COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
3M CO | COM | 88579Y101 | 33,559 | 193,600 | SH | | DFND | 1 | 193,600 | 0 | 0 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 495 | 18,535 | SH | | DFND | 1 | 18,535 | 0 | 0 |
ADVANCED ENERGY INDUSTRIES INC | COM | 007973100 | 205 | 3,650 | SH | | DFND | 1 | 3,650 | 0 | 0 |
AKARI THERAPEUTICS PLC | COM | 00972G108 | 2,828 | 1,400,096 | SH | | DFND | 1 | 1,400,096 | 0 | 0 |
ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 267 | 44,520 | SH | | DFND | 1 | 44,520 | 0 | 0 |
ALLERGAN PLC | SPONSORED ADR | G0177J108 | 32,766 | 195,700 | SH | | DFND | 1 | 195,700 | 0 | 0 |
ALPHABET INC CLASS C | CL C | 38259P706 | 4,216 | 3,900 | SH | | DFND | 1 | 0 | 0 | 3,900 |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 511 | 121,363 | SH | | DFND | 1 | 121,363 | 0 | 0 |
ALTRIA GROUP INC | COM | 02209S103 | 11,637 | 245,770 | SH | | DFND | 1 | 245,770 | 0 | 0 |
AMERISOURCEBERGEN CORP | COM | 03073E105 | 221 | 2,590 | SH | | DFND | 1 | 2,590 | 0 | 0 |
AMGEN INC | COM | 031162100 | 6,201 | 33,650 | SH | | DFND | 1 | 33,650 | 0 | 0 |
ANAVEX LIFE SCIENCES CORP | COM | 032797300 | 587 | 174,080 | SH | | DFND | 1 | 174,080 | 0 | 0 |
ANHEUSER-BUSCH INBEV NV | SPONSORED ADR | 03524A108 | 10,958 | 123,800 | SH | | DFND | 1 | 123,800 | 0 | 0 |
APPLIED MATERIALS INC | COM | 038222105 | 208 | 4,630 | SH | | DFND | 1 | 4,630 | 0 | 0 |
BANK OF NEW YORK MELLON CORP | COM | 064058100 | 13,995 | 316,990 | SH | | DFND | 1 | 316,990 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 6,041 | 23,970 | SH | | DFND | 1 | 23,970 | 0 | 0 |
BERKSHIRE HATHAWAY INC CLASS A | CL A | 084670108 | 237,171 | 745 | SH | | DFND | 1 | 745 | 0 | 0 |
BERKSHIRE HATHAWAY INC CLASS B | CL B | 084670702 | 576 | 2,700 | SH | | DFND | 1 | 2,700 | 0 | 0 |
BHP BILLITON PLC | COM | 05545E209 | 11,547 | 225,930 | SH | | DFND | 1 | 225,930 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 3,305 | 14,130 | SH | | DFND | 1 | 14,130 | 0 | 0 |
BOEING CO | COM | 097023105 | 21,076 | 57,900 | SH | | DFND | 1 | 57,900 | 0 | 0 |
BRITISH AMERICAN TOBACCO PLC | COM | 110448107 | 675 | 19,350 | SH | | DFND | 1 | 19,350 | 0 | 0 |
CALITHERA BIOSCIENCES,INC | COM | 13089P101 | 195 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
CELGENE CORP | COM | 151020104 | 3,289 | 35,580 | SH | | DFND | 1 | 35,580 | 0 | 0 |
CHINA MOBILE LIMITED | SPONSORED ADR | 16941M109 | 2,188 | 48,300 | SH | | DFND | 1 | 48,300 | 0 | 0 |
CIGNA CORPORATION | COM | 125509109 | 4,146 | 26,316 | SH | | DFND | 1 | 26,316 | 0 | 0 |
CISCO SYSTEMS INC | COM | 17275R102 | 5,686 | 103,900 | SH | | DFND | 1 | 103,900 | 0 | 0 |
COCA COLA CO | COM | 191216100 | 2,342 | 46,000 | SH | | DFND | 1 | 46,000 | 0 | 0 |
