Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts” and to the use of our report dated March 12, 2018 (except Note 12, as to which the date is June 11, 2018) in the Registration Statement (Form S-1) and the related Prospectus of Rhythm Pharmaceuticals, Inc. for the registration of 6,591,800 shares of its common stock.
| /s/ Ernst & Young LLP |
Boston, Massachusetts
June 18, 2018
