COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
3M CO | COM | 88579Y101 | 27,976 | 142,210 | SH | | DFND | 1 | 142,210 | 0 | 0 |
58.COM, INC | SPONSORED ADR | 31680Q104 | 225 | 3,240 | SH | | DFND | 1 | 3,240 | 0 | 0 |
ABEONA THERAPEUTICS INC | COM | 00289Y107 | 530 | 33,101 | SH | | DFND | 1 | 33,101 | 0 | 0 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 916 | 60,000 | SH | | DFND | 1 | 60,000 | 0 | 0 |
ACHAOGEN INC | COM | 004449104 | 520 | 60,000 | SH | | DFND | 1 | 60,000 | 0 | 0 |
ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 775 | 30,000 | SH | | DFND | 1 | 30,000 | 0 | 0 |
ADVANCED ENERGY INDUSTRIES, INC | COM | 007973100 | 222 | 3,830 | SH | | DFND | 1 | 3,830 | 0 | 0 |
AKARI THERAPEUTICS PLC | COM | 00972G108 | 1,646 | 843,849 | SH | | DFND | 1 | 843,849 | 0 | 0 |
ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 857 | 107,858 | SH | | DFND | 1 | 107,858 | 0 | 0 |
ALLERGAN PLC | SPONSORED ADR | G0177J108 | 19,461 | 116,730 | SH | | DFND | 1 | 116,730 | 0 | 0 |
ALLIANCE DATA SYSTEMS CORPORATION | COM | 018581108 | 285 | 1,220 | SH | | DFND | 1 | 1,220 | 0 | 0 |
ALLISON TRANSMISSION HOLDINGS,INC | COM | 01973R101 | 252 | 6,220 | SH | | DFND | 1 | 6,220 | 0 | 0 |
ALPHABET INC CLASS C | CL C | 38259P706 | 4,351 | 3,900 | SH | | DFND | 1 | 0 | 0 | 3,900 |
ALTRIA GROUP INC | COM | 02209S103 | 1,846 | 32,500 | SH | | DFND | 1 | 32,500 | 0 | 0 |
AMC NETWORKS INC | COM | 00164V103 | 316 | 5,080 | SH | | DFND | 1 | 5,080 | 0 | 0 |
AMERICAN EXPRESS CO | COM | 025816109 | 1,725 | 17,600 | SH | | DFND | 1 | 17,600 | 0 | 0 |
AMGEN INC | COM | 031162100 | 8,884 | 48,130 | SH | | DFND | 1 | 48,130 | 0 | 0 |
ANHEUSER-BUSCH INBEV NV | SPONSORED ADR | 03524A108 | 6,952 | 69,000 | SH | | DFND | 1 | 69,000 | 0 | 0 |
ANTHEM INC | COM | 036752103 | 271 | 1,140 | SH | | DFND | 1 | 1,140 | 0 | 0 |
AUTOHOME INC | SPONSORED ADR | 05278C107 | 270 | 2,670 | SH | | DFND | 1 | 2,670 | 0 | 0 |
BAIDU INC | COM | 056752108 | 277 | 1,140 | SH | | DFND | 1 | 1,140 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 5,462 | 22,800 | SH | | DFND | 1 | 22,800 | 0 | 0 |
BERKSHIRE HATHAWAY INC CLASS A | CL A | 084670108 | 201,377 | 714 | SH | | DFND | 1 | 714 | 0 | 0 |
BHP BILLITON PLC | COM | 05545E209 | 9,463 | 210,530 | SH | | DFND | 1 | 210,530 | 0 | 0 |
BIODELIVERY SCIENCES INTERNATIONAL INC | COM | 09060J106 | 713 | 241,567 | SH | | DFND | 1 | 241,567 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 5,787 | 19,940 | SH | | DFND | 1 | 19,940 | 0 | 0 |
