MetaVia (MTVA) 10-Q 13 May 22 2022 Q1 Quarterly report Financial data

Document and Entity Information

Document and Entity Information - shares	3 Months Ended
	Mar. 31, 2022	May 11, 2022
Cover [Abstract]
Document Type	10-Q
Document Quarterly Report	true
Document Period End Date	Mar. 31, 2022
Document Transition Report	false
Entity File Number	001-37809
Entity Registrant Name	NeuroBo Pharmaceuticals, Inc.
Entity Incorporation, State or Country Code	DE
Entity Tax Identification Number	47-2389984
Entity Address, Address Line One	200 Berkeley Street, Office 19th Floor
Entity Address, City or Town	Boston
Entity Address, State or Province	MA
Entity Address, Postal Zip Code	02116
City Area Code	857
Local Phone Number	702-9600
Title of 12(b) Security	Common stock
Trading Symbol	NRBO
Security Exchange Name	NASDAQ
Entity Current Reporting Status	Yes
Entity Interactive Data Current	Yes
Entity Filer Category	Non-accelerated Filer
Entity Small Business	true
Entity Emerging Growth Company	false
Entity Shell Company	false
Entity Common Stock, Shares Outstanding		26,661,771
Entity Central Index Key	0001638287
Current Fiscal Year End Date	--12-31
Document Fiscal Year Focus	2022
Document Fiscal Period Focus	Q1
Amendment Flag	false

Condensed Consolidated Balance

Condensed Consolidated Balance Sheets - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Current assets:
Cash	$ 11,557	$ 16,387
Prepaid expenses	1,707	197
Total current assets	13,264	16,584
Right-of-use assets and other	99	105
Property and equipment, net	98	110
Total assets	13,461	16,799
Current liabilities:
Accounts payable	776	830
Accrued liabilities	693	1,301
Lease liability, short-term	27	26
Total current liabilities	1,496	2,157
Lease liability, long-term	37	45
Total liabilities	1,533	2,202
Commitments and contingencies (Notes 4, 5, and 10)
Stockholders' equity
Preferred stock, $0.001 par value per share; 10,000,000 shares authorized as of March 31, 2022 and December 31, 2021; no shares issued or outstanding as of March 31, 2022 and December 31, 2021.
Common stock, $0.001 par value per share, 100,000,000 shares authorized as of March 31, 2022 and December 31, 2021; 26,661,771 shares issued and outstanding as of March 31, 2022 and December 31, 2021.	27	27
Additional paid-in capital	96,601	96,394
Accumulated other comprehensive income	3	4
Accumulated deficit	(84,703)	(81,828)
Total stockholders' equity	11,928	14,597
Total liabilities and stockholders' equity	$ 13,461	$ 16,799

Condensed Consolidated Balanc_2

Condensed Consolidated Balance Sheets (Parenthetical) - $ / shares	Mar. 31, 2022	Dec. 31, 2021
Condensed Consolidated Balance Sheets
Preferred stock, par value (in dollar per share)	$ 0.001	$ 0.001
Preferred stock, shares authorized	10,000,000	10,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollar per share)	$ 0.001	$ 0.001
Common stock, shares authorized	100,000,000	100,000,000
Common stock, shares issued	26,661,771	26,661,771
Common stock, shares outstanding	26,661,771	26,661,771

Condensed Consolidated Statemen

Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Operating expenses:
Research and development	$ 920	$ 1,143
General and administrative	1,955	2,187
Total operating expenses	2,875	3,330
Loss from operations	(2,875)	(3,330)
Interest income		6
Loss before income taxes	(2,875)	(3,324)
Provision for income taxes	0	0
Net loss	(2,875)	(3,324)
Other comprehensive loss, net of tax	(1)	(7)
Comprehensive loss	$ (2,876)	$ (3,331)
Loss per share:
Net loss per share, basic	$ (0.11)	$ (0.15)
Net loss per share, diluted	$ (0.11)	$ (0.15)
Weighted average common shares outstanding:
Basic	26,661,771	21,615,626
Diluted	26,661,771	21,615,626

Condensed Consolidated Statem_2

Condensed Consolidated Statements of Changes in Stockholder's Equity - USD ($) $ in Thousands	Common Stock	Additional Paid-in Capital	Accumulated Other Comprehensive Income	Accumulated Deficit	Total
Balance at beginning of period at Dec. 31, 2020	$ 20	$ 73,713	$ 14	$ (66,544)	$ 7,203
Balance at beginning of period (shares) at Dec. 31, 2020	19,671,182
Increase (Decrease) in Stockholders' Equity
Issuance of common stock and warrants in connection with equity financing	$ 2	9,998			10,000
Issuance of common stock and warrants in connection with equity financing (in shares)	2,500,000
Transaction costs in connection with equity financing		(908)			(908)
Stock-based compensation		187			187
Foreign currency translation adjustment			(7)		(7)
Net loss				(3,324)	(3,324)
Balance at end of period at Mar. 31, 2021	$ 22	82,990	7	(69,868)	13,151
Balance at end of period (shares) at Mar. 31, 2021	22,171,182
Balance at beginning of period at Dec. 31, 2021	$ 27	96,394	4	(81,828)	14,597
Balance at beginning of period (shares) at Dec. 31, 2021	26,661,771
Increase (Decrease) in Stockholders' Equity
Stock-based compensation		207			207
Foreign currency translation adjustment			(1)		(1)
Net loss				(2,875)	(2,875)
Balance at end of period at Mar. 31, 2022	$ 27	$ 96,601	$ 3	$ (84,703)	$ 11,928
Balance at end of period (shares) at Mar. 31, 2022	26,661,771

Condensed Consolidated Statem_3

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Operating activities
Net loss	$ (2,875)	$ (3,324)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation	207	187
Non-cash lease expense	6	5
Depreciation	12	12
Change in assets and liabilities, net of the effects of the asset acquisition:
Prepaid expenses and other assets	(1,510)	(265)
Accounts payable	(54)	(2,106)
Accrued and other liabilities	(615)	(650)
Net cash used in operating activities	(4,829)	(6,141)
Financing activities
Proceeds from equity offering		10,000
Issuance costs		(908)
Net cash provided by financing activities		9,092
Net (decrease) increase in cash	(4,829)	2,951
Net foreign exchange difference	(1)	(5)
Cash at beginning of period	16,387	10,089
Cash at end of period	$ 11,557	$ 13,035

