Sofinnova Investments 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Aclaris Therapeutics	COMM	00461U105	2,064	1,911,573	SH		SOLE		1,911,573	0	0
Amarin	ADR	023111206	78,958	5,208,305	SH		SOLE		5,208,305	0	0
Apellis Pharmaceuticals, Inc	COMM	03753U106	1,194	49,580	SH		SOLE		49,580	0	0
Ascendis Pharma A/S	ADR	04351P101	106,903	1,109,874	SH		SOLE		1,109,874	0	0
Audentes Therapeutics	COMM	05070R104	26,226	933,640	SH		SOLE		933,640	0	0
Chiasma	COMM	16706W102	8,070	1,630,221	SH		SOLE		1,630,221	0	0
Coherus BioSciences	COMM	19249H103	39,167	1,933,221	SH		SOLE		1,933,221	0	0
Entasis Therapeutics Holdings Inc.	COMM	293614103	7,034	1,180,178	SH		SOLE		1,180,178	0	0
Iterum Therapeutics	COMM	G6333L101	9,962	1,726,514	SH		SOLE		1,726,514	0	0
Karuna Therapeutics, Inc.	COMM	48576A100	28,223	1,729,352	SH		SOLE		1,729,352	0	0
Kiniksa Pharmaceuticals, Ltd	COMM CL A	G5269C101	7,852	922,700	SH		SOLE		922,700	0	0
Merus N.V.	COMM	N5749R100	34,946	1,961,039	SH		SOLE		1,961,039	0	0
Natera	COMM	632307104	101,698	3,100,560	SH		SOLE		3,100,560	0	0
Nextcure, Inc	COMM	65343E108	77,799	2,521,856	SH		SOLE		2,521,856	0	0
Nucana Biomed Ltd	ADR	67022C106	16,411	2,266,666	SH		SOLE		2,266,666	0	0
Nucana Biomed Ltd	Ordinary Shares	GB00BYWYV	17,376	2,400,000	SH		SOLE		2,400,000	0	0
ObsEva SA	COMM	H5861P103	39,564	4,749,623	SH		SOLE		4,749,623	0	0
PDS Biotechnology Corporation	COMM	70465T107	482	142,635	SH		SOLE		142,635	0	0
Principia Biopharma	COMM	74257L108	40,023	1,417,258	SH		SOLE		1,417,258	0	0
Spark Therapeutics	COMM	84652J103	46,674	481,270	SH		SOLE		481,270	0	0
Synlogic Inc.	COMM	87166L100	1,317	574,972	SH		SOLE		574,972	0	0
Y-mAbs Therapeutics, Inc	COMM	984241109	54,837	2,104,278	SH		SOLE		2,104,278	0	0
Acceleron Pharma Inc	COMM	00434H108	4,727	119,653	SH		SOLE		119,653	0	0
Aimmune Therapeutics Inc	COMM	00900T107	2,128	101,630	SH		SOLE		101,630	0	0
Akebia Therapeutics Inc	COMM	00972D105	1,452	370,288	SH		SOLE		370,288	0	0
Align Technology Inc	COMM	016255101	546	3,017	SH		SOLE		3,017	0	0
Allergan plc	COMM	G0177J108	8,159	48,481	SH		SOLE		48,481	0	0
Amgen Inc	COMM	031162100	5,235	27,051	SH		SOLE		27,051	0	0
Amicus Therapeutics Inc	COMM	03152W109	2,677	333,834	SH		SOLE		333,834	0	0
Applied Therapeutics Inc	COMM	03828A101	553	50,350	SH		SOLE		50,350	0	0
ArQule Inc	COMM	04269E107	856	119,395	SH		SOLE		119,395	0	0
Beigene Ltd	COMM	07725L902	1,861	15,200	SH	Call	SOLE		15,200	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	441	153,942	SH		SOLE		153,942	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	2,024	30,029	SH		SOLE		30,029	0	0
Bristol-Myers Squibb Co	COMM	110122108	7,109	140,193	SH		SOLE		140,193	0	0
Calithera Biosciences Inc	COMM	13089P101	885	286,326	SH		SOLE		286,326	0	0
Cytokinetics Inc	COMM	23282W605	704	61,838	SH		SOLE		61,838	0	0
Dermira Inc	COMM	24983L104	1,854	290,195	SH		SOLE		290,195	0	0
Dicerna Pharmaceuticals Inc	COMM	253031108	1,443	100,454	SH		SOLE		100,454	0	0
Fate Therapeutics Inc	COMM	31189P102	1,737	111,838	SH		SOLE		111,838	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	1,243	408,895	SH		SOLE		408,895	0	0
