| Document and Entity Information | Jul. 13, 2023 |
| Document And Entity Information [Line Items] | |
| Document Type | 8-K |
| Document Period End Date | Jul. 13, 2023 |
| Entity Registrant Name | AEGLEA BIOTHERAPEUTICS, INC. |
| Entity Incorporation, State or Country Code | DE |
| Securities Act File Number | 001-37722 |
| Entity Tax Identification Number | 46-4312787 |
| Entity Address, Address Line One | 221 Crescent Street |
| Entity Address, Address Line Two | Building 17 |
| Entity Address, Address Line Three | Suite 102B |
| Entity Address, City or Town | Waltham |
| Entity Address, State or Province | MA |
| Entity Address, Postal Zip Code | 02453 |
| City Area Code | 617 |
| Local Phone Number | 651-5940 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Title of 12(b) Security | Common Stock, par value $0.0001 per share |
| Trading Symbol | AGLE |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | false |
| Entity Central Index Key | 0001636282 |
| Amendment Flag | false |
| Former Address [Member] | |
| Document And Entity Information [Line Items] | |
| Entity Address, Address Line One | 805 Las Cimas Parkway |
| Entity Address, Address Line Two | Suite 100 |
| Entity Address, City or Town | Austin |
| Entity Address, State or Province | TX |
| Entity Address, Postal Zip Code | 78746 |
