| Document and Entity Information | Feb. 13, 2023 |
| Cover [Abstract] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Feb. 13, 2023 |
| Entity File Number | 001-40894 |
| Entity Registrant Name | IsoPlexis Corporation |
| Entity Central Index Key | 0001615055 |
| Entity Incorporation, State or Country Code | DE |
| Entity Tax Identification Number | 46-2179799 |
| Entity Address, Address Line One | 35 NE Industrial Road |
| Entity Address, City or Town | Branford |
| Entity Address, State or Province | CT |
| Entity Address, Postal Zip Code | 06405 |
| City Area Code | 203 |
| Local Phone Number | 208-4111 |
| Title of 12(b) Security | Common Stock, par value $0.001 per share |
| Trading Symbol | ISO |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | true |
| Entity Ex Transition Period | false |
| Written Communications | true |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
