Senseonics (SENS) 8-K Changes in Registrant's Certifying Accountant

Exhibit 16.1

March 15, 2022

Securities and Exchange Commission

100 F Street, N.E.

Washington, DC 20549

Ladies and Gentlemen:

We have read Item 4.01 of Form 8-K dated March 15, 2022 of Senseonics Holdings, Inc. and are in agreement with the statements contained in the first through fifth paragraphs on page 2 therein. We have no basis to agree or disagree with other statements of the registrant contained therein.

/s/ Ernst & Young LLP

Tysons, Virginia