Checkpoint Therapeutics (CKPT) 10-K 16 Mar 18 2017 FY Annual report Financial data

Document And Entity Information

Document And Entity Information - USD ($)	12 Months Ended
	Dec. 31, 2017	Mar. 13, 2018	Jun. 30, 2017
Document Information [Line Items]
Document Type	10-K
Amendment Flag	false
Document Period End Date	Dec. 31, 2017
Document Fiscal Year Focus	2,017
Document Fiscal Period Focus	FY
Entity Registrant Name	Checkpoint Therapeutics, Inc.
Entity Central Index Key	1,651,407
Current Fiscal Year End Date	--12-31
Entity Well-known Seasoned Issuer	No
Entity Voluntary Filers	No
Entity Current Reporting Status	Yes
Entity Filer Category	Accelerated Filer
Entity Public Float			$ 123,985,657
Common Class A [Member]
Document Information [Line Items]
Entity Common Stock, Shares Outstanding		7,000,000
Common Stock [Member]
Document Information [Line Items]
Entity Common Stock, Shares Outstanding		25,015,088

BALANCE SHEETS

BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Current Assets:
Cash and cash equivalents	$ 19,225	$ 35,086
Prepaid expenses and other assets	1,857	71
Other receivables - related party	331	821
Total current assets	21,413	35,978
Total Assets	21,413	35,978
Current Liabilities:
Accounts payable and accrued expenses	5,762	3,355
Accounts payable and accrued expenses - related party	610	318
Total current liabilities	6,372	3,673
Total Liabilities	6,372	3,673
Commitments and Contingencies
Stockholders' Equity
Common Stock Value	2	2
Common stock issuable, 591,836 and 721,699 shares as of December 31, 2017 and 2016, respectively	2,296	3,919
Additional paid-in capital	71,772	64,736
Accumulated deficit	(59,030)	(36,353)
Total Stockholders' Equity	15,041	32,305
Total Liabilities and Stockholders' Equity	21,413	35,978
Common Class A [Member]
Stockholders' Equity
Common Stock Value	1	1
Total Stockholders' Equity	$ 1	$ 1

BALANCE SHEETS _Parenthetical_

BALANCE SHEETS [Parenthetical] - $ / shares	Dec. 31, 2017	Dec. 31, 2016
Common Stock, Par or Stated Value Per Share	$ 0.0001	$ 0.0001
Common Stock, Shares Authorized	50,000,000	50,000,000
Common Stock, Shares, Issued	18,512,429	17,426,876
Common Stock, Shares, Outstanding	18,512,429	17,426,876
Common Stock, Shares Subscribed but Unissued	591,836	721,699
Common Class A [Member]
Common Stock, Shares Authorized	15,000,000
Common Stock, Shares, Issued	7,000,000	7,000,000
Common Stock, Shares, Outstanding	7,000,000	7,000,000

STATEMENTS OF OPERATIONS

STATEMENTS OF OPERATIONS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenue - related party	$ 1,725	$ 2,570	$ 590
Operating expenses:
Research and development	19,081	20,267	11,323
General and administrative	5,419	4,467	2,488
Total operating expenses	24,500	24,734	13,811
Loss from operations	(22,775)	(22,164)	(13,221)
Other income (expense)
Interest income	98	47	2
Interest expense and debt amortization	0	(344)	(235)
Change in fair value of warrant liabilities	0	0	(438)
Total other income (expense)	98	(297)	(671)
Net Loss	$ (22,677)	$ (22,461)	$ (13,892)
Loss per Share:
Basic and diluted net loss per common share outstanding	$ (1)	$ (1.04)	$ (1.41)
Basic and diluted weighted average number of common shares outstanding	22,618,931	21,544,205	9,855,668

