ 200,000	$ 500,000
Incentive Stock Options
Equity Incentive Plan
Granted (in shares)			7,142
Stock Option
Equity Incentive Plan
Weighted average fair value of warrants granted (in dollars per share)			$ 3.05	$ 258.30
2020 Equity Incentive Plan
Equity Incentive Plan
Shares available under equity incentive plan (in shares)		4,761	1,008,096		5,000,000	317,480
Shares available under equity incentive plan increased (in shares)	1,167,480
Percentage of common stock reserved for issuance equity incentive plan		10%
Options to purchase shares of common stock (in shares)			159,384
Number of shares authorized under the plan			1,167,480
Options forfeited			11	475
Options cancelled			109
Vesting period			36 months
2020 Equity Incentive Plan | Maximum
Equity Incentive Plan
Shares available under equity incentive plan (in shares)					1,167,480
2020 Equity Incentive Plan | Minimum
Equity Incentive Plan
Shares available under equity incentive plan (in shares)					317,480
2020 Equity Incentive Plan | Restricted Stock Units
Equity Incentive Plan
Number of awards outstanding			74,065				0
Awards issued (in shares)			160,239
Vesting period			1 year
Equity Incentive Plan 2014
Equity Incentive Plan
Shares available under equity incentive plan (in shares)			1,024
Options to purchase shares of common stock (in shares)			732
Equity Incentive Plan 2014 | Restricted Stock
Equity Incentive Plan
Aggregate unrecognized restricted Common Stock expense			$ 388,000
Number of awards outstanding			130
Omnibus Equity Incentive Plan | Restricted Stock
Equity Incentive Plan
Shares reserved subject to issuance (in shares)			292

Equity Incentive Plan - Stock o

Equity Incentive Plan - Stock option activity (Details) - $ / shares	6 Months Ended		12 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Dec. 31, 2022	Dec. 31, 2021
Numbers of Shares
Granted (in shares)	5,000	3,219
Expired (in shares)	(109)
Average Exercise Price
Expired (in dollars per share)	$ 4,363.67
Stock option
Numbers of Shares
Granted (in shares)	7,142
Equity Incentive Plan | Stock option
Numbers of Shares
Outstanding at beginning (in shares)	4,076	1,941	1,941
Granted (in shares)	5,000	3,219
Canceled (in shares)		(202)
Forfeited (in shares)	(11)	(475)
Outstanding at ending (in shares)	8,956	4,483	4,076	1,941
Exercisable (in shares)	5,271	2,093
Average Exercise Price
Outstanding at beginning (in dollars per share)	$ 958.14	$ 2,470.99	$ 2,470.99
Granted (in dollars per share)	3.73	291.90
Canceled (in dollars per share)		278.14
Forfeited (in dollars per share)	573.68	852.60
Outstanding at ending (in dollars per share)	397.33	1,096.20	$ 958.14	$ 2,470.99
Exercisable (in dollars per share)	$ 574.49	$ 2,226
Remaining Contract Life (Years)
Stock option outstanding, remaining contractual life (Years)	8 years 11 months 4 days	8 years 6 months 7 days	8 years 2 months 19 days	7 years 3 months 10 days
Granted (in years)	9 years 10 months 28 days	8 years 29 days
Forfeited (in years)	0 years
Exercisable (in years)	8 years 8 months 8 days	7 years 7 months 2 days

Equity Incentive Plan - Weighte

Equity Incentive Plan - Weighted-average assumptions (Details) - Stock Option	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Equity Incentive Plan
Contractual term (in years)	6 years 6 months	6 years 6 months
Expected Volatility	98.80%	90.92%
Risk-free interest rate	4.08%	1.11%
Expected Dividend yield	0%	0%

Equity Incentive Plan - RSU act

Equity Incentive Plan - RSU activity under the 2020 Plan (Details) - 2020 Equity Incentive Plan - Restricted Stock Units	6 Months Ended
	Jun. 30, 2023 $ / shares shares
Number of Shares
Outstanding at beginning (in shares) | shares	0
Awards issued (in shares) | shares	160,239
Vested (in shares) | shares	(77,095)
Cancelled (in shares) | shares	9,079
Outstanding at ending (in shares) | shares	74,065
Weighted-Average Grant Date Fair Value
Outstanding at beginning (in dollars per share) | $ / shares	$ 0
Awarded (in dollars per share) | $ / shares	6.20
Vested (in dollars per share) | $ / shares	6.20
Cancelled (in dollars per share) | $ / shares	6.20
Outstanding at ending (in dollars per share) | $ / shares	$ 6.20
Weighted-Average Remaining Recognition Period (Years)	6 months

