Sofinnova Investments 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Aclaris Therapeutics	COMM	00461U105	3,097	1,911,573	SH		SOLE		1,911,573	0	0
Akouos, Inc	ADR	00973J101	34,089	1,515,073	SH		SOLE		1,515,073	0	0
Amarin	ADR	023111206	36,041	5,208,305	SH		SOLE		5,208,305	0	0
Apellis Pharmaceuticals, Inc	COMM	03753U106	1,619	49,580	SH		SOLE		49,580	0	0
Ascendis Pharma A/S	ADR	04351P101	164,150	1,109,874	SH		SOLE		1,109,874	0	0
Chiasma	COMM	16706W102	8,771	1,630,221	SH		SOLE		1,630,221	0	0
Coherus BioSciences	COMM	19249H103	34,527	1,933,221	SH		SOLE		1,933,221	0	0
Entasis Therapeutics Holdings Inc.	COMM	293614103	3,493	1,180,178	SH		SOLE		1,180,178	0	0
Galera Therapeutics, Inc	COMM	36338D108	22,018	3,083,712	SH		SOLE		3,083,712	0	0
Karuna Therapeutics, Inc.	COMM	48576A100	210,169	1,885,602	SH		SOLE		1,885,602	0	0
Kiniksa Pharmaceuticals, Ltd	COMM CL A	G5269C101	20,634	809,803	SH		SOLE		809,803	0	0
Merus N.V.	COMM	N5749R100	21,095	1,311,039	SH		SOLE		1,311,039	0	0
Natera	COMM	632307104	154,594	3,100,560	SH		SOLE		3,100,560	0	0
Nextcure, Inc	COMM	65343E108	57,285	2,671,856	SH		SOLE		2,671,856	0	0
Nucana Biomed Ltd	ADR	67022C106	12,263	2,266,666	SH		SOLE		2,266,666	0	0
Nucana Biomed Ltd	Ordinary Shares	GBOOBYWYV	12,984	2,400,000	SH		SOLE		2,400,000	0	0
ObsEva SA	COMM	H5861P103	27,975	4,749,623	SH		SOLE		4,749,623	0	0
PDS Biotechnology Corporation	COMM	70465T107	287	142,635	SH		SOLE		142,635	0	0
Principia Biopharma	COMM	74257L108	84,738	1,417,258	SH		SOLE		1,417,258	0	0
Synlogic Inc.	COMM	87166L100	1,167	574,972	SH		SOLE		574,972	0	0
Y-mAbs Therapeutics, Inc	COMM	984241109	94,793	2,194,278	SH		SOLE		2,194,278	0	0
Abbvie Inc	COMM	00287Y109	10,772	109,717	SH		SOLE		109,717	0	0
Acceleron Pharma Inc	COMM	00434H108	9,016	94,641	SH		SOLE		94,641	0	0
Akebia Therapeutics Inc	COMM	00972D105	4,032	296,912	SH		SOLE		296,912	0	0
Alnylam Pharmaceuticals Inc	COMM	02043Q907	9,672	65,300	SH	Call	SOLE		65,300	0	0
Amgen Inc	COMM	031162950	17,336	73,500	SH	Put	SOLE		73,500	0	0
Applied Genetic Technologies Corp	COMM	03820J100	2,582	466,103	SH		SOLE		466,103	0	0
Arena Pharmaceuticals Inc	COMM	040047607	382	6,065	SH		SOLE		6,065	0	0
Axsome Therapeutics Inc	COMM	05464T104	3,116	37,871	SH		SOLE		37,871	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	2,821	592,106	SH		SOLE		592,106	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	3,378	27,390	SH		SOLE		27,390	0	0
Blueprint Medicines Corp	COMM	09627Y109	3,231	41,427	SH		SOLE		41,427	0	0
Calithera Biosciences Inc	COMM	13089P101	2,092	396,177	SH		SOLE		396,177	0	0
ChemoCentryx Inc	COMM	16383L106	2,428	42,192	SH		SOLE		42,192	0	0
Compugen Ltd	COMM	M25722105	678	45,107	SH		SOLE		45,107	0	0
Constellation Pharmaceuticals Inc	COMM	210373106	2,709	90,144	SH		SOLE		90,144	0	0
