| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 3M CO | COM | 88579Y101 | 33,991 | 206,760 | SH | | DFND | 1 | 206,760 | 0 | 0 |
| ADVANCED ENERGY INDUSTRIES INC | COM | 007973100 | 210 | 3,650 | SH | | DFND | 1 | 3,650 | 0 | 0 |
| AKARI THERAPEUTICS PLC | COM | 00972G108 | 2,565 | 1,500,096 | SH | | DFND | 1 | 1,500,096 | 0 | 0 |
| ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 422 | 80,020 | SH | | DFND | 1 | 80,020 | 0 | 0 |
| ALLERGAN PLC | SPONSORED ADR | G0177J108 | 32,934 | 195,700 | SH | | DFND | 1 | 195,700 | 0 | 0 |
| ALLISON TRANSMISSION HOLDINGS,INC | COM | 01973R101 | 201 | 4,270 | SH | | DFND | 1 | 4,270 | 0 | 0 |
| ALPHABET INC CLASS C | CL C | 38259P706 | 4,754 | 3,900 | SH | | DFND | 1 | 0 | 0 | 3,900 |
| ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 735 | 185,587 | SH | | DFND | 1 | 185,587 | 0 | 0 |
| ALTRIA GROUP INC | COM | 02209S103 | 10,466 | 255,900 | SH | | DFND | 1 | 255,900 | 0 | 0 |
| AMERISOURCEBERGEN CORP | COM | 03073E105 | 213 | 2,590 | SH | | DFND | 1 | 2,590 | 0 | 0 |
| AMGEN INC | COM | 031162100 | 6,512 | 33,650 | SH | | DFND | 1 | 33,650 | 0 | 0 |
| ANAVEX LIFE SCIENCES CORP | COM | 032797300 | 1,479 | 468,110 | SH | | DFND | 1 | 468,110 | 0 | 0 |
| ANHEUSER-BUSCH INBEV NV | SPONSORED ADR | 03524A108 | 8,916 | 93,700 | SH | | DFND | 1 | 93,700 | 0 | 0 |
| APPLIED MATERIALS INC | COM | 038222105 | 231 | 4,630 | SH | | DFND | 1 | 4,630 | 0 | 0 |
| BANK OF NEW YORK MELLON CORP | COM | 064058100 | 14,435 | 319,290 | SH | | DFND | 1 | 319,290 | 0 | 0 |
| BECTON DICKINSON & CO | COM | 075887109 | 6,063 | 23,970 | SH | | DFND | 1 | 23,970 | 0 | 0 |
| BERKSHIRE HATHAWAY INC CLASS A | CL A | 084670108 | 233,874 | 750 | SH | | DFND | 1 | 750 | 0 | 0 |
| BERKSHIRE HATHAWAY INC CLASS B | CL B | 084670702 | 562 | 2,700 | SH | | DFND | 1 | 2,700 | 0 | 0 |
| BHP BILLITON PLC | COM | 05545E209 | 9,679 | 225,930 | SH | | DFND | 1 | 225,930 | 0 | 0 |
| BIOGEN INC | COM | 09062X103 | 3,290 | 14,130 | SH | | DFND | 1 | 14,130 | 0 | 0 |
| BOEING CO | COM | 097023105 | 22,029 | 57,900 | SH | | DFND | 1 | 57,900 | 0 | 0 |
| BRITISH AMERICAN TOBACCO PLC | COM | 110448107 | 714 | 19,350 | SH | | DFND | 1 | 19,350 | 0 | 0 |
| CALITHERA BIOSCIENCES,INC | COM | 13089P101 | 155 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
| CELGENE CORP | COM | 151020104 | 207 | 2,080 | SH | | DFND | 1 | 2,080 | 0 | 0 |
| CHINA MOBILE LIMITED | SPONSORED ADR | 16941M109 | 2,000 | 48,300 | SH | | DFND | 1 | 48,300 | 0 | 0 |
| CIGNA CORPORATION | COM | 125509109 | 3,995 | 26,316 | SH | | DFND | 1 | 26,316 | 0 | 0 |
| CISCO SYSTEMS INC | COM | 17275R102 | 5,134 | 103,900 | SH | | DFND | 1 | 103,900 | 0 | 0 |
| COLGATE-PALMOLIVE COMPANY | COM | 194162103 | 956 | 13,000 | SH | | DFND | 1 | 13,000 | 0 | 0 |