Forty Seven Inc	COMM	34983P104	998	155,394	SH		SOLE		155,394	0	0
Halozyme Therapeutics Inc	COMM	40637H109	2,892	186,446	SH		SOLE		186,446	0	0
Health Care Select Sector SPDR	COMM	81369Y950	8,202	91,000	SH	Put	SOLE		91,000	0	0
Heron Therapeutics Inc	COMM	427746902	995	53,800	SH	Call	SOLE		53,800	0	0
Heron Therapeutics Inc	COMM	427746102	562	30,358	SH		SOLE		30,358	0	0
Homology Medicines Inc	COMM	438083107	776	42,877	SH		SOLE		42,877	0	0
Kadmon Holdings Inc	COMM	48283N106	1,959	777,390	SH		SOLE		777,390	0	0
Kala Pharmaceuticals Inc	COMM	483119103	549	144,378	SH		SOLE		144,378	0	0
MacroGenics Inc	COMM	556099109	2,211	173,299	SH		SOLE		173,299	0	0
Mirati Therapeutics Inc	COMM	60468T105	703	9,027	SH		SOLE		9,027	0	0
MyoKardia Inc	COMM	62857M105	1,759	33,728	SH		SOLE		33,728	0	0
Neurocrine Biosciences Inc	COMM	64125C109	5,070	56,260	SH		SOLE		56,260	0	0
Orchard Therapeutics PLC	ADR	68570P101	1,022	85,987	SH		SOLE		85,987	0	0
Otonomy Inc	COMM	68906L105	1,118	467,940	SH		SOLE		467,940	0	0
PTC Therapeutics Inc	COMM	69366J200	2,847	84,185	SH		SOLE		84,185	0	0
Pfizer Inc	COMM	717081103	4,480	124,684	SH		SOLE		124,684	0	0
Reata Pharmaceuticals Inc	COMM	75615P953	3,581	44,600	SH	Put	SOLE		44,600	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	3,475	43,278	SH		SOLE		43,278	0	0
Sarepta Therapeutics Inc	COMM	803607100	2,348	31,169	SH		SOLE		31,169	0	0
Savara Inc	COMM	805111101	424	160,124	SH		SOLE		160,124	0	0
Sunesis Pharmaceuticals Inc	COMM	867328700	248	344,373	SH		SOLE		344,373	0	0
Syndax Pharmaceuticals Inc	COMM	87164F905	226	30,300	SH	Call	SOLE		30,300	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	548	73,313	SH		SOLE		73,313	0	0
Syndax Pharmaceuticals Inc	COMM	87164F955	445	59,600	SH	Put	SOLE		59,600	0	0
TG Therapeutics Inc	COMM	88322Q108	2,853	508,086	SH		SOLE		508,086	0	0
United Therapeutics Corp	COMM	91307C102	4,535	56,861	SH		SOLE		56,861	0	0
Vertex Pharmaceuticals Inc	COMM	92532F100	5,933	35,022	SH		SOLE		35,022	0	0
XBiotech Inc	COMM	98400H102	1,118	106,899	SH		SOLE		106,899	0	0
Zymeworks Inc	COMM	98985W102	1,417	57,154	SH		SOLE		57,154	0	0
Acceleron Pharma Inc	COMM	00434H108	2,884	72,988	SH		OTR	1	72,988	0	0
Aimmune Therapeutics Inc	COMM	00900T107	1,298	61,995	SH		OTR	1	61,995	0	0
Akebia Therapeutics Inc	COMM	00972D105	848	216,441	SH		OTR	1	216,441	0	0
Align Technology Inc	COMM	016255101	320	1,767	SH		OTR	1	1,767	0	0
Allergan plc	COMM	G0177J108	4,843	28,776	SH		OTR	1	28,776	0	0
Amgen Inc	COMM	031162100	3,193	16,501	SH		OTR	1	16,501	0	0
Amicus Therapeutics Inc	COMM	03152W109	1,555	193,920	SH		OTR	1	193,920	0	0
Applied Therapeutics Inc	COMM	03828A101	333	30,324	SH		OTR	1	30,324	0	0
ArQule Inc	COMM	04269E107	498	69,485	SH		OTR	1	69,485	0	0
Beigene Ltd	COMM	07725L902	1,078	8,800	SH	Call	OTR	1	8,800	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	262	91,299	SH		OTR	1	91,299	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	1,221	18,115	SH		OTR	1	18,115	0	0
Bristol-Myers Squibb Co	COMM	110122108	4,337	85,519	SH		OTR	1	85,519	0	0
