Jounce Therapeutics (JNCE) S-3 Shelf registration

Exhibit 12.1

Statement Regarding Computation of Ratios

(amounts in thousands)

	Year Ended December 31,
	2017			2016			2015			2014
Computation of Earnings:
Net loss	$	(16,443	)	$	(13,703	)	$	(28,532	)	$	(10,516	)
Add back: Fixed charges
Interest expense(1)	1,057			540			273			101
Net loss as adjusted	(15,386		)	(13,163		)	(28,259		)	(10,415		)
Computation of Fixed Charges:
Interest expense(1)	1,057			540			273			101
Deficiency(2)	$	(16,443	)	$	(13,703	)	$	(28,532	)	$	(10,516	)
Ratios of earnings to fixed charges	*			*			*			*

⁽¹⁾ Fixed charges consist of 30% of rent expense associated with our facility leases, which is considered to be a reasonable estimate of the interest factor.

⁽²⁾ Earnings were insufficient to cover fixed charges by the amounts indicated.

* Less than 1:1 coverage