BOEING CO | COM | 097023105 | 21,573 | 64,300 | SH | | DFND | 1 | 64,300 | 0 | 0 |
BRIGHT SCHOLAR EDUCATION HOLDINGS LTD | SPONSORED ADR | 109199109 | 268 | 16,140 | SH | | DFND | 1 | 16,140 | 0 | 0 |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 3,436 | 62,080 | SH | | DFND | 1 | 62,080 | 0 | 0 |
BRITISH AMERICAN TOBACCO PLC | COM | 110448107 | 976 | 19,350 | SH | | DFND | 1 | 19,350 | 0 | 0 |
THE BUCKLE, INC | COM | 118440106 | 307 | 11,400 | SH | | DFND | 1 | 11,400 | 0 | 0 |
CA INC | COM | 12673P105 | 267 | 7,490 | SH | | DFND | 1 | 7,490 | 0 | 0 |
CALITHERA BIOSCIENCES,INC | COM | 13089P101 | 500 | 100,000 | SH | | DFND | 1 | 100,000 | 0 | 0 |
CANNAE HOLDINGS INC | COM | 13765N107 | 249 | 13,400 | SH | | DFND | 1 | 13,400 | 0 | 0 |
CELGENE CORP | COM | 151020104 | 5,112 | 64,370 | SH | | DFND | 1 | 64,370 | 0 | 0 |
CHECK POINT SOFTWARE TECHNOLOGIES LTD | COM | M22465104 | 245 | 2,510 | SH | | DFND | 1 | 2,510 | 0 | 0 |
CHINA MOBILE LIMITED | SPONSORED ADR | 16941M109 | 1,323 | 29,800 | SH | | DFND | 1 | 29,800 | 0 | 0 |
CIGNA CORPORATION | COM | 125509109 | 255 | 1,500 | SH | | DFND | 1 | 1,500 | 0 | 0 |
CIRRUS LOGIC, INC | COM | 172755100 | 250 | 6,530 | SH | | DFND | 1 | 6,530 | 0 | 0 |
CISCO SYSTEMS INC | COM | 17275R102 | 6,799 | 158,000 | SH | | DFND | 1 | 158,000 | 0 | 0 |
COCA COLA CO | COM | 191216100 | 2,018 | 46,000 | SH | | DFND | 1 | 46,000 | 0 | 0 |
COLGATE-PALMOLIVE COMPANY | COM | 194162103 | 7,499 | 115,700 | SH | | DFND | 1 | 115,700 | 0 | 0 |
CORCEPT THERAPEUTICS INC | COM | 218352102 | 472 | 30,000 | SH | | DFND | 1 | 30,000 | 0 | 0 |
CTRIP.COM INTERNATIONAL, LTD | SPONSORED ADR | 22943F100 | 288 | 6,050 | SH | | DFND | 1 | 6,050 | 0 | 0 |
DANAHER CORP | COM | 235851102 | 21,295 | 215,800 | SH | | DFND | 1 | 215,800 | 0 | 0 |
DAVITA HEALTHCARE PARTNERS INC | COM | 23918K108 | 18,745 | 269,940 | SH | | DFND | 1 | 269,940 | 0 | 0 |
DELUXE CORP | COM | 248019101 | 228 | 3,440 | SH | | DFND | 1 | 3,440 | 0 | 0 |
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND | ETF | 233051879 | 1,610 | 60,700 | SH | | DFND | 1 | 60,700 | 0 | 0 |
DIAMOND OFFSHORE DRILLING INC | COM | 25271C102 | 734 | 35,200 | SH | | DFND | 1 | 35,200 | 0 | 0 |
DYNAVAX TECHNOLOGIES CORPORATION | COM | 268158201 | 1,994 | 130,755 | SH | | DFND | 1 | 130,755 | 0 | 0 |
