COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABIOMED INC | COM | 003654100 | 3,992 | 104,888 | SH | | DFND | 2 | 0 | 0 | 104,888 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 3,014 | 94,925 | SH | | DFND | 2 | 0 | 0 | 94,925 |
ACCELERON PHARMA INC | COM | 00434H108 | 409 | 10,500 | SH | | DFND | 2 | 0 | 0 | 10,500 |
ACCENTURE PLC IRELAND | SHS CLASS A | G1151C101 | 122 | 1,370 | SH | | DFND | 1 | 1,370 | 0 | 0 |
ACORDA THERAPEUTICS INC | COM | 00484M106 | 654 | 16,000 | SH | | DFND | 2 | 0 | 0 | 16,000 |
ACTAVIS PLC | SHS | G0083B108 | 22,182 | 86,174 | SH | | DFND | 2 | 0 | 0 | 86,174 |
ADVANCED SEMICONDUCTOR ENGR | SPONSORED ADR | 00756M404 | 79 | 12,900 | SH | | DFND | 1 | 12,900 | 0 | 0 |
AEGERION PHARMACEUTICALS INC | COM | 00767E102 | 1,171 | 55,940 | SH | | DFND | 2 | 0 | 0 | 55,940 |
AERIE PHARMACEUTICALS INC | COM | 00771V108 | 2,653 | 90,903 | SH | | DFND | 2 | 0 | 0 | 90,903 |
AIR METHODS CORP | COM PAR $.06 | 009128307 | 7,272 | 165,151 | SH | | DFND | 2 | 0 | 0 | 165,151 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 8,634 | 46,661 | SH | | DFND | 2 | 0 | 0 | 46,661 |
ALEXZA PHARMACEUTICALS INC | COM NEW | 015384209 | 596 | 400,273 | SH | | DFND | 2 | 0 | 0 | 400,273 |
ALLERGAN INC | COM | 018490102 | 12,215 | 57,460 | SH | | DFND | 2 | 0 | 0 | 57,460 |
ALLIANCE DATA SYSTEMS CORP | COM | 018581108 | 169,602 | 592,910 | SH | | DFND | 2 | 372,450 | 0 | 220,460 |
ALLIANCE DATA SYSTEMS CORP | COM | 018581108 | 13,968 | 48,830 | SH | | DFND | 1 | 48,830 | 0 | 0 |
ALPHATEC HOLDINGS INC | COM | 02081G102 | 1,253 | 888,628 | SH | | DFND | 2 | 0 | 0 | 888,628 |
AMERICAN INTL GROUP INC | COM NEW | 026874784 | 264,616 | 4,724,440 | SH | | DFND | 2 | 2,977,200 | 0 | 1,747,240 |
AMERICAN INTL GROUP INC | COM NEW | 026874784 | 21,676 | 387,000 | SH | | DFND | 1 | 387,000 | 0 | 0 |
AMERICAN WTR WKS CO INC NEW | COM | 030420103 | 356 | 6,680 | SH | | DFND | 1 | 6,680 | 0 | 0 |
AMERISOURCEBERGEN CORP | COM | 03073E105 | 16,599 | 184,110 | SH | | DFND | 2 | 0 | 0 | 184,110 |
AMERISOURCEBERGEN CORP | COM | 03073E105 | 252 | 2,790 | SH | | DFND | 1 | 2,790 | 0 | 0 |
AMGEN INC | COM | 031162100 | 40,338 | 253,238 | SH | | DFND | 2 | 0 | 0 | 253,238 |
AON PLC | SHS CL A | G0408V102 | 119 | 1,260 | SH | | DFND | 1 | 1,260 | 0 | 0 |
ATHENAHEALTH INC | COM | 04685W103 | 3,821 | 26,222 | SH | | DFND | 2 | 0 | 0 | 26,222 |
