Sofinnova Investments 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Aclaris Therapeutics, Inc.	Common Stock	00461U105	26,972	1,539,480	SH		SOLE		1,539,480	0	0
Adamas Pharmaceuticals, Inc.	Common Stock	00548A106	387	16,206	SH		SOLE		16,206	0	0
Aduro Biotech, Inc.	Common Stock	00739L101	155	16,694	SH		SOLE		16,694	0	0
Affimed N.V.	Common Stock	N01045108	205	110,834	SH		SOLE		110,834	0	0
Aimmune Therapeutics, Inc.	Common Stock	00900T107	646	20,308	SH		SOLE		20,308	0	0
Alexion Pharmaceuticals, Inc.	Common Stock	015351109	1,017	9,126	SH		SOLE		9,126	0	0
Allergan plc	Common Stock	G0177J108	1,578	9,379	SH		SOLE		9,379	0	0
Amarin Corp PLC	Common Stock	023111206	9,998	3,321,588	SH		SOLE		3,321,588	0	0
Apellis Pharmaceuticals, Inc	Common Stock	03753U106	20,159	911,752	SH		SOLE		911,752	0	0
Ardelyx, Inc.	Common Stock	039697107	501	99,166	SH		SOLE		99,166	0	0
Ascendis Pharma A/S	Common Stock	04351P101	162,160	2,479,514	SH		SOLE		2,479,514	0	0
AstraZeneca PLC	ADRS	046353108	763	21,832	SH		SOLE		21,832	0	0
aTyr Pharma Inc	Common Stock	002120103	4,945	1,866,126	SH		SOLE		1,866,126	0	0
Audentes Therapeutics	Common Stock	05070R104	41,478	1,380,303	SH		SOLE		1,380,303	0	0
Auris Medical Holding AG	Common Shares	H0381L104	1,251	781,818	SH		SOLE		781,818	0	0
Bristol-Myers Squibb Company	Common Stock	110122108	951	15,033	SH		SOLE		15,033	0	0
Calithera Biosciences, Inc.	Common Stock	13089P101	126	19,928	SH		SOLE		19,928	0	0
Catalyst Pharmaceuticals, Inc.	Common Stock	14888U101	354	148,055	SH		SOLE		148,055	0	0
Chiasma, Inc.	Common Stock	16706W102	2,445	1,630,221	SH		SOLE		1,630,221	0	0
Cidara Therapeutics, Inc.	Common Stock	171757107	52	12,952	SH		SOLE		12,952	0	0
Clearside Biomedical, Inc.	Common Stock	185063104	380	35,379	SH		SOLE		35,379	0	0
Coherus BioSciences, Inc.	Common Stock	19249H103	31,970	2,893,221	SH		SOLE		2,893,221	0	0
Dermira, Inc.	Common Stock	24983L104	386	48,320	SH		SOLE		48,320	0	0
Edge Therapeutics, Inc.	Common Stock	279870109	3,366	2,852,711	SH		SOLE		2,852,711	0	0
Exelixis Inc	Common Stock	30161Q104	206	9,300	SH	Call	SOLE		0	0	0
Foamix Pharmaceuticals Ltd.	Common Stock	M46135105	369	72,017	SH		SOLE		72,017	0	0
GW Pharmaceuticals PLC	Common Stock	36197T103	410	3,637	SH		SOLE		3,637	0	0
Heron Therapeutics, Inc.	Common Stock	427746102	832	30,133	SH		SOLE		30,133	0	0
Histogenics Corporation	Common Stock	43358V109	5,712	2,077,040	SH		SOLE		2,077,040	0	0
Ionis Pharmaceuticals, Inc.	Common Stock	462222100	374	8,476	SH		SOLE		8,476	0	0
Iovance Biotherapeutics, Inc.	Common Stock	462260100	523	30,958	SH		SOLE		30,958	0	0
Kadmon Holdings, Inc.	Common Stock	48283N106	539	126,865	SH		SOLE		126,865	0	0
Kadmon Holdings, Inc.	Warrant	48283N106	255	59,909	SH		SOLE		0	0	0
Kala Pharmaceuticals, Inc.	Common Stock	483119103	323	20,409	SH		SOLE		20,409	0	0
MediciNova, Inc.	Common Stock	58468P206	336	32,875	SH		SOLE		32,875	0	0
Merus N.V.	Common Stock	N5749R100	36,338	1,961,039	SH		SOLE		1,961,039	0	0
Mirati Therapeutics, Inc.	Common Stock	60468T105	267	8,688	SH		SOLE		8,688	0	0
Natera, Inc.	Common Stock	632307104	28,742	3,100,560	SH		SOLE		3,100,560	0	0
NuCana plc	American Depositary Shares	67022C106	88,293	4,666,666	SH		SOLE		4,666,666	0	0
ObsEva SA	Common Stock	H5861P103	64,096	4,749,623	SH		SOLE		4,749,623	0	0
OncoMed Pharmaceuticals, Inc.	Common Stock	68234X102	213	67,033	SH		SOLE		67,033	0	0
OncoSec Medical Incorporated	Common Stock	68234L207	126	66,965	SH		SOLE		66,965	0	0
Otonomy, Inc.	Common Stock	68906L105	414	98,624	SH		SOLE		98,624	0	0
PTC Therapeutics, Inc.	Common Stock	69366J200	696	25,729	SH		SOLE		25,729	0	0
Radius Health Inc.	Common Stock	750469207	605	16,847	SH		SOLE		16,847	0	0
Reata Pharmaceuticals Inc	Common Stock	75615P103	603	29,383	SH		SOLE		29,383	0	0
Regeneron Pharmaceuticals, Inc.	Common Stock	75886F107	449	1,304	SH		SOLE		1,304	0	0
Rigel Pharmaceuticals, Inc	Common Stock	766559603	252	71,300	SH	Put	SOLE		71,300	0	0
Rigel Pharmaceuticals, Inc.	Common Stock	766559603	365	102,974	SH		SOLE		102,974	0	0
Sierra Oncology, Inc.	Common Stock	82640U107	203	98,126	SH		SOLE		98,126	0	0
Spark Therapeutics, Inc.	Common Stock	84652J103	32,048	481,270	SH		SOLE		481,270	0	0
Spectrum Pharmaceuticals Inc.	Common Stock	84763A108	241	15,000	SH	Call	SOLE		0	0	0
Stemline Therapeutics INC	Common Stock	85858C107	193	12,640	SH		SOLE		12,640	0	0
Syndax Pharmaceuticals, Inc.	Common Stock	87164F105	173	12,124	SH		SOLE		12,124	0	0
Synlogic, Inc.	Common Stock	87166L100	5,393	574,972	SH		SOLE		574,972	0	0