The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
3M CO | COM | 88579Y101 | 21,314 | 111,400 | SH | DFND | 1 | 111,400 | 0 | 0 | |
ABEONA Therapeutics | COM | 00289Y107 | 150 | 30,000 | SH | DFND | 1 | 30,000 | 0 | 0 | |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 2,063 | 60,000 | SH | DFND | 1 | 60,000 | 0 | 0 | |
ACORDA THERAPEUTICS INC | COM | 00484M106 | 210 | 10,000 | SH | DFND | 1 | 10,000 | 0 | 0 | |
ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 188 | 37,662 | SH | DFND | 1 | 37,662 | 0 | 0 | |
ALLERGAN PLC | SPONSORED ADR | G0177J108 | 17,059 | 71,400 | SH | DFND | 1 | 71,400 | 0 | 0 | |
ALPHABET INC | CL C | 38259P706 | 3,235 | 3,900 | SH | DFND | 1 | 0 | 0 | 3,900 | |
AMAG PHARMACEUTICALS INC | COM | 00163U106 | 902 | 40,000 | SH | DFND | 1 | 40,000 | 0 | 0 | |
AMERICAN EXPRESS CO | COM | 025816109 | 1,392 | 17,600 | SH | DFND | 1 | 17,600 | 0 | 0 | |
AMGEN INC | COM | 031162100 | 6,809 | 41,500 | SH | DFND | 1 | 41,500 | 0 | 0 | |
Anheuser-Busch InBev | SPONSORED ADR | 03524A108 | 1,109 | 10,100 | SH | DFND | 1 | 10,100 | 0 | 0 | |
ANI PHARMACEUTICALS INC | COM | 00182C103 | 248 | 5,000 | SH | DFND | 1 | 5,000 | 0 | 0 | |
AURINIA PHARMACEUTICALS INC | COM | 05156V102 | 440 | 60,000 | SH | DFND | 1 | 60,000 | 0 | 0 | |
BECTON DICKINSON & CO | COM | 075887109 | 4,182 | 22,800 | SH | DFND | 1 | 22,800 | 0 | 0 | |
BERKSHIRE HATHAWAY INC | CL A | 084670108 | 174,645 | 699 | SH | DFND | 1 | 699 | 0 | 0 | |
BIODELIVERY SCIENCES INTERNATIONAL INC | COM | 09060J106 | 503 | 264,610 | SH | DFND | 1 | 264,610 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 6,015 | 22,000 | SH | DFND | 1 | 22,000 | 0 | 0 | |
BIOTIME INC | COM | 09066L105 | 122 | 35,274 | SH | DFND | 1 | 35,274 | 0 | 0 | |
BIOVERATIV INC | COM | 09075E100 | 599 | 11,000 | SH | DFND | 1 | 11,000 | 0 | 0 | |
BOEING CO | COM | 097023105 | 13,424 | 75,900 | SH | DFND | 1 | 75,900 | 0 | 0 | |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 3,736 | 68,700 | SH | DFND | 1 | 68,700 | 0 | 0 | |
CELGENE CORP | COM | 151020104 | 7,142 | 57,400 | SH | DFND | 1 | 57,400 | 0 | 0 | |
CELLDEX THERAPEUTICS INC | COM | 15117B103 | 181 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
CHICAGO BRIDGE & IRON CO N V | N Y REGISTRY SH | 167250109 | 6,827 | 222,000 | SH | DFND | 1 | 222,000 | 0 | 0 | |
CISCO SYSTEMS INC | COM | 17275R102 | 7,946 | 235,100 | SH | DFND | 1 | 235,100 | 0 | 0 | |
COCA COLA CO | COM | 191216100 | 1,952 | 46,000 | SH | DFND | 1 | 46,000 | 0 | 0 | |
CONCERT PHARMACEUTICALS INC | COM | 206022105 | 200 | 11,743 | SH | DFND | 1 | 11,743 | 0 | 0 | |
DANAHER CORP | COM | 235851102 | 17,996 | 210,400 | SH | DFND | 1 | 210,400 | 0 | 0 | |
DAVITA HEALTHCARE PARTNERS INC | COM | 23918K108 | 19,637 | 288,900 | SH | DFND | 1 | 288,900 | 0 | 0 | |
DBV TECHNOLOGIES SA | SPONSORED ADR | 23306J101 | 1,026 | 29,119 | SH | DFND | 1 | 29,119 | 0 | 0 | |
DIAMOND OFFSHORE DRILLING INC | COM | 25271C102 | 1,836 | 109,900 | SH | DFND | 1 | 109,900 | 0 | 0 | |
DYNAVAX TECHNOLOGIES CORPORATION | COM | 268158201 | 298 | 50,000 | SH | DFND | 1 | 50,000 | 0 | 0 | |
EIGER BIOPHARMACEUTICALS INC | COM | 28249U105 | 118 | 10,320 | SH | DFND | 1 | 10,320 | 0 | 0 | |
EXXON MOBIL CORPORATION | COM | 30231G102 | 6,683 | 81,493 | SH | DFND | 1 | 81,493 | 0 | 0 | |