AUSPEX PHARMACEUTICALS INC | COM | 05211J102 | 5,139 | 97,921 | SH | | DFND | 2 | 0 | 0 | 97,921 |
AUTOZONE INC | COM | 053332102 | 326 | 527 | SH | | DFND | 1 | 527 | 0 | 0 |
BCE INC | COM NEW | 05534B760 | 404 | 7,580 | SH | | DFND | 1 | 7,580 | 0 | 0 |
BIOGEN IDEC INC | COM | 09062X103 | 33,773 | 99,492 | SH | | DFND | 2 | 0 | 0 | 99,492 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 10,368 | 114,685 | SH | | DFND | 2 | 0 | 0 | 114,685 |
CARA THERAPEUTICS INC | COM | 140755109 | 2,112 | 211,841 | SH | | DFND | 2 | 0 | 0 | 211,841 |
CATAMARAN CORP | COM | 148887102 | 17,256 | 333,456 | SH | | DFND | 2 | 0 | 0 | 333,456 |
CELGENE CORP | COM | 151020104 | 38,395 | 343,238 | SH | | DFND | 2 | 0 | 0 | 343,238 |
CEMPRA INC | COM | 15130J109 | 5,562 | 236,584 | SH | | DFND | 2 | 0 | 0 | 236,584 |
CENTENE CORP DEL | COM | 15135B101 | 12,950 | 124,700 | SH | | DFND | 2 | 0 | 0 | 124,700 |
CEPHEID | COM | 15670R107 | 4,787 | 88,421 | SH | | DFND | 2 | 0 | 0 | 88,421 |
CERNER CORP | COM | 156782104 | 7,822 | 120,978 | SH | | DFND | 2 | 0 | 0 | 120,978 |
CITIGROUP INC | COM NEW | 172967424 | 280,119 | 5,176,850 | SH | | DFND | 2 | 3,278,500 | 0 | 1,898,350 |
CITIGROUP INC | COM NEW | 172967424 | 23,343 | 431,400 | SH | | DFND | 1 | 431,400 | 0 | 0 |
CMS ENERGY CORP | COM | 125896100 | 164 | 4,730 | SH | | DFND | 1 | 4,730 | 0 | 0 |
COMCAST CORP NEW | CL A | 20030N101 | 324 | 5,590 | SH | | DFND | 1 | 5,590 | 0 | 0 |
CREDICORP LTD | COM | G2519Y108 | 66 | 415 | SH | | DFND | 1 | 415 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 328,940 | 3,415,430 | SH | | DFND | 2 | 2,140,700 | 0 | 1,274,730 |
CVS HEALTH CORP | COM | 126650100 | 27,436 | 284,870 | SH | | DFND | 1 | 284,870 | 0 | 0 |
DANAHER CORP DEL | COM | 235851102 | 6,595 | 76,946 | SH | | DFND | 2 | 0 | 0 | 76,946 |
DAVITA HEALTHCARE PARTNERS I | COM | 23918K108 | 7,460 | 98,491 | SH | | DFND | 2 | 0 | 0 | 98,491 |
DEX INC | COM | 252131107 | 3,849 | 69,925 | SH | | DFND | 2 | 0 | 0 | 69,925 |
DISCOVER FINL SVCS | COM | 254709108 | 256 | 3,910 | SH | | DFND | 1 | 3,910 | 0 | 0 |
DISNEY WALT CO | COM DISNEY | 254687106 | 28,143 | 298,794 | SH | | DFND | 1 | 298,794 | 0 | 0 |
DISNEY WALT CO | COM DISNEY | 254687106 | 343,173 | 3,643,410 | SH | | DFND | 2 | 2,286,400 | 0 | 1,357,010 |
DR PEPPER SNAPPLE GROUP INC | COM | 26138E109 | 116 | 1,620 | SH | | DFND | 1 | 1,620 | 0 | 0 |
