Exhibit 99.2
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CORRECTING and REPLACING — Unum Therapeutics Announces 2019 Goals and Expected Milestones
In a release issued yesterday under the same headline by Unum Therapeutics Inc. (NASDAQ: UMRX), please note the anticipated 2019 milestone for BOXR1030 has been changed from initiating clinical development to initiating preclinical development in the last paragraph. The corrected release follows:
- Multiple Data Readouts fromATTCK-20-03 andATTCK-17-01 Expected in 2019 -
- Initial Data onATTCK-34-01, Unum’s First Program in Solid Tumors, Expected in Second Half of 2019 -
- First Development Candidate from BOXR Platform Advancing Toward Clinical Development -
CAMBRIDGE, Mass., Jan. 04, 2019 (GLOBE NEWSWIRE) — Unum Therapeutics Inc. (NASDAQ: UMRX), a clinical-stage biopharmaceutical company focused on the development of novel cellular immunotherapies, today announced its anticipated milestones for 2019.
“Unum made substantial progress in 2018 as we reported early data from our programs innon-Hodgkin lymphoma and multiple myeloma, while simultaneously expanding applications of our ACTR platform into solid tumors and introducing a second novel technology platform, BOXR, designed to improve the functionality of engineered T cells,” said Chuck Wilson, CEO of Unum. “We expect 2019 also to be a year of significant momentum, with data expected from all four of our ongoing clinical programs, including readouts from theATTCK-20-03 andATTCK-17-01 trials, as well as an initial data readout from our first study in solid tumors. Additionally, we continue to innovate in the field of cell therapy and have recently nominated our first development candidate from our BOXR technology platform to advance toward clinical development.”
Anticipated 2019 Milestones
ACTR707 + rituximab in r/r NHL
| • | | Complete the dose escalation phase ofATTCK-20-03, the ongoing, multicenter Phase 1 study testing ACTR707 in combination with rituximab to treat patients with relapsed/refractory B cellnon-Hodgkin lymphoma. Advance into cohort expansion to confirm the preliminary recommended Phase 2 dose. |
| • | | Report results from the dose escalation phase and preliminary data from the cohort expansion phase of theATTCK-20-03 study. |
ACTR087 + SEA-BCMA in r/r multiple myeloma
| • | | Progress dose escalation of ACTR087 andSEA-BCMA inATTCK-17-01, a Phase 1, multi-center, open-label trial designed to test the safety, tolerability and anti-myeloma activity of the combination in patients with r/r multiple myeloma. |
| • | | Report clinical data from multiple cohorts of the dose escalation phase. |
ACTR707 + trastuzumab in HER2+ advanced cancers
| • | | Enroll and dose patients in Unum’s first ACTR T cell study in solid tumors,ATTCK-34-01, a multicenter,single-arm, open-label dose escalation study evaluating ACTR T cells in combination with trastuzumab in patients with HER2+ advanced cancers. |
| • | | Report initial clinical data from ongoing dose escalation. |
ACTR087 + rituximab in r/r NHL
| • | | Complete enrollment inATTCK-20-2, a Phase I clinical trial evaluating safety and anti-lymphoma activity of ACTR087 in combination with rituximab in patients with relapsed or refractory B cell NHL, and report data from the trial. |
BOXR Platform
| • | | Continued progress with new Bolt-On Chimeric Receptor technology platform (“BOXR”) that improves T cell functionality by countering immunosuppression in solid tumor cancers. Initiate preclinical development of BOXR1030, which has been nominated as the first product candidate from this platform. |
About Unum Therapeutics
Unum Therapeutics is a clinical-stage biopharmaceutical company focused on the development and commercialization of novel immunotherapy products designed to harness the power of a patient’s immune system to cure cancer. Unum’s novel proprietary technologies include Antibody-Coupled T cell Receptor (ACTR), a universal, engineered cell therapy intended to be used in combination with a wide range of tumor-specific antibodies to target different tumor types, and Bolt-On Chimeric Receptor (BOXR), an approach for improving T cell functionality to enable solid tumor cancer applications. Unum has four product candidates currently in Phase I clinical testing, including: ACTR707 used in combination with rituximab, an anti-CD20 antibody, in adult patients with relapsed or refractory non-Hodgkin lymphoma (r/r NHL); ACTR087 used in combination with the novel antibodySEA-BCMA in adult patients with relapsed or refractory multiple myeloma; and ACTR707 used in combination with trastuzumab, an anti-human epidermal growth factor receptor 2 (HER2) antibody, in adult patients with HER2+ advanced cancer.