Cytokinetics Inc	COMM	23282W605	1,644	69,767	SH		SOLE		69,767	0	0
Eli Lilly & Co	COMM	532457108	10,644	64,834	SH		SOLE		64,834	0	0
Gilead Sciences Inc	COMM	375558103	13,519	175,706	SH		SOLE		175,706	0	0
SPDR Ser Tr	S&P Biotech	81369Y959	6,535	65,300	SH	Put	SOLE		65,300	0	0
Homology Medicines Inc	COMM	438083107	2,185	143,831	SH		SOLE		143,831	0	0
Horizon Therapeutics PLC	COMM	G46188101	6,120	110,120	SH		SOLE		110,120	0	0
Immunovant Inc	COMM	45258J102	447	18,338	SH		SOLE		18,338	0	0
Insmed Inc	COMM	457669307	5,801	210,646	SH		SOLE		210,646	0	0
Intellia Therapeutics Inc	COMM	45826J105	527	25,050	SH		SOLE		25,050	0	0
Intra-Cellular Therapies Inc	COMM	46116X101	2,704	105,346	SH		SOLE		105,346	0	0
Intra-Cellular Therapies Inc	COMM	46116X951	2,462	95,900	SH	Put	SOLE		95,900	0	0
Invesco QQQ Trust	UNIT SER 1	46090E953	3,244	13,100	SH	Put	SOLE		13,100	0	0
Jazz Pharmaceuticals PLC	COMM	G50871105	11,693	105,975	SH		SOLE		105,975	0	0
Kadmon Holdings Inc	COMM	48283N106	3,412	666,381	SH		SOLE		666,381	0	0
Kala Pharmaceuticals Inc	COMM	483119103	2,319	220,610	SH		SOLE		220,610	0	0
Kura Oncology Inc	COMM	50127T109	4,337	266,058	SH		SOLE		266,058	0	0
Liquidia Technologies Inc	COMM	53635D202	2,933	348,305	SH		SOLE		348,305	0	0
Menlo Therapeutics Inc	COMM	586858102	547	316,027	SH		SOLE		316,027	0	0
Merck & Co Inc	COMM	58933Y105	15,233	196,985	SH		SOLE		196,985	0	0
Mersana Therapeutics Inc	COMM	59045L106	1,408	60,184	SH		SOLE		60,184	0	0
Mirati Therapeutics Inc	COMM	60468T105	401	3,514	SH		SOLE		3,514	0	0
Mirum Pharmaceuticals Inc	COMM	604749101	4,590	235,882	SH		SOLE		235,882	0	0
MyoKardia Inc	COMM	62857M105	4,718	48,826	SH		SOLE		48,826	0	0
Novocure Ltd	COMM	G6674U908	1,293	21,800	SH	Call	SOLE		21,800	0	0
Oric Pharmaceuticals Inc	COMM	68622P109	255	7,569	SH		SOLE		7,569	0	0
Otonomy Inc	COMM	68906L105	2,672	738,154	SH		SOLE		738,154	0	0
PTC Therapeutics Inc	COMM	69366J200	9,710	191,358	SH		SOLE		191,358	0	0
PTC Therapeutics Inc	COMM	69366J900	1,324	26,100	SH	Call	SOLE		26,100	0	0
Pfizer Inc	COMM	717081903	2,492	76,200	SH	Call	SOLE		76,200	0	0
Protagonist Therapeutics Inc	COMM	74366E102	2,508	142,020	SH		SOLE		142,020	0	0
Puma Biotechnology Inc	COMM	74587V107	5,427	520,370	SH		SOLE		520,370	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	886	5,680	SH		SOLE		5,680	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	271	147,828	SH		SOLE		147,828	0	0
SPDR Ser Tr	S&P Biotech	78464A950	7,310	65,300	SH	Put	SOLE		65,300	0	0
Supernus Pharmaceuticals Inc	COMM	868459108	4,959	208,815	SH		SOLE		208,815	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	601	40,583	SH		SOLE		40,583	0	0
TG Therapeutics Inc	COMM	88322Q108	5,910	303,374	SH		SOLE		303,374	0	0