| CORCEPT THERAPEUTICS INC | COM | 218352102 | 237 | 16,790 | SH | | DFND | 1 | 16,790 | 0 | 0 |
| CORVUS PHARMACEUTICALS INC | COM | 221015100 | 391 | 130,000 | SH | | DFND | 1 | 130,000 | 0 | 0 |
| DANAHER CORP | COM | 235851102 | 31,168 | 215,800 | SH | | DFND | 1 | 215,800 | 0 | 0 |
| DAVITA HEALTHCARE PARTNERS INC | COM | 23918K108 | 2,421 | 42,420 | SH | | DFND | 1 | 42,420 | 0 | 0 |
| DELUXE CORP | COM | 248019101 | 211 | 4,300 | SH | | DFND | 1 | 4,300 | 0 | 0 |
| DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND | ETF | 233051879 | 7,360 | 271,680 | SH | | DFND | 1 | 271,680 | 0 | 0 |
| DIAMOND OFFSHORE DRILLING INC | COM | 25271C102 | 196 | 35,200 | SH | | DFND | 1 | 35,200 | 0 | 0 |
| DYNAVAX TECHNOLOGIES CORPORATION | COM | 268158201 | 377 | 105,573 | SH | | DFND | 1 | 105,573 | 0 | 0 |
| COCA COLA CO | COM | 191216100 | 2,504 | 46,000 | SH | | DFND | 1 | 46,000 | 0 | 0 |
| ECOLAB INC | COM | 278865100 | 416 | 2,100 | SH | | DFND | 1 | 2,100 | 0 | 0 |
| EMCOR GROUP INC | COM | 29084Q100 | 221 | 2,570 | SH | | DFND | 1 | 2,570 | 0 | 0 |
| EVOLUS INC | COM | 30052C107 | 1,070 | 68,500 | SH | | DFND | 1 | 68,500 | 0 | 0 |
| EXXON MOBIL CORPORATION | COM | 30231G102 | 13,377 | 189,443 | SH | | DFND | 1 | 189,443 | 0 | 0 |
| FIAT CHRYSLER AUTOMOBILES NV | COM | N31738102 | 432 | 33,350 | SH | | DFND | 1 | 33,350 | 0 | 0 |
| FORTIVE CORP | COM | 34959J108 | 9,907 | 144,500 | SH | | DFND | 1 | 144,500 | 0 | 0 |
| FTS INTERNATIONAL INC | COM | 30283W104 | 42 | 18,640 | SH | | DFND | 1 | 18,640 | 0 | 0 |
| GAMESTOP CORP-CLASS A | CL A | 36467W109 | 122 | 22,120 | SH | | DFND | 1 | 22,120 | 0 | 0 |
| GENERAL ELECTRIC COMPANY | COM | 369604103 | 7,015 | 784,700 | SH | | DFND | 1 | 784,700 | 0 | 0 |
| GENERAL MILLS,INC | COM | 370334104 | 364 | 6,600 | SH | | DFND | 1 | 6,600 | 0 | 0 |
| GILEAD SCIENCES INC | COM | 375558103 | 5,338 | 84,220 | SH | | DFND | 1 | 84,220 | 0 | 0 |
| GRAFTECH INTERNATIONAL LTD | COM | 384313508 | 181 | 14,150 | SH | | DFND | 1 | 14,150 | 0 | 0 |
| INNOVIVA INC | COM | 45781M101 | 151 | 14,340 | SH | | DFND | 1 | 14,340 | 0 | 0 |
| INTERNATIONAL BUSINESS MACHINES CORP | COM | 459200101 | 3,084 | 21,210 | SH | | DFND | 1 | 21,210 | 0 | 0 |
| INTUITIVE SURGICAL INC | COM | 46120E602 | 10,070 | 18,650 | SH | | DFND | 1 | 18,650 | 0 | 0 |
| INTL FLAVORS & FRAGRANCES | COM | 459506101 | 665 | 5,420 | SH | | DFND | 1 | 5,420 | 0 | 0 |
| ISHARES CORE HIGH DIVIDEND ETF | ETF | 46429B663 | 3,208 | 34,070 | SH | | DFND | 1 | 34,070 | 0 | 0 |
| ISHARES MSCI RUSSIA ETF | ETF | 46434G798 | 305 | 7,850 | SH | | DFND | 1 | 7,850 | 0 | 0 |
| ISHARES MSCI SOUTH KOREA ETF | ETF | 464286772 | 1,699 | 30,150 | SH | | DFND | 1 | 30,150 | 0 | 0 |
| ISHARES NASDAQ BIOTECHNOLOGY | ETF | 464287556 | 3,235 | 32,510 | SH | | DFND | 1 | 32,510 | 0 | 0 |