STATEMENTS OF STOCKHOLDERS' EQU

STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) $ in Thousands	Total	Common Stock [Member]	Common Stock Issuable [Member]	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Common Class A [Member]
Balances at Dec. 31, 2014	$ 0	$ 0	$ 0	$ (1)	$ 0	$ 1
Balances (in Shares) at Dec. 31, 2014		1,000,000				7,000,000
Cash received for issuance of founder shares	1	$ 0	0	1	0	$ 0
Issuance of common shares for cash	57,817	$ 1	0	57,816	0	$ 0
Issuance of common shares for cash (in Shares)		11,563,400				0
Offering costs	(6,321)	$ 0	0	(6,321)	0	$ 0
Stock-based compensation expense	265	$ 0	0	265	0	$ 0
Stock-based compensation expense (in Shares)		1,000,000				0
Issuance of common shares - Founders Agreement	1,269	$ 0	0	1,269	0	$ 0
Issuance of common shares - Founders Agreement (in Shares)		289,085				0
Common shares issuable - Founders Agreement	3,024	$ 0	3,024	0	0	$ 0
Common shares issuable - Founders Agreement (in Shares)		0				0
Issuance of restricted stock and warrants for services	2,987	$ 0	0	2,987	0	$ 0
Issuance of restricted stock and warrants for services (in Shares)		1,500,000				0
Issuance of common shares for license expenses	633	$ 0	0	633	0	$ 0
Issuance of common shares for license expenses (in Shares)		636,830				0
Issuance of warrants	613	$ 0	0	613	0	$ 0
Net loss	(13,892)	0	0	0	(13,892)	0
Balances at Dec. 31, 2015	46,396	$ 1	3,024	57,262	(13,892)	$ 1
Balances (in Shares) at Dec. 31, 2015		15,989,315				7,000,000
Issuance of common shares and warrants for cash	570	$ 0	0	570	0	$ 0
Issuance of common shares and warrants for cash (in Shares)		126,640				0
Stock-based compensation expense	3,867	$ 0	0	3,867	0	$ 0
Stock-based compensation expense (in Shares)		619,000				0
Issuance of common shares - Founders Agreement	14	$ 1	(3,024)	3,037	0	$ 0
Issuance of common shares - Founders Agreement (in Shares)		691,921				0
Common shares issuable - Founders Agreement	3,919	$ 0	3,919	0	0	$ 0
Common shares issuable - Founders Agreement (in Shares)		0				0
Net loss	(22,461)	$ 0	0	0	(22,461)	$ 0
Balances at Dec. 31, 2016	32,305	$ 2	3,919	64,736	(36,353)	$ 1
Balances (in Shares) at Dec. 31, 2016		17,426,876				7,000,000
Stock-based compensation expense	3,117	$ 0	0	3,117	0	$ 0
Stock-based compensation expense (in Shares)		359,303				0
Issuance of common shares - Founders Agreement	0	$ 0	(3,919)	3,919	0	$ 0
Issuance of common shares - Founders Agreement (in Shares)		721,699				0
Common shares issuable - Founders Agreement	2,296	$ 0	2,296	0	0	$ 0
Common shares issuable - Founders Agreement (in Shares)		0				0
Exercise of warrants	0	$ 0	0	0	0	$ 0
Exercise of warrants (in Shares)		4,551				0
Net loss	(22,677)	$ 0	0	0	(22,677)	$ 0
Balances at Dec. 31, 2017	$ 15,041	$ 2	$ 2,296	$ 71,772	$ (59,030)	$ 1
Balances (in Shares) at Dec. 31, 2017		18,512,429				7,000,000

STATEMENTS OF CASH FLOWS

STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Cash Flows from Operating Activities:
Net loss	$ (22,677)	$ (22,461)	$ (13,892)
Adjustments to reconcile net loss to net cash used in operating activities:
Stock-based compensation expense	3,117	3,867	3,252
Change in fair value of warrant liabilities	0	0	438
Issuance of common shares - Founders Agreement	0	14	1,269
Common shares issuable - Founders Agreement	2,296	3,919	3,024
Issuance of common shares for license expenses	0	0	633
Amortization of debt discount	0	324	89
Research and development-licenses acquired, expensed	400	3,160	2,525
Changes in operating assets and liabilities:
Prepaid expenses and other assets	(1,786)	100	(171)
Other receivables - related party	490	(756)	(65)
Accounts payable and accrued expenses	2,699	1,883	1,790
Net cash used in operating activities	(15,461)	(9,950)	(1,108)
Cash Flows from Investing Activities:
Purchase of research and development licenses	(400)	(3,160)	(2,525)
Net cash used in investing activities	(400)	(3,160)	(2,525)
Cash Flows from Financing Activities:
Proceeds from note payable, net of debt discount	0	0	2,554
Payment of note payable	0	(2,792)	0
Proceeds from issuance of common stock, net of offering costs of $0, $0 and $6,321, respectively	0	570	51,496
Cash received for issuance of founders shares	0	0	1
Net cash (used in) provided by financing activities	0	(2,222)	54,051
Net (decrease) increase in cash and cash equivalents	(15,861)	(15,332)	50,418
Cash and cash equivalents at beginning of period	35,086	50,418	0
Cash and cash equivalents at end of period	19,225	35,086	50,418
Supplemental disclosure of cash flow information:
Cash paid for interest	0	20	56
Supplemental disclosure of noncash investing and financing activities:
Debt discount associated with warrant liabilities	0	0	175
Issuance of common shares - Founders Agreement	$ 3,919	$ 3,024	$ 0

STATEMENTS OF CASH FLOWS _Paren

STATEMENTS OF CASH FLOWS [Parenthetical] - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Payments of Stock Issuance Costs	$ 0	$ 0	$ 6,321