DYNAVAX TECHNOLOGIES CORP | COM NEW ADDED | 268158201 | 589 | 34,962 | SH | | DFND | 2 | 0 | 0 | 34,962 |
EAGLE PHARMACEUTICALS INC | COM | 269796108 | 1,463 | 94,407 | SH | | DFND | 2 | 0 | 0 | 94,407 |
EDISON INTL | COM | 281020107 | 291 | 4,450 | SH | | DFND | 1 | 4,450 | 0 | 0 |
ELEVEN BIOTHERAPEUTICS INC | COM | 286221106 | 801 | 67,434 | SH | | DFND | 2 | 0 | 0 | 67,434 |
ENBRIDGE INC | COM | 29250N105 | 129 | 2,500 | SH | | DFND | 1 | 2,500 | 0 | 0 |
EPAM SYS INC | COM | 29414B104 | 69 | 1,450 | SH | | DFND | 1 | 1,450 | 0 | 0 |
EVOKE PHARMA INC | COM | 30049G104 | 266 | 45,100 | SH | | DFND | 2 | 0 | 0 | 45,100 |
EXAMWORKS GROUP INC | COM | 30066A105 | 2,908 | 69,925 | SH | | DFND | 2 | 0 | 0 | 69,925 |
EXPRESS SCRIPTS HLDG CO | COM | 30219G108 | 16,917 | 199,801 | SH | | DFND | 2 | 0 | 0 | 199,801 |
EXPRESS SCRIPTS HLDG CO | COM | 30219G108 | 305 | 3,600 | SH | | DFND | 1 | 3,600 | 0 | 0 |
FACEBOOK INC | CL A | 30303M102 | 260,456 | 3,338,325 | SH | | DFND | 2 | 2,097,400 | 0 | 1,240,925 |
FACEBOOK INC | CL A | 30303M102 | 20,985 | 268,975 | SH | | DFND | 1 | 268,975 | 0 | 0 |
GENERAL MLS INC | COM | 370334104 | 203 | 3,800 | SH | | DFND | 2 | 0 | 0 | 3,800 |
GILEAD SCIENCES INC | COM | 375558103 | 383,977 | 4,073,592 | SH | | DFND | 2 | 2,129,400 | 0 | 1,944,192 |
GILEAD SCIENCES INC | COM | 375558103 | 26,313 | 279,150 | SH | | DFND | 1 | 279,150 | 0 | 0 |
GOOGLE INC | CL A | 38259P508 | 176,911 | 333,379 | SH | | DFND | 2 | 208,270 | 0 | 125,109 |
GOOGLE INC | CL A | 38259P508 | 14,338 | 27,020 | SH | | DFND | 1 | 27,020 | 0 | 0 |
GOOGLE INC | CL C | 38259P706 | 228,175 | 433,464 | SH | | DFND | 2 | 274,030 | 0 | 159,434 |
GOOGLE INC | CL C | 38259P706 | 17,917 | 34,037 | SH | | DFND | 1 | 34,037 | 0 | 0 |
HCA HOLDINGS INC | COM | 40412C101 | 17,832 | 242,975 | SH | | DFND | 2 | 0 | 0 | 242,975 |
HDFC BANK LTD | ADR REPS 3 SHS | 40415F101 | 226,424 | 4,461,550 | SH | | DFND | 2 | 4,382,300 | 0 | 79,250 |
HDFC BANK LTD | ADR REPS 3 SHS | 40415F101 | 4,661 | 91,840 | SH | | DFND | 1 | 91,840 | 0 | 0 |
HEALTH NET INC | COM | 42222G108 | 1,123 | 20,977 | SH | | DFND | 2 | 0 | 0 | 20,977 |
HOME DEPOT INC | COM | 437076102 | 372,409 | 3,547,770 | SH | | DFND | 2 | 2,224,500 | 0 | 1,323,270 |
HOME DEPOT INC | COM | 437076102 | 30,979 | 295,120 | SH | | DFND | 1 | 295,120 | 0 | 0 |
HORMEL FOODS CORP | COM | 440452100 | 226 | 4,330 | SH | | DFND | 1 | 4,330 | 0 | 0 |
