Santander Uk F-3ASR Automatic shelf registration (foreign)

Exhibit 23.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in this Registration Statement on Form F-3 of Santander UK Group Holdings plc of our report dated 4 March 2021 relating to the financial statements, which appears in Santander UK Group Holdings plc's Annual Report on Form 20-F for the year ended December 31, 2020. We also consent to the reference to us under the heading “Experts” in such Registration Statement.

/s/ PricewaterhouseCoopers LLP
London, United Kingdom
6  July 2021