Sofinnova Investments 13F-HR/A Quarterly holdings report by institutional manager (amended)

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Adamas Pharmaceuticals Inc	COMM	00548A106	754	29,192	SH		SOLE		29,192	0	0
Aduro Biotech Inc	COMM	00739L101	174	24,857	SH		SOLE		24,857	0	0
Aimmune Therapeutics Inc	COMM	00900T107	1,036	38,528	SH		SOLE		38,528	0	0
Alexion Pharmaceuticals Inc	COMM	015351109	1,800	14,498	SH		SOLE		14,498	0	0
Allergan plc	COMM	G0177J108	1,916	11,490	SH		SOLE		11,490	0	0
AMAG Pharmaceuticals Inc	COMM	00163U106	287	14,695	SH		SOLE	1	14,695	0	0
AstraZeneca PLC	ADR	046353108	1,193	33,981	SH		SOLE		33,981	0	0
bluebird bio Inc	COMM	09609G100	896	5,707	SH		SOLE		5,707	0	0
Blueprint Medicines Corp	COMM	09627Y109	603	9,499	SH		SOLE		9,499	0	0
Calithera Biosciences Inc	COMM	13089P101	153	30,622	SH		SOLE		30,622	0	0
Catalyst Pharmaceuticals Inc	COMM	14888U101	503	161,089	SH		SOLE		161,089	0	0
Celgene Corp	COMM	151020104	1,510	19,014	SH		SOLE		19,014	0	0
ChemoCentryx Inc	COMM	16383L106	90	6,836	SH		SOLE		6,836	0	0
Clearside Biomedical Inc	COMM	185063104	477	44,620	SH		SOLE		44,620	0	0
Conatus Pharmaceuticals Inc	COMM	20600T108	380	88,742	SH		SOLE		88,742	0	0
CRISPR Therapeutics AG	COMM	H17182108	1,210	20,600	SH	Put	SOLE		20,600	0	0
Dermira Inc	COMM	24983L104	345	37,543	SH		SOLE		37,543	0	0
Esperion Therapeutics Inc	COMM	29664W105	610	15,571	SH		SOLE		15,571	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	361	72,017	SH		SOLE		72,017	0	0
Forty Seven Inc	COMM	34983P104	39	2,442	SH		SOLE		2,442	0	0
GW Pharmaceuticals PLC	ADR	36197T103	907	6,497	SH		SOLE		6,497	0	0
Heron Therapeutics Inc	COMM	427746102	1,035	26,644	SH		SOLE		26,644	0	0
Innate Pharma SA	COMM	F5277D100	62	11,418	SH		SOLE		11,418	0	0
Intercept Pharmaceuticals Inc	COMM	45845P108	923	11,005	SH		SOLE		11,005	0	0
Kadmon Holdings Inc	COMM	48283N106	552	138,249	SH		SOLE		138,249	0	0
Kadmon Holdings Inc	Warrant	48283N106	38	59,909	SH		SOLE		59,909	0	0
Kala Pharmaceuticals Inc	COMM	483119103	443	32,248	SH		SOLE		32,248	0	0
Kura Oncology Inc	COMM	50127T109	315	17,295	SH		SOLE		17,295	0	0
OncoMed Pharmaceuticals Inc	COMM	68234X102	159	68,899	SH		SOLE		68,899	0	0
Otonomy Inc	COMM	68906L105	385	99,874	SH		SOLE		99,874	0	0
PTC Therapeutics Inc	COMM	69366J200	442	13,104	SH		SOLE		13,104	0	0
Puma Biotechnology Inc	COMM	74587V107	378	6,384	SH		SOLE		6,384	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	325	9,307	SH		SOLE		9,307	0	0
Rhythm Pharmaceuticals Inc	COMM	76243J105	452	14,452	SH		SOLE		14,452	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	663	234,107	SH		SOLE		234,107	0	0
