Sofinnova Investments 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Aclaris Therapeutics	COMM	00461U105	4,186	1,911,573	SH		SOLE		1,911,573	0	0
Amarin	ADR	023111206	100,989	5,208,305	SH		SOLE		5,208,305	0	0
Apellis Pharmaceuticals, Inc	COMM	03753U106	1,256	49,580	SH		SOLE		49,580	0	0
Ascendis Pharma A/S	ADR	04351P101	126,645	1,099,824	SH		SOLE		1,099,824	0	0
Audentes Therapeutics	COMM	05070R104	35,348	933,640	SH		SOLE		933,640	0	0
Chiasma	COMM	16706W102	12,178	1,630,221	SH		SOLE		1,630,221	0	0
Coherus BioSciences	COMM	19249H103	46,260	2,093,221	SH		SOLE		2,093,221	0	0
Entasis Therapeutics Holdings Inc.	COMM	293614103	7,612	1,180,178	SH		SOLE		1,180,178	0	0
Iterum Therapeutics	COMM	G6333L101	11,878	1,726,514	SH		SOLE		1,726,514	0	0
Karuna Therapeutics, Inc.	COMM	48576A100	34,622	1,729,352	SH		SOLE		1,729,352	0	0
Kiniksa Pharmaceuticals, Ltd	COMM CL A	G5269C101	12,493	922,700	SH		SOLE		922,700	0	0
Merus N.V.	COMM	N5749R100	28,729	1,961,039	SH		SOLE		1,961,039	0	0
Natera	COMM	632307104	85,513	3,100,560	SH		SOLE		3,100,560	0	0
Nextcure, Inc	COMM	65343E108	37,777	2,521,856	SH		SOLE		2,521,856	0	0
Nucana Biomed Ltd	ADR	67022C106	23,528	2,266,666	SH		SOLE		2,266,666	0	0
Nucana Biomed Ltd	Ordinary Shares	GB00BYWYV	24,912	2,400,000	SH		SOLE		2,400,000	0	0
ObsEva SA	COMM	H5861P103	53,718	4,749,623	SH		SOLE		4,749,623	0	0
PDS Biotechnology Corporation	COMM	70465T107	854	142,635	SH		SOLE		142,635	0	0
Principia Biopharma	COMM	74257L108	67,648	2,038,208	SH		SOLE		2,038,208	0	0
Spark Therapeutics	COMM	84652J103	49,272	481,270	SH		SOLE		481,270	0	0
Synlogic Inc.	COMM	87166L100	5,232	574,972	SH		SOLE		574,972	0	0
Y-mAbs Therapeutics, Inc	COMM	984241109	48,125	2,104,278	SH		SOLE		2,104,278	0	0
ACADIA Pharmaceuticals Inc	COMM	004225108	1,493	55,850	SH		SOLE		55,850	0	0
AbbVie Inc	COMM	00287Y109	753	10,352	SH		SOLE		10,352	0	0
Acceleron Pharma Inc	COMM	00434H108	3,570	86,908	SH		SOLE		86,908	0	0
Acorda Therapeutics Inc	COMM	00484M106	537	70,066	SH		SOLE		70,066	0	0
Adverum Biotechnologies Inc	COMM	00773U108	802	67,444	SH		SOLE		67,444	0	0
Akebia Therapeutics Inc	COMM	00972D105	1,475	304,787	SH		SOLE		304,787	0	0
Allergan plc	COMM	G0177J108	5,103	30,481	SH		SOLE		30,481	0	0
Allergan plc	COMM	G0177J908	3,014	18,000	SH	Call	SOLE		18,000	0	0
Alnylam Pharmaceuticals Inc	COMM	02043Q107	725	9,994	SH		SOLE		9,994	0	0
Amgen Inc	COMM	031162950	3,317	18,000	SH	Put	SOLE		18,000	0	0
Amicus Therapeutics Inc	COMM	03152W109	3,032	242,971	SH		SOLE		242,971	0	0
Applied Therapeutics Inc	COMM	03828A101	415	50,350	SH		SOLE		50,350	0	0
ArQule Inc	COMM	04269E107	1,114	101,215	SH		SOLE		101,215	0	0
Autolus Therapeutics PLC	ADR	05280R100	380	23,616	SH		SOLE		23,616	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	583	153,942	SH		SOLE		153,942	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	2,572	30,029	SH		SOLE		30,029	0	0
Bristol-Myers Squibb Co	COMM	110122908	1,628	35,900	SH	Call	SOLE		35,900	0	0
