COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBVIE INC | COM | 00287Y109 | 10,137 | 125,780 | SH | | DFND | 2 | 125,780 | 0 | 0 |
ACADIA HEALTHCARE PANY IN | COM | 00404A109 | 1,574 | 53,712 | SH | | DFND | 2 | 53,712 | 0 | 0 |
ACCELERATE DIAGNOSTICS INC | COM | 00430H102 | 2,411 | 114,683 | SH | | DFND | 2 | 114,683 | 0 | 0 |
ACLARIS THERAPEUTICS INC | COM | 00461U105 | 890 | 148,506 | SH | | DFND | 2 | 148,506 | 0 | 0 |
AERIE PHARMACEUTICALS INC | COM | 00771V108 | 6,467 | 136,142 | SH | | DFND | 2 | 136,142 | 0 | 0 |
AIMMUNE THERAPEUTICS INC | COM | 00900T107 | 4,084 | 182,709 | SH | | DFND | 2 | 182,709 | 0 | 0 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 6,397 | 47,325 | SH | | DFND | 2 | 47,325 | 0 | 0 |
ALGONQUIN PWR UTILS CORP | COM | 015857105 | 1,201 | 79,900 | SH | | DFND | 1 | 79,900 | 0 | 0 |
ALGONQUIN PWR UTILS CORP | COM | 015857105 | 1,323 | 88,000 | SH | | DFND | 2 | 88,000 | 0 | 0 |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 146,128 | 800,919 | SH | | DFND | 2 | 254,512 | 0 | 546,407 |
ALIBABA GROUP HLDG LTD | SPONSORED ADS | 01609W102 | 13,660 | 74,868 | SH | | DFND | 1 | 74,868 | 0 | 0 |
ALLERGAN PLC | SHS | G0177J108 | 11,111 | 75,890 | SH | | DFND | 2 | 75,890 | 0 | 0 |
ALLSTATE CORP | COM | 020002101 | 563 | 5,978 | SH | | DFND | 1 | 5,978 | 0 | 0 |
ALLSTATE CORP | COM | 020002101 | 712 | 7,559 | SH | | DFND | 2 | 7,559 | 0 | 0 |
ALPHABET INC | CAP STK CL C | 02079K107 | 538,252 | 458,747 | SH | | DFND | 2 | 294,395 | 0 | 164,352 |
ALPHABET INC | CAP STK CL C | 02079K107 | 24,519 | 20,897 | SH | | DFND | 1 | 20,897 | 0 | 0 |
ALPHABET INC | CAP STK CL A | 02079K305 | 1,023 | 869 | SH | | DFND | 2 | 0 | 0 | 869 |
AMARIN CORP PLC | SPONS ADR NEW | 023111206 | 15,805 | 761,329 | SH | | DFND | 2 | 761,329 | 0 | 0 |
AMAZON INC | COM | 023135106 | 511,155 | 287,045 | SH | | DFND | 2 | 166,871 | 0 | 120,174 |
AMAZON INC | COM | 023135106 | 29,322 | 16,466 | SH | | DFND | 1 | 16,466 | 0 | 0 |
AMERICAN TOWER CORP NEW | COM | 03027X100 | 19,148 | 97,166 | SH | | DFND | 1 | 97,166 | 0 | 0 |
AMERICAN TOWER CORP NEW | COM | 03027X100 | 395,773 | 2,008,389 | SH | | DFND | 2 | 1,273,922 | 0 | 734,467 |
AMGEN INC | COM | 031162100 | 15,348 | 80,787 | SH | | DFND | 2 | 80,787 | 0 | 0 |
ANTHEM INC | COM | 036752103 | 1,006 | 3,505 | SH | | DFND | 1 | 3,505 | 0 | 0 |
ANTHEM INC | COM | 036752103 | 1,317 | 4,590 | SH | | DFND | 2 | 4,590 | 0 | 0 |
ARAMARK | COM | 03852U106 | 1,074 | 36,333 | SH | | DFND | 2 | 36,333 | 0 | 0 |
ARAMARK | COM | 03852U106 | 848 | 28,682 | SH | | DFND | 1 | 28,682 | 0 | 0 |
AT&T INC | COM | 00206R102 | 1,068 | 34,066 | SH | | DFND | 1 | 34,066 | 0 | 0 |
AT&T INC | COM | 00206R102 | 1,353 | 43,153 | SH | | DFND | 2 | 43,153 | 0 | 0 |
ATLANTICA YIELD PLC | SHS | G0751N103 | 1,268 | 65,143 | SH | | DFND | 2 | 65,143 | 0 | 0 |
ATLANTICA YIELD PLC | SHS | G0751N103 | 1,001 | 51,426 | SH | | DFND | 1 | 51,426 | 0 | 0 |
