COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
3M CO | COM | 88579Y101 | 37,006 | 209,760 | SH | | DFND | 1 | 209,760 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 216 | 2,440 | SH | | DFND | 1 | 2,440 | 0 | 0 |
ADVANCED ENERGY INDUSTRIES INC | COM | 007973100 | 260 | 3,650 | SH | | DFND | 1 | 3,650 | 0 | 0 |
AKARI THERAPEUTICS PLC | COM | 00972G108 | 2,625 | 1,500,096 | SH | | DFND | 1 | 1,500,096 | 0 | 0 |
ALDEYRA THERAPEUTICS INC | COM | 01438T106 | 465 | 80,020 | SH | | DFND | 1 | 80,020 | 0 | 0 |
ALLERGAN PLC | SPONSORED ADR | G0177J108 | 37,412 | 195,700 | SH | | DFND | 1 | 195,700 | 0 | 0 |
ALLISON TRANSMISSION HOLDINGS INC | COM | 01973R101 | 206 | 4,270 | SH | | DFND | 1 | 4,270 | 0 | 0 |
ALPHABET INC CLASS C | CL C | 38259P706 | 8,102 | 6,060 | SH | | DFND | 1 | 0 | 0 | 6,060 |
ALPINE IMMUNE SCIENCES INC | COM | 02083G100 | 712 | 185,287 | SH | | DFND | 1 | 185,287 | 0 | 0 |
ALTRIA GROUP INC | COM | 02209S103 | 13,873 | 277,960 | SH | | DFND | 1 | 277,960 | 0 | 0 |
AMERISOURCEBERGEN CORP | COM | 03073E105 | 220 | 2,590 | SH | | DFND | 1 | 2,590 | 0 | 0 |
AMGEN INC | COM | 031162100 | 8,112 | 33,650 | SH | | DFND | 1 | 33,650 | 0 | 0 |
ANAVEX LIFE SCIENCES CORP | COM | 032797300 | 1,112 | 429,200 | SH | | DFND | 1 | 429,200 | 0 | 0 |
ANHEUSER-BUSCH INBEV NV | SPONSORED ADR | 03524A108 | 7,687 | 93,700 | SH | | DFND | 1 | 93,700 | 0 | 0 |
APPLIED MATERIALS INC | COM | 038222105 | 283 | 4,630 | SH | | DFND | 1 | 4,630 | 0 | 0 |
BANK OF NEW YORK MELLON CORP | COM | 064058100 | 16,070 | 319,290 | SH | | DFND | 1 | 319,290 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 6,519 | 23,970 | SH | | DFND | 1 | 23,970 | 0 | 0 |
BERKSHIRE HATHAWAY INC CLASS A | CL A | 084670108 | 258,088 | 760 | SH | | DFND | 1 | 760 | 0 | 0 |
BERKSHIRE HATHAWAY INC CLASS B | CL B | 084670702 | 612 | 2,700 | SH | | DFND | 1 | 2,700 | 0 | 0 |
BHP BILLITON PLC | COM | 05545E209 | 10,621 | 225,930 | SH | | DFND | 1 | 225,930 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 252 | 850 | SH | | DFND | 1 | 850 | 0 | 0 |
BOEING CO | COM | 097023105 | 18,862 | 57,900 | SH | | DFND | 1 | 57,900 | 0 | 0 |
BRITISH AMERICAN TOBACCO PLC | COM | 110448107 | 919 | 21,650 | SH | | DFND | 1 | 21,650 | 0 | 0 |
CHINA MOBILE LIMITED | SPONSORED ADR | 16941M109 | 2,042 | 48,300 | SH | | DFND | 1 | 48,300 | 0 | 0 |
CIGNA CORPORATION | COM | 125509109 | 5,381 | 26,316 | SH | | DFND | 1 | 26,316 | 0 | 0 |
CISCO SYSTEMS INC | COM | 17275R102 | 4,983 | 103,900 | SH | | DFND | 1 | 103,900 | 0 | 0 |
COCA COLA CO | COM | 191216100 | 2,546 | 46,000 | SH | | DFND | 1 | 46,000 | 0 | 0 |