Bristol-Myers Squibb Co	COMM	110122108	2,828	62,368	SH		SOLE		62,368	0	0
Calithera Biosciences Inc	COMM	13089P101	741	190,075	SH		SOLE		190,075	0	0
Clovis Oncology Inc	COMM	189464100	669	44,966	SH		SOLE		44,966	0	0
Deciphera Pharmaceuticals Inc	COMM	24344T951	810	35,900	SH	Put	SOLE		35,900	0	0
Dermira Inc	COMM	24983L104	2,263	236,746	SH		SOLE		236,746	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	973	408,895	SH		SOLE		408,895	0	0
Forty Seven Inc	COMM	34983P104	452	42,665	SH		SOLE		42,665	0	0
Halozyme Therapeutics Inc	COMM	40637H109	4,200	244,475	SH		SOLE		244,475	0	0
Heron Therapeutics Inc	COMM	427746102	4,134	222,360	SH		SOLE		222,360	0	0
Incyte Corp	COMM	45337C102	2,124	24,998	SH		SOLE		24,998	0	0
Intra-Cellular Therapies Inc	COMM	46116X901	819	63,100	SH	Call	SOLE		63,100	0	0
Intra-Cellular Therapies Inc	COMM	46116X101	588	45,291	SH		SOLE		45,291	0	0
Kadmon Holdings Inc	COMM	48283N106	1,601	777,390	SH		SOLE		777,390	0	0
Kala Pharmaceuticals Inc	COMM	483119103	671	105,105	SH		SOLE		105,105	0	0
MacroGenics Inc	COMM	556099109	3,360	197,969	SH		SOLE		197,969	0	0
MorphoSys AG	COMM	D55040105	3,315	34,528	SH		SOLE		34,528	0	0
Neurocrine Biosciences Inc	COMM	64125C109	4,721	55,921	SH		SOLE		55,921	0	0
Novo Nordisk A/S	ADR	670100205	5,931	116,204	SH		SOLE		116,204	0	0
Orchard Therapeutics PLC	ADR	68570P101	1,795	128,298	SH		SOLE		128,298	0	0
Osmotica Pharmaceuticals PLC	COMM	G6S41R101	707	186,030	SH		SOLE		186,030	0	0
Otonomy Inc	COMM	68906L105	1,287	467,940	SH		SOLE		467,940	0	0
PTC Therapeutics Inc	COMM	69366J200	5,984	132,983	SH		SOLE		132,983	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	3,931	41,660	SH		SOLE		41,660	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	812	87,170	SH		SOLE		87,170	0	0
TG Therapeutics Inc	COMM	88322Q108	3,924	453,638	SH		SOLE		453,638	0	0
Uniqure NV	COMM	N90064101	1,407	18,000	SH	Call	SOLE		18,000	0	0
Vertex Pharmaceuticals Inc	COMM	92532F100	3,265	17,803	SH		SOLE		17,803	0	0
XBiotech Inc	COMM	98400H102	903	119,117	SH		SOLE		119,117	0	0
Zogenix Inc	COMM	98978L904	865	18,100	SH	Call	SOLE		18,100	0	0
Zymeworks Inc	COMM	98985W102	1,484	67,470	SH		SOLE		67,470	0	0
ACADIA Pharmaceuticals Inc	COMM	004225108	888	33,222	SH		OTR	1	33,222	0	0
AbbVie Inc	COMM	00287Y109	449	6,168	SH		OTR	1	6,168	0	0
Acceleron Pharma Inc	COMM	00434H108	2,126	51,752	SH		OTR	1	51,752	0	0
Acorda Therapeutics Inc	COMM	00484M106	319	41,539	SH		OTR	1	41,539	0	0
Adverum Biotechnologies Inc	COMM	00773U108	478	40,162	SH		OTR	1	40,162	0	0
Akebia Therapeutics Inc	COMM	00972D105	878	181,392	SH		OTR	1	181,392	0	0
Allergan plc	COMM	G0177J108	3,026	18,076	SH		OTR	1	18,076	0	0
Allergan plc	COMM	G0177J908	1,792	10,700	SH	Call	OTR	1	10,700	0	0
Alnylam Pharmaceuticals Inc	COMM	02043Q107	432	5,952	SH		OTR	1	5,952	0	0
Amgen Inc	COMM	031162950	1,953	10,600	SH	Put	OTR	1	10,600	0	0
Amicus Therapeutics Inc	COMM	03152W109	1,811	145,118	SH		OTR	1	145,118	0	0