The Company and Basis of Presen

The Company and Basis of Presentation	3 Months Ended
	Mar. 31, 2022
The Company and Basis of Presentation
The Company and Basis of Presentation	1. The Company and Basis of Presentation ​ NeuroBo Pharmaceuticals, Inc. (together with its subsidiaries, the “Company” or “NeuroBo”), is a clinical-stage biotechnology company with four therapeutics programs designed to impact a range of indications in viral, neurodegenerative and cardiometabolic disease: ● ANA001 , which is a proprietary oral niclosamide formulation and is being developed as a treatment for patients with moderate coronavirus disease (COVID-19). ANA001 is currently being studied in a 60-subject Phase 2 clinical trial conducted in the United States, with a Phase 3 component dependent on the outcome of the Phase 2 data.; ● NB-01 , which was primarily focused on the development of a treatment for painful diabetic neuropathy (PDN). The Company is currently exploring alternatives with respect to the future of NB-01, including bringing the NB-01 asset to the market through a different regulatory pathway, such as with an orphan drug indication or as a nutraceutical; ● NB-02 , which has the potential to treat the symptoms of cognitive impairment and modify the progression of neurodegenerative diseases associated with the malfunction of a protein called tau, and with amyloid beta plaque deposition. The Company has postponed continued work on the Investigation New Drug application to the FDA for NB-02 and the first human clinical trials for NB-02 until global health and macroeconomic conditions improve. The Company is also considering engaging with a strategic partner with respect to further development of NB-02; and ● Gemcabene , which is currently being assessed as an acute indication for COVID-19 in combination with ANA001. Gemcabene was previously focused on developing and commercializing therapies for the treatment of dyslipidemia, a serious medical condition that increases the risk of life-threatening cardiovascular disease, focused on orphan indications such as homozygous familial hypercholesterolemia, as well as nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. The Company’s operations have consisted principally of performing research and development activities, clinical development and raising capital. The Company’s activities are subject to significant risks and uncertainties, including failing to secure additional funding before sustainable revenues and profit from operations are achieved. ​ COVID-19 The Company is subject to risks and uncertainties as a result of the COVID-19 pandemic. The extent of the impact of the COVID-19 pandemic on the Company’s business continues to be highly uncertain and difficult to predict, as the responses that the Company, other businesses and governments are taking continue to evolve. Furthermore, economies worldwide have also been negatively impacted by the COVID-19 pandemic, and it is possible that it could cause a lasting national or global economic recession. Policymakers around the globe have responded with fiscal policy actions to support the healthcare industry and economy as a whole. The magnitude and overall effectiveness of these actions remain uncertain. ​ To date, with the exception the postponement of first human clinical trials for NB-02, the Company has not experienced any significant external changes in our business that would have a significant negative impact on our consolidated statements of operations or cash flows. ​ Exclusive of the development of certain of the Company’s proposed therapies, the severity of the impact of the COVID-19 pandemic on the Company’s business will depend on a number of factors, including, but not limited to, the duration and severity of the pandemic and the extent and severity of the impact on the Company’s service providers, suppliers, contract research organizations and the Company’s clinical trials, all of which are uncertain and cannot be predicted. As of the date of issuance of Company’s financial statements, the extent to which the COVID-19 pandemic may in the future materially impact the Company’s financial condition, liquidity or results of operations is uncertain. ​ War in Ukraine ​ The Company is subject to risks and uncertainties as a result of the war in Ukraine that commenced in February 2022. The severity of the impact will depend on the Company’s abilities to advance its Phase 2 clinical trial for ANA001 at clinical trial sites outside of Poland and Ukraine. ​ Basis of presentation and consolidation principles The accompanying condensed consolidated financial statements have been prepared by the Company pursuant to the rules and regulations of the Securities and Exchange Commission (“SEC”). Certain information and footnote disclosures normally included in annual financial statements prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) have been condensed or omitted pursuant to such rules and regulations. The condensed consolidated financial statements may not include all disclosures required by GAAP; however, the Company believes that the disclosures are adequate to make the information presented not misleading. These unaudited condensed financial statements should be read in conjunction with the audited financial statements and the notes thereto for the fiscal year ended December 31, 2021 included in the Company’s Annual Report on Form 10-K filed with the SEC on March 31, 2022 ​ In the opinion of management, all adjustments, consisting of only normal recurring adjustments that are necessary to present fairly the financial position, results of operations, and cash flows for the interim periods, have been made. The results of operations for the interim periods are not necessarily indicative of the operating results for the full fiscal year or any future periods. ​ The condensed consolidated financial statements of the Company include a South Korean subsidiary, NeuroBo Co., LTD., which is fully owned by the Company. All significant intercompany accounts and transactions have been eliminated in the preparation of the financial statements. ​ Going Concern From its inception through March 31, 2022, the Company has devoted substantially all of its efforts to drug discovery and development and conducting clinical trials. The Company has a limited operating history and the sales and income potential of the Company's business and market are unproven. Successful transition to attaining profitable operations is dependent upon achieving a level of revenues adequate to support the Company's cost structure. As of March 31, 2022, the Company had $11.6 million in cash. The Company has experienced net losses and negative cash flows from operating activities since its inception and had an accumulated deficit of $84.7 million as of March 31, 2022. ​ To date, the Company has raised capital principally through the registered offerings and private placements of common stock, warrants and redeemable convertible preferred stock as well as via the issuance of convertible notes. The Company will need to continue to raise a substantial amount of funds until it is able to generate sufficient revenues to fund its development activities. ​ The determination as to whether the Company can continue as a going concern contemplates the realization of assets and the satisfaction of liabilities in the normal course of business. The Company expects to continue to incur net losses and negative cash flows from operations into the foreseeable future. Successful transition to profitable operations is dependent upon achieving a level of revenues adequate to support the Company's cost structure. The Company has incurred net losses since inception and has relied on its ability to fund its operations through debt and equity financings. These conditions raise substantial doubt about the Company's ability to continue as a going concern. The accompanying consolidated financial statements have been prepared assuming that the Company will continue as a going concern and do not include any adjustments that might result from the outcome of this uncertainty. This basis of accounting contemplates the recovery of the Company's assets and the satisfaction of liabilities in the normal course of business. ​ The Company believes that its existing cash will be sufficient to fund its operations into the fourth quarter of 2022. The Company plans to continue to fund its operations and capital funding needs through a combination of equity offerings, debt financings, or other sources, potentially including collaborations, licenses and other similar arrangements. There can be no assurance that the Company will be able to obtain any sources of financing on acceptable terms, or at all. To the extent that the Company can raise additional funds by issuing equity securities, the Company's stockholders may experience significant dilution. Any debt financing, if available, may involve restrictive covenants that impact the Company's ability to conduct its business. If the Company is unable to raise additional capital, it may have a material adverse effect on the Company. ​