ICICI BK LTD | ADR | 45104G104 | 27,323 | 2,365,590 | SH | | DFND | 2 | 0 | 0 | 2,365,590 |
ICICI BK LTD | ADR | 45104G104 | 2,309 | 199,900 | SH | | DFND | 1 | 199,900 | 0 | 0 |
INFOSYS LTD | SPONSORED ADR | 456788108 | 106 | 3,360 | SH | | DFND | 1 | 3,360 | 0 | 0 |
INNOCOLL AG | SPONSORED ADR | 45780Q103 | 1,455 | 245,184 | SH | | DFND | 2 | 0 | 0 | 245,184 |
INSULET CORP | COM | 45784P101 | 3,161 | 68,620 | SH | | DFND | 2 | 0 | 0 | 68,620 |
ISIS PHARMACEUTICALS INC | COM | 464330109 | 7,790 | 126,180 | SH | | DFND | 2 | 0 | 0 | 126,180 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 16,202 | 98,954 | SH | | DFND | 2 | 0 | 0 | 98,954 |
JOHNSON & JOHNSON | COM | 478160104 | 37,978 | 363,186 | SH | | DFND | 2 | 0 | 0 | 363,186 |
JOHNSON & JOHNSON | COM | 478160104 | 208 | 1,985 | SH | | DFND | 1 | 1,985 | 0 | 0 |
K2M GROUP HLDGS INC | COM | 48273J107 | 2,111 | 101,151 | SH | | DFND | 2 | 0 | 0 | 101,151 |
KERYX BIOPHARMACEUTICALS INC | COM | 492515101 | 11,398 | 805,502 | SH | | DFND | 2 | 0 | 0 | 805,502 |
KYTHERA BIOPHARMACEUTICALS I | COM | 501570105 | 3,261 | 94,017 | SH | | DFND | 2 | 0 | 0 | 94,017 |
L BRANDS INC | COM | 501797104 | 350,233 | 4,046,595 | SH | | DFND | 2 | 2,534,600 | 0 | 1,511,995 |
L BRANDS INC | COM | 501797104 | 28,764 | 332,340 | SH | | DFND | 1 | 332,340 | 0 | 0 |
LDR HLDG CORP | COM | 50185U105 | 2,521 | 76,917 | SH | | DFND | 2 | 0 | 0 | 76,917 |
LORILLARD INC | COM | 544147101 | 2,581 | 41,000 | SH | | DFND | 2 | 0 | 0 | 41,000 |
LUMENIS LTD | SHS CL B | M6778Q121 | 526 | 56,362 | SH | | DFND | 2 | 0 | 0 | 56,362 |
MASIMO CORP | COM | 574795100 | 2,265 | 86,008 | SH | | DFND | 2 | 0 | 0 | 86,008 |
MASTERCARD INC | CL A | 57636Q104 | 2,843 | 33,000 | SH | | DFND | 2 | 0 | 0 | 33,000 |
MCKESSON CORP | COM | 58155Q103 | 403 | 1,940 | SH | | DFND | 1 | 1,940 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 2,283 | 11,000 | SH | | DFND | 2 | 0 | 0 | 11,000 |
MEDIVATION INC | COM | 58501N101 | 13,864 | 139,182 | SH | | DFND | 2 | 0 | 0 | 139,182 |
MEDNAX INC | COM | 58502B106 | 2,311 | 34,962 | SH | | DFND | 2 | 0 | 0 | 34,962 |
MERCK & CO INC NEW | COM | 58933Y105 | 21,364 | 376,197 | SH | | DFND | 2 | 0 | 0 | 376,197 |
MICROSOFT CORP | COM | 594918104 | 382,479 | 8,234,210 | SH | | DFND | 2 | 5,181,900 | 0 | 3,052,310 |
MICROSOFT CORP | COM | 594918104 | 31,659 | 681,575 | SH | | DFND | 1 | 681,575 | 0 | 0 |
MIMEDX GROUP INC | COM | 602496101 | 2,306 | 200,000 | SH | | DFND | 2 | 0 | 0 | 200,000 |
