Sofinnova Investments 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Aclaris Therapeutics	Common Shares	00461U105	22,353	1,539,480	SH		SOLE		1,539,480	0	0
Amarin	Ordinary Shares	023111206	0	1	SH		SOLE		1	0	0
Amarin	Common Shares - ADR	023111206	84,739	5,208,305	SH		SOLE		5,208,305	0	0
Apellis Pharmaceuticals, Inc	Common Shares	03753U106	9,772	549,580	SH		SOLE		549,580	0	0
Ascendis Pharma A/S	Ordinary Shares	04351P101	104,942	1,480,976	SH		SOLE		1,480,976	0	0
Ascendis Pharma A/S	Common Shares - ADR	04351P101	70,756	998,538	SH		SOLE		998,538	0	0
Audentes Therapeutics	Common Shares	05070R104	36,963	933,640	SH		SOLE		933,640	0	0
Auris Medical Holding AG	Warrant(s)	H0381L104	0	140,000	SH		SOLE		140,000	0	0
Chiasma	Common Shares	16706W102	5,869	1,630,221	SH		SOLE		1,630,221	0	0
Chiasma	Warrant(s)	16706W102	0	136,881	SH		SOLE		136,881	0	0
Coherus BioSciences	Common Shares	19249H103	47,326	2,868,221	SH		SOLE		2,868,221	0	0
Edge Therapeutics	Common Shares	279870109	2,339	2,852,711	SH		SOLE		2,852,711	0	0
Entasis Therapeutics Holdings Inc.	Common Shares	293614103	12,840	1,180,178	SH		SOLE		1,180,178	0	0
Histogenics	Common Shares	43358V109	1,132	2,077,040	SH		SOLE		2,077,040	0	0
Iterum Therapeutics	Common Shares	G6333L101	11,438	1,726,514	SH		SOLE		1,726,514	0	0
Kiniksa Pharmaceuticals, Ltd	Common Shares - Class A	G5269C101	23,529	922,700	SH		SOLE		922,700	0	0
Merus N.V.	Common Shares	N5749R100	38,711	1,961,039	SH		SOLE		1,961,039	0	0
Natera	Common Shares	632307104	74,227	3,100,560	SH		SOLE		3,100,560	0	0
Nucana Biomed	Ordinary Shares	GB00BYWYV	99,680	4,000,000	SH		SOLE		4,000,000	0	0
Nucana Biomed	Common Shares - ADR	67022C106	16,613	666,666	SH		SOLE		666,666	0	0
ObsEva SA	Common Shares	H5861P103	85,636	4,749,623	SH		SOLE		4,749,623	0	0
Principia Biopharma	Common Shares	74257L108	59,556	2,038,208	SH		SOLE		2,038,208	0	0
Principia Biopharma	Warrant(s)	74257L108	0	20,938	SH		SOLE		20,938	0	0
Spark Therapeutics	Common Shares	84652J103	26,253	481,270	SH		SOLE		481,270	0	0
Synlogic Inc. (fmrly Mirna)	Common Shares	87166L100	8,170	574,972	SH		SOLE		574,972	0	0
Y-mAbs Therapeutics, Inc	Common Shares	984241109	55,890	2,104,278	SH		SOLE		2,104,278	0	0
Adamas Pharmaceuticals Inc	COMM	00548A106	976	48,743	SH		SOLE		48,743	0	0
Adaptimmune Therapeutics PLC	ADR	00653A107	172	12,678	SH		SOLE		12,678	0	0
Aduro Biotech Inc	COMM	00739L101	196	26,712	SH		SOLE		26,712	0	0
Aimmune Therapeutics Inc	COMM	00900T107	853	31,263	SH		SOLE		31,263	0	0
Alexion Pharmaceuticals Inc	COMM	015351109	1,278	9,196	SH		SOLE		9,196	0	0
Allergan plc	COMM	G0177J108	2,577	13,529	SH		SOLE		13,529	0	0
Amicus Therapeutics Inc	COMM	03152W109	760	62,834	SH		SOLE		62,834	0	0