Applied Therapeutics Inc	COMM	03828A101	250	30,324	SH		OTR	1	30,324	0	0
ArQule Inc	COMM	04269E107	663	60,239	SH		OTR	1	60,239	0	0
Autolus Therapeutics PLC	ADR	05280R100	227	14,104	SH		OTR	1	14,104	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	346	91,299	SH		OTR	1	91,299	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	1,552	18,115	SH		OTR	1	18,115	0	0
Bristol-Myers Squibb Co	COMM	110122908	970	21,400	SH	Call	OTR	1	21,400	0	0
Bristol-Myers Squibb Co	COMM	110122108	1,683	37,113	SH		OTR	1	37,113	0	0
Calithera Biosciences Inc	COMM	13089P101	441	113,008	SH		OTR	1	113,008	0	0
Clovis Oncology Inc	COMM	189464100	398	26,761	SH		OTR	1	26,761	0	0
Deciphera Pharmaceuticals Inc	COMM	24344T951	483	21,400	SH	Put	OTR	1	21,400	0	0
Dermira Inc	COMM	24983L104	1,348	140,956	SH		OTR	1	140,956	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	549	230,742	SH		OTR	1	230,742	0	0
Forty Seven Inc	COMM	34983P104	269	25,364	SH		OTR	1	25,364	0	0
Halozyme Therapeutics Inc	COMM	40637H109	2,532	147,379	SH		OTR	1	147,379	0	0
Heron Therapeutics Inc	COMM	427746102	2,461	132,387	SH		OTR	1	132,387	0	0
Incyte Corp	COMM	45337C102	1,264	14,878	SH		OTR	1	14,878	0	0
Intra-Cellular Therapies Inc	COMM	46116X901	488	37,600	SH	Call	OTR	1	37,600	0	0
Intra-Cellular Therapies Inc	COMM	46116X101	350	26,970	SH		OTR	1	26,970	0	0
Kadmon Holdings Inc	COMM	48283N106	966	468,954	SH		OTR	1	468,954	0	0
Kala Pharmaceuticals Inc	COMM	483119103	406	63,588	SH		OTR	1	63,588	0	0
MacroGenics Inc	COMM	556099109	1,999	117,813	SH		OTR	1	117,813	0	0
MorphoSys AG	COMM	D55040105	1,973	20,546	SH		OTR	1	20,546	0	0
Neurocrine Biosciences Inc	COMM	64125C109	2,812	33,301	SH		OTR	1	33,301	0	0
Novo Nordisk A/S	ADR	670100205	3,528	69,122	SH		OTR	1	69,122	0	0
Orchard Therapeutics PLC	ADR	68570P101	1,110	79,372	SH		OTR	1	79,372	0	0
Osmotica Pharmaceuticals PLC	COMM	G6S41R101	426	112,146	SH		OTR	1	112,146	0	0
Otonomy Inc	COMM	68906L105	781	283,853	SH		OTR	1	283,853	0	0
PTC Therapeutics Inc	COMM	69366J200	3,564	79,193	SH		OTR	1	79,193	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	2,341	24,809	SH		OTR	1	24,809	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	483	51,880	SH		OTR	1	51,880	0	0
TG Therapeutics Inc	COMM	88322Q108	2,335	269,999	SH		OTR	1	269,999	0	0
Uniqure NV	COMM	N90064101	836	10,700	SH	Call	OTR	1	10,700	0	0
Vertex Pharmaceuticals Inc	COMM	92532F100	1,970	10,742	SH		OTR	1	10,742	0	0
XBiotech Inc	COMM	98400H102	537	70,855	SH		OTR	1	70,855	0	0
Zogenix Inc	COMM	98978L904	511	10,700	SH	Call	OTR	1	10,700	0	0
Zymeworks Inc	COMM	98985W102	884	40,170	SH		OTR	1	40,170	0	0
ACADIA Pharmaceuticals Inc	COMM	004225108	1,778	66,504	SH		OTR	2	66,504	0	0
AbbVie Inc	COMM	00287Y109	901	12,391	SH		OTR	2	12,391	0	0
Acceleron Pharma Inc	COMM	00434H108	4,206	102,383	SH		OTR	2	102,383	0	0
Acorda Therapeutics Inc	COMM	00484M106	632	82,431	SH		OTR	2	82,431	0	0
Adverum Biotechnologies Inc	COMM	00773U108	945	79,453	SH		OTR	2	79,453	0	0
Akebia Therapeutics Inc	COMM	00972D105	1,753	362,177	SH		OTR	2	362,177	0	0