Organization and Description of

Organization and Description of Business Operations	12 Months Ended
	Dec. 31, 2017
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Organization, Consolidation, Basis of Presentation, Business Description and Accounting Policies [Text Block]	Note 1 - Organization and Description of Business Operations Checkpoint Therapeutics, Inc. (the “Company” or “Checkpoint”) was incorporated in Delaware on November 10, 2014. Checkpoint is a clinical-stage, immuno-oncology biopharmaceutical company focused on the acquisition, development and commercialization of novel treatments for patients with solid tumor cancers. The Company may acquire rights to these technologies by licensing the rights or otherwise acquiring an ownership interest in the technologies, funding their research and development and eventually either out-licensing or bringing the technologies to market. The Company may also enter into collaboration agreements with third and related parties including sponsored research agreements to develop these technologies for liquid tumors while retaining the rights in solid tumors. The Company is a majority-controlled subsidiary of Fortress Biotech, Inc. (“Fortress”). The Company’s common stock is listed on the NASDAQ Capital Market and trades under the symbol “CKPT.” Liquidity and Capital Resources The Company has incurred substantial operating losses since its inception, and expects to continue to incur significant operating losses for the foreseeable future and may never become profitable. As of December 31, 2017, the Company had an accumulated deficit of $ 59.0 In March 2018, the Company announced the pricing of an underwritten public offering, whereby it sold 4,600,000 690,000 4.35 23.0 20.9 2.1 The Company expects to continue to use the proceeds from previous financing transactions primarily for general corporate purposes, which may include financing the Company’s growth, developing new or existing product candidates, and funding capital expenditures, acquisitions and investments. The Company currently anticipates that its cash and cash equivalents balances at December 31, 2017 combined with the additional capital raised in the first quarter of 2018, are sufficient to fund its anticipated operating cash requirements for approximately the next 18 to 21 months.