AnaptysBio Inc	COMM	032724106	979	9,808	SH		SOLE		9,808	0	0
ArQule Inc	COMM	04269E107	304	53,734	SH		SOLE		53,734	0	0
AstraZeneca PLC	ADR	046353108	1,344	33,965	SH		SOLE		33,965	0	0
AstraZeneca PLC	COMM	046353108	1,080	27,300	SH	Call	SOLE		27,300	0	0
Biohaven Pharmaceutical Holding Company Ltd	COMM	G11196105	705	18,784	SH		SOLE		18,784	0	0
Blueprint Medicines Corp	COMM	09627Y109	565	7,240	SH		SOLE		7,240	0	0
Catalyst Pharmaceuticals Inc	COMM	14888U101	675	178,518	SH		SOLE		178,518	0	0
Clearside Biomedical Inc	COMM	185063104	526	85,510	SH		SOLE		85,510	0	0
Conatus Pharmaceuticals Inc	COMM	20600T108	441	76,034	SH		SOLE		76,034	0	0
Dermira Inc	COMM	24983L104	761	69,798	SH		SOLE		69,798	0	0
Epizyme Inc	COMM	29428V104	435	41,084	SH		SOLE		41,084	0	0
Esperion Therapeutics Inc	COMM	29664W105	229	5,165	SH		SOLE		5,165	0	0
Exelixis Inc	COMM	30161Q104	1,009	56,960	SH		SOLE		56,960	0	0
Fate Therapeutics Inc	COMM	31189P102	241	14,800	SH		SOLE		14,800	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	540	94,204	SH		SOLE		94,204	0	0
Heron Therapeutics Inc	COMM	427746102	1,318	41,646	SH		SOLE		41,646	0	0
Kadmon Holdings Inc	COMM	48283N106	639	191,168	SH		SOLE		191,168	0	0
Kadmon Holdings Inc	Warrant	48283N106	0	59,909	SH		SOLE		59,909	0	0
Kala Pharmaceuticals Inc	COMM	483119103	133	13,472	SH		SOLE		13,472	0	0
Kura Oncology Inc	COMM	50127T109	605	34,568	SH		SOLE		34,568	0	0
Molecular Partners AG	COMM	H55351102	652	29,092	SH		SOLE		29,092	0	0
MorphoSys AG	COMM	D55040105	452	4,227	SH		SOLE		4,227	0	0
OncoMed Pharmaceuticals Inc	COMM	68234X102	146	68,899	SH		SOLE		68,899	0	0
Otonomy Inc	COMM	68906L105	296	107,674	SH		SOLE		107,674	0	0
Puma Biotechnology Inc	COMM	74587V107	2,176	47,458	SH		SOLE		47,458	0	0
Rhythm Pharmaceuticals Inc	COMM	76243J105	646	22,162	SH		SOLE		22,162	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	1,475	459,442	SH		SOLE		459,442	0	0
Sanofi SA	ADR	80105N105	2,598	58,153	SH		SOLE		58,153	0	0
Sarepta Therapeutics Inc	COMM	803607100	682	4,221	SH		SOLE		4,221	0	0
Savara Inc	COMM	805111101	1,084	97,138	SH		SOLE		97,138	0	0
Spring Bank Pharmaceuticals Inc	COMM	849431101	325	26,954	SH		SOLE		26,954	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	197	24,405	SH		SOLE		24,405	0	0
TESARO Inc	COMM	881569107	1,230	31,533	SH		SOLE		31,533	0	0
Adamas Pharmaceuticals Inc	COMM	00548A106	3,888	194,205	SH		OTR	2	194,205	0	0
Adaptimmune Therapeutics PLC	ADR	00653A107	685	50,488	SH		OTR	2	50,488	0	0
Aduro Biotech Inc	COMM	00739L101	783	106,483	SH		OTR	2	106,483	0	0
Aimmune Therapeutics Inc	COMM	00900T107	3,425	125,554	SH		OTR	2	125,554	0	0