MYLAN INC | COM | 628530107 | 19,560 | 346,999 | SH | | DFND | 2 | 0 | 0 | 346,999 |
NIKE INC | CL B | 654106103 | 1,518 | 15,790 | SH | | DFND | 1 | 15,790 | 0 | 0 |
NIKE INC | CL B | 654106103 | 4,476 | 46,550 | SH | | DFND | 2 | 0 | 0 | 46,550 |
NORTHROP GRUMMAN CORP | COM | 666807102 | 3,464 | 23,500 | SH | | DFND | 2 | 0 | 0 | 23,500 |
NPS PHARMACEUTICALS INC | COM | 62936P103 | 1,751 | 48,947 | SH | | DFND | 2 | 0 | 0 | 48,947 |
NUVASIVE INC | COM | 670704105 | 2,979 | 63,160 | SH | | DFND | 2 | 0 | 0 | 63,160 |
OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 1,368 | 100,460 | SH | | DFND | 2 | 0 | 0 | 100,460 |
PFIZER INC | COM | 717081103 | 32,281 | 1,036,315 | SH | | DFND | 2 | 0 | 0 | 1,036,315 |
PG&E CORP | COM | 69331C108 | 256 | 4,810 | SH | | DFND | 1 | 4,810 | 0 | 0 |
PHILIP MORRIS INTL INC | COM | 718172109 | 231 | 2,835 | SH | | DFND | 1 | 2,835 | 0 | 0 |
PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 1,048 | 37,013 | SH | | DFND | 2 | 0 | 0 | 37,013 |
PRAXAIR INC | COM | 74005P104 | 234,399 | 1,809,190 | SH | | DFND | 2 | 1,134,200 | 0 | 674,990 |
PRAXAIR INC | COM | 74005P104 | 19,260 | 148,660 | SH | | DFND | 1 | 148,660 | 0 | 0 |
QIWI PLC | SPON ADR REP B | 74735M108 | 361 | 17,875 | SH | | DFND | 2 | 0 | 0 | 17,875 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 1,477 | 3,600 | SH | | DFND | 2 | 0 | 0 | 3,600 |
REPROS THERAPEUTICS INC | COM NEW | 76028H209 | 1,346 | 135,000 | SH | | DFND | 2 | 0 | 0 | 135,000 |
ROSS STORES INC | COM | 778296103 | 136 | 1,440 | SH | | DFND | 1 | 1,440 | 0 | 0 |
SALIX PHARMACEUTICALS INC | COM | 795435106 | 21,152 | 184,025 | SH | | DFND | 2 | 0 | 0 | 184,025 |
SERVICE CORP INTL | COM | 817565104 | 402 | 17,700 | SH | | DFND | 1 | 17,700 | 0 | 0 |
SHIRE PLC | SPONSORED ADR | 82481R106 | 17,749 | 83,509 | SH | | DFND | 2 | 0 | 0 | 83,509 |
SORRENTO THERAPEUTICS INC | COM NEW | 83587F202 | 2,742 | 272,301 | SH | | DFND | 2 | 0 | 0 | 272,301 |
SPECTRANETICS CORP | COM | 84760C107 | 4,286 | 123,956 | SH | | DFND | 2 | 0 | 0 | 123,956 |
STEMLINE THERAPEUTICS INC | COM | 85858C107 | 364 | 21,350 | SH | | DFND | 2 | 0 | 0 | 21,350 |
STRYKER CORP | COM | 863667101 | 141 | 1,500 | SH | | DFND | 1 | 1,500 | 0 | 0 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 1,079 | 130,000 | SH | | DFND | 2 | 0 | 0 | 130,000 |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADR | 874039100 | 272 | 12,150 | SH | | DFND | 1 | 12,150 | 0 | 0 |