Sarepta Therapeutics Inc	COMM	803607100	659	4,986	SH		SOLE		4,986	0	0
Savara Inc	COMM	805111101	299	26,441	SH		SOLE		26,441	0	0
Spectrum Pharmaceuticals Inc	COMM	84763A108	367	17,488	SH		SOLE		17,488	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	87	12,354	SH		SOLE		12,354	0	0
AMAG Pharmaceuticals Inc	COMM	00163U106	814	41,727	SH		OTR		41,727	0	0
Adamas Pharmaceuticals Inc	COMM	00548A106	2,142	82,912	SH		OTR	1	82,912	0	0
Aduro Biotech Inc	COMM	00739L101	494	70,601	SH		OTR	1	70,601	0	0
Aimmune Therapeutics Inc	COMM	00900T107	2,944	109,496	SH		OTR	1	109,496	0	0
Alexion Pharmaceuticals Inc	COMM	015351109	5,112	41,179	SH		OTR	1	41,179	0	0
Allergan plc	COMM	G0177J108	5,441	32,635	SH		OTR	1	32,635	0	0
AstraZeneca PLC	ADR	046353108	3,387	96,478	SH		OTR	1	96,478	0	0
Blueprint Medicines Corp	COMM	09627Y109	1,713	26,979	SH		OTR	1	26,979	0	0
CRISPR Therapeutics AG	COMM	H17182108	3,437	58,500	SH	Put	OTR	1	58,500	0	0
Calithera Biosciences Inc	COMM	13089P101	435	86,939	SH		OTR	1	86,939	0	0
Catalyst Pharmaceuticals Inc	COMM	14888U101	1,523	488,243	SH		OTR	1	488,243	0	0
Celgene Corp	COMM	151020104	4,288	53,991	SH		OTR	1	53,991	0	0
ChemoCentryx Inc	COMM	16383L106	257	19,514	SH		OTR	1	19,514	0	0
Clearside Biomedical Inc	COMM	185063104	1,354	126,652	SH		OTR	1	126,652	0	0
Conatus Pharmaceuticals Inc	COMM	20600T108	1,082	252,723	SH		OTR	1	252,723	0	0
Dermira Inc	COMM	24983L104	981	106,593	SH		OTR	1	106,593	0	0
Esperion Therapeutics Inc	COMM	29664W105	1,733	44,224	SH		OTR	1	44,224	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	1,091	217,670	SH		OTR	1	217,670	0	0
Forty Seven Inc	COMM	34983P104	111	6,935	SH		OTR	1	6,935	0	0
GW Pharmaceuticals PLC	ADR	36197T103	2,575	18,452	SH		OTR	1	18,452	0	0
Heron Therapeutics Inc	COMM	427746102	2,939	75,645	SH		OTR	1	75,645	0	0
Innate Pharma SA	COMM	F5277D100	177	32,422	SH		OTR	1	32,422	0	0
Intercept Pharmaceuticals Inc	COMM	45845P108	2,622	31,248	SH		OTR	1	31,248	0	0
Kadmon Holdings Inc	COMM	48283N106	1,570	393,476	SH		OTR	1	393,476	0	0
Kadmon Holdings Inc	Warrant	48283N106	154	240,091	SH		OTR	1	240,091	0	0
Kala Pharmaceuticals Inc	COMM	483119103	1,259	91,662	SH		OTR	1	91,662	0	0
Kura Oncology Inc	COMM	50127T109	894	49,121	SH		OTR	1	49,121	0	0
OncoMed Pharmaceuticals Inc	COMM	68234X102	483	209,088	SH		OTR	1	209,088	0	0
Otonomy Inc	COMM	68906L105	1,146	297,559	SH		OTR	1	297,559	0	0
PTC Therapeutics Inc	COMM	69366J200	1,255	37,203	SH		OTR	1	37,203	0	0
Puma Biotechnology Inc	COMM	74587V107	1,073	18,132	SH		OTR	1	18,132	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	925	26,439	SH		OTR	1	26,439	0	0