Significant Accounting Policies

Significant Accounting Policies	12 Months Ended
	Dec. 31, 2017
Accounting Policies [Abstract]
Significant Accounting Policies [Text Block]	Note 2 - Significant Accounting Policies The Company’s financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“GAAP”) and include all adjustments necessary for the fair presentation of the Company’s financial position for the periods presented. The Company has no subsidiaries. Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision maker, or decision making group, in deciding how to allocate resources and in assessing performance. The Company views its operations and manages its business in one operating and reporting segment. The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting period. Actual results could differ from those estimates. The Company considers all short-term investments with an original maturity of three months or less when purchased to be cash equivalents. Other receivables consist of amounts due to the Company from TGTX, a related party, and are recorded at the invoiced amount (see Note 3). Research and development costs are expensed as incurred. Advance payments for goods and services that will be used in future research and development activities are expensed when the activity has been performed or when the goods have been received rather than when the payment is made. Upfront and milestone payments due to third parties that perform research and development services on the Company’s behalf will be expensed as services are rendered or when the milestone is achieved. Research and development costs primarily consist of personnel related expenses, including salaries, benefits, travel, and other related expenses, stock-based compensation, payments made to third parties for license and milestone costs related to in-licensed products and technology, payments made to third party contract research organizations for preclinical and clinical studies, investigative sites for clinical trials, consultants, the cost of acquiring and manufacturing clinical trial materials, costs associated with regulatory filings, laboratory costs and other supplies. In accordance with Accounting Standards Codification (“ASC”) 730-10-25-1, Research and Development Under the Founder’s Agreement with Checkpoint dated March 17, 2015, and amended and restated on July 11, 2016, Fortress is entitled to an annual equity fee on each anniversary of the Agreement equal to 2.5 The Company records the Annual Equity Fee in connection with the Founders Agreement with Fortress as contingent consideration. Contingent consideration is recorded when probable and reasonably estimable. The Company’s future share prices and shares outstanding cannot be estimated prior to the issuance of the Annual Equity Fee due to the nature of its assets and the Company’s stage of development. Due to these uncertainties, the Company has concluded that it is unable to reasonably estimate the contingent consideration until shares are actually issued on March 17 of each year. Because the issuance of shares on March 17, 2017 occurred prior to the issuance of the December 31, 2016 financial statements, the Company recorded approximately $ 3.9 In October 2017, the Founder’s Agreement was amended to change the issuance date of the Annual Equity Fee from the anniversary date of the Agreement to January 1 of each year beginning in 2018. The Annual Equity Fee payable on January 1, 2018 will be prorated such that it will only be payable for the portion of 2017 between March 17, 2017 and December 31, 2017. Because the issuance of shares on January 1, 2018 under the amended Founder’s Agreement occurred prior to the issuance of the December 31, 2017 financial statements, the Company recorded approximately $ 2.3 The Company expenses stock-based compensation to employees over the requisite service period based on the estimated grant-date fair value of the awards and forfeiture rates. The Company accounts for forfeitures as they occur. For stock-based compensation awards to non-employees, the Company re-measures the fair value of the non-employee awards at each reporting period prior to vesting and finally at the vesting date of the award. Changes in the estimated fair value of these non-employee awards are recognized as stock-based compensation expense in the period of change. The Company estimates the fair value of stock option grants using the Black-Scholes option pricing model. The assumptions used in calculating the fair value of stock-based awards represent management’s best estimates and involve inherent uncertainties and the application of management’s judgment. All stock-based compensation costs are recorded in general and administrative or research and development costs in the statements of operations based upon the underlying individual’s role at the Company. The Company follows the accounting guidance in ASC 820 for its fair value measurements of financial assets and liabilities measured at fair value on a recurring basis. Under this accounting guidance, fair value is defined as an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or a liability. The accounting guidance requires fair value measurements be classified and disclosed in one of the following three categories: Level 1: Quoted prices in active markets for identical assets or liabilities. Level 2: Observable inputs other than Level 1 prices, for similar assets or liabilities that are directly or indirectly observable in the marketplace. Level 3: Unobservable inputs which are supported by little or no market activity and that are financial instruments whose values are determined using pricing models, discounted cash flow methodologies, or similar techniques, as well as instruments for which the determination of fair value requires significant judgment or estimation. The fair value hierarchy also requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. Assets and liabilities measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The carrying amount of the Company’s financial instruments, including cash and cash equivalents and accounts payable approximate their fair values. Collaborative Arrangements The Company is paid by TGTX, a related party, a share of the cost of the license, development and future milestone payments that are payable under the agreements as described in Note 3. The gross amount of these payments are reported as revenue in the accompanying Statements of Operations. The Company acts as a principal, bears credit risk, obtains subcontractors and may perform part of the services required in the transactions. Consistent with ASC 605-45-15 these payments are treated as revenue to the Company. The actual expenses creating the payments by TGTX are reflected as research and development expenses. The Company recognizes revenue for the performance of services or the shipment of products when each of the following four criteria is met: (i) persuasive evidence of an arrangement exists; (ii) products are delivered or as services are rendered; (iii) the sales price is fixed or determinable; and (iv) collectability is reasonably assured. The Company follows ASC 605-25, Revenue Recognition - Multiple-Element Arrangements Collaborative Arrangements ASC 605-25 provides guidance relating to the separability of deliverables included in an arrangement into different units of accounting and the allocation of arrangement consideration to the units of accounting. The evaluation of multiple-element arrangements requires management to make judgments about (i) the identification of deliverables, (ii) whether such deliverables are separable from the other aspects of the contractual relationship, (iii) the estimated selling price of each deliverable, and (iv) the expected period of performance for each deliverable. To determine the units of accounting under a multiple-element arrangement, management evaluates certain separation criteria, including whether the deliverables have stand-alone value, based on the relevant facts and circumstances for each arrangement. Management then estimates the selling price for each unit of accounting and allocates the arrangement consideration to each unit utilizing the relative selling price method. The allocated consideration for each unit of accounting is recognized over the related obligation period in accordance with the applicable revenue recognition criteria. If there are deliverables in an arrangement that are not separable from other aspects of the contractual relationship, they are treated as a combined unit of accounting, with the allocated revenue for the combined unit recognized in a manner consistent with the revenue recognition applicable to the final deliverable in the combined unit. Payments received prior to satisfying the relevant revenue recognition criteria are recorded as deferred revenue in the Balance Sheet and recognized as revenue in the Statements of Operations when the related revenue recognition criteria are met. See Note 3 for a description of the collaborative arrangement. Revenue Recognition - Milestone Method The Company follows ASC 605-28, Revenue Recognition-Milestone Method The Company records income taxes using the asset and liability method. Deferred income tax assets and liabilities are recognized for the future tax effects attributable to temporary differences between the financial statement carrying amounts of existing assets and liabilities and their respective income tax bases, and operating loss and tax credit carryforwards. The Company establishes a valuation allowance if management believes it is more likely than not that the deferred tax assets will not be recovered based on an evaluation of objective verifiable evidence. For tax positions that are more likely than not of being sustained upon audit, the Company recognizes the largest amount of the benefit that is greater than 50% likely of being realized. For tax positions that are not more likely than not of being sustained upon audit, the Company does not recognize any portion of the benefit. The Company files a separate tax return under Subchapter C of the Internal Revenue Code. Prior to October 1, 2015, the Company was a subsidiary included in the consolidated tax return of Fortress. As a result of issuances of its common stock, the Company exited the consolidated tax group for federal and state income tax purposes. For financial reporting purposes, the Company calculated income tax provision and deferred income tax balances for the year ended December 31, 2015 as if it was a separate entity and had filed its own separate tax return under Subchapter C of the Internal Revenue Code. Net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding during the period. Since dividends are declared, paid and set aside among the holders of shares of common stock and Class A common stock pro-rata on an as-if-converted basis, the two-class method of computing net loss per share is not required. Diluted net loss per share does not reflect the effect of shares of common stock to be issued upon the exercise of stock options and warrants, as their inclusion would be anti-dilutive. December 31, 2017 2016 2015 Warrants (Note 7) 4,326,555 4,331,106 4,286,782 Stock options (Note 7) 60,000 60,000 - Unvested restricted stock (Note 7) 2,611,116 2,533,063 2,500,000 Total 6,997,671 6,924,169 6,786,782 In August 2014, the FASB issued ASU No. 2014-15, Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern In March 2016, the FASB issued ASU No. 2016-09 Compensation-Stock Compensation (Topic 718), Improvements to Employee Share-Based Payment Accounting (“ASU 2016-09”) In May 2014, the FASB issued ASU 2014-09, Revenue from Contracts with Customers (Topic 606), Revenue from Contracts with Customers (Topic 606): Deferral of the Effective Date Revenue from Contracts with Customers (Topic 606): Principal versus Agent Considerations (Reporting Revenue Gross versus Net), Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing, Revenue from Contracts with Customers (Topic 606): Narrow-Scope Improvements and Practical Expedients. In January 2017, the issued an 2017-01, “ Business Combinations (Topic 805) Clarifying the Definition of a Business In May 2017, the issued an ASU”) 2017-09, Compensation-Stock Compensation (Topic 718): Scope of Modification Accounting