FORTIVE CORP | COM | 34959J108 | 6,335 | 105,200 | SH | DFND | 1 | 105,200 | 0 | 0 | |
GILEAD SCIENCES INC | COM | 375558103 | 3,511 | 51,700 | SH | DFND | 1 | 51,700 | 0 | 0 | |
INTERNATIONAL BUSINESS MACHS | COM | 459200101 | 83,134 | 477,400 | SH | DFND | 1 | 477,400 | 0 | 0 | |
INTUITIVE SURGICAL INC | COM | 46120E602 | 5,955 | 7,770 | SH | DFND | 1 | 7,770 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 21,410 | 171,900 | SH | DFND | 1 | 171,900 | 0 | 0 | |
KRAFT HEINZ COMPANY | COM | 500754106 | 1,754 | 19,320 | SH | DFND | 1 | 19,320 | 0 | 0 | |
LIGAND PHARMACEUTICALS INC | COM | 53220K504 | 1,058 | 10,000 | SH | DFND | 1 | 10,000 | 0 | 0 | |
MASTERCARD INC | CL A | 57636Q104 | 1,125 | 10,000 | SH | DFND | 1 | 10,000 | 0 | 0 | |
MCDONALDS CORP | COM | 580135101 | 1,304 | 10,060 | SH | DFND | 1 | 10,060 | 0 | 0 | |
MEDTRONIC INC | COM | 585055106 | 4,084 | 50,700 | SH | DFND | 1 | 50,700 | 0 | 0 | |
NATIONAL OILWELL VARCO INC | COM | 637071101 | 10,636 | 265,300 | SH | DFND | 1 | 265,300 | 0 | 0 | |
NESTLE | SPONSORED ADR | 641069406 | 3,184 | 41,400 | SH | DFND | 1 | 41,400 | 0 | 0 | |
NOVO-NORDISK A S | SPONSORED ADR | 670100205 | 14,528 | 423,800 | SH | DFND | 1 | 423,800 | 0 | 0 | |
NOW INC | COM | 67011P100 | 944 | 55,675 | SH | DFND | 1 | 55,675 | 0 | 0 | |
OCERA THERAPEUTICS INC | COM | 67552A108 | 328 | 250,000 | SH | DFND | 1 | 250,000 | 0 | 0 | |
OPKO HEALTH INC | COM | 68375N103 | 715 | 89,405 | SH | DFND | 1 | 89,405 | 0 | 0 | |
PHILLIPS 66 | COM | 718546104 | 16,185 | 204,300 | SH | DFND | 1 | 204,300 | 0 | 0 | |
POTASH CORP SASK INC | COM | 73755L107 | 12,443 | 728,500 | SH | DFND | 1 | 728,500 | 0 | 0 | |
PRAXAIR INC | COM | 74005P104 | 17,911 | 151,020 | SH | DFND | 1 | 151,020 | 0 | 0 | |
PROQR THERAPEUTICS NV | COM | N71542109 | 121 | 24,144 | SH | DFND | 1 | 24,144 | 0 | 0 | |
ROCHE HOLDING A G | SPONSORED ADR | 771195104 | 5,477 | 171,000 | SH | DFND | 1 | 171,000 | 0 | 0 | |
ROPER TECHNOGIES INC | COM | 776696106 | 14,578 | 70,600 | SH | DFND | 1 | 70,600 | 0 | 0 | |
SANOFI | SPONSORED ADR | 80105N105 | 7,751 | 171,300 | SH | DFND | 1 | 171,300 | 0 | 0 | |
SELECTA BIOSCIENCES INC | COM | 816212104 | 349 | 24,369 | SH | DFND | 1 | 24,369 | 0 | 0 | |
STERICYCLE INC | COM | 858912108 | 10,776 | 130,000 | SH | DFND | 1 | 130,000 | 0 | 0 | |
SYNERGY PHARMACEUTICALS INC | COM | 871639308 | 699 | 150,000 | SH | DFND | 1 | 150,000 | 0 | 0 | |
SYNTEL INC | COM | 87162H103 | 332 | 19,700 | SH | DFND | 1 | 19,700 | 0 | 0 | |
TG THERAPEUTICS INC | COM | 88322Q108 | 699 | 60,000 | SH | DFND | 1 | 60,000 | 0 | 0 | |
TWENTY-FIRST CENTURY FOX INC | COM | 90130A200 | 925 | 29,100 | SH | DFND | 1 | 29,100 | 0 | 0 | |
UNITED TECHNOLOGIES CORP | COM | 913017109 | 12,702 | 113,200 | SH | DFND | 1 | 113,200 | 0 | 0 | |
UNITED THERAPEUTICS CORP | COM | 91307C102 | 2,694 | 19,900 | SH | DFND | 1 | 19,900 | 0 | 0 | |
US BANCORP | COM | 902973304 | 5,814 | 112,900 | SH | DFND | 1 | 111,290 | 0 | 0 | |
VISA INC | CL A | 92826C839 | 15,277 | 171,900 | SH | DFND | 1 | 171,900 | 0 | 0 | |
WABTEC CORPORATION | COM | 929740108 | 1,849 | 23,700 | SH | DFND | 1 | 23,700 | 0 | 0 | |
WELLS FARGO & CO | COM | 949746101 | 85,962 | 1,544,420 | SH | DFND | 1 | 1,544,420 | 0 | 0 |