Exhibit 99.1
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10 15 20 30 25 40 70 60 50 85 100 Y ea s t: P i chi a pas t or i s
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IL - 17 is a cytokine that plays a key role in the development of psoriatic lesions, which are in essence an acute, local (dermis) flareup of a chronic underlying disease . It allows for local (rather than systemic) administration of anti – IL - 17 drugs to stop the cytokine cascade .
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• • • Image source: https:// www.researchgate.net/publication/272185735_Three - Dimensional_Skin_Models_of_Psoriasis
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Píesence of Psoíiasin (S100A7) in an InflammaSkin Model with ľ - Cell activation No induction ľ - cell activation leads to significant incíease in IL - 17A expíession • healthy ex vivo skin samples of one donoí, gíowing in a well • •
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10 1 10 2 10 3 10 4 10 5 10 6 Titer [TCID 50 /g] limit of detection ٓٓٓٓ ٓٓٓٓ ٓٓٓٓ ٓٓٓٓ 9 8 7 6 5 4 3 2 1 SARS - CoV - 2 RNA copies/ml BALF ٓٓ ٓٓٓٓ ٓ ٓٓ de t e c t i o n limit
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