COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
3M CO | COM | 88579Y101 | 38,716 | 186,330 | SH | | DFND | 1 | 186,330 | 0 | 0 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 537 | 20,000 | SH | | DFND | 1 | 20,000 | 0 | 0 |
AKARI THERAPEUTICS PLC | COM | 00972G108 | 5,120 | 1,430,096 | SH | | DFND | 1 | 1,430,096 | 0 | 0 |
ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 402 | 44,520 | SH | | DFND | 1 | 44,520 | 0 | 0 |
ALLERGAN PLC | SPONSORED ADR | G0177J108 | 27,267 | 186,240 | SH | | DFND | 1 | 186,240 | 0 | 0 |
ALLISON TRANSMISSION HOLDINGS,INC | COM | 01973R101 | 279 | 6,220 | SH | | DFND | 1 | 6,220 | 0 | 0 |
ALPHABET INC CLASS C | CL C | 38259P706 | 4,576 | 3,900 | SH | | DFND | 1 | 0 | 0 | 3,900 |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 844 | 122,972 | SH | | DFND | 1 | 122,972 | 0 | 0 |
ALTRIA GROUP INC | COM | 02209S103 | 8,338 | 145,190 | SH | | DFND | 1 | 145,190 | 0 | 0 |
AMC NETWORKS INC | COM | 00164V103 | 288 | 5,080 | SH | | DFND | 1 | 5,080 | 0 | 0 |
AMGEN INC | COM | 031162100 | 6,484 | 34,130 | SH | | DFND | 1 | 34,130 | 0 | 0 |
ANAVEX LIFE SCIENCES CORP | COM | 032797300 | 531 | 174,080 | SH | | DFND | 1 | 174,080 | 0 | 0 |
ANHEUSER-BUSCH INBEV NV | SPONSORED ADR | 03524A108 | 10,395 | 123,800 | SH | | DFND | 1 | 123,800 | 0 | 0 |
ANTHEM INC | COM | 036752103 | 327 | 1,140 | SH | | DFND | 1 | 1,140 | 0 | 0 |
AT&T INC | COM | 00206R102 | 3,048 | 97,200 | SH | | DFND | 1 | 97,200 | 0 | 0 |
AUTOHOME INC | SPONSORED ADR | 05278C107 | 281 | 2,670 | SH | | DFND | 1 | 2,670 | 0 | 0 |
AVEO PHARMACEUTICALS INC | COM | 053588109 | 66 | 80,000 | SH | | DFND | 1 | 80,000 | 0 | 0 |
BANK OF NEW YORK MELLON CORP | COM | 064058100 | 15,137 | 300,160 | SH | | DFND | 1 | 300,160 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 5,694 | 22,800 | SH | | DFND | 1 | 22,800 | 0 | 0 |
BERKSHIRE HATHAWAY INC CLASS A | CL A | 084670108 | 223,803 | 743 | SH | | DFND | 1 | 743 | 0 | 0 |
BERKSHIRE HATHAWAY INC CLASS B | CL B | 084670702 | 482 | 2,400 | SH | | DFND | 1 | 2,400 | 0 | 0 |
BHP BILLITON PLC | COM | 05545E209 | 11,260 | 233,230 | SH | | DFND | 1 | 233,230 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 3,371 | 14,260 | SH | | DFND | 1 | 14,260 | 0 | 0 |
BOEING CO | COM | 097023105 | 22,084 | 57,900 | SH | | DFND | 1 | 57,900 | 0 | 0 |
BRIGHT SCHOLAR EDUCATION HOLDINGS LTD | SPONSORED ADR | 109199109 | 167 | 16,140 | SH | | DFND | 1 | 16,140 | 0 | 0 |
BRISTOL-MYERS SQUIBB CO | COM | 110122108 | 2,962 | 62,080 | SH | | DFND | 1 | 62,080 | 0 | 0 |
BRITISH AMERICAN TOBACCO PLC | COM | 110448107 | 807 | 19,350 | SH | | DFND | 1 | 19,350 | 0 | 0 |
THE BUCKLE, INC | COM | 118440106 | 213 | 11,400 | SH | | DFND | 1 | 11,400 | 0 | 0 |
CALITHERA BIOSCIENCES,INC | COM | 13089P101 | 337 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
CANNAE HOLDINGS INC | COM | 13765N107 | 325 | 13,400 | SH | | DFND | 1 | 13,400 | 0 | 0 |