| JACK HENRY & ASSOCIATES INC | COM | 426281101 | 2,000 | 13,700 | SH | | DFND | 1 | 13,700 | 0 | 0 |
| JOHNSON & JOHNSON | COM | 478160104 | 40,678 | 314,410 | SH | | DFND | 1 | 314,410 | 0 | 0 |
| KLA-TENCOR CORP | COM | 482480100 | 257 | 1,610 | SH | | DFND | 1 | 1,610 | 0 | 0 |
| THE KRAFT HEINZ COMPANY | COM | 500754106 | 1,320 | 47,250 | SH | | DFND | 1 | 47,250 | 0 | 0 |
| LAM RESEARCH CORP | COM | 512807108 | 236 | 1,020 | SH | | DFND | 1 | 1,020 | 0 | 0 |
| LINDE PUBLIC LIMITED COMPANY | COM | G5494J103 | 29,256 | 151,020 | SH | | DFND | 1 | 151,020 | 0 | 0 |
| MASTERCARD INC | CL A | 57636Q104 | 2,716 | 10,000 | SH | | DFND | 1 | 10,000 | 0 | 0 |
| MC DERMOTT INTERNATIONAL,INC | COM | 580037703 | 153 | 75,600 | SH | | DFND | 1 | 75,600 | 0 | 0 |
| MEDTRONIC INC | COM | 585055106 | 8,331 | 76,700 | SH | | DFND | 1 | 76,700 | 0 | 0 |
| MERSANA THERAPEUTICS INC | COM | 59045L106 | 143 | 90,246 | SH | | DFND | 1 | 90,246 | 0 | 0 |
| METLIFE INC | COM | 59156R108 | 979 | 20,760 | SH | | DFND | 1 | 20,760 | 0 | 0 |
| THE MICHAELS COS INC | COM | 59408Q106 | 151 | 15,450 | SH | | DFND | 1 | 15,450 | 0 | 0 |
| MOODYS CORPORATION | COM | 20775CZK3 | 10,539 | 51,450 | SH | | DFND | 1 | 51,450 | 0 | 0 |
| NATIONAL OILWELL VARCO INC | COM | 637071101 | 931 | 43,900 | SH | | DFND | 1 | 43,900 | 0 | 0 |
| NDAQ US | COM | 631103108 | 1,113 | 11,200 | SH | | DFND | 1 | 11,200 | 0 | 0 |
| NESTLE SA | SPONSORED ADR | 641069406 | 24,621 | 227,130 | SH | | DFND | 1 | 227,130 | 0 | 0 |
| NIC INC | COM | 62914B100 | 240 | 11,620 | SH | | DFND | 1 | 11,620 | 0 | 0 |
| NOVO NORDISK A/S | SPONSORED ADR | 670100205 | 11,001 | 212,790 | SH | | DFND | 1 | 212,790 | 0 | 0 |
| NOW INC | COM | 67011P100 | 639 | 55,675 | SH | | DFND | 1 | 55,675 | 0 | 0 |
| NUTRIEN LTD | COM | 67077M108 | 16,276 | 326,310 | SH | | DFND | 1 | 326,310 | 0 | 0 |
| OMNICOM GROUP INC | COM | 681919106 | 632 | 8,070 | SH | | DFND | 1 | 8,070 | 0 | 0 |
| PHILLIPS 66 | COM | 718546104 | 15,521 | 151,570 | SH | | DFND | 1 | 151,570 | 0 | 0 |
| THE PROCTER&GAMBLE COMPANY | COM | 742718109 | 6,250 | 50,250 | SH | | DFND | 1 | 50,250 | 0 | 0 |
| PRESTIGE CONSUMER HEALTHCARE | COM | 74112D101 | 241 | 6,960 | SH | | DFND | 1 | 6,960 | 0 | 0 |
| RAYTHEON COMPANY | COM | 755111507 | 212 | 1,080 | SH | | DFND | 1 | 1,080 | 0 | 0 |
| REVANCE THERAPEUTICS INC | COM | 761330109 | 1,041 | 80,100 | SH | | DFND | 1 | 80,100 | 0 | 0 |
| ROCHE HOLDING AG | SPONSORED ADR | 771195104 | 8,104 | 222,320 | SH | | DFND | 1 | 222,320 | 0 | 0 |
| ROPER TECHNOLOGIES INC | COM | 776696106 | 25,176 | 70,600 | SH | | DFND | 1 | 70,600 | 0 | 0 |
| ROYAL DUTCH SHELL PLC CLASS B | CL B | 780259107 | 8,938 | 149,210 | SH | | DFND | 1 | 149,210 | 0 | 0 |
| SEAGATE TECHNOLOGY | COM | G7945M107 | 215 | 4,000 | SH | | DFND | 1 | 4,000 | 0 | 0 |