United Therapeutics Corp	COMM	91307C102	16,048	132,624	SH		SOLE		132,624	0	0
Zymeworks Inc	COMM	98985W102	4,394	121,815	SH		SOLE		121,815	0	0
iShares Tr	Russell 2000 ETF	464287955	4,367	30,500	SH	Put	SOLE		30,500	0	0
Abbvie Inc	COMM	00287Y109	4,067	41,422	SH		OTR	1	41,422	0	0
Acceleron Pharma Inc	COMM	00434H108	3,408	35,774	SH		OTR	1	35,774	0	0
Akebia Therapeutics Inc	COMM	00972D105	1,525	112,262	SH		OTR	1	112,262	0	0
Alnylam Pharmaceuticals Inc	COMM	02043Q907	3,658	24,700	SH	Call	OTR	1	24,700	0	0
Amgen Inc	COMM	031162950	6,510	27,600	SH	Put	OTR	1	27,600	0	0
Applied Genetic Technologies Corp	COMM	03820J100	973	175,613	SH		OTR	1	175,613	0	0
Arena Pharmaceuticals Inc	COMM	040047607	144	2,292	SH		OTR	1	2,292	0	0
Axsome Therapeutics Inc	COMM	05464T104	1,178	14,319	SH		OTR	1	14,319	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	1,063	223,133	SH		OTR	1	223,133	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	1,275	10,340	SH		OTR	1	10,340	0	0
Blueprint Medicines Corp	COMM	09627Y109	1,217	15,607	SH		OTR	1	15,607	0	0
Calithera Biosciences Inc	COMM	13089P101	787	149,096	SH		OTR	1	149,096	0	0
ChemoCentryx Inc	COMM	16383L106	918	15,954	SH		OTR	1	15,954	0	0
Compugen Ltd	COMM	M25722105	256	17,030	SH		OTR	1	17,030	0	0
Constellation Pharmaceuticals Inc	COMM	210373106	1,024	34,077	SH		OTR	1	34,077	0	0
Cytokinetics Inc	COMM	23282W605	621	26,340	SH		OTR	1	26,340	0	0
Eli Lilly & Co	COMM	532457108	4,021	24,493	SH		OTR	1	24,493	0	0
Gilead Sciences Inc	COMM	375558103	5,104	66,335	SH		OTR	1	66,335	0	0
Select Sector SPDR Tr	SBI Healthcare	81369Y959	2,472	24,700	SH	Put	OTR	1	24,700	0	0
Homology Medicines Inc	COMM	438083107	826	54,376	SH		OTR	1	54,376	0	0
Horizon Therapeutics PLC	COMM	G46188101	2,314	41,630	SH		OTR	1	41,630	0	0
Immunovant Inc	COMM	45258J102	168	6,900	SH		OTR	1	6,900	0	0
Insmed Inc	COMM	457669307	2,193	79,643	SH		OTR	1	79,643	0	0
Intellia Therapeutics Inc	COMM	45826J105	199	9,459	SH		OTR	1	9,459	0	0
Intra-Cellular Therapies Inc	COMM	46116X951	929	36,200	SH	Put	OTR	1	36,200	0	0
Intra-Cellular Therapies Inc	COMM	46116X101	1,021	39,793	SH		OTR	1	39,793	0	0
Invesco QQQ Trust	UNIT SER 1	46090E953	1,213	4,900	SH	Put	OTR	1	4,900	0	0
Jazz Pharmaceuticals PLC	COMM	G50871105	4,417	40,035	SH		OTR	1	40,035	0	0
Kadmon Holdings Inc	COMM	48283N106	1,290	251,920	SH		OTR	1	251,920	0	0
Kala Pharmaceuticals Inc	COMM	483119103	876	83,359	SH		OTR	1	83,359	0	0
Kura Oncology Inc	COMM	50127T109	1,637	100,445	SH		OTR	1	100,445	0	0
Liquidia Technologies Inc	COMM	53635D202	1,109	131,694	SH		OTR	1	131,694	0	0
Menlo Therapeutics Inc	COMM	586858102	207	119,406	SH		OTR	1	119,406	0	0
Merck & Co Inc	COMM	58933Y105	5,739	74,217	SH		OTR	1	74,217	0	0
Mersana Therapeutics Inc	COMM	59045L106	531	22,681	SH		OTR	1	22,681	0	0