CELGENE CORP | COM | 151020104 | 3,337 | 35,370 | SH | | DFND | 1 | 35,370 | 0 | 0 |
CHECK POINT SOFTWARE TECHNOLOGIES LTD | COM | M22465104 | 317 | 2,510 | SH | | DFND | 1 | 2,510 | 0 | 0 |
CHINA MOBILE LIMITED | SPONSORED ADR | 16941M109 | 2,463 | 48,300 | SH | | DFND | 1 | 48,300 | 0 | 0 |
CIGNA CORPORATION | COM | 125509109 | 4,615 | 28,697 | SH | | DFND | 1 | 28,697 | 0 | 0 |
CIRRUS LOGIC, INC | COM | 172755100 | 275 | 6,530 | SH | | DFND | 1 | 6,530 | 0 | 0 |
CISCO SYSTEMS INC | COM | 17275R102 | 5,610 | 103,900 | SH | | DFND | 1 | 103,900 | 0 | 0 |
COCA COLA CO | COM | 191216100 | 2,156 | 46,000 | SH | | DFND | 1 | 46,000 | 0 | 0 |
COLGATE-PALMOLIVE COMPANY | COM | 194162103 | 9,739 | 142,090 | SH | | DFND | 1 | 142,090 | 0 | 0 |
CONATUS PHARMACEUTICALS INC | COM | 20600T108 | 217 | 200,488 | SH | | DFND | 1 | 200,488 | 0 | 0 |
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 523 | 130,000 | SH | | DFND | 1 | 130,000 | 0 | 0 |
DANAHER CORP | COM | 235851102 | 28,490 | 215,800 | SH | | DFND | 1 | 215,800 | 0 | 0 |
DAVITA HEALTHCARE PARTNERS INC | COM | 23918K108 | 4,065 | 74,880 | SH | | DFND | 1 | 74,880 | 0 | 0 |
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND | ETF | 233051879 | 7,091 | 246,800 | SH | | DFND | 1 | 246,800 | 0 | 0 |
DIAMOND OFFSHORE DRILLING INC | COM | 25271C102 | 369 | 35,200 | SH | | DFND | 1 | 35,200 | 0 | 0 |
DYNAVAX TECHNOLOGIES CORPORATION | COM | 268158201 | 772 | 105,573 | SH | | DFND | 1 | 105,573 | 0 | 0 |
ECOLAB INC | COM | 278865100 | 371 | 2,100 | SH | | DFND | 1 | 2,100 | 0 | 0 |
EQUIFAX INC | COM | 294429AN5 | 331 | 2,790 | SH | | DFND | 1 | 2,790 | 0 | 0 |
EXXON MOBIL CORPORATION | COM | 30231G102 | 11,175 | 138,303 | SH | | DFND | 1 | 138,303 | 0 | 0 |
F5 NETWORKS, INC | COM | 315616102 | 261 | 1,660 | SH | | DFND | 1 | 1,660 | 0 | 0 |
FORTIVE CORP | COM | 34959J108 | 11,887 | 141,700 | SH | | DFND | 1 | 141,700 | 0 | 0 |
GENERAL ELECTRIC COMPANY | COM | 369604103 | 20,830 | 2,085,100 | SH | | DFND | 1 | 2,085,100 | 0 | 0 |
GENERAL MILLS,INC | COM | 370334104 | 14,769 | 285,400 | SH | | DFND | 1 | 285,400 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 5,503 | 84,650 | SH | | DFND | 1 | 84,650 | 0 | 0 |
GRAY TELEVISION, INC | COM | 389375106 | 468 | 21,890 | SH | | DFND | 1 | 21,890 | 0 | 0 |
H&R BLOCK, INC | COM | 093671105 | 234 | 9,760 | SH | | DFND | 1 | 9,760 | 0 | 0 |
HOLOGIC, INC | COM | 436440101 | 332 | 6,850 | SH | | DFND | 1 | 6,850 | 0 | 0 |
HOSTESS BRANDS,INC | COM | 44109J106 | 223 | 17,810 | SH | | DFND | 1 | 17,810 | 0 | 0 |
HOULIHAN LOKEY, INC | COM | 441593100 | 263 | 5,740 | SH | | DFND | 1 | 5,740 | 0 | 0 |
INTERDIGITAL INC | COM | 45867G101 | 216 | 3,270 | SH | | DFND | 1 | 3,270 | 0 | 0 |
INTERNATIONAL BUSINESS MACHINES CORP | COM | 459200101 | 20,362 | 144,310 | SH | | DFND | 1 | 144,310 | 0 | 0 |
INTUITIVE SURGICAL INC | COM | 46120E602 | 10,641 | 18,650 | SH | | DFND | 1 | 18,650 | 0 | 0 |