Summary of Significant Accounti

Summary of Significant Accounting Policies	3 Months Ended
	Mar. 31, 2022
Summary of Significant Accounting Policies
Summary of Significant Accounting Policies	2. Summary of Significant Accounting Policies ​ Use of estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, expenses, and related disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of expenses during the reporting period. The most significant estimates in the Company's condensed consolidated financial statements relate to accrued expenses and the fair value of stock-based compensation and warrant issuances. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgements about the carrying values of assets and liabilities. Actual results could differ from those estimates. Changes in estimates are reflected in reported results in the period in which they become known. ​ General and Administrative Expenses ​ General and administrative expenses consist primarily of personnel-related costs, including salaries and stock-based compensation costs, for personnel in functions not directly associated with research and development activities. Other significant costs include legal fees related to intellectual property and corporate matters and professional fees for accounting and other services. ​ Research and Development Costs ​ Research and development costs are charged to expense as incurred. Research and development expenses are comprised of costs incurred in performing research and development activities, including clinical trial costs, manufacturing costs for both clinical and pre-clinical materials as well as other contracted services, license fees, and other external costs. Nonrefundable advance payments for goods and services that will be used in future research and development activities are expensed when the activity is performed or when the goods have been received, rather than when payment is made, in accordance with Accounting Standards Codification (“ASC”) 730, Research and Development ​ Stock-Based Compensation ​ The Company accounts for stock-based compensation in accordance with the provisions of ASC 718, Compensation — Stock Compensation ​ Recent Accounting Pronouncements Not Yet Adopted ​ From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board ("FASB") or other standard setting bodies that are adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on its consolidated financial position or results of operations upon adoption. ​ In June 2016, the FASB issued ASU 2016-13, “Financial Instruments – Credit Losses” ​

Balance Sheet Detail

Balance Sheet Detail	3 Months Ended
	Mar. 31, 2022
Balance Sheet Detail
Balance Sheet Detail	3. Balance Sheet Detail ​ Property and Equipment ​ Property and equipment consist of the following as of: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ ​ December 31, ​ ​ ​ 2022 ​ ​ 2021 ​ Research and development equipment ​ $ 158 ​ ​ $ 158 ​ Office equipment ​ ​ 63 ​ ​ ​ 63 ​ Total property and equipment ​ ​ 221 ​ ​ ​ 221 ​ Less accumulated depreciation ​ ​ (123) ​ ​ ​ (111) ​ Property and equipment, net ​ $ 98 ​ ​ $ 110 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Accrued liabilities ​ Accrued liabilities consist of the following as of: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ December 31, ​ ​ 2022 ​ 2021 External research and development expenses ​ $ 446 ​ $ 854 ​ Payroll related ​ 174 ​ 376 ​ Professional services ​ ​ 37 ​ ​ 59 ​ Other ​ 36 ​ 12 ​ Total ​ $ 693 ​ $ 1,301 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​

Commitments and Contingencies

Commitments and Contingencies	3 Months Ended
	Mar. 31, 2022
Commitments and Contingencies
Commitments and Contingencies	4. Commitments and Contingencies ​ Operating Leases ​ Boston Lease ​ On May 14, 2021, the Company entered into a non-cancelable operating lease for its corporate headquarters located in Boston Massachusetts. The agreement, effective August 1, 2021, has a six month term, and rental costs of approximately $3 per month prior to the application of certain rent concessions granted by the landlord in the amount of approximately $2 over the term of the lease. per month. In February 2022, the Company signed an amendment to extend the lease term until June 30, 2022. ​ Prior to August 2021, the Company entered a non-cancelable operating lease for its corporate headquarters effective February 1, 2021. The lease had a six month term, and rental costs of approximately $3 per month prior to the application of certain rent concessions granted by the landlord in the amount of approximately $1 over the term of the lease. Prior to February 1, 2021, a non-cancelable operating lease was in effect as of February 1, 2020 which had a one-year term and rental costs of $21 per month prior to the application of certain rent concessions granted by the landlord in the amount of $32. ​ No assets and liabilities were recognized for the corporate headquarters leases at March 31, 2022 and December 31, 2021. Due to the short-term nature of the leases, the Company recognized lease payments as an expense on a straight-line basis over the remaining lease term. For the three months ended March 31, 2022 and 2021, expense under the corporate headquarters leases in the aggregate was $4 and $35, respectively. ​ Lease in Korea ​ In May 2019, the Company entered an operating lease for its new facility in Korea (the “Korea Lease”). The initial lease term is five years with an option to renew for an additional five-year term. The lease commenced on July 2, 2019 and expires on July 1, 2024. The operating lease is subject to a deposit, base rent payments and additional charges for utilities and other common costs. The Company’s lease liability represents the net present value of future lease payments utilizing a discount rate of 10%, which corresponds to the Company’s incremental borrowing rate. As of March 31, 2022, the weighted average remaining lease term was 2.25 years. For the three month periods ended March 31, 2022 and 2021, the Company recorded non-cash expense of $6 and $5 , respectively related to the Korea Lease. During the three month periods ended March 31, 2022 and 2021, the Company made cash payments of ​ The following table reconciles the undiscounted lease liabilities to the total lease liabilities recognized on the consolidated balance sheet as of March 31, 2022: ​ ​ ​ ​ ​ ​ ​ ​ As of ​ ​ ​ December 31, ​ 2022 (April 1 to December 31) ​ ​ 24 ​ 2023 ​ ​ 32 ​ 2024 ​ ​ 16 ​ Total lease payments ​ ​ 72 ​ Less effect of discounting ​ ​ (8) ​ Total ​ ​ 64 ​ Short-term portion ​ ​ (27) ​ Long-term portion ​ $ 37 ​ ​ ​ ​ ​ ​ ​ Xiehecheng Cultivation Service Agreement ​ On September 1, 2018, the Company entered into a cultivation service agreement with Xiehecheng Chinese Herm Limited Corporation for the cultivation of two plants used to manufacture the Company's clinical assets. ​ As of March 31, 2022, future minimum payments under the agreement, which is cancellable annually at the end of each research year, are as follows: ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ ​ ​ ​ ​ ​ 2022 ​ $ 132 ​ ​ ​ $ 132 ​ ​ ​ ​ ​ ​ ​ ANA Merger Milestone Payments On December 31, 2020, the Company acquired 100% of ANA Therapeutics, Inc., a Delaware corporation (“ANA”), pursuant to an Agreement and Plan of Merger, dated December 31, 2020 (the “2020 Merger Agreement” or “2020 Merger”). Pursuant to the 2020 Merger Agreement, following the closing of the 2020 Merger, the Company is obligated to pay milestone payments (each, a “Milestone Payment”) to certain persons identified in the 2020 Merger Agreement (each a “Stakeholder” and collectively, the “Stakeholders”) in the form, time and manner as set forth in the 2020 Merger Agreement, upon the achievement of the following milestone events set forth below by the Company or any of its affiliates (each, a “Milestone Event”): ​ ​ ​ ​ ​ ​ Milestone Event ​ ​ ​ ​ ​ Milestone Payment First receipt of Marketing Approval (as defined in the 2020 Merger Agreement) from the FDA for any Niclosamide Product (as defined in the 2020 Merger Agreement) ​ ​ $ 45.0 million ​ ​ ​ ​ ​ Sales Milestones: ​ ​ ​ ​ ​ ​ Milestone Event – Worldwide Cumulative Net Sales of a Niclosamide Product ​ ​ ​ ​ ​ equal to or greater than: ​ ​ ​ ​ ​ Milestone Payment $500 million ​ ​ ​ $ $9.0 million $1 billion ​ $ 13.5 million $3 billion ​ $ 36.0 million $5 billion ​ $ 72.0 million ​ Additionally, pursuant to the 2020 Merger Agreement, the Company is obligated to pay a royalty of two and a half percent ( 2.5% ) of annual worldwide net sales of each Niclosamide Product (as defined in the 2020 Merger Agreement) As of March 31, 2022, no royalty Payments had been accrued as there were no potential milestones yet considered probable. YourChoice License Agreement In connection with 2020 Merger, the Company assumed the a license agreement between ANA and Your Choice Therapeutics, Inc. (the “YourChoice Agreement”).. Prior to the 2020 Merger, YourChoice granted to ANA, during the term of the YourChoice Agreement, an exclusive, worldwide, fee-bearing license derived from the licensed intellectual property throughout the world. The fees due under the YourChoice Agreement include royalty payments of Gemphire Contingent Value Rights Agreement. On December 30, 2019, the Company was party to a definitive merger agreement (the “2019 Merger”) with Gemphire Therapeutics, Inc. (“Gemphire”). In connection with the 2019 Merger, Gemphire entered into the Contingent Value Rights Agreement (the “CVR Agreement”) with Grand Rapids Holders’ Representative, LLC, as representative of Gemphire’s stockholders prior to the 2019 Merger (the “Holders’ Representative”), and Computershare Inc. and Computershare Trust Company, N.A. as the rights agents (collectively, the “Rights Agent”). Under the CVR Agreement, which NeuroBo assumed in connection with the 2019 Merger, the holders of Gemphire shares at the time of the 2019 Merger (collectively, the “CVR Holders”) were entitled to receive 80% of the proceeds from the grant, sale, or transfer of rights to Gemcabene. On March 23, 2021, NeuroBo, the Holders’ Representative, and the Rights Agent entered into the First Amendment to Contingent Value Rights Agreement (the “CVR Amendment”) to amend the CVR Agreement. Pursuant to the CVR Amendment, (i) the CVR Holders will continue to have the right to receive 80% of the proceeds from the grant, sale, or transfer of rights to Gemcabene as a treatment for cardiovascular conditions and (ii) the CVR Holders will now also receive 10% of the proceeds from the grant, sale, or transfer of rights to Gemcabene as a treatment for any indication outside of treating cardiometabolic diseases, including COVID-19. As of March 31, 2022, no obligations had been accrued as there were no potential payments under the CVR Agreement or the CVR Amendment that were yet considered probable. Pfizer License Agreement Upon the close of the 2019 Merger, an exclusive license agreement with Pfizer, Inc. (“Pfizer”) for the clinical product candidate Gemcabene (the “Pfizer Agreement”) was assumed by the Company. Under the Pfizer Agreement, in exchange for this worldwide exclusive right and license to certain patent rights to make, use, sell, offer for sale and import the clinical product Gemcabene, the Company has agreed to certain milestone and royalty payments on future sales. ​ The Company agreed to make milestone payments totaling up to $37 million upon the achievement of certain milestones, including the first new drug application (or its foreign equivalent) in any country, regulatory approval in each of the United States, Europe and Japan, the first anniversary of the first regulatory approval in any country, and upon achieving certain aggregate sales levels of Gemcabene. Future milestone payments under the Pfizer Agreement, if any, are not expected to begin for at least several years and extend over a number of subsequent years. ​ The Company also agreed to pay Pfizer tiered royalties on a country-by-country basis based upon the annual amount of net sales, as specified in the Pfizer Agreement, until the later of: (a) five (5) years after the first commercial sale in such country; (b) the expiration of all regulatory or data exclusivity for Gemcabene in such country; and (c) the expiration or abandonment of the last valid claim of the licensed patents, including any patent term extensions or supplemental protection certificates in such country (collectively, the Royalty Term). Under the Pfizer Agreement, the Company is obligated to use commercially reasonable efforts to develop and commercialize Gemcabene. ​ As of March 31, 2022, there was sufficient uncertainty with regard to both the outcome of the clinical trials and the ability to obtain sufficient funding to support any of the cash milestone payments, and as such, no liabilities were recorded related to the Pfizer Agreement. ​ Contingencies ​ From time to time, the Company may be subject to various claims and suits arising in the ordinary course of business. The Company does not expect that the resolution of these matters will have a material adverse effect on its financial position or results of operations.