Alexion Pharmaceuticals Inc	COMM	015351109	5,104	36,718	SH		OTR	2	36,718	0	0
Allergan plc	COMM	G0177J108	10,273	53,932	SH		OTR	2	53,932	0	0
Amicus Therapeutics Inc	COMM	03152W109	3,028	250,487	SH		OTR	2	250,487	0	0
AnaptysBio Inc	COMM	032724106	3,901	39,101	SH		OTR	2	39,101	0	0
ArQule Inc	COMM	04269E107	1,240	218,997	SH		OTR	2	218,997	0	0
AstraZeneca PLC	ADR	046353108	5,348	135,164	SH		OTR	2	135,164	0	0
AstraZeneca PLC	COMM	046353108	4,297	108,600	SH	Call	OTR	2	108,600	0	0
Biohaven Pharmaceutical Holding Company Ltd	COMM	G11196105	2,807	74,751	SH		OTR	2	74,751	0	0
Blueprint Medicines Corp	COMM	09627Y109	2,251	28,831	SH		OTR	2	28,831	0	0
Catalyst Pharmaceuticals Inc	COMM	14888U101	3,337	882,791	SH		OTR	2	882,791	0	0
Clearside Biomedical Inc	COMM	185063104	2,096	340,885	SH		OTR	2	340,885	0	0
Conatus Pharmaceuticals Inc	COMM	20600T108	1,756	302,678	SH		OTR	2	302,678	0	0
Dermira Inc	COMM	24983L104	3,032	278,167	SH		OTR	2	278,167	0	0
Epizyme Inc	COMM	29428V104	1,734	163,615	SH		OTR	2	163,615	0	0
Esperion Therapeutics Inc	COMM	29664W105	912	20,547	SH		OTR	2	20,547	0	0
Exelixis Inc	COMM	30161Q104	4,017	226,685	SH		OTR	2	226,685	0	0
Fate Therapeutics Inc	COMM	31189P102	960	58,907	SH		OTR	2	58,907	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	2,152	375,543	SH		OTR	2	375,543	0	0
Heron Therapeutics Inc	COMM	427746102	5,255	166,024	SH		OTR	2	166,024	0	0
Kadmon Holdings Inc	COMM	48283N106	3,199	957,858	SH		OTR	2	957,858	0	0
Kala Pharmaceuticals Inc	COMM	483119103	537	54,373	SH		OTR	2	54,373	0	0
Kura Oncology Inc	COMM	50127T109	2,446	139,775	SH		OTR	2	139,775	0	0
Molecular Partners AG	COMM	H55351102	2,596	115,868	SH		OTR	2	115,868	0	0
MorphoSys AG	COMM	D55040105	1,802	16,850	SH		OTR	2	16,850	0	0
OncoMed Pharmaceuticals Inc	COMM	68234X102	251	118,257	SH		OTR	2	118,257	0	0
Otonomy Inc	COMM	68906L105	1,602	582,545	SH		OTR	2	582,545	0	0
Puma Biotechnology Inc	COMM	74587V107	8,674	189,190	SH		OTR	2	189,190	0	0
Rhythm Pharmaceuticals Inc	COMM	76243J105	2,634	90,312	SH		OTR	2	90,312	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	5,879	1,831,567	SH		OTR	2	1,831,567	0	0
Sanofi SA	ADR	80105N105	10,356	231,827	SH		OTR	2	231,827	0	0
Sarepta Therapeutics Inc	COMM	803607100	2,714	16,801	SH		OTR	2	16,801	0	0
Savara Inc	COMM	805111101	4,418	395,834	SH		OTR	2	395,834	0	0
Spring Bank Pharmaceuticals Inc	COMM	849431101	1,294	107,422	SH		OTR	2	107,422	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	785	97,183	SH		OTR	2	97,183	0	0
TESARO Inc	COMM	881569107	4,901	125,637	SH		OTR	2	125,637	0	0
Adamas Pharmaceuticals Inc	COMM	00548A106	2,058	102,808	SH		OTR	1	102,808	0	0
Adaptimmune Therapeutics PLC	ADR	00653A107	363	26,753	SH		OTR	1	26,753	0	0