ISHARES CORE HIGH DIVIDEND ETF | ETF | 46429B663 | 2,279 | 24,430 | SH | | DFND | 1 | 24,430 | 0 | 0 |
ISHARES MSCI RUSSIA ETF | ETF | 46434G798 | 271 | 7,850 | SH | | DFND | 1 | 7,850 | 0 | 0 |
ISHARES MSCI SOUTH KOREA ETF | ETF | 464286772 | 430 | 7,050 | SH | | DFND | 1 | 7,050 | 0 | 0 |
ISHARES NASDAQ BIOTECHNOLOGY | ETF | 464287556 | 3,180 | 28,440 | SH | | DFND | 1 | 28,440 | 0 | 0 |
JACK HENRY & ASSOCIATES INC | COM | 426281101 | 1,901 | 13,700 | SH | | DFND | 1 | 13,700 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 40,673 | 290,960 | SH | | DFND | 1 | 290,960 | 0 | 0 |
KBR, INC | COM | 48242W106 | 287 | 15,040 | SH | | DFND | 1 | 15,040 | 0 | 0 |
KLA-TENCOR CORPORATION | COM | 482480100 | 283 | 2,370 | SH | | DFND | 1 | 2,370 | 0 | 0 |
THE KRAFT HEINZ COMPANY | COM | 500754106 | 704 | 21,550 | SH | | DFND | 1 | 21,550 | 0 | 0 |
LINDE PUBLIC LIMITED COMPANY | COM | G5494J103 | 26,569 | 151,020 | SH | | DFND | 1 | 151,020 | 0 | 0 |
MASTERCARD INC | CL A | 57636Q104 | 2,355 | 10,000 | SH | | DFND | 1 | 10,000 | 0 | 0 |
MC DERMOTT INTERNATIONAL,INC | COM | 580037703 | 562 | 75,600 | SH | | DFND | 1 | 75,600 | 0 | 0 |
MEDTRONIC INC | COM | 585055106 | 4,618 | 50,700 | SH | | DFND | 1 | 50,700 | 0 | 0 |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 475 | 90,246 | SH | �� | DFND | 1 | 90,246 | 0 | 0 |
THE MICHAELS COS INC | COM | 59408Q106 | 161 | 14,120 | SH | | DFND | 1 | 14,120 | 0 | 0 |
MOODYS CORPORATION | COM | 20775CZK3 | 9,317 | 51,450 | SH | | DFND | 1 | 51,450 | 0 | 0 |
MSG NETWORKS INC | COM | 553573106 | 251 | 11,540 | SH | | DFND | 1 | 11,540 | 0 | 0 |
NATIONAL OILWELL VARCO INC | COM | 637071101 | 1,169 | 43,900 | SH | | DFND | 1 | 43,900 | 0 | 0 |
NESTLE SA | SPONSORED ADR | 641069406 | 21,650 | 227,130 | SH | | DFND | 1 | 227,130 | 0 | 0 |
NOVO NORDISK A/S | SPONSORED ADR | 670100205 | 12,988 | 248,290 | SH | | DFND | 1 | 248,290 | 0 | 0 |
NOW INC | COM | 67011P100 | 777 | 55,675 | SH | | DFND | 1 | 55,675 | 0 | 0 |
NUTRIEN LTD | COM | 67077M108 | 17,216 | 326,310 | SH | | DFND | 1 | 326,310 | 0 | 0 |
OMNICOM GROUP INC | COM | 681919106 | 401 | 5,500 | SH | | DFND | 1 | 5,500 | 0 | 0 |
ONESMART INTERNATIONAL EDUCATION GROUP LIMITED | SPONSORED ADR | 68276W103 | 189 | 23,940 | SH | | DFND | 1 | 23,940 | 0 | 0 |
ORACLE CORPORATION | COM | 68389X105 | 301 | 5,600 | SH | | DFND | 1 | 5,600 | 0 | 0 |
PACCAR INC | COM | 693718108 | 253 | 3,710 | SH | | DFND | 1 | 3,710 | 0 | 0 |
PHILLIPS 66 | COM | 718546104 | 14,425 | 151,570 | SH | | DFND | 1 | 151,570 | 0 | 0 |
PREMIER, INC | COM | 74051N102 | 283 | 8,200 | SH | | DFND | 1 | 8,200 | 0 | 0 |
PROTEOSTASIS THERAPEUTICS IN | COM | 74373B109 | 63 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
THE PROCTER&GAMBLE COMPANY | COM | 742718109 | 13,438 | 129,150 | SH | | DFND | 1 | 129,150 | 0 | 0 |
ROCHE HOLDING AG | SPONSORED ADR | 771195104 | 5,733 | 166,700 | SH | | DFND | 1 | 166,700 | 0 | 0 |