Calithera Biosciences Inc	COMM	13089P101	530	171,514	SH		OTR	1	171,514	0	0
Cytokinetics Inc	COMM	23282W605	429	37,721	SH		OTR	1	37,721	0	0
Dermira Inc	COMM	24983L104	1,131	177,021	SH		OTR	1	177,021	0	0
Dicerna Pharmaceuticals Inc	COMM	253031108	880	61,277	SH		OTR	1	61,277	0	0
Fate Therapeutics Inc	COMM	31189P102	1,059	68,222	SH		OTR	1	68,222	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	701	230,742	SH		OTR	1	230,742	0	0
Forty Seven Inc	COMM	34983P104	587	91,363	SH		OTR	1	91,363	0	0
Halozyme Therapeutics Inc	COMM	40637H109	1,764	113,733	SH		OTR	1	113,733	0	0
Health Care Select Sector SPDR	COMM	81369Y950	4,759	52,800	SH	Put	OTR	1	52,800	0	0
Heron Therapeutics Inc	COMM	427746102	577	31,200	SH	Call	OTR	1	31,200	0	0
Heron Therapeutics Inc	COMM	427746102	343	18,523	SH		OTR	1	18,523	0	0
Homology Medicines Inc	COMM	438083107	473	26,155	SH		OTR	1	26,155	0	0
Kadmon Holdings Inc	COMM	48283N106	1,182	468,954	SH		OTR	1	468,954	0	0
Kala Pharmaceuticals Inc	COMM	483119103	321	84,381	SH		OTR	1	84,381	0	0
MacroGenics Inc	COMM	556099109	1,318	103,265	SH		OTR	1	103,265	0	0
Mirati Therapeutics Inc	COMM	60468T105	429	5,506	SH		OTR	1	5,506	0	0
MyoKardia Inc	COMM	62857M105	1,057	20,263	SH		OTR	1	20,263	0	0
Neurocrine Biosciences Inc	COMM	64125C109	3,085	34,231	SH		OTR	1	34,231	0	0
Orchard Therapeutics PLC	ADR	68570P101	595	50,089	SH		OTR	1	50,089	0	0
Otonomy Inc	COMM	68906L105	678	283,853	SH		OTR	1	283,853	0	0
PTC Therapeutics Inc	COMM	69366J200	1,737	51,353	SH		OTR	1	51,353	0	0
Pfizer Inc	COMM	717081103	2,602	72,427	SH		OTR	1	72,427	0	0
Reata Pharmaceuticals Inc	COMM	75615P953	2,071	25,800	SH	Put	OTR	1	25,800	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	2,139	26,647	SH		OTR	1	26,647	0	0
Sarepta Therapeutics Inc	COMM	803607100	1,437	19,075	SH		OTR	1	19,075	0	0
Savara Inc	COMM	805111101	246	93,014	SH		OTR	1	93,014	0	0
Sunesis Pharmaceuticals Inc	COMM	867328700	144	200,133	SH		OTR	1	200,133	0	0
Syndax Pharmaceuticals Inc	COMM	87164F905	131	17,600	SH	Call	OTR	1	17,600	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	321	42,941	SH		OTR	1	42,941	0	0
Syndax Pharmaceuticals Inc	COMM	87164F955	263	35,200	SH	Put	OTR	1	35,200	0	0
TG Therapeutics Inc	COMM	88322Q108	1,740	309,936	SH		OTR	1	309,936	0	0
United Therapeutics Corp	COMM	91307C102	2,766	34,685	SH		OTR	1	34,685	0	0
Vertex Pharmaceuticals Inc	COMM	92532F100	3,713	21,918	SH		OTR	1	21,918	0	0
XBiotech Inc	COMM	98400H102	661	63,236	SH		OTR	1	63,236	0	0
Zymeworks Inc	COMM	98985W102	825	33,283	SH		OTR	1	33,283	0	0
Acceleron Pharma Inc	COMM	00434H108	8,519	215,621	SH		OTR	2	215,621	0	0
Aimmune Therapeutics Inc	COMM	00900T107	3,835	183,145	SH		OTR	2	183,145	0	0
Akebia Therapeutics Inc	COMM	00972D105	2,511	640,462	SH		OTR	2	640,462	0	0
Align Technology Inc	COMM	016255101	944	5,216	SH		OTR	2	5,216	0	0
Allergan plc	COMM	G0177J108	9,622	57,176	SH		OTR	2	57,176	0	0
Amgen Inc	COMM	031162100	9,433	48,748	SH		OTR	2	48,748	0	0
Amicus Therapeutics Inc	COMM	03152W109	1,566	195,220	SH		OTR	2	195,220	0	0
Applied Therapeutics Inc	COMM	03828A101	674	61,330	SH		OTR	2	61,330	0	0