License Agreements

License Agreements	12 Months Ended
	Dec. 31, 2017
Licenses Acquired [Abstract]
Licenses Acquired [Text Block]	Note 3 - License Agreements Dana-Farber Cancer Institute In March 2015, the Company entered into an exclusive license agreement with Dana-Farber to develop a portfolio of fully human immuno-oncology targeted antibodies. Under the terms of the agreement, Checkpoint paid Dana-Farber an up-front licensing fee of $ 1.0 500,000 32,500 0.065 5 10 136,830 0.6 21.5 60.0 In October 2017 the Company dosed the first patient in a Phase 1 clinical study of its anti-PD-LI antibody, CK-301. In connection with the license agreement with Dana-Farber, the Company entered into a collaboration agreement with TGTX, a related party, to develop and commercialize the anti-PD-L1 and anti-GITR antibody research programs in the field of hematological malignancies, while the Company retains the right to develop and commercialize these antibodies in the field of solid tumors. Michael Weiss, Chairman of the Board of Directors of Checkpoint and Fortress’ Executive Vice Chairman, Strategic Development, is also the Executive Chairman, President and Chief Executive Officer and a stockholder of TGTX. Under the terms of the collaboration agreement, TGTX paid the Company $ 0.5 21.5 7.0 14.5 60.0 84,000 590,000 NeuPharma, Inc. In March 2015, Fortress entered into an exclusive license agreement with NeuPharma to develop and commercialize novel irreversible, 3rd generation EGFR inhibitors, including CK-101, on a worldwide basis other than certain Asian countries. On the same date, Fortress assigned all of its right and interest in the EGFR inhibitors to the Company. Under the terms of the license agreement, the Company paid NeuPharma an up-front licensing fee of $ 1.0 40.0 22.5 40.0 In September 2016, the Company dosed the first patient in a Phase 1/2 clinical study of CK-101, which is currently ongoing as of December 31, 2017. Under the terms of the license agreement with NeuPharma, the Company expensed a non-refundable milestone payment of $ 1.0 In connection with the license agreement with NeuPharma, in March 2015, Fortress entered into an option agreement with TGTX, a related party, which agreement was assigned to the Company by Fortress on the same date, for a global collaboration of certain compounds licensed. The option agreement will expire on December 31, 2018, unless both parties agree to extend the option period. Also, in connection with the license agreement with NeuPharma, the Company entered into a Sponsored Research Agreement with NeuPharma for certain research and development activities. Effective January 11, 2016, TGTX agreed to assume all costs associated with this Sponsored Research Agreement and paid the Company for all amounts previously paid by the Company. This assumption of costs by TGTX survives any termination or expiration of the option agreement. For the years ended December 31, 2017 and 2016, the Company recognized approximately $ 0.6 1.0 Teva Pharmaceutical Industries Ltd. (through its subsidiary, Cephalon, Inc.) In December 2015, Fortress entered into a license agreement with Teva Pharmaceutical Industries Ltd. through its subsidiary, Cephalon, Inc. (“Cephalon”). This agreement was assigned to the Company by Fortress on the same date. Under the terms of the license agreement, Checkpoint obtained an exclusive, worldwide license to Cephalon’s patents relating to CEP-8983 and its small molecule prodrug, CEP-9722, a PARP inhibitor, which the Company now refers to as CK-102. The Company paid Cephalon an up-front licensing fee of $ 0.5 220.0 206.5 Jubilant Biosys Limited In May 2016, the Company entered into a license agreement with Jubilant Biosys Limited (“Jubilant”), whereby the Company obtained an exclusive, worldwide license to Jubilant’s family of patents covering compounds that inhibit BET proteins such as BRD4, including CK-103. Under the terms of the agreement, the Company paid Jubilant an up-front licensing fee of $ 2.0 89.0 59.5 89.0 In connection with the license agreement with Jubilant, the Company entered into a sublicense agreement with TGTX, a related party, to develop and commercialize the compounds licensed in the field of hematological malignancies, while the Company retains the right to develop and commercialize these compounds in the field of solid tumors. Michael Weiss, Chairman of the Board of Directors of Checkpoint and Fortress’ Executive Vice Chairman, Strategic Development, is also the Executive Chairman, President and Chief Executive Officer and a stockholder of TGTX. Under the terms of the Sublicense Agreement, TGTX paid the Company $ 1.0 87.2 25.5 61.7 89.0 50 1.0 1.5

