CVI Investments SC 13G AVENUE THERAPEUTICS / CVI Investments ownership change

CUSIP No:   05360L304

EXHIBIT II

JOINT FILING AGREEMENT

This will confirm the agreement by and among the undersigned that the Schedule 13G filed with the Securities and Exchange Commission on or about the date hereof with respect to the beneficial ownership by the undersigned of the shares of common stock of Avenue Therapeutics, Inc., $0.0001 par value per share, is being filed, and all amendments thereto will be filed, on behalf of each of the persons and entities named below in accordance with Rule 13d-1(k) under the Securities Exchange Act of 1934, as amended. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

Dated as of October 17, 2022

CVI INVESTMENTS, INC.	HEIGHTS CAPITAL MANAGEMENT, INC.
By: Heights Capital Management, Inc. pursuant to a Limited Power of Attorney	By:	/s/ Brian Sopinsky
	Name: Brian Sopinsky

By:	/s/ Brian Sopinsky	Title: Secretary
Name: Brian Sopinsky
Title: Secretary