COLGATE-PALMOLIVE COMPANY | COM | 194162103 | 10,184 | 142,090 | SH | | DFND | 1 | 142,090 | 0 | 0 |
CORCEPT THERAPEUTICS INC | COM | 218352102 | 187 | 16,790 | SH | | DFND | 1 | 16,790 | 0 | 0 |
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 486 | 130,000 | SH | | DFND | 1 | 130,000 | 0 | 0 |
DANAHER CORP | COM | 235851102 | 30,842 | 215,800 | SH | | DFND | 1 | 215,800 | 0 | 0 |
DAVITA HEALTHCARE PARTNERS INC | COM | 23918K108 | 2,387 | 42,420 | SH | | DFND | 1 | 42,420 | 0 | 0 |
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND | ETF | 233051879 | 7,407 | 263,040 | SH | | DFND | 1 | 263,040 | 0 | 0 |
DIAMOND OFFSHORE DRILLING INC | COM | 25271C102 | 312 | 35,200 | SH | | DFND | 1 | 35,200 | 0 | 0 |
DYNAVAX TECHNOLOGIES CORPORATION | COM | 268158201 | 421 | 105,573 | SH | | DFND | 1 | 105,573 | 0 | 0 |
ECOLAB INC | COM | 278865100 | 415 | 2,100 | SH | | DFND | 1 | 2,100 | 0 | 0 |
EMCOR GROUP INC | COM | 29084Q100 | 226 | 2,570 | SH | | DFND | 1 | 2,570 | 0 | 0 |
EQUIFAX INC | COM | 294429AN5 | 377 | 2,790 | SH | | DFND | 1 | 2,790 | 0 | 0 |
EVOLUS INC | COM | 30052C107 | 1,001 | 68,500 | SH | | DFND | 1 | 68,500 | 0 | 0 |
EXXON MOBIL CORPORATION | COM | 30231G102 | 10,598 | 138,303 | SH | | DFND | 1 | 138,303 | 0 | 0 |
FORTIVE CORP | COM | 34959J108 | 11,551 | 141,700 | SH | | DFND | 1 | 141,700 | 0 | 0 |
FTS INTERNATIONAL INC | COM | 30283W104 | 104 | 18,640 | SH | | DFND | 1 | 18,640 | 0 | 0 |
GAMESTOP CORP-CLASS A | CL A | 36467W109 | 121 | 22,120 | SH | | DFND | 1 | 22,120 | 0 | 0 |
GENERAL ELECTRIC COMPANY | COM | 369604103 | 11,595 | 1,104,300 | SH | | DFND | 1 | 1,104,300 | 0 | 0 |
GENERAL MILLS,INC | COM | 370334104 | 3,792 | 72,200 | SH | | DFND | 1 | 72,200 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 5,690 | 84,220 | SH | | DFND | 1 | 84,220 | 0 | 0 |
GRAFTECH INTERNATIONAL LTD | COM | 384313508 | 163 | 14,150 | SH | | DFND | 1 | 14,150 | 0 | 0 |
HP INC | COM | 40434L105 | 204 | 9,790 | SH | | DFND | 1 | 9,790 | 0 | 0 |
H&R BLOCK INC | COM | 093671105 | 222 | 7,590 | SH | | DFND | 1 | 7,590 | 0 | 0 |
INNOVIVA INC | COM | 45781M101 | 209 | 14,340 | SH | | DFND | 1 | 14,340 | 0 | 0 |
INTERNATIONAL BUSINESS MACHINES CORP | COM | 459200101 | 3,132 | 22,710 | SH | | DFND | 1 | 22,710 | 0 | 0 |
INTUITIVE SURGICAL INC | COM | 46120E602 | 9,783 | 18,650 | SH | | DFND | 1 | 18,650 | 0 | 0 |
INTL FLAVORS & FRAGRANCES | COM | 459506101 | 474 | 3,270 | SH | | DFND | 1 | 3,270 | 0 | 0 |
ISHARES CORE HIGH DIVIDEND ETF | ETF | 46429B663 | 2,758 | 29,190 | SH | | DFND | 1 | 29,190 | 0 | 0 |
ISHARES MSCI RUSSIA ETF | ETF | 46434G798 | 309 | 7,850 | SH | | DFND | 1 | 7,850 | 0 | 0 |