License and Collaboration Agree

License and Collaboration Agreement	3 Months Ended
	Mar. 31, 2022
License and Collaboration Agreement
License and Collaboration Agreement	5. License and Collaboration Agreement Beijing SL License and Collaboration Agreement ​ Upon the close of the 2019 Merger, the License and Collaboration Agreement (the “Beijing SL Agreement”) with Beijing SL Pharmaceutical Co., Ltd. (“Beijing SL”) was assumed by the Company, pursuant to which the Company granted Beijing SL an exclusive royalty-bearing license to research, develop, manufacture and commercialize pharmaceutical products comprising, as an active ingredient, Gemcabene in mainland China, Hong Kong, Macau and Taiwan. The terms of the Beijing SL Agreement include payments based upon achievement of milestones and royalties on net product sales. Under the Beijing SL Agreement, the Company has variable consideration in the form of milestone payments. As of March 31, 2022, no revenue under the Beijing SL Agreement has been recognized. ​ ​

Stockholders Equity

Stockholders Equity	3 Months Ended
	Mar. 31, 2022
Stockholders' Equity
Stockholders' Equity	6. Stockholders’ Equity ​ Warrants ​ The following warrants were outstanding as of March 31, 2022 and December 31, 2021: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Number of Warrants: ​ ​ ​ ​ ​ Warrant Issuance ​ March 31, 2022 December 31, 2021 ​ Exercise Price ​ Expiration Date March 2017 ​ - 39,115 ​ $ 260.00 ​ March 2022 July 2018 ​ 1,440 1,440 ​ $ 186.75 ​ July 2028 April 2020 ​ 37,500 37,500 ​ $ 12.50 ​ April 2025 January 2021 ​ 2,500,000 2,500,000 ​ $ 6.03 ​ July 2026 October 2021 ​ 4,307,693 4,307,693 ​ $ 3.75 ​ April 2025 Total ​ 6,846,633 6,885,748 ​ ​ ​ ​ ​ ​