TATA MTRS LTD | SPONSORED ADR | 876568502 | 209 | 4,950 | SH | | DFND | 1 | 4,950 | 0 | 0 |
TD AMERITRADE HLDG CORP | COM | 87236Y108 | 191,024 | 5,338,850 | SH | | DFND | 2 | 3,361,100 | 0 | 1,977,750 |
TD AMERITRADE HLDG CORP | COM | 87236Y108 | 14,995 | 419,100 | SH | | DFND | 1 | 419,100 | 0 | 0 |
TETRAPHASE PHARMACEUTICALS I | COM | 88165N105 | 3,115 | 78,440 | SH | | DFND | 2 | 0 | 0 | 78,440 |
TEVA PHARMACEUTICAL INDS LTD | ADR | 881624209 | 2,070 | 36,000 | SH | | DFND | 2 | 0 | 0 | 36,000 |
THERAVANCE BIOPHARMA INC | COM | G8807B106 | 179 | 11,987 | SH | | DFND | 2 | 0 | 0 | 11,987 |
THERAVANCE INC | COM | 88338T104 | 594 | 41,955 | SH | | DFND | 2 | 0 | 0 | 41,955 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 112 | 890 | SH | | DFND | 1 | 890 | 0 | 0 |
TORONTO DOMINION BK ONT | COM NEW | 891160509 | 406 | 7,320 | SH | | DFND | 1 | 7,320 | 0 | 0 |
TRANSENTERIX INC | COM NEW | 89366M201 | 981 | 337,169 | SH | | DFND | 2 | 0 | 0 | 337,169 |
TROVAGENE INC | COM NEW | 897238309 | 725 | 168,584 | SH | | DFND | 2 | 0 | 0 | 168,584 |
UNION PAC CORP | COM | 907818108 | 36,615 | 307,350 | SH | | DFND | 1 | 307,350 | 0 | 0 |
UNION PAC CORP | COM | 907818108 | 447,953 | 3,760,200 | SH | | DFND | 2 | 2,381,600 | 0 | 1,378,600 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 33,275 | 329,158 | SH | | DFND | 2 | 0 | 0 | 329,158 |
VALEANT PHARMACEUTICALS INTL | COM | 91911K102 | 19,314 | 134,961 | SH | | DFND | 2 | 0 | 0 | 134,961 |
VERIZON MUNICATIONS INC | COM | 92343V104 | 287 | 6,140 | SH | | DFND | 1 | 6,140 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 2,602 | 21,900 | SH | | DFND | 2 | 0 | 0 | 21,900 |
VISA INC | COM CL A | 92826C839 | 684,249 | 2,609,645 | SH | | DFND | 2 | 1,638,500 | 0 | 971,145 |
VISA INC | COM CL A | 92826C839 | 55,643 | 212,215 | SH | | DFND | 1 | 212,215 | 0 | 0 |
WELLCARE HEALTH PLANS INC | COM | 94946T106 | 3,443 | 41,955 | SH | | DFND | 2 | 0 | 0 | 41,955 |
WELLS FARGO & CO NEW | COM | 949746101 | 328,482 | 5,992,019 | SH | | DFND | 2 | 3,737,800 | 0 | 2,254,219 |
WELLS FARGO & CO NEW | COM | 949746101 | 27,034 | 493,150 | SH | | DFND | 1 | 493,150 | 0 | 0 |
YANDEX N V | SHS CLASS A | N97284108 | 271 | 15,100 | SH | | DFND | 2 | 0 | 0 | 15,100 |
ZIMMER HLDGS INC | COM | 98956P102 | 8,103 | 71,441 | SH | | DFND | 2 | 0 | 0 | 71,441 |