Rhythm Pharmaceuticals Inc	COMM	76243J105	1,283	41,047	SH		OTR	1	41,047	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	1,882	664,917	SH		OTR	1	664,917	0	0
Sarepta Therapeutics Inc	COMM	803607100	1,872	14,160	SH		OTR	1	14,160	0	0
Savara Inc	COMM	805111101	850	75,099	SH		OTR	1	75,099	0	0
Spectrum Pharmaceuticals Inc	COMM	84763A108	1,043	49,743	SH		OTR	1	49,743	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	246	35,027	SH		OTR	1	35,027	0	0
bluebird bio Inc	COMM	09609G100	2,544	16,209	SH		OTR	1	16,209	0	0
AMAG Pharmaceuticals Inc	COMM	00163U106	1,679	86,089	SH		OTR	2	86,089	0	0
Adamas Pharmaceuticals Inc	COMM	00548A106	4,425	171,294	SH		OTR	2	171,294	0	0
Aduro Biotech Inc	COMM	00739L101	1,021	145,860	SH		OTR	2	145,860	0	0
Aimmune Therapeutics Inc	COMM	00900T107	6,105	227,020	SH		OTR	2	227,020	0	0
Alexion Pharmaceuticals Inc	COMM	015351109	10,562	85,075	SH		OTR	2	85,075	0	0
Allergan plc	COMM	G0177J108	11,241	67,425	SH		OTR	2	67,425	0	0
AstraZeneca PLC	ADR	046353108	6,999	199,341	SH		OTR	2	199,341	0	0
Blueprint Medicines Corp	COMM	09627Y109	3,537	55,722	SH		OTR	2	55,722	0	0
CRISPR Therapeutics AG	COMM	H17182108	7,104	120,900	SH	Put	OTR	2	120,900	0	0
Calithera Biosciences Inc	COMM	13089P101	898	179,662	SH		OTR	2	179,662	0	0
Catalyst Pharmaceuticals Inc	COMM	14888U101	2,498	800,625	SH		OTR	2	800,625	0	0
Celgene Corp	COMM	151020104	8,847	111,394	SH		OTR	2	111,394	0	0
ChemoCentryx Inc	COMM	16383L106	552	41,908	SH		OTR	2	41,908	0	0
Clearside Biomedical Inc	COMM	185063104	2,797	261,632	SH		OTR	2	261,632	0	0
Conatus Pharmaceuticals Inc	COMM	20600T108	2,214	517,385	SH		OTR	2	517,385	0	0
Dermira Inc	COMM	24983L104	2,026	220,204	SH		OTR	2	220,204	0	0
Esperion Therapeutics Inc	COMM	29664W105	3,581	91,366	SH		OTR	2	91,366	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	1,967	392,712	SH		OTR	2	392,712	0	0
Forty Seven Inc	COMM	34983P104	229	14,323	SH		OTR	2	14,323	0	0
GW Pharmaceuticals PLC	ADR	36197T103	5,319	38,121	SH		OTR	2	38,121	0	0
Heron Therapeutics Inc	COMM	427746102	6,072	156,296	SH		OTR	2	156,296	0	0
Innate Pharma SA	COMM	F5277D100	365	66,948	SH		OTR	2	66,948	0	0
Intercept Pharmaceuticals Inc	COMM	45845P108	5,418	64,564	SH		OTR	2	64,564	0	0
Kadmon Holdings Inc	COMM	48283N106	3,742	937,858	SH		OTR	2	937,858	0	0
Kala Pharmaceuticals Inc	COMM	483119103	2,464	179,466	SH		OTR	2	179,466	0	0
Kura Oncology Inc	COMM	50127T109	1,847	101,484	SH		OTR	2	101,484	0	0
OncoMed Pharmaceuticals Inc	COMM	68234X102	273	118,257	SH		OTR	2	118,257	0	0
Otonomy Inc	COMM	68906L105	2,243	582,545	SH		OTR	2	582,545	0	0
PTC Therapeutics Inc	COMM	69366J200	2,590	76,772	SH		OTR	2	76,772	0	0