ISHARES MSCI SOUTH KOREA ETF | ETF | 464286772 | 422 | 7,050 | SH | | DFND | 1 | 7,050 | 0 | 0 |
ISHARES NASDAQ BIOTECHNOLOGY | ETF | 464287556 | 3,547 | 32,510 | SH | | DFND | 1 | 32,510 | 0 | 0 |
JACK HENRY & ASSOCIATES INC | COM | 426281101 | 1,835 | 13,700 | SH | | DFND | 1 | 13,700 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 43,680 | 313,610 | SH | | DFND | 1 | 313,610 | 0 | 0 |
THE KRAFT HEINZ COMPANY | COM | 500754106 | 1,287 | 41,450 | SH | | DFND | 1 | 41,450 | 0 | 0 |
LINDE PUBLIC LIMITED COMPANY | COM | G5494J103 | 30,325 | 151,020 | SH | | DFND | 1 | 151,020 | 0 | 0 |
MANPOWERGROUP INC | COM | 56418H100 | 222 | 2,300 | SH | | DFND | 1 | 2,300 | 0 | 0 |
MASTERCARD INC | CL A | 57636Q104 | 2,645 | 10,000 | SH | | DFND | 1 | 10,000 | 0 | 0 |
MC DERMOTT INTERNATIONAL,INC | COM | 580037703 | 730 | 75,600 | SH | | DFND | 1 | 75,600 | 0 | 0 |
MEDTRONIC INC | COM | 585055106 | 7,470 | 76,700 | SH | | DFND | 1 | 76,700 | 0 | 0 |
MERITOR INC | COM | 59001K100 | 205 | 8,470 | SH | | DFND | 1 | 8,470 | 0 | 0 |
MERSANA THERAPEUTICS INC | COM | 59045L106 | 365 | 90,246 | SH | | DFND | 1 | 90,246 | 0 | 0 |
THE MICHAELS COS INC | COM | 59408Q106 | 134 | 15,450 | SH | | DFND | 1 | 15,450 | 0 | 0 |
MOODYS CORPORATION | COM | 20775CZK3 | 10,049 | 51,450 | SH | | DFND | 1 | 51,450 | 0 | 0 |
NATIONAL OILWELL VARCO INC | COM | 637071101 | 976 | 43,900 | SH | | DFND | 1 | 43,900 | 0 | 0 |
NDAQ US | COM | 631103108 | 1,077 | 11,200 | SH | | DFND | 1 | 11,200 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 210 | 5,900 | SH | | DFND | 1 | 5,900 | 0 | 0 |
NESTLE SA | SPONSORED ADR | 641069406 | 23,485 | 227,130 | SH | | DFND | 1 | 227,130 | 0 | 0 |
NIC INC | COM | 62914B100 | 186 | 11,620 | SH | | DFND | 1 | 11,620 | 0 | 0 |
NOVO NORDISK A/S | SPONSORED ADR | 670100205 | 10,861 | 212,790 | SH | | DFND | 1 | 212,790 | 0 | 0 |
NOW INC | COM | 67011P100 | 822 | 55,675 | SH | | DFND | 1 | 55,675 | 0 | 0 |
NUTRIEN LTD | COM | 67077M108 | 17,445 | 326,310 | SH | | DFND | 1 | 326,310 | 0 | 0 |
OMNICOM GROUP INC | COM | 681919106 | 661 | 8,070 | SH | | DFND | 1 | 8,070 | 0 | 0 |
PHILLIPS 66 | COM | 718546104 | 14,178 | 151,570 | SH | | DFND | 1 | 151,570 | 0 | 0 |
PRESTIGE CONSUMER HEALTHCARE | COM | 74112D101 | 220 | 6,960 | SH | | DFND | 1 | 6,960 | 0 | 0 |
THE PROCTER&GAMBLE COMPANY | COM | 742718109 | 10,126 | 92,350 | SH | | DFND | 1 | 92,350 | 0 | 0 |
PROTEOSTASIS THERAPEUTICS IN | COM | 74373B109 | 23 | 23,367 | SH | | DFND | 1 | 23,367 | 0 | 0 |
REVANCE THERAPEUTICS INC | COM | 761330109 | 1,039 | 80,100 | SH | | DFND | 1 | 80,100 | 0 | 0 |
ROCHE HOLDING AG | SPONSORED ADR | 771195104 | 5,851 | 166,700 | SH | | DFND | 1 | 166,700 | 0 | 0 |
ROPER TECHNOLOGIES INC | COM | 776696106 | 25,858 | 70,600 | SH | | DFND | 1 | 70,600 | 0 | 0 |