ROPER TECHNOLOGIES INC | COM | 776696106 | 24,143 | 70,600 | SH | | DFND | 1 | 70,600 | 0 | 0 |
ROYAL DUTCH SHELL PLC CLASS B | CL B | 780259107 | 5,030 | 78,660 | SH | | DFND | 1 | 78,660 | 0 | 0 |
SANOFI-AVENTIS SA | SPONSORED ADR | 80105N105 | 3,152 | 71,190 | SH | | DFND | 1 | 71,190 | 0 | 0 |
SESEN BIO INC | COM | 817763105 | 218 | 212,055 | SH | | DFND | 1 | 212,055 | 0 | 0 |
SIERRA ONCOLOGY INC | COM | 82640U107 | 428 | 250,000 | SH | | DFND | 1 | 250,000 | 0 | 0 |
SINCLAIR BROADCAST GROUP, INC | COM | 829226109 | 334 | 8,670 | SH | | DFND | 1 | 8,670 | 0 | 0 |
SOPHIRIS BIO INC | COM | 83578Q209 | 199 | 200,900 | SH | | DFND | 1 | 200,900 | 0 | 0 |
SPRING BANK PHARMACEUTICALS | COM | 849431101 | 562 | 53,536 | SH | | DFND | 1 | 53,536 | 0 | 0 |
STEMLINE THERAPEUTICS INC | COM | 85858C107 | 194 | 15,136 | SH | | DFND | 1 | 15,136 | 0 | 0 |
STERICYCLE INC | COM | 858912108 | 3,233 | 59,400 | SH | | DFND | 1 | 59,400 | 0 | 0 |
STORE CAPITAL CORPORATION | REIT | 862121100 | 1,229 | 36,700 | SH | | DFND | 1 | 36,700 | 0 | 0 |
TARO PHARMACEUTICAL INDUSTRIES LTD | COM | M8737E108 | 277 | 2,560 | SH | | DFND | 1 | 2,560 | 0 | 0 |
TEGNA INC | COM | 87901J105 | 335 | 23,790 | SH | | DFND | 1 | 23,790 | 0 | 0 |
TG THERAPEUTICS INC | COM | 88322Q108 | 402 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
UNITED TECHNOLOGIES CORP | COM | 913017109 | 13,701 | 106,300 | SH | | DFND | 1 | 106,300 | 0 | 0 |
UNITED THERAPEUTICS CORPORATION | COM | 91307C102 | 270 | 2,300 | SH | | DFND | 1 | 2,300 | 0 | 0 |
US BANCORP | COM | 902973304 | 5,624 | 116,700 | SH | | DFND | 1 | 116,700 | 0 | 0 |
VANGUARD CONSUMER STAPLES ETF | ETF | 92204A207 | 5,896 | 40,600 | SH | | DFND | 1 | 40,600 | 0 | 0 |
VANGUARD FTSE EMERGING MARKETS ETF | ETF | 922042858 | 4,035 | 94,930 | SH | | DFND | 1 | 94,930 | 0 | 0 |
VANGUARD S&P 500 ETF | ETF | 922908363 | 10,101 | 38,920 | SH | | DFND | 1 | 38,920 | 0 | 0 |
VANGUARD SMALL- CAP ETF | ETF | 922908751 | 1,588 | 10,390 | SH | | DFND | 1 | 10,390 | 0 | 0 |
VIKING THERAPEUTICS IN | COM | 92686J106 | 497 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
VISA INC CLASS A | CL A | 92826C839 | 23,944 | 153,300 | SH | | DFND | 1 | 153,300 | 0 | 0 |
VISTAGEN THERAPEUTICS INC | COM | 92840H202 | 14 | 10,635 | SH | | DFND | 1 | 10,635 | 0 | 0 |
WABTEC CORPORATION | COM | 929740108 | 14,506 | 196,770 | SH | | DFND | 1 | 196,770 | 0 | 0 |
WARRIOR MET COAL INC | COM | 93627C101 | 350 | 11,500 | SH | | DFND | 1 | 11,500 | 0 | 0 |
WATERS CORPORATION | COM | 941848103 | 13,177 | 52,350 | SH | | DFND | 1 | 52,350 | 0 | 0 |
WELLS FARGO & CO | COM | 949746101 | 74,626 | 1,544,420 | SH | | DFND | 1 | 1,544,420 | 0 | 0 |
YUM!BRANDS, INC | COM | 988498101 | 298 | 2,990 | SH | | DFND | 1 | 2,990 | 0 | 0 |
ZAFGEN INC | COM | 98885E103 | 412 | 150,521 | SH | | DFND | 1 | 150,521 | 0 | 0 |
ZTO EXPRESS CAYMAN INC | SPONSORED ADR | 98980A105 | 299 | 16,330 | SH | | DFND | 1 | 16,330 | 0 | 0 |