AVERY DENNISON CORP | COM | 053611109 | 396 | 3,500 | SH | | DFND | 2 | 3,500 | 0 | 0 |
BAIDU INC | SPON ADR REP A | 056752108 | 37,460 | 227,239 | SH | | DFND | 2 | 71,240 | 0 | 155,999 |
BAIDU INC | SPON ADR REP A | 056752108 | 3,353 | 20,342 | SH | | DFND | 1 | 20,342 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 13,224 | 52,955 | SH | | DFND | 2 | 52,955 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 9,822 | 41,551 | SH | | DFND | 2 | 41,551 | 0 | 0 |
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 19,649 | 381,751 | SH | | DFND | 2 | 381,751 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 6,116 | 68,851 | SH | | DFND | 2 | 68,851 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 14,093 | 367,194 | SH | | DFND | 2 | 367,194 | 0 | 0 |
CARA THERAPEUTICS INC | COM | 140755109 | 2,815 | 143,460 | SH | | DFND | 2 | 143,460 | 0 | 0 |
CELGENE CORP | COM | 151020104 | 9,244 | 97,986 | SH | | DFND | 2 | 97,986 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 9,946 | 187,306 | SH | | DFND | 2 | 187,306 | 0 | 0 |
CERNER CORP | COM | 156782104 | 2,879 | 50,329 | SH | | DFND | 2 | 50,329 | 0 | 0 |
CIGNA CORP NEW | COM | 125523100 | 4,827 | 30,018 | SH | | DFND | 2 | 30,018 | 0 | 0 |
CLOVIS ONCOLOGY INC | COM | 189464100 | 1,577 | 63,530 | SH | | DFND | 2 | 63,530 | 0 | 0 |
COCA COLA CO | COM | 191216100 | 355,261 | 7,581,331 | SH | | DFND | 2 | 4,920,422 | 0 | 2,660,909 |
COCA COLA CO | COM | 191216100 | 18,600 | 396,924 | SH | | DFND | 1 | 396,924 | 0 | 0 |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 2,707 | 198,464 | SH | | DFND | 2 | 198,464 | 0 | 0 |
COLLEGIUM PHARMACEUTICAL INC | COM | 19459J104 | 3,573 | 236,021 | SH | | DFND | 2 | 236,021 | 0 | 0 |
CROWN CASTLE INTL CORP NEW | COM | 22822V101 | 1,446 | 11,296 | SH | | DFND | 2 | 11,296 | 0 | 0 |
CROWN CASTLE INTL CORP NEW | COM | 22822V101 | 1,101 | 8,604 | SH | | DFND | 1 | 8,604 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 462 | 8,567 | SH | | DFND | 1 | 8,567 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 28,422 | 527,015 | SH | | DFND | 2 | 527,015 | 0 | 0 |
DERMIRA INC | COM | 24983L104 | 4,402 | 324,884 | SH | | DFND | 2 | 324,884 | 0 | 0 |
DEX INC | COM | 252131107 | 3,210 | 26,949 | SH | | DFND | 2 | 26,949 | 0 | 0 |
DYNAVAX TECHNOLOGIES CORP | COM NEW | 268158201 | 3,629 | 496,412 | SH | | DFND | 2 | 496,412 | 0 | 0 |
ECOLAB INC | COM | 278865100 | 567,903 | 3,216,849 | SH | | DFND | 2 | 2,076,380 | 0 | 1,140,469 |
ECOLAB INC | COM | 278865100 | 26,668 | 151,061 | SH | | DFND | 1 | 151,061 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 8,790 | 45,943 | SH | | DFND | 2 | 45,943 | 0 | 0 |
EQUINIX INC | COM | 29444U700 | 747 | 1,649 | SH | | DFND | 2 | 1,649 | 0 | 0 |
EQUINIX INC | COM | 29444U700 | 585 | 1,291 | SH | | DFND | 1 | 1,291 | 0 | 0 |