ArQule Inc	COMM	04269E107	1,466	204,507	SH		OTR	2	204,507	0	0
Beigene Ltd	COMM	07725L902	3,184	26,000	SH	Call	OTR	2	26,000	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	778	271,493	SH		OTR	2	271,493	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	2,477	36,752	SH		OTR	2	36,752	0	0
Bristol-Myers Squibb Co	COMM	110122108	12,811	252,637	SH		OTR	2	252,637	0	0
Calithera Biosciences Inc	COMM	13089P101	1,567	507,012	SH		OTR	2	507,012	0	0
Cytokinetics Inc	COMM	23282W605	1,268	111,433	SH		OTR	2	111,433	0	0
Dermira Inc	COMM	24983L104	3,342	522,952	SH		OTR	2	522,952	0	0
Dicerna Pharmaceuticals Inc	COMM	253031108	2,600	181,024	SH		OTR	2	181,024	0	0
Fate Therapeutics Inc	COMM	31189P102	3,130	201,540	SH		OTR	2	201,540	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	1,701	559,617	SH		OTR	2	559,617	0	0
Forty Seven Inc	COMM	34983P104	1,750	272,541	SH		OTR	2	272,541	0	0
Halozyme Therapeutics Inc	COMM	40637H109	5,211	335,988	SH		OTR	2	335,988	0	0
Health Care Select Sector SPDR	COMM	81369Y950	14,078	156,200	SH	Put	OTR	2	156,200	0	0
Heron Therapeutics Inc	COMM	427746102	1,706	92,200	SH	Call	OTR	2	92,200	0	0
Heron Therapeutics Inc	COMM	427746102	1,012	54,721	SH		OTR	2	54,721	0	0
Homology Medicines Inc	COMM	438083107	1,398	77,265	SH		OTR	2	77,265	0	0
Kadmon Holdings Inc	COMM	48283N106	3,436	1,363,414	SH		OTR	2	1,363,414	0	0
Kala Pharmaceuticals Inc	COMM	483119103	949	249,447	SH		OTR	2	249,447	0	0
MacroGenics Inc	COMM	556099109	3,892	304,990	SH		OTR	2	304,990	0	0
Mirati Therapeutics Inc	COMM	60468T105	1,267	16,267	SH		OTR	2	16,267	0	0
MyoKardia Inc	COMM	62857M105	3,126	59,935	SH		OTR	2	59,935	0	0
Neurocrine Biosciences Inc	COMM	64125C109	9,118	101,188	SH		OTR	2	101,188	0	0
Orchard Therapeutics PLC	ADR	68570P101	1,750	147,330	SH		OTR	2	147,330	0	0
Otonomy Inc	COMM	68906L105	1,640	686,172	SH		OTR	2	686,172	0	0
PTC Therapeutics Inc	COMM	69366J200	5,131	151,707	SH		OTR	2	151,707	0	0
Pfizer Inc	COMM	717081103	7,671	213,496	SH		OTR	2	213,496	0	0
Portola Pharmaceuticals Inc	COMM	737010108	1,588	59,191	SH		OTR	2	59,191	0	0
Reata Pharmaceuticals Inc	COMM	75615P953	6,279	78,200	SH	Put	OTR	2	78,200	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	6,322	78,744	SH		OTR	2	78,744	0	0
Sarepta Therapeutics Inc	COMM	803607100	4,231	56,170	SH		OTR	2	56,170	0	0
Savara Inc	COMM	805111101	727	274,180	SH		OTR	2	274,180	0	0
Sunesis Pharmaceuticals Inc	COMM	867328700	424	589,441	SH		OTR	2	589,441	0	0
Syndax Pharmaceuticals Inc	COMM	87164F905	389	52,100	SH	Call	OTR	2	52,100	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	948	126,896	SH		OTR	2	126,896	0	0
Syndax Pharmaceuticals Inc	COMM	87164F955	786	105,200	SH	Put	OTR	2	105,200	0	0
TG Therapeutics Inc	COMM	88322Q108	5,141	915,606	SH		OTR	2	915,606	0	0
United Therapeutics Corp	COMM	91307C102	8,172	102,468	SH		OTR	2	102,468	0	0
Vertex Pharmaceuticals Inc	COMM	92532F100	10,970	64,750	SH		OTR	2	64,750	0	0
XBiotech Inc	COMM	98400H102	1,972	188,528	SH		OTR	2	188,528	0	0
Zymeworks Inc	COMM	98985W102	2,430	98,001	SH		OTR	2	98,001	0	0