| SESEN BIO INC | COM | 817763105 | 248 | 211,855 | SH | | DFND | 1 | 211,855 | 0 | 0 |
| SIERRA ONCOLOGY INC | COM | 82640U107 | 195 | 500,138 | SH | | DFND | 1 | 500,138 | 0 | 0 |
| SOPHIRIS BIO INC | COM | 83578Q209 | 176 | 300,900 | SH | | DFND | 1 | 300,900 | 0 | 0 |
| SPDR PORT SHRT TRM TRSRY | ETF | 78468R101 | 11,303 | 376,500 | SH | | DFND | 1 | 376,500 | 0 | 0 |
| SPRING BANK PHARMACEUTICALS | COM | 849431101 | 554 | 160,914 | SH | | DFND | 1 | 160,914 | 0 | 0 |
| STERICYCLE INC | COM | 858912108 | 3,025 | 59,400 | SH | | DFND | 1 | 59,400 | 0 | 0 |
| STORE CAPITAL CORPORATION | REIT | 862121100 | 1,373 | 36,700 | SH | | DFND | 1 | 36,700 | 0 | 0 |
| SYNCHRONY FINANCIAL | COM | 87165B103 | 215 | 6,300 | SH | | DFND | 1 | 6,300 | 0 | 0 |
| TEGNA INC | COM | 87901J105 | 189 | 12,180 | SH | | DFND | 1 | 12,180 | 0 | 0 |
| TG THERAPEUTICS INC | COM | 88322Q108 | 281 | 50,000 | SH | | DFND | 1 | 50,000 | 0 | 0 |
| THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 291 | 1,000 | SH | | DFND | 1 | 1,000 | 0 | 0 |
| THE TRAVELERS COMPANIES INC | COM | 893939AE8 | 223 | 1,500 | SH | | DFND | 1 | 1,500 | 0 | 0 |
| UNITED TECHNOLOGIES CORP | COM | 913017109 | 2,041 | 14,950 | SH | | DFND | 1 | 14,950 | 0 | 0 |
| US BANCORP | COM | 902973304 | 7,049 | 127,370 | SH | | DFND | 1 | 127,370 | 0 | 0 |
| VANGUARD CONSUMER STAPLES ETF | ETF | 92204A207 | 6,356 | 40,600 | SH | | DFND | 1 | 40,600 | 0 | 0 |
| VANGUARD FTSE EMERGING MARKETS ETF | ETF | 922042858 | 4,747 | 117,910 | SH | | DFND | 1 | 117,910 | 0 | 0 |
| VANGUARD HEALTH CARE ETF | ETF | 92204A504 | 1,122 | 6,690 | SH | | DFND | 1 | 6,690 | 0 | 0 |
| VANGUARD S&P 500 ETF | ETF | 922908363 | 12,976 | 47,600 | SH | | DFND | 1 | 47,600 | 0 | 0 |
| VANGUARD SMALL- CAP ETF | ETF | 922908751 | 2,231 | 14,500 | SH | | DFND | 1 | 14,500 | 0 | 0 |
| VANGUARD SHORT-TERM BOND ETF | ETF | 921937827 | 9,259 | 114,600 | SH | | DFND | 1 | 114,600 | 0 | 0 |
| VECTOR GROUP LTD | COM | 92240M108 | 225 | 18,890 | SH | | DFND | 1 | 18,890 | 0 | 0 |
| VISA INC CLASS A | CL A | 92826C839 | 26,369 | 153,300 | SH | | DFND | 1 | 153,300 | 0 | 0 |
| WABTEC CORPORATION | COM | 929740108 | 9,721 | 135,270 | SH | | DFND | 1 | 135,270 | 0 | 0 |
| WATERS CORPORATION | COM | 941848103 | 11,686 | 52,350 | SH | | DFND | 1 | 52,350 | 0 | 0 |
| WEIGHT WATCHERS INTL INC | COM | 948626106 | 401 | 10,600 | SH | | DFND | 1 | 10,600 | 0 | 0 |
| WELLS FARGO & CO | COM | 949746101 | 82,716 | 1,639,880 | SH | | DFND | 1 | 1,639,880 | 0 | 0 |
| WESTERN DIGITAL CORP | COM | 958102105 | 227 | 3,810 | SH | | DFND | 1 | 3,810 | 0 | 0 |
| ZAFGEN INC | COM | 98885E103 | 148 | 200,621 | SH | | DFND | 1 | 200,621 | 0 | 0 |
| ZOETIS INC | COM | 98978V103 | 1,121 | 9,000 | SH | | DFND | 1 | 9,000 | 0 | 0 |