Stock-Based Compensation

Stock-Based Compensation	3 Months Ended
	Mar. 31, 2022
Stock-Based Compensation
Stock-Based Compensation	7. Stock-based Compensation ​ Stock-based compensation expense was included in general and administrative costs as follows in the accompanying statements of comprehensive loss: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Three Months Ended ​ ​ ​ March 31, ​ ​ ​ 2022 ​ 2021 ​ General and administrative ​ $ 207 ​ $ 187 ​ ​ Stock Options ​ In December 2019, in connection with the 2019 Merger, the Company assumed a previously adopted stock option plan (the "2018 Plan") and adopted the 2019 Equity Incentive Plan (the “2019 Plan”), and in November 2021, the Company adopted the 2021 Inducement Plan. The 2018 Plan, the 2019 Plan and the 2021 Inducement Plan provide for the grant of stock options, restricted stock and other equity awards of the Company's common stock to employees, officers, consultants, and directors. Options expire within a period of not more than ten years from the date of grant. ​ The following table summarizes the Company’s activity related to its stock options for the three months ended March 31, 2022: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ‑ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ​ Average ​ Aggregate ​ ​ ​ ​ ​ Average ​ Remaining ​ Intrinsic ​ ​ ​ Number of ​ Exercise ​ Contractual ​ Value(1) ​ ​ ​ Options ​ Price ​ Term (years) ​ (in thousands) ​ Outstanding at December 31, 2021 ​ 974,999 ​ $ 3.99 ​ 9.3 ​ $ — ​ Granted ​ 40,000 ​ $ 1.02 ​ — ​ ​ — ​ Exercised ​ - ​ $ — ​ — ​ $ — ​ Forfeited/Cancelled ​ (33,334) ​ $ 6.04 ​ — ​ ​ — ​ Outstanding at March 31, 2022 ​ 981,665 ​ $ 3.80 ​ 9.1 ​ $ - ​ Vested and expected to vest at March 31, 2022 ​ 981,665 ​ $ 3.80 ​ 9.1 ​ $ - ​ Options exercisable at March 31, 2022 ​ 203,332 ​ $ 7.86 ​ 8.0 ​ $ - ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ During the three month period ended March 31, 2022, 40,000 stock options were granted to a non-employee director that vest over a three year period. There were no stock options granted during the three months ended March 31, 2021. The weighted average fair value per share of options granted during the three months ended March 31, 2022 was $0.70. ​ The Company measures the fair value of stock options on the date of grant using the Black-Scholes option pricing model. The Company does not have history to support a calculation of volatility and expected term. As such, the Company has used a weighted-average volatility considering the volatilities of several guideline companies. For purposes of identifying similar entities, the Company considered characteristics such as industry, length of trading history, and stage of life cycle. The assumed dividend yield was based on the Company’s expectation of not paying dividends in the foreseeable future. The average expected life of the options was determined based on the mid-point between the vesting date and the end of the contractual term according to the “simplified method” as described in Staff Accounting Bulletin 110. The risk-free interest rate is determined by reference to implied yields available from U.S. Treasury securities with a remaining term equal to the expected life assumed at the date of grant. The Company records forfeitures when they occur. ​ The weighted-average assumptions used in the Black-Scholes option-pricing model are as follows: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Three Months Ended ​ ​ ​ March 31, ​ ​ 2022 ​ 2021 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Expected stock price volatility ​ ​ ​ 80.7 % ​ ​ — % Expected life of options (years) ​ ​ ​ 5.8 ​ ​ ​ — ​ Expected dividend yield ​ ​ ​ — % ​ ​ — % Risk free interest rate ​ ​ ​ 1.72 % ​ ​ — % ​ Evergreen provision ​ Under the 2019 Plan, the shares reserved automatically increase on January 1st of each year, for a period of not more than ten years commencing on January 1, 2020 and ending on (and including) January 1, 2029, to an amount equal to the lesser of 4% of the common shares outstanding as of January 1 st ​ During the three months s ended March 31 2022 and 2021, 23,888 and 25,000 stock options vested, respectively. During the three months ended March 31, 2022, and 2021, 33,334 and 270,287 stock options were forfeited, respectively. As of March 31, 2022, 8,709,299 shares in the aggregate were available for future issuance under the 2021 Inducement Plan, the 2019 Plan and 2018 Plan. Unrecognized stock-based compensation cost for the stock options issued under all stock options plans was $1.1 million as of March 31, 2022. The unrecognized stock-based expense is expected to be recognized over a weighted average period of 1.7 years.

Net Loss Per Common Share

Net Loss Per Common Share	3 Months Ended
	Mar. 31, 2022
Net Loss Per Common Share
Net Loss Per Common Share	8. Net Loss Per Common Share ​ Basic net loss per share is computed by dividing the net loss by the weighted-average number of common shares outstanding for the period, without consideration for potentially dilutive securities if their effect is antidilutive. Diluted net loss per share is computed by dividing the net loss by the weighted average number of shares of common stock and dilutive common stock equivalents outstanding for the period determined using the treasury stock method. Dilutive common stock equivalents are comprised of options outstanding under the Company's stock option plans and warrants. For all periods presented, there is no difference in the number of shares used to calculate basic and diluted shares outstanding as inclusion of the potentially dilutive securities would be antidilutive. ​ The following potential common shares were not considered in the computation of diluted net loss per share as their effect would have been anti-dilutive: ​ ​ ​ ​ ​ ​ ​ ​ Three Months Ended ​ ​ March 31, ​ 2022 2021 Stock options ​ 981,665 ​ 650,068 Warrants ​ 6,846,633 ​ 2,578,055 ​

Income Taxes

Income Taxes	3 Months Ended
	Mar. 31, 2022
Income Taxes
Income Taxes	9. Income Taxes ​ The effective tax rate for the three months ended March 31, 2022 and 2021 was zero percent. As a result of the analysis of all available evidence as of March 31, 2022 and December 31, 2021, the Company recorded a full valuation allowance on its net deferred tax assets. Consequently, the Company reported no income tax benefit for the three months ended March 31, 2022 and 2021. If the Company’s assumptions change and the Company believes that it will be able to realize these deferred tax assets, the tax benefits relating to any reversal of the valuation allowance on deferred tax assets will be recognized as a reduction of future income tax expense. If the assumptions do not change, each period the Company could record an additional valuation allowance on any increases in the deferred tax assets. ​ On December 27, 2020, the President of the United States signed the Consolidated Appropriations Act, 2021 (“Consolidated Appropriations Act”) into law. The Consolidated Appropriations Act is intended to enhance and expand certain provisions of the Coronavirus Aid, Relief, and Economic Security Act (“CARES Act”), allows for the deductions of expenses related to the Paycheck Protection Program funds received by companies, and provides an update to meals and entertainment expensing for 2021. The Consolidated Appropriations Act did not have a material impact to the Company’s income tax provision. ​ ​

Related Party Transactions

Related Party Transactions	3 Months Ended
	Mar. 31, 2022
Related Party Transactions
Related Party Transactions	10. Related Party Transactions ​ Agreements with Dong-A ST ​ On September 28, 2018, Private NeuroBo entered into a five year manufacturing and supply agreement with Dong-A ST Co., Ltd. (“Dong-A ST”) for manufacturing and supply of NB-01 drug substance and placebos for the purpose of research and development to be used in Phase 3 clinical trials (the “Manufacturing Agreement”). There were no manufacturing related costs under the Manufacturing Agreement for the three months ended March 31, 2022 and 2021. The product manufacturing related costs, when incurred, are reflected as research and development expenses. ​ On June 7, 2020, the Company entered into a manufacturing and supply agreement (the “Manufacturing and Supply Agreement”) with Dong-A ST for the manufacturing and supply of NB-02 drug product and placebo for the purpose of research and development of NB-02, including but not limited to, the use in the first NB-02 human clinical trial to be conducted by the Company. Under the terms of the Manufacturing and Supply Agreement, upon receipt of a purchase order from the Company no later than 270 days prior to the requested delivery date, Dong-A ST has agreed to produce for the Company tablets of the NB-02 drug substance and placebos at a specified supply price. The Company is obligated to manufacture, or have manufactured, and supply to Dong-A ST the active pharmaceutical ingredients which are necessary to manufacture the NB-02 drug product. The Manufacturing and Supply Agreement has a five year term, subject to earlier termination under certain circumstances. The Company recognized no product manufacturing related costs under the Manufacturing and Supply Agreement for during the three months ended March 31, 2022 and 2021. None of the costs incurred under the Manufacturing Agreement remained unpaid as of March 31, 2022 or December 31, 2021. ​