Aduro Biotech Inc	COMM	00739L101	414	56,384	SH		OTR	1	56,384	0	0
Aimmune Therapeutics Inc	COMM	00900T107	1,786	65,478	SH		OTR	1	65,478	0	0
Alexion Pharmaceuticals Inc	COMM	015351109	2,703	19,446	SH		OTR	1	19,446	0	0
Allergan plc	COMM	G0177J108	5,440	28,560	SH		OTR	1	28,560	0	0
Amicus Therapeutics Inc	COMM	03152W109	1,604	132,648	SH		OTR	1	132,648	0	0
AnaptysBio Inc	COMM	032724106	2,066	20,706	SH		OTR	1	20,706	0	0
ArQule Inc	COMM	04269E107	643	113,540	SH		OTR	1	113,540	0	0
AstraZeneca PLC	ADR	046353108	2,828	71,479	SH		OTR	1	71,479	0	0
AstraZeneca PLC	COMM	046353108	2,275	57,500	SH	Call	OTR	1	57,500	0	0
Biohaven Pharmaceutical Holding Company Ltd	COMM	G11196105	1,484	39,531	SH		OTR	1	39,531	0	0
Blueprint Medicines Corp	COMM	09627Y109	1,192	15,268	SH		OTR	1	15,268	0	0
Catalyst Pharmaceuticals Inc	COMM	14888U101	1,846	488,243	SH		OTR	1	488,243	0	0
Clearside Biomedical Inc	COMM	185063104	1,110	180,519	SH		OTR	1	180,519	0	0
Conatus Pharmaceuticals Inc	COMM	20600T108	929	160,203	SH		OTR	1	160,203	0	0
Dermira Inc	COMM	24983L104	1,606	147,328	SH		OTR	1	147,328	0	0
Epizyme Inc	COMM	29428V104	918	86,619	SH		OTR	1	86,619	0	0
Esperion Therapeutics Inc	COMM	29664W105	483	10,887	SH		OTR	1	10,887	0	0
Exelixis Inc	COMM	30161Q104	2,125	119,949	SH		OTR	1	119,949	0	0
Fate Therapeutics Inc	COMM	31189P102	508	31,184	SH		OTR	1	31,184	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	1,140	198,872	SH		OTR	1	198,872	0	0
Heron Therapeutics Inc	COMM	427746102	2,783	87,919	SH		OTR	1	87,919	0	0
Kadmon Holdings Inc	COMM	48283N106	1,314	393,476	SH		OTR	1	393,476	0	0
Kadmon Holdings Inc	Warrant	48283N106	0	240,091	SH		OTR	1	240,091	0	0
Kala Pharmaceuticals Inc	COMM	483119103	274	27,810	SH		OTR	1	27,810	0	0
Kura Oncology Inc	COMM	50127T109	1,278	73,042	SH		OTR	1	73,042	0	0
MorphoSys AG	COMM	D55040105	954	8,923	SH		OTR	1	8,923	0	0
OncoMed Pharmaceuticals Inc	COMM	68234X102	442	208,588	SH		OTR	1	208,588	0	0
Otonomy Inc	COMM	68906L105	818	297,559	SH		OTR	1	297,559	0	0
Puma Biotechnology Inc	COMM	74587V107	4,594	100,187	SH		OTR	1	100,187	0	0
Rhythm Pharmaceuticals Inc	COMM	76243J105	1,366	46,828	SH		OTR	1	46,828	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	3,113	969,922	SH		OTR	1	969,922	0	0
Sanofi SA	ADR	80105N105	5,484	122,766	SH		OTR	1	122,766	0	0
Sarepta Therapeutics Inc	COMM	803607100	1,436	8,893	SH		OTR	1	8,893	0	0
Savara Inc	COMM	805111101	2,291	205,253	SH		OTR	1	205,253	0	0
Spring Bank Pharmaceuticals Inc	COMM	849431101	666	55,270	SH		OTR	1	55,270	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	416	51,524	SH		OTR	1	51,524	0	0
TESARO Inc	COMM	881569107	2,594	66,505	SH		OTR	1	66,505	0	0