Related Party Agreements

Related Party Agreements	12 Months Ended
	Dec. 31, 2017
Related Party Transactions [Abstract]
Related Party Transactions Disclosure [Text Block]	Note 4 - Related Party Agreements Founders Agreement and Management Services Agreement with Fortress Effective March 17, 2015, the Company entered into a Founders Agreement with Fortress, which was amended and restated on July 11, 2016 (the “Founders Agreement”). The Founders Agreement provides, that in exchange for the time and capital expended in the formation of Checkpoint and the identification of specific assets the acquisition of which resulted in the formation of a viable emerging growth life science company, the Company assumed $ 2.8 (12) In October 2017, the Founder’s Agreement was further amended to change the issuance date of the Annual Equity Fee from the anniversary date of the Agreement to January 1 of each year beginning in 2018. The Annual Equity Fee payable on January 1, 2018 will be prorated such that it will only be payable for the portion of 2017 between March 17, 2017 and December 31, 2017. Effective March 17, 2015, the Company entered into a Management Services Agreement (the “MSA”) with Fortress. Pursuant to the terms of the MSA, for a period of five (5) years, Fortress will render advisory and consulting services to the Company. Services provided under the MSA may include, without limitation, (i) advice and assistance concerning any and all aspects of Checkpoint’s operations, clinical trials, financial planning and strategic transactions and financings and (ii) conducting relations on behalf of the Company with accountants, attorneys, financial advisors and other professionals (collectively, the “Services”). The Company is obligated to utilize clinical research services, medical education, communication and marketing services and investor relations/public relation services of companies or individuals designated by Fortress, provided those services are offered at market prices. However, the Company is not obligated to take or act upon any advice rendered from Fortress and Fortress shall not be liable for any of the Company’s actions or inactions based upon their advice. Fortress and its affiliates, including all members of its Board of Directors, have been contractually exempt from fiduciary duties to the Company relating to corporate opportunities. In consideration for the Services, the Company will pay Fortress an annual consulting fee of $ 0.5 1.0 100 0.5 0.5 0.4 Caribe BioAdvisors, LLC In December 2016, the Company entered into an advisory agreement effective January 1, 2017 with Caribe BioAdvisors, LLC (“Caribe”), owned by Michael Weiss, to provide the advisory services of Mr. Weiss as Chairman of the Board. Pursuant to the agreement, Caribe will be paid an annual cash fee of $ 60,000

Notes Payable

Notes Payable	12 Months Ended
	Dec. 31, 2017
Debt Disclosure [Abstract]
Debt Disclosure [Text Block]	Note 5 - Notes Payable NSC Note In March 2015, Fortress closed the private placement of a promissory note for $ 10 2.8 139,592 25 10 2.8 324 As of December 31, 2016, the NSC Note was fully paid off. For the years ended December 31, 2016 and 2015, the Company recorded costs of approximately $ 324 89 20,000 146,000 8 NSC Note Payable Discount NSC Note Payable, December 31, 2015 balance $ 2,792 $ (324) 2,468 Payment of NSC debt (2,792) - (2,792) Amortization of debt discount - 324 324 December 31, 2016 balance $ - $ - $ -

Commitments and Contingencies

Commitments and Contingencies	12 Months Ended
	Dec. 31, 2017
Commitments and Contingencies Disclosure [Abstract]
Commitments and Contingencies Disclosure [Text Block]	Note 6 - Commitments and Contingencies Leases The Company is not a party to any leases for office space or equipment. License Agreements The Company has undertaken to make contingent milestone payments to the licensors of its portfolio of product candidates. In addition, the Company would pay royalties to such licensors based on a percentage of net sales of each product candidate following regulatory marketing approval (See Note 3). Litigation The Company recognizes a liability for a contingency when it is probable that liability has been incurred and when the amount of loss can be reasonably estimated. When a range of probable loss can be estimated, the Company accrues the most likely amount of such loss, and if such amount is not determinable, then the Company accrues the minimum of the range of probable loss. As of December 31, 2016 and 2017, there was no litigation against the Company.