Subsequent Events

Subsequent Events	3 Months Ended
	Mar. 31, 2022
Subsequent Events
Subsequent Events	11. Subsequent Events ​ On April 19, 2022, the Company terminated its Korea Lease effective April 30, 2022. ​ On May11, 2022, the Company terminated the 2018 Plan. As of the date of termination, there were outstanding awards under the 2018 Plan. As a result of the termination, the ​ ​ ​

Summary of Significant Accoun_2

Summary of Significant Accounting Policies (Policies)	3 Months Ended
	Mar. 31, 2022
Summary of Significant Accounting Policies
Use of Estimates	Use of estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets, liabilities, expenses, and related disclosure of contingent assets and liabilities at the date of the consolidated financial statements and the reported amounts of expenses during the reporting period. The most significant estimates in the Company's condensed consolidated financial statements relate to accrued expenses and the fair value of stock-based compensation and warrant issuances. The Company bases its estimates on historical experience and on various other assumptions that are believed to be reasonable, the results of which form the basis for making judgements about the carrying values of assets and liabilities. Actual results could differ from those estimates. Changes in estimates are reflected in reported results in the period in which they become known.
General and Administrative Expenses	General and Administrative Expenses ​ General and administrative expenses consist primarily of personnel-related costs, including salaries and stock-based compensation costs, for personnel in functions not directly associated with research and development activities. Other significant costs include legal fees related to intellectual property and corporate matters and professional fees for accounting and other services.
Research and Development Costs	Research and Development Costs ​ Research and development costs are charged to expense as incurred. Research and development expenses are comprised of costs incurred in performing research and development activities, including clinical trial costs, manufacturing costs for both clinical and pre-clinical materials as well as other contracted services, license fees, and other external costs. Nonrefundable advance payments for goods and services that will be used in future research and development activities are expensed when the activity is performed or when the goods have been received, rather than when payment is made, in accordance with Accounting Standards Codification (“ASC”) 730, Research and Development
Stock-Based Compensation	Stock-Based Compensation ​ The Company accounts for stock-based compensation in accordance with the provisions of ASC 718, Compensation — Stock Compensation
Recent Accounting Pronouncements Not Yet Adopted	Recent Accounting Pronouncements Not Yet Adopted ​ From time to time, new accounting pronouncements are issued by the Financial Accounting Standards Board ("FASB") or other standard setting bodies that are adopted by the Company as of the specified effective date. Unless otherwise discussed, the Company believes that the impact of recently issued standards that are not yet effective will not have a material impact on its consolidated financial position or results of operations upon adoption. ​ In June 2016, the FASB issued ASU 2016-13, “Financial Instruments – Credit Losses”

Balance Sheet Detail (Tables)

Balance Sheet Detail (Tables)	3 Months Ended
	Mar. 31, 2022
Balance Sheet Detail
Schedule of property and equipment	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ ​ December 31, ​ ​ ​ 2022 ​ ​ 2021 ​ Research and development equipment ​ $ 158 ​ ​ $ 158 ​ Office equipment ​ ​ 63 ​ ​ ​ 63 ​ Total property and equipment ​ ​ 221 ​ ​ ​ 221 ​ Less accumulated depreciation ​ ​ (123) ​ ​ ​ (111) ​ Property and equipment, net ​ $ 98 ​ ​ $ 110 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
Schedule of accrued liabilities	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ December 31, ​ ​ 2022 ​ 2021 External research and development expenses ​ $ 446 ​ $ 854 ​ Payroll related ​ 174 ​ 376 ​ Professional services ​ ​ 37 ​ ​ 59 ​ Other ​ 36 ​ 12 ​ Total ​ $ 693 ​ $ 1,301 ​ ​ ​ ​ ​ ​ ​ ​ ​

Commitments and Contingencies (

Commitments and Contingencies (Tables)	3 Months Ended
	Mar. 31, 2022
Schedule of future minimum payments of other commitments	As of March 31, 2022, future minimum payments under the agreement, which is cancellable annually at the end of each research year, are as follows: ​ ​ ​ ​ ​ ​ ​ ​ March 31, ​ ​ ​ ​ ​ ​ 2022 ​ $ 132 ​ ​ ​ $ 132 ​ ​ ​ ​ ​ ​
ANA Merger
Schedule of milestone events	​ ​ ​ ​ ​ ​ Milestone Event ​ ​ ​ ​ ​ Milestone Payment First receipt of Marketing Approval (as defined in the 2020 Merger Agreement) from the FDA for any Niclosamide Product (as defined in the 2020 Merger Agreement) ​ ​ $ 45.0 million ​ ​ ​ ​ ​ Sales Milestones: ​ ​ ​ ​ ​ ​ Milestone Event – Worldwide Cumulative Net Sales of a Niclosamide Product ​ ​ ​ ​ ​ equal to or greater than: ​ ​ ​ ​ ​ Milestone Payment $500 million ​ ​ ​ $ $9.0 million $1 billion ​ $ 13.5 million $3 billion ​ $ 36.0 million $5 billion ​ $ 72.0 million
Head Quarters in Boston Lease
Schedule that reconciles the undiscounted lease liabilities to the total lease liabilities recognized on the unaudited consolidated balance sheet	​ The following table reconciles the undiscounted lease liabilities to the total lease liabilities recognized on the consolidated balance sheet as of March 31, 2022: ​ ​ ​ ​ ​ ​ ​ ​ As of ​ ​ ​ December 31, ​ 2022 (April 1 to December 31) ​ ​ 24 ​ 2023 ​ ​ 32 ​ 2024 ​ ​ 16 ​ Total lease payments ​ ​ 72 ​ Less effect of discounting ​ ​ (8) ​ Total ​ ​ 64 ​ Short-term portion ​ ​ (27) ​ Long-term portion ​ $ 37 ​ ​ ​ ​ ​ ​

Stockholders Equity (Tables)