EXACT SCIENCES CORP | COM | 30063P105 | 5,105 | 58,932 | SH | | DFND | 2 | 58,932 | 0 | 0 |
EXXON MOBIL CORP | COM | 30231G102 | 325,033 | 4,022,687 | SH | | DFND | 2 | 2,395,467 | 0 | 1,627,220 |
EXXON MOBIL CORP | COM | 30231G102 | 16,032 | 198,422 | SH | | DFND | 1 | 198,422 | 0 | 0 |
FIDELITY NATL INFORMATION SV | COM | 31620M106 | 253 | 2,240 | SH | | DFND | 1 | 2,240 | 0 | 0 |
FIDELITY NATL INFORMATION SV | COM | 31620M106 | 460 | 4,071 | SH | | DFND | 2 | 4,071 | 0 | 0 |
FIRST REP BK SAN FRANCISCO C | COM | 33616C100 | 298,964 | 2,975,948 | SH | | DFND | 2 | 1,981,993 | 0 | 993,955 |
FIRST REP BK SAN FRANCISCO C | COM | 33616C100 | 14,385 | 143,190 | SH | | DFND | 1 | 143,190 | 0 | 0 |
FOAMIX PHARMACEUTICALS LTD | SHS | M46135105 | 1,661 | 442,884 | SH | | DFND | 2 | 442,884 | 0 | 0 |
FRANCO NEVADA CORP | COM | 351858105 | 1,465 | 19,526 | SH | | DFND | 2 | 19,526 | 0 | 0 |
FRANCO NEVADA CORP | COM | 351858105 | 468 | 6,233 | SH | | DFND | 1 | 6,233 | 0 | 0 |
GEOPARK LTD | USD SHS | G38327105 | 105 | 6,082 | SH | | DFND | 1 | 6,082 | 0 | 0 |
GEOPARK LTD | USD SHS | G38327105 | 204 | 11,823 | SH | | DFND | 2 | 11,823 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 12,781 | 196,598 | SH | | DFND | 2 | 196,598 | 0 | 0 |
GLAUKOS CORP | COM | 377322102 | 3,469 | 44,265 | SH | | DFND | 2 | 44,265 | 0 | 0 |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 3,957 | 23,473 | SH | | DFND | 2 | 23,473 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 14,721 | 112,905 | SH | | DFND | 2 | 112,905 | 0 | 0 |
HDFC BANK LTD | SPONSORED ADS | 40415F101 | 183,609 | 1,584,063 | SH | | DFND | 2 | 929,755 | 0 | 654,308 |
HDFC BANK LTD | SPONSORED ADS | 40415F101 | 11,509 | 99,289 | SH | | DFND | 1 | 99,289 | 0 | 0 |
HERON THERAPEUTICS INC | COM | 427746102 | 6,161 | 252,069 | SH | | DFND | 2 | 252,069 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 9,647 | 199,328 | SH | | DFND | 2 | 199,328 | 0 | 0 |
HOME DEPOT INC | COM | 437076102 | 548,597 | 2,858,913 | SH | | DFND | 2 | 1,804,235 | 0 | 1,054,678 |
HOME DEPOT INC | COM | 437076102 | 27,870 | 145,242 | SH | | DFND | 1 | 145,242 | 0 | 0 |
HORIZON PHARMA PLC | SHS | G4617B105 | 5,063 | 191,544 | SH | | DFND | 2 | 191,544 | 0 | 0 |
ICICI BK LTD | ADR | 45104G104 | 56,272 | 4,910,304 | SH | | DFND | 2 | 1,538,656 | 0 | 3,371,648 |
ICICI BK LTD | ADR | 45104G104 | 5,147 | 449,127 | SH | | DFND | 1 | 449,127 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 4,507 | 14,505 | SH | | DFND | 2 | 14,505 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 3,331 | 38,726 | SH | | DFND | 2 | 38,726 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 3,288 | 113,110 | SH | | DFND | 2 | 113,110 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 5,009 | 52,672 | SH | | DFND | 2 | 52,672 | 0 | 0 |
