MetaVia (MTVA) 8-K Departure of Directors or Certain Officers

Exhibit 10.1

AMENDMENT No. 1

TO THE

Gemphire Therapeutics Inc.

INDUCEMENT PLAN

The Gemphire Therapeutics Inc. Inducement Plan (the “Plan”) is hereby amended in the following respects, effective April 9, 2018, in accordance with Section 2(b)(vi) of the Plan.

The first sentence of Section 3(a) of the Plan is deleted in its entirety and replaced with the following sentence:

“Subject to the provisions of Section 9 relating to adjustments upon changes in stock, the aggregate number of shares of Common Stock that may be issued pursuant to Stock Awards after the Effective Date shall not exceed, in the aggregate, 450,000 shares (the “Share Reserve”).”