Mirati Therapeutics Inc	COMM	60468T105	152	1,328	SH		OTR	1	1,328	0	0
Mirum Pharmaceuticals Inc	COMM	604749101	1,735	89,150	SH		OTR	1	89,150	0	0
MyoKardia Inc	COMM	62857M105	1,776	18,385	SH		OTR	1	18,385	0	0
Novocure Ltd	COMM	G6674U908	486	8,200	SH	Call	OTR	1	8,200	0	0
Oric Pharmaceuticals Inc	COMM	68622P109	96	2,858	SH		OTR	1	2,858	0	0
Otonomy Inc	COMM	68906L105	1,028	283,853	SH		OTR	1	283,853	0	0
PTC Therapeutics Inc	COMM	69366J200	3,658	72,085	SH		OTR	1	72,085	0	0
PTC Therapeutics Inc	COMM	69366J900	502	9,900	SH	Call	OTR	1	9,900	0	0
Pfizer Inc	COMM	717081903	942	28,800	SH	Call	OTR	1	28,800	0	0
Protagonist Therapeutics Inc	COMM	74366E102	947	53,626	SH		OTR	1	53,626	0	0
Puma Biotechnology Inc	COMM	74587V107	2,055	196,982	SH		OTR	1	196,982	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	335	2,146	SH		OTR	1	2,146	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	102	55,898	SH		OTR	1	55,898	0	0
SPDR Ser Tr	S&P Biotech	78464A950	2,765	24,700	SH	Put	OTR	1	24,700	0	0
Supernus Pharmaceuticals Inc	COMM	868459108	1,868	78,672	SH		OTR	1	78,672	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	227	15,286	SH		OTR	1	15,286	0	0
TG Therapeutics Inc	COMM	88322Q108	2,233	114,646	SH		OTR	1	114,646	0	0
United Therapeutics Corp	COMM	91307C102	6,066	50,133	SH		OTR	1	50,133	0	0
Zymeworks Inc	COMM	98985W102	1,654	45,848	SH		OTR	1	45,848	0	0
iShares Tr	Russell 2000 ETF	464287955	1,647	11,500	SH	Put	OTR	1	11,500	0	0
Abbvie Inc	COMM	00287Y109	9,899	100,820	SH		OTR	2	100,820	0	0
Acceleron Pharma Inc	COMM	00434H108	8,286	86,975	SH		OTR	2	86,975	0	0
Akebia Therapeutics Inc	COMM	00972D105	3,704	272,718	SH		OTR	2	272,718	0	0
Alnylam Pharmaceuticals Inc	COMM	02043Q907	8,887	60,000	SH	Call	OTR	2	60,000	0	0
Amgen Inc	COMM	031162950	15,897	67,400	SH	Put	OTR	2	67,400	0	0
Applied Genetic Technologies Corp	COMM	03820J100	2,790	503,538	SH		OTR	2	503,538	0	0
Arena Pharmaceuticals Inc	COMM	040047607	351	5,572	SH		OTR	2	5,572	0	0
Axsome Therapeutics Inc	COMM	05464T104	2,862	34,788	SH		OTR	2	34,788	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	2,586	542,609	SH		OTR	2	542,609	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	3,104	25,167	SH		OTR	2	25,167	0	0
Blueprint Medicines Corp	COMM	09627Y109	2,953	37,857	SH		OTR	2	37,857	0	0
Calithera Biosciences Inc	COMM	13089P101	2,614	495,126	SH		OTR	2	495,126	0	0
ChemoCentryx Inc	COMM	16383L106	2,231	38,770	SH		OTR	2	38,770	0	0
Compugen Ltd	COMM	M25722105	623	41,450	SH		OTR	2	41,450	0	0
Constellation Pharmaceuticals Inc	COMM	210373106	2,490	82,866	SH		OTR	2	82,866	0	0
Cytokinetics Inc	COMM	23282W605	1,511	64,110	SH		OTR	2	64,110	0	0
Eli Lilly & Co	COMM	532457108	9,781	59,573	SH		OTR	2	59,573	0	0
Gilead Sciences Inc	COMM	375558103	12,422	161,453	SH		OTR	2	161,453	0	0