CORCEPT THERAPEUTICS INC | COM | 218352102 | 203 | 16,790 | SH | | DFND | 1 | 16,790 | 0 | 0 |
CORVUS PHARMACEUTICALS INC | COM | 221015100 | 435 | 80,000 | SH | | DFND | 1 | 80,000 | 0 | 0 |
DANAHER CORP | COM | 235851102 | 33,121 | 215,800 | SH | | DFND | 1 | 215,800 | 0 | 0 |
DAVITA HEALTHCARE PARTNERS INC | COM | 23918K108 | 302 | 4,020 | SH | | DFND | 1 | 4,020 | 0 | 0 |
DELUXE CORP | COM | 248019101 | 215 | 4,300 | SH | | DFND | 1 | 4,300 | 0 | 0 |
DEUTSCHE X-TRACKERS HARVEST CSI 300 CHINA A-SHARES FUND | ETF | 233051879 | 8,053 | 271,680 | SH | | DFND | 1 | 271,680 | 0 | 0 |
DIAMOND OFFSHORE DRILLING INC | COM | 25271C102 | 253 | 35,200 | SH | | DFND | 1 | 35,200 | 0 | 0 |
DYNAVAX TECHNOLOGIES CORPORATION | COM | 268158201 | 604 | 105,573 | SH | | DFND | 1 | 105,573 | 0 | 0 |
ECOLAB INC | COM | 278865100 | 405 | 2,100 | SH | | DFND | 1 | 2,100 | 0 | 0 |
EMCOR GROUP INC | COM | 29084Q100 | 222 | 2,570 | SH | | DFND | 1 | 2,570 | 0 | 0 |
EXXON MOBIL CORPORATION | COM | 30231G102 | 13,450 | 192,750 | SH | | DFND | 1 | 192,750 | 0 | 0 |
FACEBOOK INC CLASS A | CL A | 30303M102 | 205 | 1,000 | SH | | DFND | 1 | 1,000 | 0 | 0 |
FIAT CHRYSLER AUTOMOBILES NV | COM | N31738102 | 490 | 33,350 | SH | | DFND | 1 | 33,350 | 0 | 0 |
FORTIVE CORP | COM | 34959J108 | 11,038 | 144,500 | SH | | DFND | 1 | 144,500 | 0 | 0 |
FTS INTERNATIONAL INC | COM | 30283W104 | 19 | 18,640 | SH | | DFND | 1 | 18,640 | 0 | 0 |
GAMESTOP CORP-CLASS A | CL A | 36467W109 | 134 | 22,120 | SH | | DFND | 1 | 22,120 | 0 | 0 |
GENERAL ELECTRIC COMPANY | COM | 369604103 | 561 | 50,280 | SH | | DFND | 1 | 50,280 | 0 | 0 |
GENERAL MILLS INC | COM | 370334104 | 353 | 6,600 | SH | | DFND | 1 | 6,600 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 1,407 | 21,650 | SH | | DFND | 1 | 21,650 | 0 | 0 |
GRAFTECH INTERNATIONAL LTD | COM | 384313508 | 164 | 14,150 | SH | | DFND | 1 | 14,150 | 0 | 0 |
HP INC | COM | 40434L105 | 201 | 9,790 | SH | | DFND | 1 | 9,790 | 0 | 0 |
INNOVIVA INC | COM | 45781M101 | 203 | 14,340 | SH | | DFND | 1 | 14,340 | 0 | 0 |
INTERNATIONAL BUSINESS MACHINES CORP | COM | 459200101 | 2,843 | 21,210 | SH | | DFND | 1 | 21,210 | 0 | 0 |
INTUITIVE SURGICAL INC | COM | 46120E602 | 11,025 | 18,650 | SH | | DFND | 1 | 18,650 | 0 | 0 |
ISHARES CORE HIGH DIVIDEND ETF | ETF | 46429B663 | 3,341 | 34,070 | SH | | DFND | 1 | 34,070 | 0 | 0 |
ISHARES MSCI RUSSIA ETF | ETF | 46434G798 | 335 | 7,850 | SH | | DFND | 1 | 7,850 | 0 | 0 |
ISHARES MSCI SOUTH KOREA ETF | ETF | 464286772 | 1,875 | 30,150 | SH | | DFND | 1 | 30,150 | 0 | 0 |