INTERSECT ENT INC | COM | 46071F103 | 3,971 | 123,514 | SH | | DFND | 2 | 123,514 | 0 | 0 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 1,786 | 146,671 | SH | | DFND | 2 | 146,671 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 7,496 | 13,137 | SH | | DFND | 2 | 13,137 | 0 | 0 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 2,156 | 226,681 | SH | | DFND | 2 | 226,681 | 0 | 0 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 4,256 | 29,774 | SH | | DFND | 2 | 29,774 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 46,439 | 332,208 | SH | | DFND | 2 | 332,208 | 0 | 0 |
JOHNSON & JOHNSON | COM | 478160104 | 267 | 1,912 | SH | | DFND | 1 | 1,912 | 0 | 0 |
LHC GROUP INC | COM | 50187A107 | 5,062 | 45,657 | SH | | DFND | 2 | 45,657 | 0 | 0 |
LILLY ELI & CO | COM | 532457108 | 11,918 | 91,848 | SH | | DFND | 2 | 91,848 | 0 | 0 |
LIVANOVA PLC | SHS | G5509L101 | 8,088 | 83,163 | SH | | DFND | 2 | 83,163 | 0 | 0 |
MERCK & CO INC | COM | 58933Y105 | 27,442 | 329,955 | SH | | DFND | 2 | 329,955 | 0 | 0 |
MICROSOFT CORP | COM | 594918104 | 459,219 | 3,893,670 | SH | | DFND | 2 | 2,612,241 | 0 | 1,281,429 |
MICROSOFT CORP | COM | 594918104 | 20,268 | 171,850 | SH | | DFND | 1 | 171,850 | 0 | 0 |
MONDELEZ INTL INC | CL A | 609207105 | 32,047 | 641,976 | SH | | DFND | 2 | 641,976 | 0 | 0 |
MONDELEZ INTL INC | CL A | 609207105 | 503 | 10,068 | SH | | DFND | 1 | 10,068 | 0 | 0 |
MYLAN N V | SHS EURO | N59465109 | 7,297 | 257,473 | SH | | DFND | 2 | 257,473 | 0 | 0 |
NEOGENOMICS INC | COM NEW | 64049M209 | 3,056 | 149,378 | SH | | DFND | 2 | 149,378 | 0 | 0 |
NOVOCURE LTD | ORD SHS | G6674U108 | 5,205 | 108,059 | SH | | DFND | 2 | 108,059 | 0 | 0 |
OBALON THERAPEUTICS INC | COM | 67424L100 | 395 | 274,399 | SH | | DFND | 2 | 274,399 | 0 | 0 |
OPEN TEXT CORP | COM | 683715106 | 900 | 17,535 | SH | | DFND | 2 | 17,535 | 0 | 0 |
OPEN TEXT CORP | COM | 683715106 | 714 | 13,919 | SH | | DFND | 1 | 13,919 | 0 | 0 |
PARATEK PHARMACEUTICALS INC | COM | 699374302 | 2,520 | 470,150 | SH | | DFND | 2 | 470,150 | 0 | 0 |
PFENEX INC | COM | 717071104 | 2,176 | 352,153 | SH | | DFND | 2 | 352,153 | 0 | 0 |
PFIZER INC | COM | 717081103 | 345 | 8,125 | SH | | DFND | 1 | 8,125 | 0 | 0 |
PFIZER INC | COM | 717081103 | 32,958 | 776,028 | SH | | DFND | 2 | 776,028 | 0 | 0 |
PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 5,530 | 159,366 | SH | | DFND | 2 | 159,366 | 0 | 0 |
PROCTER AND GAMBLE CO | COM | 742718109 | 372,648 | 3,581,430 | SH | | DFND | 2 | 2,320,932 | 0 | 1,260,498 |
PROCTER AND GAMBLE CO | COM | 742718109 | 17,398 | 167,212 | SH | | DFND | 1 | 167,212 | 0 | 0 |
PROGRESSIVE CORP OHIO | COM | 743315103 | 1,029 | 14,268 | SH | | DFND | 1 | 14,268 | 0 | 0 |
PROGRESSIVE CORP OHIO | COM | 743315103 | 1,305 | 18,106 | SH | | DFND | 2 | 18,106 | 0 | 0 |
PUMA BIOTECHNOLOGY INC | COM | 74587V107 | 1,520 | 39,179 | SH | | DFND | 2 | 39,179 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 3,019 | 25,329 | SH | | DFND | 2 | 25,329 | 0 | 0 |