Equity Incentive Plan - Total s

Equity Incentive Plan - Total stock-based compensation expense (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Equity Incentive Plan
Total stock-based compensation expense	$ 292,704	$ 374,907	$ 651,020	$ 593,136
Research and development
Equity Incentive Plan
Total stock-based compensation expense	38,165	24,839	76,245	71,246
General and administrative
Equity Incentive Plan
Total stock-based compensation expense	$ 254,539	$ 350,068	$ 574,775	$ 521,891

Leases (Details)

Leases (Details)	3 Months Ended		6 Months Ended
	Jun. 30, 2023 USD ($) ft² property	Jun. 30, 2022 USD ($)	Jun. 30, 2023 USD ($) ft² property	Jun. 30, 2022 USD ($)
Leases
Operating lease, expense | $	$ 35,000	$ 50,000	$ 72,000	$ 78,000
Number of real property operating leases | property	1		1
Boca Raton, Florida
Leases
Area of real estate property (Square Foot) | ft²	3,472		3,472

Leases - Weighted-average remai

Leases - Weighted-average remaining lease term and discount rate (Details)	Jun. 30, 2023
Leases
Weighted-average remaining lease term (years)	3 years 2 months 12 days
Weighted-average discount rate	7%

Leases - Maturities of operatin

Leases - Maturities of operating lease liabilities (Details)	Jun. 30, 2023 USD ($)
Leases
2023 (remainder of year)	$ 42,360
2024	86,202
2025	88,788
2026	60,593
Total lease payments	277,943
Less imputed interest	(29,717)
Present value of lease liabilities	$ 248,226

Net Loss per Common Share - Com

Net Loss per Common Share - Common Stock that may potentially be issued (Details) - $ / shares	6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022
Net Loss per Common Share
Total shares of Common Stock issuable	5,693,089	67,294
Common stock warrants
Net Loss per Common Share
Total shares of Common Stock issuable	5,520,575	59,233
Stock options
Net Loss per Common Share
Total shares of Common Stock issuable	8,956	4,483
RSUs not yet issued
Net Loss per Common Share
Total shares of Common Stock issuable	160,239
Convertible preferred stock
Net Loss per Common Share
Total shares of Common Stock issuable	3,157	3,416
Preferred stock, convertible, conversion price (in dollars per share)	$ 1,617.70
Restricted stock not yet issued
Net Loss per Common Share
Total shares of Common Stock issuable	162	162

Employee Benefit Plans (Details

Employee Benefit Plans (Details) - USD ($)	3 Months Ended		6 Months Ended
	Jun. 30, 2023	Jun. 30, 2022	Jun. 30, 2023	Jun. 30, 2022
Employee Benefit Plans
Defined benefit plan, plan assets, contributions by employer	$ 21,000	$ 29,000	$ 47,000	$ 76,000
Defined contribution plan, employers matching contribution, annual vesting percentage			6%
Minimum
Employee Benefit Plans
Defined contribution plan, maximum annual contributions per employee, percent			1%
Maximum
Employee Benefit Plans
Defined contribution plan, maximum annual contributions per employee, percent			100%

Subsequent Events (Details)

Subsequent Events (Details) - USD ($)	Jul. 21, 2023	Mar. 02, 2022
Subsequent Events
Warrant exercise price		$ 264.60
Warrants term		5 years
Subsequent events | Public Offering
Subsequent Events
Gross proceeds	$ 2,100,000
Other offering expenses	$ 350,000
Subsequent events | July 2023 Offering
Subsequent Events
Stock issued during period, shares, new issues (in shares)	610,000
Shares of common stock	$ 0.64
Warrant exercised to purchase shares of common stock	1
Subsequent events | July 2023 Pre-Funded Warrants
Subsequent Events
Stock issued during period, shares, new issues (in shares)	2,675,000
Warrant exercise price	$ 0.0001
Warrant exercised to purchase shares of common stock	2,246,000
Subsequent events | July 2023 Warrants
Subsequent Events
Stock issued during period, shares, new issues (in shares)	6,570,000
Warrant exercise price	$ 0.64
Warrants term	5 years