ISHARES NASDAQ BIOTECHNOLOGY | ETF | 464287556 | 3,918 | 32,510 | SH | | DFND | 1 | 32,510 | 0 | 0 |
JACK HENRY & ASSOCIATES INC | COM | 426281101 | 1,996 | 13,700 | SH | | DFND | 1 | 13,700 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 45,863 | 314,410 | SH | | DFND | 1 | 314,410 | 0 | 0 |
KLA-TENCOR CORP | COM | 482480100 | 287 | 1,610 | SH | | DFND | 1 | 1,610 | 0 | 0 |
THE KRAFT HEINZ COMPANY | COM | 500754106 | 2,037 | 63,400 | SH | | DFND | 1 | 63,400 | 0 | 0 |
LAM RESEARCH CORP | COM | 512807108 | 298 | 1,020 | SH | | DFND | 1 | 1,020 | 0 | 0 |
LINDE PUBLIC LIMITED COMPANY | COM | G5494J103 | 32,152 | 151,020 | SH | | DFND | 1 | 151,020 | 0 | 0 |
MANPOWERGROUP INC | COM | 56418H100 | 223 | 2,300 | SH | | DFND | 1 | 2,300 | 0 | 0 |
MASTERCARD INC | CL A | 57636Q104 | 2,986 | 10,000 | SH | | DFND | 1 | 10,000 | 0 | 0 |
MEDTRONIC INC | COM | 585055106 | 8,702 | 76,700 | SH | | DFND | 1 | 76,700 | 0 | 0 |
MERITOR INC | COM | 59001K100 | 222 | 8,470 | SH | | DFND | 1 | 8,470 | 0 | 0 |
METLIFE INC | COM | 59156R108 | 1,058 | 20,760 | SH | | DFND | 1 | 20,760 | 0 | 0 |
THE MICHAELS COS INC | COM | 59408Q106 | 125 | 15,450 | SH | | DFND | 1 | 15,450 | 0 | 0 |
MOODYS CORPORATION | COM | 20775CZK3 | 12,215 | 51,450 | SH | | DFND | 1 | 51,450 | 0 | 0 |
NASDAQ INC | COM | 631103108 | 1,200 | 11,200 | SH | | DFND | 1 | 11,200 | 0 | 0 |
NESTLE SA | SPONSORED ADR | 641069406 | 24,589 | 227,130 | SH | | DFND | 1 | 227,130 | 0 | 0 |
NIC INC | COM | 62914B100 | 260 | 11,620 | SH | | DFND | 1 | 11,620 | 0 | 0 |
NOVO NORDISK A/S | SPONSORED ADR | 670100205 | 6,766 | 116,900 | SH | | DFND | 1 | 116,900 | 0 | 0 |
NUTRIEN LTD | COM | 67077M108 | 15,634 | 326,310 | SH | | DFND | 1 | 326,310 | 0 | 0 |
OMNICOM GROUP INC | COM | 681919106 | 654 | 8,070 | SH | | DFND | 1 | 8,070 | 0 | 0 |
PHILLIPS 66 | COM | 718546104 | 16,886 | 151,570 | SH | | DFND | 1 | 151,570 | 0 | 0 |
PRESTIGE CONSUMER HEALTHCARE | COM | 74112D101 | 282 | 6,960 | SH | | DFND | 1 | 6,960 | 0 | 0 |
THE PROCTER&GAMBLE COMPANY | COM | 742718109 | 2,170 | 17,370 | SH | | DFND | 1 | 17,370 | 0 | 0 |
RAYTHEON COMPANY | COM | 755111507 | 237 | 1,080 | SH | | DFND | 1 | 1,080 | 0 | 0 |
ROCHE HOLDING AG | SPONSORED ADR | 771195104 | 9,040 | 222,320 | SH | | DFND | 1 | 222,320 | 0 | 0 |
ROPER TECHNOLOGIES INC | COM | 776696106 | 25,009 | 70,600 | SH | | DFND | 1 | 70,600 | 0 | 0 |
ROYAL DUTCH SHELL PLC CLASS B | CL B | 780259107 | 9,635 | 160,660 | SH | | DFND | 1 | 160,660 | 0 | 0 |
SEAGATE TECHNOLOGY | COM | G7945M107 | 238 | 4,000 | SH | | DFND | 1 | 4,000 | 0 | 0 |
SESEN BIO INC | COM | 817763105 | 220 | 211,855 | SH | | DFND | 1 | 211,855 | 0 | 0 |