ECOLAB INC | COM | 278865100 | 295 | 2,100 | SH | | DFND | 1 | 2,100 | 0 | 0 |
EXPRESS SCRIPTS HOLDING INC | COM | 30219G108 | 8,627 | 111,740 | SH | | DFND | 1 | 111,740 | 0 | 0 |
EXXON MOBIL CORPORATION | COM | 30231G102 | 10,787 | 130,393 | SH | | DFND | 1 | 130,393 | 0 | 0 |
F5 NETWORKS, INC | COM | 315616102 | 286 | 1,660 | SH | | DFND | 1 | 1,660 | 0 | 0 |
FORTIVE CORP | COM | 34959J108 | 10,926 | 141,700 | SH | | DFND | 1 | 141,700 | 0 | 0 |
GENERAL ELECTRIC COMPANY | COM | 369604103 | 6,891 | 506,300 | SH | | DFND | 1 | 506,300 | 0 | 0 |
GENERAL MILLS,INC | COM | 370334104 | 7,568 | 171,000 | SH | | DFND | 1 | 171,000 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 8,462 | 119,450 | SH | | DFND | 1 | 119,450 | 0 | 0 |
GRAY TELEVISION, INC | COM | 389375106 | 346 | 21,890 | SH | | DFND | 1 | 21,890 | 0 | 0 |
H&R BLOCK, INC | COM | 093671105 | 222 | 9,760 | SH | | DFND | 1 | 9,760 | 0 | 0 |
HOLOGIC, INC | COM | 436440101 | 272 | 6,850 | SH | | DFND | 1 | 6,850 | 0 | 0 |
HOSTESS BRANDS,INC | COM | 44109J106 | 242 | 17,810 | SH | | DFND | 1 | 17,810 | 0 | 0 |
HOULIHAN LOKEY, INC | COM | 441593100 | 294 | 5,740 | SH | | DFND | 1 | 5,740 | 0 | 0 |
ISHARES CORE HIGH DIVIDEND ETF | COM | 46429B663 | 450 | 5,300 | SH | | DFND | 1 | 5,300 | 0 | 0 |
INTERDIGITAL INC | COM | 45867G101 | 265 | 3,270 | SH | | DFND | 1 | 3,270 | 0 | 0 |
INTERNATIONAL BUSINESS MACHINES CORP | COM | 459200101 | 31,655 | 226,590 | SH | | DFND | 1 | 226,590 | 0 | 0 |
INTUITIVE SURGICAL INC | COM | 46120E602 | 8,924 | 18,650 | SH | | DFND | 1 | 18,650 | 0 | 0 |
ISHARES NASDAQ BIOTECHNOLOGY | ETF | 464287556 | 2,844 | 25,900 | SH | | DFND | 1 | 25,900 | 0 | 0 |
JACK HENRY & ASSOCIATES INC | COM | 426281101 | 1,786 | 13,700 | SH | | DFND | 1 | 13,700 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 29,961 | 246,920 | SH | | DFND | 1 | 246,920 | 0 | 0 |
KBR, INC | COM | 48242W106 | 270 | 15,040 | SH | | DFND | 1 | 15,040 | 0 | 0 |
KLA-TENCOR CORPORATION | COM | 482480100 | 243 | 2,370 | SH | | DFND | 1 | 2,370 | 0 | 0 |
THE KRAFT HEINZ COMPANY | COM | 500754106 | 12,769 | 203,260 | SH | | DFND | 1 | 203,260 | 0 | 0 |
LINN ENERGY INC | COM | 53601P304 | 260 | 6,720 | SH | | DFND | 1 | 6,720 | 0 | 0 |
LOEWS CORPORATION | COM | 540424108 | 468 | 9,700 | SH | | DFND | 1 | 9,700 | 0 | 0 |
MASTERCARD INC | CL A | 57636Q104 | 1,965 | 10,000 | SH | | DFND | 1 | 10,000 | 0 | 0 |