Puma Biotechnology Inc	COMM	74587V107	2,213	37,420	SH		OTR	2	37,420	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	1,894	54,163	SH		OTR	2	54,163	0	0
Rhythm Pharmaceuticals Inc	COMM	76243J105	2,651	84,801	SH		OTR	2	84,801	0	0
Rigel Pharmaceuticals Inc	COMM	766559603	3,888	1,373,703	SH		OTR	2	1,373,703	0	0
Sarepta Therapeutics Inc	COMM	803607100	3,867	29,254	SH		OTR	2	29,254	0	0
Savara Inc	COMM	805111101	1,756	155,152	SH		OTR	2	155,152	0	0
Spectrum Pharmaceuticals Inc	COMM	84763A108	2,153	102,734	SH		OTR	2	102,734	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	360	51,232	SH		OTR	2	51,232	0	0
bluebird bio Inc	COMM	09609G100	5,251	33,455	SH		OTR	2	33,455	0	0
Aclaris Therapeutics	Common Shares	00461U105	30,743	1,539,480	SH		SOLE		1,539,480	0	0
Amarin	American Depositary Shares	023111206	10,264	3,321,587	SH		SOLE		3,321,587	0	0
Amarin	Ordinary Shares	023111206	0	1	SH		SOLE		1	0	0
Amarin	Series A Preferred Stock	023111PR2	12,010	3,886,718	SH		SOLE		3,886,718	0	0
Apellis Pharmaceuticals, Inc	Common Shares	03753U106	13,548	615,802	SH		SOLE		615,802	0	0
Ascendis Pharma A/S	American Depositary Shares	04351P101	66,423	998,538	SH		SOLE		998,538	0	0
Ascendis Pharma A/S	Ordinary Shares	04351P101	98,515	1,480,976	SH		SOLE		1,480,976	0	0
Audentes Therapeutics	Common Shares	05070R104	35,674	933,640	SH		SOLE		933,640	0	0
Auris Medical Holding AG (frmlyAuris Medical)	Warrant(s)	H0381L104	0	140,000	SH		SOLE		140,000	0	0
Chiasma	Common Shares	16706W102	2,445	1,630,221	SH		SOLE		1,630,221	0	0
Chiasma	Warrant(s)	16706W102	0	136,881	SH		SOLE		136,881	0	0
Coherus BioSciences (frmly Intekrin)	Common Shares	19249H103	40,505	2,893,221	SH		SOLE		2,893,221	0	0
Edge Therapeutics	Common Shares	279870109	2,938	2,852,711	SH		SOLE		2,852,711	0	0
Histogenics	Common Shares	43358V109	5,193	2,077,040	SH		SOLE		2,077,040	0	0
Iterum Therapeutics	Common Shares	G6333L101	18,802	1,726,514	SH		SOLE		1,726,514	0	0
Kiniksa Pharmaceuticals, Ltd	Common Stock Class A	G5269C101	16,009	922,700	SH		SOLE		922,700	0	0
Merus N.V.	Common Shares	N5749R100	44,633	1,961,039	SH		SOLE		1,961,039	0	0
Natera	Common Shares	632307104	58,353	3,100,560	SH		SOLE		3,100,560	0	0
Nucana Biomed	American Depositary Shares	67022C106	12,667	666,666	SH		SOLE		666,666	0	0
Nucana Biomed	Ordinary Shares	GB00BYWYV	76,000	4,000,000	SH		SOLE		4,000,000	0	0
ObsEva SA	Common Shares	H5861P103	71,909	4,749,623	SH		SOLE		4,749,623	0	0
Spark Therapeutics	Common Shares	84652J103	39,830	481,270	SH		SOLE		481,270	0	0
Synlogic Inc. (fmrly Mirna)	Common Shares	87166L100	5,652	574,972	SH		SOLE		574,972	0	0