Rhythm Pharmaceuticals (RYTM) S-8 Registration of securities for employees

Exhibit 107.1

CALCULATION OF FILING FEE TABLE

FORM S-8

(Form Type)

RHYTHM PHARMACEUTICALS, INC.

(Exact Name of Registrant as Specified in its Charter)

Table I: Newly Registered Securities

Plan	Security Type	Security Class Title	Fee Calculation Rule	Amount Registered1			Proposed Maximum Offering Price Per Unit			Maximum Aggregate Offering Price		Fee Rate	Amount of Registration Fee
2017 Incentive Award Plan	Equity	Common Stock, par value $0.001 per share	Rule 457(c) and 457(h)		2,264,497	2	$	24.91	3	$	56,408,620.27	$110.20 per million dollars	$	6,216.23
	Total Offering Amounts									$	56,408,620.27		$	6,216.23
	Total Fee Offsets												$	—
	Net Fee Due												$	6,216.23

1	In accordance with Rule 416(a) under the Securities Act of 1933, as amended (the “Securities Act”), this registration statement shall be deemed to cover any additional securities that may from time to time be offered or issued under the Rhythm Pharmaceuticals, Inc. 2017 Incentive Award Plan (the “Incentive Plan”) to prevent dilution resulting from stock splits, stock dividends or similar transactions. In addition, pursuant to Rule 416(c) under the Securities Act, this registration statement also covers an indeterminate amount of interests to be offered or sold pursuant to the Incentive Plan.
2	Consists of 2,264,497 shares of Common Stock that may become issuable under the Incentive Plan pursuant to its terms.
3	Estimated solely for the purpose of calculating the registration fee pursuant to Rules 457(c) and 457(h) of the Securities Act of 1933, as amended, and based upon the average of the high and low prices of the Common Stock as reported on the Nasdaq Global Select Market on February 24, 2023.