MC DERMOTT INTERNATIONAL,INC | COM | 580037703 | 1,506 | 76,638 | SH | | DFND | 1 | 76,638 | 0 | 0 |
MCDONADLD'S CORP | COM | 580135101 | 1,576 | 10,060 | SH | | DFND | 1 | 10,060 | 0 | 0 |
MCKESSON CORPORATION | COM | 58155Q103 | 232 | 1,740 | SH | | DFND | 1 | 1,740 | 0 | 0 |
MEDTRONIC INC | COM | 585055106 | 4,340 | 50,700 | SH | | DFND | 1 | 50,700 | 0 | 0 |
THE MICHAELS COS INC | COM | 59408Q106 | 271 | 14,120 | SH | | DFND | 1 | 14,120 | 0 | 0 |
MSG NETWORKS INC | COM | 553573106 | 276 | 11,540 | SH | | DFND | 1 | 11,540 | 0 | 0 |
NATIONAL OILWELL VARCO INC | COM | 637071101 | 9,769 | 225,100 | SH | | DFND | 1 | 225,100 | 0 | 0 |
NESTLE SA | SPONSORED ADR | 641069406 | 14,798 | 191,110 | SH | | DFND | 1 | 191,110 | 0 | 0 |
NOVO NORDISK A/S | SPONSORED ADR | 670100205 | 15,637 | 339,040 | SH | | DFND | 1 | 339,040 | 0 | 0 |
NOW INC | COM | 67011P100 | 742 | 55,675 | SH | | DFND | 1 | 55,675 | 0 | 0 |
NUTRIEN LTD | COM | 67077M108 | 20,466 | 376,360 | SH | | DFND | 1 | 376,360 | 0 | 0 |
OCULAR THERAPEUTIX INC | COM | 67576A100 | 540 | 80,011 | SH | | DFND | 1 | 80,011 | 0 | 0 |
OMNICOM GROUP INC | COM | 681919106 | 419 | 5,500 | SH | | DFND | 1 | 5,500 | 0 | 0 |
ONESMART INTERNATIONAL EDUCATION GROUP LIMITED | SPONSORED ADR | 68276W103 | 266 | 23,940 | SH | | DFND | 1 | 23,940 | 0 | 0 |
ORACLE CORPORATION | COM | 68389X105 | 247 | 5,600 | SH | | DFND | 1 | 5,600 | 0 | 0 |
PACCAR INC | COM | 693718108 | 230 | 3,710 | SH | | DFND | 1 | 3,710 | 0 | 0 |
PHILLIPS 66 | COM | 718546104 | 27,569 | 245,470 | SH | | DFND | 1 | 245,470 | 0 | 0 |
PRAXAIR INC | COM | 74005P104 | 23,884 | 151,020 | SH | | DFND | 1 | 151,020 | 0 | 0 |
PREMIER, INC | COM | 74051N102 | 298 | 8,200 | SH | | DFND | 1 | 8,200 | 0 | 0 |
THE PROCTER&GAMBLE COMPANY | COM | 742718109 | 13,598 | 174,200 | SH | | DFND | 1 | 174,200 | 0 | 0 |
PROGENICS PHARMACEUTICALS INC | COM | 743187106 | 1,608 | 200,000 | SH | | DFND | 1 | 200,000 | 0 | 0 |
RE/MAX HOLDINGS, INC | COM | 75524W108 | 234 | 4,470 | SH | | DFND | 1 | 4,470 | 0 | 0 |
RMR GROUP INC | COM | 74967R106 | 260 | 3,310 | SH | | DFND | 1 | 3,310 | 0 | 0 |
ROCHE HOLDING AG | SPONSORED ADR | 771195104 | 4,606 | 166,700 | SH | | DFND | 1 | 166,700 | 0 | 0 |
ROPER TECHNOLOGIES INC | COM | 776696106 | 19,595 | 71,020 | SH | | DFND | 1 | 71,020 | 0 | 0 |
ROYAL DUTCH SHELL PLC CLASS B | CL B | 780259107 | 4,868 | 67,000 | SH | | DFND | 1 | 67,000 | 0 | 0 |