Stockholders' Equity

Stockholders' Equity	12 Months Ended
	Dec. 31, 2017
Stockholders' Equity Note [Abstract]
Shareholders' Equity and Share-based Payments [Text Block]	Note 7 - Stockholders’ Equity Common Stock The Company is authorized to issue 50,000,000 0.0001 15,000,000 7,000,000 Pursuant to the Founders Agreement, the Company issued 721,699 2.5 In November 2017, the Company filed a shelf registration statement on Form S-3 (the "S-3"), which was declared effective in December 2017. Under the S-3, the Company may sell up to a total of $ 100 3.0 During the year ended December 31, 2017, the Company did not sell any shares of common stock under the ATM. The S-3 is currently the Company’s only active shelf registration statement. Subsequent to the underwritten public offering that was completed on March 12, 2018, approximately $ 77.0 Offerings of Common Stock and Warrants In February 2016, the Company closed on proceeds of $ 0.6 10,000 3,500 7.00 45,000 126,640 44,324 Pursuant to the Founders Agreement, the Company issued 3,166 2.5 Also, pursuant to the Founders Agreement, the Company issued 721,699 2.5 3.9 In October 2017, the Founder’s Agreement was amended to change the issuance date of the Annual Equity Fee from the anniversary date of the Agreement to January 1 of each year beginning in 2018. The Annual Equity Fee payable on January 1, 2018 will be prorated such that it will only be payable for the portion of 2017 between March 17, 2017 and December 31, 2017. Because the issuance of shares on January 1, 2018 under the amended Founder’s Agreement occurred prior to the issuance of the December 31, 2017 financial statements, the Company recorded approximately $ 2.3 Equity Incentive Plan The Company has in effect the Amended and Restated 2015 Incentive Plan (“2015 Incentive Plan’). The 2015 Incentive Plan was adopted in March 2015 by our stockholders. Under the 2015 Incentive Plan, the compensation committee of the Company’s board of directors is authorized to grant stock-based awards to directors, officers, employees and consultants. An amendment to the 2015 Incentive Plan was approved by stockholders in June 2017 to increase the shares available for issuance to 5,000,000 10 As of December 31, 2017, 2,961,697 Restricted Stock In March 2015, the Company issued a restricted stock grant to Dr. Wayne Marasco for services in connection with its Scientific Advisory Board. Dr. Marasco was issued a grant for 1.5 25 48 139,303 0.5 0.9 2.5 3.0 Certain employees and directors have been awarded restricted stock under the 2015 Incentive Plan. The Company incurred approximately $ 1.8 1.3 0.3 226 58 Weighted Average Grant Date Fair Number of Units Value Nonvested at December 31, 2016 2,533,063 $ 2.93 Granted 359,303 7.69 Vested (281,250) 0.07 Nonvested at December 31, 2017 2,611,116 $ 3.89 As of December 31, 2017, there was $ 2.9 1.2 333,334 Stock Options Stock Options Weighted Average Weighted Average Outstanding as of December 31, 2016 60,000 $ 5.43 9.96 Granted - - Outstanding as of December 31, 2017 60,000 $ 5.43 9.09 Upon the exercise of stock options, the Company will issue new shares of its common stock. Warrants Warrants Weighted Average Weighted Average Outstanding as of December 31, 2016 4,331,106 $ 6.62 4.67 Granted - - Exercised (4,551) - Outstanding as of December 31, 2017 4,326,555 $ 6.62 3.67 Upon the exercise of warrants, the Company will issue new shares of its common stock. Stock-Based Compensation For the year ended December 31, 2017 2016 2015 Research and development $ 1,180 $ 2,557 $ 2,987 General and administrative 1,937 1,310 265 Total stock-based compensation expense $ 3,117 $ 3,867 $ 3,252

Income Taxes

Income Taxes	12 Months Ended
	Dec. 31, 2017
Income Tax Disclosure [Abstract]
Income Tax Disclosure [Text Block]	Note 8 - Income Taxes The Company has accumulated net losses since inception and has not recorded an income tax provision or benefit during the years ended December 31, 2017 and 2016. For the years ended December 31, 2017 2016 Statutory federal income tax rate 35 % 35 % State taxes, net of federal tax benefit 11 % 1 % Credits 2 % 3 % Change in federal tax rate (27) % - Change in state tax rate 8 % (2) % Provision to return 5 % 5 % Stock based compensation shortfall (4) % (4) % Other - (2) % Change in valuation allowance (30) % (36) % Income taxes provision (benefit) - - As of December 31, 2017 2016 Deferred tax assets: Net operating loss carryovers $ 10,662 $ 5,148 Stock compensation and other 1,839 1,624 Change in fair value of warrant liabilities 149 157 Amortization of license 5,410 4,656 Accruals and reserves 11 25 Tax credits 905 733 Start Up Costs 46 54 Total deferred tax assets 19,022 12,397 Less valuation allowance (19,022) (12,397) Deferred tax asset, net of valuation allowance $ - $ - On December 22, 2017, “H.R.1”, formerly known as the “Tax Cuts and Jobs Act”, was signed into law. Among other items, H.R.1 reduces the federal corporate tax rate to 21 35 6.2 The Company has determined, based upon available evidence, that it is more likely than not that the net deferred tax asset will not be realized and, accordingly, has provided a full valuation allowance against its net deferred tax asset. A valuation allowance of approximately $ 19.0 12.4 As of December 31, 2017, the Company had federal and state net operating loss carryforwards of approximately $ 31.3 60.5 2035 2035 There are no significant matters determined to be unrecognized tax benefits taken or expected to be taken in a tax return, in accordance with ASC 740 “Income Taxes” (“ASC 740”), which clarifies the accounting for uncertainty in income taxes recognized in the financial statements, that have been recorded on the Company’s financial statements for the year ended December 31, 2017. The Company does not anticipate a material change to unrecognized tax benefits in the next twelve months. Additionally, ASC 740 provides guidance on the recognition of interest and penalties related to income taxes. There were no interest or penalties related to income taxes that have been accrued or recognized as of and for the period ended December 31, 2017. The federal and state tax returns for the periods ended December 31, 2015, 2016 and 2017 are currently open for examination under the applicable federal and state income tax statues of limitations.