Stockholders Equity (Tables)	3 Months Ended
	Mar. 31, 2022
Stockholders' Equity
Schedule of warrants outstanding	The following warrants were outstanding as of March 31, 2022 and December 31, 2021: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Number of Warrants: ​ ​ ​ ​ ​ Warrant Issuance ​ March 31, 2022 December 31, 2021 ​ Exercise Price ​ Expiration Date March 2017 ​ - 39,115 ​ $ 260.00 ​ March 2022 July 2018 ​ 1,440 1,440 ​ $ 186.75 ​ July 2028 April 2020 ​ 37,500 37,500 ​ $ 12.50 ​ April 2025 January 2021 ​ 2,500,000 2,500,000 ​ $ 6.03 ​ July 2026 October 2021 ​ 4,307,693 4,307,693 ​ $ 3.75 ​ April 2025 Total ​ 6,846,633 6,885,748 ​ ​ ​ ​ ​

Stock-Based Compensation (Table

Stock-Based Compensation (Tables)	3 Months Ended
	Mar. 31, 2022
Stock-Based Compensation
Schedule of share-based compensation expense	Stock-based compensation expense was included in general and administrative costs as follows in the accompanying statements of comprehensive loss: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Three Months Ended ​ ​ ​ March 31, ​ ​ ​ 2022 ​ 2021 ​ General and administrative ​ $ 207 ​ $ 187 ​
Schedule of stock option plan activity	The following table summarizes the Company’s activity related to its stock options for the three months ended March 31, 2022: ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ‑ ​ ​ ​ ​ ​ ​ ​ ​ Weighted ​ Average ​ Aggregate ​ ​ ​ ​ ​ Average ​ Remaining ​ Intrinsic ​ ​ ​ Number of ​ Exercise ​ Contractual ​ Value(1) ​ ​ ​ Options ​ Price ​ Term (years) ​ (in thousands) ​ Outstanding at December 31, 2021 ​ 974,999 ​ $ 3.99 ​ 9.3 ​ $ — ​ Granted ​ 40,000 ​ $ 1.02 ​ — ​ ​ — ​ Exercised ​ - ​ $ — ​ — ​ $ — ​ Forfeited/Cancelled ​ (33,334) ​ $ 6.04 ​ — ​ ​ — ​ Outstanding at March 31, 2022 ​ 981,665 ​ $ 3.80 ​ 9.1 ​ $ - ​ Vested and expected to vest at March 31, 2022 ​ 981,665 ​ $ 3.80 ​ 9.1 ​ $ - ​ Options exercisable at March 31, 2022 ​ 203,332 ​ $ 7.86 ​ 8.0 ​ $ - ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​
Schedule of weighted-average assumptions, option-pricing model	​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Three Months Ended ​ ​ ​ March 31, ​ ​ 2022 ​ 2021 ​ ​ ​ ​ ​ ​ ​ ​ ​ ​ Expected stock price volatility ​ ​ ​ 80.7 % ​ ​ — % Expected life of options (years) ​ ​ ​ 5.8 ​ ​ ​ — ​ Expected dividend yield ​ ​ ​ — % ​ ​ — % Risk free interest rate ​ ​ ​ 1.72 % ​ ​ — %

Net Loss Per Common Share (Tabl

Net Loss Per Common Share (Tables)	3 Months Ended
	Mar. 31, 2022
Net Loss Per Common Share
Schedule of potential common shares not considered in computation of diluted net loss per share	​ ​ ​ ​ ​ ​ ​ ​ Three Months Ended ​ ​ March 31, ​ 2022 2021 Stock options ​ 981,665 ​ 650,068 Warrants ​ 6,846,633 ​ 2,578,055

The Company and Basis of Pres_2

The Company and Basis of Presentation (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
The Company and Basis of Presentation
Cash	$ 11,557	$ 16,387
Accumulated deficit	$ (84,703)	$ (81,828)

Balance Sheet Detail - Property

Balance Sheet Detail - Property and Equipment (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Balance Sheet Detail
Total property and equipment	$ 221	$ 221
Less accumulated depreciation	(123)	(111)
Property and equipment, net	98	110
Research and development equipment
Balance Sheet Detail
Total property and equipment	158	158
Office equipment
Balance Sheet Detail
Total property and equipment	$ 63	$ 63

Balance Sheet Detail - Accrued

Balance Sheet Detail - Accrued Liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Balance Sheet Detail
External research and development expenses	$ 446	$ 854
Payroll related	174	376
Professional services	37	59
Other	36	12
Total	$ 693	$ 1,301

Commitments and Contingencies -

Commitments and Contingencies - Operating Leases - (Details) - USD ($) $ in Thousands	May 14, 2021	Feb. 01, 2021	Feb. 01, 2020	May 31, 2019	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Commitments and Contingencies
Right-of-use assets and other					$ 99		$ 105
Lease asset liability					64
Operating lease, liability current					27		26
Operating lease, liability noncurrent					$ 37		45
Korea
Commitments and Contingencies
Term of contract				5 years
Option to renew				true
Renewal term				5 years
Operating lease discount rate					10.00%
Weighted average remaining lease term					2 years 3 months
Non-cash expense related to Korea lease					$ 6	$ 5
Operating lease cash payments					8	8
Head Quarters in Boston Lease
Commitments and Contingencies
Term of contract	6 months	6 months	1 year
Monthly rental cost	$ 3	$ 3	$ 21		1
Rent concessions granted by the landlord	$ 2	$ 1	$ 32
Lease expense					4	$ 35
Right-of-use assets and other					0		0
Lease asset liability					$ 0		$ 0

Commitments and Contingencies_2

Commitments and Contingencies - Operating Lease - Lease liabilities (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2021
Maturity of the lease liability was as follows (in thousands):
2022 (April 1 to December 31)	$ 24
2023	32
2024	16
Total lease payments	72
Less effect of discounting	(8)
Total	64
Short-term portion	(27)	$ (26)
Lease liability, long-term	$ 37	$ 45

Commitments and Contingencies_3

Commitments and Contingencies - Xiehecheng Cultivation Service Agreement (Details) - Xiehecheng Chinese Herm Limited Corporation - Cultivation Service Agreement $ in Thousands	Mar. 31, 2022USD ($)
Other Commitments [Line Items]
2022	$ 132
Other Commitment, Total	$ 132

Commitments and Contingencies_4

Commitments and Contingencies - ANA Merger Milestone Payment (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Dec. 31, 2020
Asset Acquisition [Line Items]
Percentage of royalty payments	2.50%
Amount of royalty payments accrued	$ 0
ANA Merger
Asset Acquisition [Line Items]
Ownership acquired		100.00%
500 million
Asset Acquisition [Line Items]
Milestone Payment	9,000
Sales based milestone payment	500,000
1 billion
Asset Acquisition [Line Items]
Milestone Payment	13,500
Sales based milestone payment	1,000,000
3 billion
Asset Acquisition [Line Items]
Milestone Payment	36,000
Sales based milestone payment	3,000,000
5 billion
Asset Acquisition [Line Items]
Milestone Payment	72,000
Sales based milestone payment	5,000,000
First Amendment to Original CVR Agreement | ANA Merger
Asset Acquisition [Line Items]
Milestone Payment	$ 45,000