SANOFI-AVENTIS SA | SPONSORED ADR | 80105N105 | 5,483 | 137,040 | SH | | DFND | 1 | 137,040 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,322 | 10,000 | SH | | DFND | 1 | 10,000 | 0 | 0 |
SENSATA TECHNOLOGIES HOLDING | COM | G8060N102 | 856 | 18,000 | SH | | DFND | 1 | 18,000 | 0 | 0 |
SINCLAIR BROADCAST GROUP, INC | COM | 829226109 | 279 | 8,670 | SH | | DFND | 1 | 8,670 | 0 | 0 |
STERICYCLE INC | COM | 858912108 | 3,108 | 47,600 | SH | | DFND | 1 | 47,600 | 0 | 0 |
STORE CAPITAL CORPORATION | REIT | 862121100 | 1,006 | 36,700 | SH | | DFND | 1 | 36,700 | 0 | 0 |
SYNCHRONY FINANCIAL | COM | 87165B103 | 210 | 6,300 | SH | | DFND | 1 | 6,300 | 0 | 0 |
SYNERGY PHARMACEUTICALS INC | COM | 871639308 | 4,002 | 2,300,000 | SH | | DFND | 1 | 2,300,000 | 0 | 0 |
SYNTEL INC | COM | 87162H103 | 1,003 | 31,270 | SH | | DFND | 1 | 31,270 | 0 | 0 |
TARO PHARMACEUTICAL INDUSTRIES LTD | COM | M8737E108 | 296 | 2,560 | SH | | DFND | 1 | 2,560 | 0 | 0 |
TEGNA INC | COM | 87901J105 | 258 | 23,790 | SH | | DFND | 1 | 23,790 | 0 | 0 |
TG THERAPEUTICS INC | COM | 88322Q108 | 2,104 | 160,000 | SH | | DFND | 1 | 160,000 | 0 | 0 |
UNITED TECHNOLOGIES CORP | COM | 913017109 | 20,711 | 165,650 | SH | | DFND | 1 | 165,650 | 0 | 0 |
UNITED THERAPEUTICS CORPORATION | COM | 91307C102 | 260 | 2,300 | SH | | DFND | 1 | 2,300 | 0 | 0 |
US BANCORP | COM | 902973304 | 5,647 | 112,900 | SH | | DFND | 1 | 112,900 | 0 | 0 |
VANGUARD CONSUMER STAPLES ETF | ETF | 92204A207 | 3,547 | 26,420 | SH | | DFND | 1 | 26,420 | 0 | 0 |
VANGUARD FTSE EMERGING MARKETS ETF | COM | 922042858 | 717 | 17,000 | SH | | DFND | 1 | 17,000 | 0 | 0 |
VANGUARD S&P 500 ETF | COM | 922908363 | 6,410 | 25,690 | SH | | DFND | 1 | 25,690 | 0 | 0 |
VISA INC CLASS A | CL A | 92826C839 | 22,768 | 171,900 | SH | | DFND | 1 | 171,900 | 0 | 0 |
WABTEC CORPORATION | COM | 929740108 | 19,003 | 192,770 | SH | | DFND | 1 | 192,770 | 0 | 0 |
WALKER & DUNLOP INC | COM | 93148P102 | 244 | 4,390 | SH | | DFND | 1 | 4,390 | 0 | 0 |
WARRIOR MET COAL INC | COM | 93627C101 | 317 | 11,500 | SH | | DFND | 1 | 11,500 | 0 | 0 |
WATERS CORPORATION | COM | 941848103 | 10,028 | 51,800 | SH | | DFND | 1 | 51,800 | 0 | 0 |
WELLS FARGO & CO | COM | 949746101 | 85,623 | 1,544,420 | SH | | DFND | 1 | 1,544,420 | 0 | 0 |
YUM!BRANDS, INC | COM | 988498101 | 234 | 2,990 | SH | | DFND | 1 | 2,990 | 0 | 0 |
ZTO EXPRESS CAYMAN INC | SPONSORED ADR | 98980A105 | 327 | 16,330 | SH | | DFND | 1 | 16,330 | 0 | 0 |