ROYAL DUTCH SHELL PLC CLASS B | CL B | 780259107 | 7,511 | 114,250 | SH | | DFND | 1 | 114,250 | 0 | 0 |
SESEN BIO INC | COM | 817763105 | 318 | 211,855 | SH | | DFND | 1 | 211,855 | 0 | 0 |
SIERRA ONCOLOGY INC | COM | 82640U107 | 141 | 252,100 | SH | | DFND | 1 | 252,100 | 0 | 0 |
SOPHIRIS BIO INC | COM | 83578Q209 | 254 | 300,900 | SH | | DFND | 1 | 300,900 | 0 | 0 |
SPRING BANK PHARMACEUTICALS | COM | 849431101 | 226 | 61,336 | SH | | DFND | 1 | 61,336 | 0 | 0 |
STERICYCLE INC | COM | 858912108 | 2,836 | 59,400 | SH | | DFND | 1 | 59,400 | 0 | 0 |
STORE CAPITAL CORPORATION | REIT | 862121100 | 1,218 | 36,700 | SH | | DFND | 1 | 36,700 | 0 | 0 |
SYNCHRONY FINANCIAL | COM | 87165B103 | 218 | 6,300 | SH | | DFND | 1 | 6,300 | 0 | 0 |
TEGNA INC | COM | 87901J105 | 185 | 12,180 | SH | | DFND | 1 | 12,180 | 0 | 0 |
TG THERAPEUTICS INC | COM | 88322Q108 | 433 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 294 | 1,000 | SH | | DFND | 1 | 1,000 | 0 | 0 |
THE TRAVELERS COMPANIES INC | COM | 893939AE8 | 224 | 1,500 | SH | | DFND | 1 | 1,500 | 0 | 0 |
UNITED TECHNOLOGIES CORP | COM | 913017109 | 1,946 | 14,950 | SH | | DFND | 1 | 14,950 | 0 | 0 |
US BANCORP | COM | 902973304 | 6,580 | 125,570 | SH | | DFND | 1 | 125,570 | 0 | 0 |
VANGUARD CONSUMER STAPLES ETF | ETF | 92204A207 | 6,040 | 40,600 | SH | | DFND | 1 | 40,600 | 0 | 0 |
VANGUARD FTSE EMERGING MARKETS ETF | ETF | 922042858 | 4,279 | 100,610 | SH | | DFND | 1 | 100,610 | 0 | 0 |
VANGUARD HEALTH CARE ETF | ETF | 92204A504 | 1,164 | 6,690 | SH | | DFND | 1 | 6,690 | 0 | 0 |
VANGUARD S&P 500 ETF | ETF | 922908363 | 11,880 | 44,140 | SH | | DFND | 1 | 44,140 | 0 | 0 |
VANGUARD SMALL- CAP ETF | ETF | 922908751 | 1,811 | 11,560 | SH | | DFND | 1 | 11,560 | 0 | 0 |
VANGUARD SHORT-TERM BOND ETF | ETF | 921937827 | 9,229 | 114,600 | SH | | DFND | 1 | 114,600 | 0 | 0 |
VECTOR GROUP LTD | COM | 92240M108 | 184 | 18,890 | SH | | DFND | 1 | 18,890 | 0 | 0 |
VIKING THERAPEUTICS IN | COM | 92686J106 | 415 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
VISA INC CLASS A | CL A | 92826C839 | 26,605 | 153,300 | SH | | DFND | 1 | 153,300 | 0 | 0 |
WABTEC CORPORATION | COM | 929740108 | 15,443 | 215,200 | SH | | DFND | 1 | 215,200 | 0 | 0 |
WATERS CORPORATION | COM | 941848103 | 11,268 | 52,350 | SH | | DFND | 1 | 52,350 | 0 | 0 |
WEIGHT WATCHERS INTL INC | COM | 948626106 | 202 | 10,600 | SH | | DFND | 1 | 10,600 | 0 | 0 |
WELLS FARGO & CO | COM | 949746101 | 68,417 | 1,445,840 | SH | | DFND | 1 | 1,445,840 | 0 | 0 |
ZAFGEN INC | COM | 98885E103 | 179 | 150,521 | SH | | DFND | 1 | 150,521 | 0 | 0 |
ZOETIS INC | COM | 98978V103 | 1,021 | 9,000 | SH | | DFND | 1 | 9,000 | 0 | 0 |