SPARK THERAPEUTICS INC | COM | 84652J103 | 4,258 | 37,392 | SH | | DFND | 2 | 37,392 | 0 | 0 |
SPRING BK PHARMACEUTICALS IN | COM | 849431101 | 547 | 52,100 | SH | | DFND | 2 | 52,100 | 0 | 0 |
STARBUCKS CORP | COM | 855244109 | 55,524 | 746,899 | SH | | DFND | 2 | 746,899 | 0 | 0 |
STEMLINE THERAPEUTICS INC | COM | 85858C107 | 4,601 | 358,082 | SH | | DFND | 2 | 358,082 | 0 | 0 |
STORE CAP CORP | COM | 862121100 | 803 | 23,979 | SH | | DFND | 1 | 23,979 | 0 | 0 |
STORE CAP CORP | COM | 862121100 | 1,098 | 32,776 | SH | | DFND | 2 | 32,776 | 0 | 0 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 607 | 17,325 | SH | | DFND | 2 | 17,325 | 0 | 0 |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 | 313 | 7,630 | SH | | DFND | 1 | 7,630 | 0 | 0 |
TAIWAN SEMICONDUCTOR MFG LTD | SPONSORED ADS | 874039100 | 5,178 | 126,422 | SH | | DFND | 2 | 126,422 | 0 | 0 |
TAKEDA PHARMACEUTICAL CO LTD | SPONSORED ADS | 874060205 | 7,463 | 366,380 | SH | | DFND | 2 | 366,380 | 0 | 0 |
TELADOC HEALTH INC | COM | 87918A105 | 5,829 | 104,834 | SH | | DFND | 2 | 104,834 | 0 | 0 |
THERAPEUTICSMD INC | COM | 88338N107 | 4,820 | 989,834 | SH | | DFND | 2 | 989,834 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 580,744 | 2,121,671 | SH | | DFND | 2 | 1,462,516 | 0 | 659,155 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 26,998 | 98,632 | SH | | DFND | 1 | 98,632 | 0 | 0 |
TORONTO DOMINION BK ONT | COM NEW | 891160509 | 1,266 | 17,452 | SH | | DFND | 2 | 17,452 | 0 | 0 |
TORONTO DOMINION BK ONT | COM NEW | 891160509 | 998 | 13,757 | SH | | DFND | 1 | 13,757 | 0 | 0 |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 2,647 | 38,168 | SH | | DFND | 2 | 38,168 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 35,218 | 142,434 | SH | | DFND | 2 | 142,434 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 788 | 3,186 | SH | | DFND | 1 | 3,186 | 0 | 0 |
US BANCORP DEL | COM NEW | 902973304 | 34,931 | 724,850 | SH | | DFND | 2 | 724,850 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 12,611 | 68,557 | SH | | DFND | 2 | 68,557 | 0 | 0 |
VIKING THERAPEUTICS INC | COM | 92686J106 | 2,307 | 232,138 | SH | | DFND | 2 | 232,138 | 0 | 0 |
VISA INC | COM CL A | 92826C839 | 1,129,553 | 7,231,917 | SH | | DFND | 2 | 4,573,842 | 0 | 2,658,075 |
VISA INC | COM CL A | 92826C839 | 57,736 | 369,653 | SH | | DFND | 1 | 369,653 | 0 | 0 |
VOCERA MUNICATIONS INC | COM | 92857F107 | 4,904 | 155,058 | SH | | DFND | 2 | 155,058 | 0 | 0 |
WELLS FARGO CO NEW | COM | 949746101 | 269,477 | 5,576,929 | SH | | DFND | 2 | 3,633,381 | 0 | 1,943,548 |
WELLS FARGO CO NEW | COM | 949746101 | 13,212 | 273,428 | SH | | DFND | 1 | 273,428 | 0 | 0 |
WEYERHAEUSER CO | COM | 962166104 | 28,350 | 1,076,306 | SH | | DFND | 2 | 1,076,306 | 0 | 0 |
WORLDPAY INC | CL A | 981558109 | 693 | 6,104 | SH | | DFND | 2 | 6,104 | 0 | 0 |
WORLDPAY INC | CL A | 981558109 | 541 | 4,765 | SH | | DFND | 1 | 4,765 | 0 | 0 |