Select Sector SPDR Tr	SBI Healthcare	81369Y959	6,004	60,000	SH	Put	OTR	2	60,000	0	0
Homology Medicines Inc	COMM	438083107	2,223	146,372	SH		OTR	2	146,372	0	0
Horizon Therapeutics PLC	COMM	G46188101	5,625	101,208	SH		OTR	2	101,208	0	0
Immunovant Inc	COMM	45258J102	372	15,275	SH		OTR	2	15,275	0	0
Insmed Inc	COMM	457669307	5,334	193,678	SH		OTR	2	193,678	0	0
Intellia Therapeutics Inc	COMM	45826J105	483	22,991	SH		OTR	2	22,991	0	0
Intra-Cellular Therapies Inc	COMM	46116X951	2,256	87,900	SH	Put	OTR	2	87,900	0	0
Intra-Cellular Therapies Inc	COMM	46116X101	2,484	96,769	SH		OTR	2	96,769	0	0
Invesco QQQ Trust	UNIT SER 1	46090E953	2,971	12,000	SH	Put	OTR	2	12,000	0	0
Jazz Pharmaceuticals PLC	COMM	G50871105	10,741	97,343	SH		OTR	2	97,343	0	0
Kadmon Holdings Inc	COMM	48283N106	3,136	612,563	SH		OTR	2	612,563	0	0
Kala Pharmaceuticals Inc	COMM	483119103	2,130	202,678	SH		OTR	2	202,678	0	0
Kura Oncology Inc	COMM	50127T109	3,985	244,476	SH		OTR	2	244,476	0	0
Liquidia Technologies Inc	COMM	53635D202	2,694	320,001	SH		OTR	2	320,001	0	0
Menlo Therapeutics Inc	COMM	586858102	502	290,138	SH		OTR	2	290,138	0	0
Merck & Co Inc	COMM	58933Y105	13,918	179,976	SH		OTR	2	179,976	0	0
Mersana Therapeutics Inc	COMM	59045L106	1,289	55,101	SH		OTR	2	55,101	0	0
Mirati Therapeutics Inc	COMM	60468T105	369	3,230	SH		OTR	2	3,230	0	0
Mirum Pharmaceuticals Inc	COMM	604749101	4,216	216,669	SH		OTR	2	216,669	0	0
MyoKardia Inc	COMM	62857M105	4,309	44,599	SH		OTR	2	44,599	0	0
Novocure Ltd	COMM	G6674U908	1,186	20,000	SH	Call	OTR	2	20,000	0	0
Oric Pharmaceuticals Inc	COMM	68622P109	234	6,942	SH		OTR	2	6,942	0	0
Otonomy Inc	COMM	68906L105	2,278	629,404	SH		OTR	2	629,404	0	0
PTC Therapeutics Inc	COMM	69366J200	8,871	174,827	SH		OTR	2	174,827	0	0
PTC Therapeutics Inc	COMM	69366J900	1,218	24,000	SH	Call	OTR	2	24,000	0	0
Pfizer Inc	COMM	717081903	2,289	70,000	SH	Call	OTR	2	70,000	0	0
Protagonist Therapeutics Inc	COMM	74366E102	2,303	130,418	SH		OTR	2	130,418	0	0
Puma Biotechnology Inc	COMM	74587V107	5,009	480,278	SH		OTR	2	480,278	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	813	5,209	SH		OTR	2	5,209	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	249	135,969	SH		OTR	2	135,969	0	0
SPDR Ser Tr	S&P Biotech	78464A950	6,717	60,000	SH	Put	OTR	2	60,000	0	0
Supernus Pharmaceuticals Inc	COMM	868459108	4,532	190,842	SH		OTR	2	190,842	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	535	36,095	SH		OTR	2	36,095	0	0
TG Therapeutics Inc	COMM	88322Q108	5,423	278,370	SH		OTR	2	278,370	0	0
United Therapeutics Corp	COMM	91307C102	14,738	121,805	SH		OTR	2	121,805	0	0
Zymeworks Inc	COMM	98985W102	4,764	132,071	SH		OTR	2	132,071	0	0
iShares Tr	Russell 2000 ETF	464287955	4,009	28,000	SH	Put	OTR	2	28,000	0	0