Allergan plc	COMM	G0177J108	6,007	35,876	SH		OTR	2	35,876	0	0
Allergan plc	COMM	G0177J908	3,566	21,300	SH	Call	OTR	2	21,300	0	0
Alnylam Pharmaceuticals Inc	COMM	02043Q107	860	11,846	SH		OTR	2	11,846	0	0
Amgen Inc	COMM	031162950	3,944	21,400	SH	Put	OTR	2	21,400	0	0
Amicus Therapeutics Inc	COMM	03152W109	2,436	195,220	SH		OTR	2	195,220	0	0
Applied Therapeutics Inc	COMM	03828A101	505	61,330	SH		OTR	2	61,330	0	0
ArQule Inc	COMM	04269E107	1,326	120,403	SH		OTR	2	120,403	0	0
Autolus Therapeutics PLC	ADR	05280R100	452	28,060	SH		OTR	2	28,060	0	0
BioCryst Pharmaceuticals Inc	COMM	09058V103	687	181,159	SH		OTR	2	181,159	0	0
Biomarin Pharmaceutical Inc	COMM	09061G101	3,148	36,752	SH		OTR	2	36,752	0	0
Bristol-Myers Squibb Co	COMM	110122908	1,936	42,700	SH	Call	OTR	2	42,700	0	0
Bristol-Myers Squibb Co	COMM	110122108	3,373	74,368	SH		OTR	2	74,368	0	0
Calithera Biosciences Inc	COMM	13089P101	884	226,756	SH		OTR	2	226,756	0	0
Clovis Oncology Inc	COMM	189464100	797	53,576	SH		OTR	2	53,576	0	0
Deciphera Pharmaceuticals Inc	COMM	24344T951	965	42,800	SH	Put	OTR	2	42,800	0	0
Dermira Inc	COMM	24983L104	2,698	282,180	SH		OTR	2	282,180	0	0
Foamix Pharmaceuticals Ltd	COMM	M46135105	1,133	476,173	SH		OTR	2	476,173	0	0
Forty Seven Inc	COMM	34983P104	538	50,774	SH		OTR	2	50,774	0	0
Halozyme Therapeutics Inc	COMM	40637H109	5,126	298,345	SH		OTR	2	298,345	0	0
Heron Therapeutics Inc	COMM	427746102	4,879	262,438	SH		OTR	2	262,438	0	0
Incyte Corp	COMM	45337C102	2,526	29,736	SH		OTR	2	29,736	0	0
Intra-Cellular Therapies Inc	COMM	46116X901	964	74,300	SH	Call	OTR	2	74,300	0	0
Intra-Cellular Therapies Inc	COMM	46116X101	697	53,694	SH		OTR	2	53,694	0	0
Kadmon Holdings Inc	COMM	48283N106	1,973	957,858	SH		OTR	2	957,858	0	0
Kala Pharmaceuticals Inc	COMM	483119103	820	128,557	SH		OTR	2	128,557	0	0
MacroGenics Inc	COMM	556099109	3,982	234,661	SH		OTR	2	234,661	0	0
MorphoSys AG	COMM	D55040105	3,943	41,061	SH		OTR	2	41,061	0	0
Neurocrine Biosciences Inc	COMM	64125C109	5,626	66,638	SH		OTR	2	66,638	0	0
Novo Nordisk A/S	ADR	670100205	7,062	138,371	SH		OTR	2	138,371	0	0
Orchard Therapeutics PLC	ADR	68570P101	2,208	157,799	SH		OTR	2	157,799	0	0
Osmotica Pharmaceuticals PLC	COMM	G6S41R101	863	227,022	SH		OTR	2	227,022	0	0
Otonomy Inc	COMM	68906L105	1,611	585,775	SH		OTR	2	585,775	0	0
PTC Therapeutics Inc	COMM	69366J200	7,053	156,727	SH		OTR	2	156,727	0	0
Reata Pharmaceuticals Inc	COMM	75615P103	4,629	49,067	SH		OTR	2	49,067	0	0
Syndax Pharmaceuticals Inc	COMM	87164F105	965	103,679	SH		OTR	2	103,679	0	0
TG Therapeutics Inc	COMM	88322Q108	4,652	537,747	SH		OTR	2	537,747	0	0
Uniqure NV	COMM	N90064101	1,665	21,300	SH	Call	OTR	2	21,300	0	0
Vertex Pharmaceuticals Inc	COMM	92532F100	3,990	21,756	SH		OTR	2	21,756	0	0
XBiotech Inc	COMM	98400H102	1,075	141,839	SH		OTR	2	141,839	0	0
Zogenix Inc	COMM	98978L904	1,013	21,200	SH	Call	OTR	2	21,200	0	0
Zymeworks Inc	COMM	98985W102	1,769	80,417	SH		OTR	2	80,417	0	0