Avenue Therapeutics (ATXI) 8-K Changes in Registrant's Certifying Accountant

Exhibit 16.1

  Tel:  212-371-4446 Fax: 212-371-9374 www.bdo.com 622 Third Ave, Suite 3100 New York, NY 10017

January 25, 2023

Securities and Exchange Commission 

100 F Street N.E. 

Washington, D.C. 20549

We have been furnished with a copy of the response to Item 4.01 of Form 8-K for the event that occurred on January 21, 2023, to be filed by our former client, Avenue Therapeutics, Inc. We agree with the statements made in response to that Item insofar as they relate to our Firm.

Very truly yours,

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