SIERRA ONCOLOGY INC | COM | 82640U107 | 171 | 500,138 | SH | | DFND | 1 | 500,138 | 0 | 0 |
SOPHIRIS BIO INC | COM | 83578Q209 | 111 | 300,900 | SH | | DFND | 1 | 300,900 | 0 | 0 |
SPDR PORT SHRT TRM TRSRY | ETF | 78468R101 | 11,280 | 376,500 | SH | | DFND | 1 | 376,500 | 0 | 0 |
SPRING BANK PHARMACEUTICALS | COM | 849431101 | 207 | 131,271 | SH | | DFND | 1 | 131,271 | 0 | 0 |
STAMPS.COM INC | COM | 852857200 | 215 | 2,580 | SH | | DFND | 1 | 2,580 | 0 | 0 |
STERICYCLE INC | COM | 858912108 | 676 | 10,600 | SH | | DFND | 1 | 10,600 | 0 | 0 |
STORE CAPITAL CORPORATION | REIT | 862121100 | 1,367 | 36,700 | SH | | DFND | 1 | 36,700 | 0 | 0 |
SYNCHRONY FINANCIAL | COM | 87165B103 | 227 | 6,300 | SH | | DFND | 1 | 6,300 | 0 | 0 |
TEGNA INC | COM | 87901J105 | 203 | 12,180 | SH | | DFND | 1 | 12,180 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 325 | 1,000 | SH | | DFND | 1 | 1,000 | 0 | 0 |
THE TRAVELERS COMPANIES INC | COM | 893939AE8 | 205 | 1,500 | SH | | DFND | 1 | 1,500 | 0 | 0 |
US BANCORP | COM | 902973304 | 7,552 | 127,370 | SH | | DFND | 1 | 127,370 | 0 | 0 |
VANGUARD CONSUMER STAPLES ETF | ETF | 92204A207 | 6,545 | 40,600 | SH | | DFND | 1 | 40,600 | 0 | 0 |
VANGUARD FTSE EMERGING MARKETS ETF | ETF | 922042858 | 5,754 | 129,390 | SH | | DFND | 1 | 129,390 | 0 | 0 |
VANGUARD HEALTH CARE ETF | ETF | 92204A504 | 1,787 | 9,320 | SH | | DFND | 1 | 9,320 | 0 | 0 |
VANGUARD S&P 500 ETF | ETF | 922908363 | 15,071 | 50,950 | SH | | DFND | 1 | 50,950 | 0 | 0 |
VANGUARD SHORT-TERM BOND ETF | ETF | 921937827 | 9,238 | 114,600 | SH | | DFND | 1 | 114,600 | 0 | 0 |
VANGUARD SMALL- CAP ETF | ETF | 922908751 | 2,402 | 14,500 | SH | | DFND | 1 | 14,500 | 0 | 0 |
VECTOR GROUP LTD | COM | 92240M108 | 266 | 19,834 | SH | | DFND | 1 | 19,834 | 0 | 0 |
VIACOMCBC INC | CL B | 92556H206 | 325 | 7,755 | SH | | DFND | 1 | 0 | 0 | 7,755 |
VISA INC CLASS A | CL A | 92826C839 | 28,805 | 153,300 | SH | | DFND | 1 | 153,300 | 0 | 0 |
WABTEC CORPORATION | COM | 929740108 | 10,625 | 136,570 | SH | | DFND | 1 | 136,570 | 0 | 0 |
WATERS CORPORATION | COM | 941848103 | 9,475 | 40,550 | SH | | DFND | 1 | 40,550 | 0 | 0 |
WEIGHT WATCHERS INTL INC | COM | 948626106 | 405 | 10,600 | SH | | DFND | 1 | 10,600 | 0 | 0 |
WELLS FARGO & CO | COM | 949746101 | 88,226 | 1,639,880 | SH | | DFND | 1 | 1,639,880 | 0 | 0 |
WESTERN DIGITAL CORP | COM | 958102105 | 242 | 3,810 | SH | | DFND | 1 | 3,810 | 0 | 0 |
ZAFGEN INC | COM | 98885E103 | 223 | 200,621 | SH | | DFND | 1 | 200,621 | 0 | 0 |
ZOETIS INC | COM | 98978V103 | 609 | 4,600 | SH | | DFND | 1 | 4,600 | 0 | 0 |