Commitments and Contingencies_5

Commitments and Contingencies - YourChoice and Pfizer License Agreement (Details) $ in Millions	1 Months Ended	3 Months Ended
	Mar. 31, 2015USD ($)	Mar. 31, 2022USD ($)
Commitments and Contingencies
Percentage of royalty payments		2.50%
Tier One Net Sales Milestone [Member]
Commitments and Contingencies
Sales based milestone payment		$ 1
Payments for specified global net sales milestones		500
Tier Two Net Sales Milestone [Member]
Commitments and Contingencies
Sales based milestone payment		1.5
Payments for specified global net sales milestones		1,000
Tier Three Net Sales Milestone [Member]
Commitments and Contingencies
Sales based milestone payment		4
Payments for specified global net sales milestones		3,000
Tier Four Net Sales Milestone [Member]
Commitments and Contingencies
Sales based milestone payment		8
Payments for specified global net sales milestones		5,000
YourChoice | License Agreements
Commitments and Contingencies
Milestones or royalty payments triggered		0
Royalty and milestone payment due		$ 19.5
Percentage of royalty payments		0.50%
YourChoice | License Agreements | Milestone Payments
Commitments and Contingencies
Royalty and milestone payment due		$ 5
Pfizer, Inc. | License Agreements
Commitments and Contingencies
Number of years after the first commercial sale	five
Milestones or royalty payments triggered		$ 0
Pfizer, Inc. | License Agreements | Milestone Payments | Maximum
Commitments and Contingencies
Potential payments upon achievement of certain milestones	37

Commitments and Contingencies_6

Commitments and Contingencies - Gemphire Contingent Value Rights Agreement (Details) - USD ($) $ in Thousands	Mar. 31, 2022	Mar. 23, 2021	Dec. 30, 2019
Commitments and Contingencies
Percentage of proceeds from the grant, sale, or transfer of rights		10.00%	80.00%
Amount of milestones accrued	$ 0

License and Collaboration Agr_2

License and Collaboration Agreement - Beijing (Details) $ in Thousands	3 Months Ended
	Mar. 31, 2022USD ($)
License Agreement with Beijing SL
License Agreements
Revenue recognized from the agreement	$ 0

Stockholders Equity - Warrants

Stockholders Equity - Warrants (Details) - $ / shares	Mar. 31, 2022	Dec. 31, 2021
Warrants
Number of Warrants	6,846,633	6,885,748
$260.00
Warrants
Number of Warrants		39,115
Exercise Price		$ 260
$186.75
Warrants
Number of Warrants	1,440	1,440
Exercise Price	$ 186.75	$ 186.75
$12.50
Warrants
Number of Warrants	37,500	37,500
Exercise Price	$ 12.50	$ 12.50
$6.03
Warrants
Number of Warrants	2,500,000	2,500,000
Exercise Price	$ 6.03	$ 6.03
$3.75
Warrants
Number of Warrants	4,307,693	4,307,693
Exercise Price	$ 3.75	$ 3.75

Stock-Based Compensation - Expe

Stock-Based Compensation - Expense (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
General and administrative
Number of Options
Stock-based compensation	$ 207	$ 187

Stock-Based Compensation - Stoc

Stock-Based Compensation - Stock Options (Details) - $ / shares	3 Months Ended		12 Months Ended
	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Stock Options, Additional Disclosures
Outstanding, Number, Beginning Balance (in shares)	974,999
Granted (in shares)	40,000
Forfeited/Cancelled (in shares)	(33,334)
Outstanding, Number, Ending Balance (in shares)	981,665		974,999
Vested and expected to vest (in shares)	981,665
Exercisable (in share)	203,332
Outstanding, Weighted Average Exercise Price, Beginning Balance (in dollars per share)	$ 3.99
Granted (in dollars per share)	1.02
Forfeited/Cancelled (in dollars per share)	6.04
Outstanding, Weighted Average Exercise Price, Ending Balance (in dollars per share)	3.80		$ 3.99
Vested and expected to vest (in dollars per share)	3.80
Exercisable (in dollars per share)	$ 7.86
Options, Outstanding, Weighted Average Remaining Contractual Term (years)	9 years 1 month 6 days		9 years 3 months 18 days
Vested and expected to vest (years)	9 years 1 month 6 days
Exercisable (years)	8 years
Stock options | Non Employee Director
Stock Options, Additional Disclosures
Vesting period	3 years
Granted (in shares)	40,000	0
Weighted average fair value per share of options granted	$ 0.70
Maximum | Stock options | 2019 Plan
Stock Options, Additional Disclosures
Expiration period	10 years

Stock Based Compensation - Assu

Stock Based Compensation - Assumptions (Details)	3 Months Ended
	Mar. 31, 2022
Stock-Based Compensation
Expected stock price volatility	80.70%
Expected life of options (years)	5 years 9 months 18 days
Risk free interest rate	1.72%

Stock-Based Compensation - Ever

Stock-Based Compensation - Evergreen provision (Details) - USD ($) $ in Millions	Jan. 01, 2022	Mar. 31, 2022	Mar. 31, 2021
2019 Plan
Number of Options
Period of automatic increase in shares reserved		10 years
Percentage of the common shares outstanding (as a percent)		4.00%
Number of shares added (In shares)	1,066,470
2019 Plan | Stock options
Number of Options
Vested		23,888	25,000
Forfeited, nonvested		33,334	270,287
Stock Plan 2018 And 2019 Plans
Unrecognized share-based compensation
Unrecognized share-based compensation cost		$ 1.1
Unrecognized share-based compensation - Weighted average period		1 year 8 months 12 days
Stock Plan 2018 And 2019 Plans | Stock options
Number of Options
Aggregate maximum number of shares of common stock that may be issued		8,709,299
Maximum | 2019 Plan
Number of Options
Aggregate maximum number of shares of common stock that may be issued		6,680,000

Net Loss Per Share of Common St

Net Loss Per Share of Common Stock - Antidilutive Securities (Details) - shares	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Stock options.
Potential common shares
Potential common shares	981,665	650,068
Warrants
Potential common shares
Potential common shares	6,846,633	2,578,055

Income Taxes (Details)

Income Taxes (Details) - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Operating loss carryforwards
Effective tax rate (as a percent)	0.00%	0.00%
Income tax benefit	$ 0	$ 0

Related Party Transactions (Det

Related Party Transactions (Details) - Dong-A ST - USD ($) $ in Thousands	Jun. 07, 2020	Sep. 28, 2018	Mar. 31, 2022	Mar. 31, 2021	Dec. 31, 2021
Manufacturing Agreement
Related Party Transactions
Term of agreement		5 years
Related party costs			$ 0	$ 0	$ 0
Manufacturing and Supply Agreement
Related Party Transactions
Term of agreement	5 years
Related party costs			$ 0	$ 0

Subsequent Events (Details)

Subsequent Events (Details) - 2018 Plan - shares	3 Months Ended
	Mar. 31, 2022	May 11, 2022
Subsequent Events
Number of shares added (In shares)	3,180,379
Subsequent Event
Subsequent Events
Awards outstanding (in shares)		0
Available for grant		0