| | (a) | Amount beneficially owned: HealthCare Royalty Partners II, L.P.: 1,245,455 HealthCare Royalty GP II, LLC: 1,245,455 HealthCare Royalty Management, LLC: 1,245,455 Clarke B. Futch: 1,245,455 Paul J. Hadden: 1,245,455 Matthew Q. Reber: 1,245,455 Christopher A. White: 1,245,455 Michael G. Carter: 1,245,455 HealthCare Royalty GP II, LLC is the general partner of HealthCare Royalty Partners II, L.P. and therefore may be deemed to beneficially own the shares beneficially owned by HealthCare Royalty Partners II, L.P. HealthCare Royalty Management, LLC is the investment manager of HealthCare Royalty GP II, LLC and therefore may be deemed to beneficially own the shares owned by HealthCare Royalty Partners II, L.P. Clarke B. Futch, Paul J. Hadden, Matthew Q. Reber, Christopher A. White and Michael G. Carter comprise the investment committee that, through HealthCare Royalty Management, LLC, is responsible for the voting and investment decisions relating to the shares beneficially owned by HealthCare Royalty Partners II, L.P. The reporting persons may be deemed to be a group as defined in Rule 13d-5(b) under the Securities Exchange Act of 1934, as amended, and each member of such group may be deemed to beneficially own the ordinary shares beneficially owned by other members constituting such group. Each of Messrs. Futch, Hadden, Reber, White and Carter disclaims beneficial ownership of all shares of common stock of the Issuer included in this report, and the filing of this Amendment No. 1 to Schedule 13G shall not be construed as an admission that any of Messrs. Futch, Hadden, Reber, White and Carter is the beneficial owner of any such securities for purposes of Section 13(d) or 13(g) of the Securities Exchange Act of 1934, as amended, or for any other purpose. |
| | (b) | Percent of class: HealthCare Royalty Partners II, L.P.: 7.3% HealthCare Royalty GP II, LLC: 7.3% HealthCare Royalty Management, LLC: 7.3% Clarke B. Futch: 7.3% Paul J. Hadden: 7.3% Matthew Q. Reber: 7.3% Christopher A. White: 7.3% Michael G. Carter: 7.3% Percentages based on 16,930,376 outstanding shares of the Issuer’s common stock as of November 1, 2016, as reported in the Issuer’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2016, plus 86,891 shares of Issuer’s common stock that are subject to warrants that are fully vested and exercisable. |