Accounts Payable and Accrued Ex

Accounts Payable and Accrued Expenses	12 Months Ended
	Dec. 31, 2017
Payables and Accruals [Abstract]
Accounts Payable, Accrued Liabilities, and Other Liabilities Disclosure, Current [Text Block]	Note 9 - Accounts Payable and Accrued Expenses For the year ended December 31, 2017 2016 Accounts payable $ 3,645 $ 2,473 Accrued compensation 405 291 Research and development 1,466 378 Other 246 213 Accounts payable and accrued expenses - related party 610 318 Total accounts payable and accrued expenses $ 6,372 $ 3,673

Quarterly Financial Data (Unaud

Quarterly Financial Data (Unaudited)	12 Months Ended
	Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract]
Quarterly Financial Information [Text Block]	Note 10 - Quarterly Financial Data (Unaudited) (in thousands, except per share data) First Quarter Second Quarter Third Quarter Fourth Quarter 2017 Total Revenue $ 693 $ 351 $ 349 $ 332 Operating expenses $ 5,107 $ 6,823 $ 6,299 $ 6,271 Other income $ 31 $ 24 $ 22 $ 21 Net loss $ (4,383) $ (6,448) $ (5,928) $ (5,918) Basic and diluted net loss per common share $ (0.20) $ (0.28) $ (0.26) $ (0.26) 2016 Total Revenue $ 277 $ 1,249 $ 546 $ 498 Operating expenses $ 3,549 $ 6,667 $ 5,685 $ 8,833 Other income/(expense) $ (333) $ 13 $ 11 $ 12 Net loss $ (3,605) $ (5,405) $ (5,128) $ (8,323) Basic and diluted net loss per common share $ (0.17) $ (0.25) $ (0.24) $ (0.38)

Subsequent Events

Subsequent Events	12 Months Ended
	Dec. 31, 2017
Subsequent Events [Abstract]
Subsequent Events [Text Block]	Note 11 - Subsequent Events On March 8, 2018, the Company announced the pricing of an underwritten public offering, whereby it sold 4,600,000 690,000 4.35 23.0 20.9 2.1

Significant Accounting Polici19

Significant Accounting Policies (Policies)	12 Months Ended
	Dec. 31, 2017
Accounting Policies [Abstract]
Basis of Accounting, Policy [Policy Text Block]	Basis of Presentation The Company’s financial statements have been prepared in conformity with accounting principles generally accepted in the United States of America (“GAAP”) and include all adjustments necessary for the fair presentation of the Company’s financial position for the periods presented. The Company has no subsidiaries.
Segment Reporting, Policy [Policy Text Block]	Segments Operating segments are defined as components of an enterprise about which separate discrete information is available for evaluation by the chief operating decision maker, or decision making group, in deciding how to allocate resources and in assessing performance. The Company views its operations and manages its business in one operating and reporting segment.
Use of Estimates, Policy [Policy Text Block]	Use of Estimates The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities and disclosure of contingent assets and liabilities at the date of the financial statements and the reported amounts of expenses during the reporting period. Actual results could differ from those estimates.
Cash and Cash Equivalents, Policy [Policy Text Block]	Cash and Cash Equivalents The Company considers all short-term investments with an original maturity of three months or less when purchased to be cash equivalents.
Receivables, Policy [Policy Text Block]	Other Receivables - Related Party Other receivables consist of amounts due to the Company from TGTX, a related party, and are recorded at the invoiced amount (see Note 3).
Research and Development Expense, Policy [Policy Text Block]	Research and Development Costs Research and development costs are expensed as incurred. Advance payments for goods and services that will be used in future research and development activities are expensed when the activity has been performed or when the goods have been received rather than when the payment is made. Upfront and milestone payments due to third parties that perform research and development services on the Company’s behalf will be expensed as services are rendered or when the milestone is achieved. Research and development costs primarily consist of personnel related expenses, including salaries, benefits, travel, and other related expenses, stock-based compensation, payments made to third parties for license and milestone costs related to in-licensed products and technology, payments made to third party contract research organizations for preclinical and clinical studies, investigative sites for clinical trials, consultants, the cost of acquiring and manufacturing clinical trial materials, costs associated with regulatory filings, laboratory costs and other supplies. In accordance with Accounting Standards Codification (“ASC”) 730-10-25-1, Research and Development
Equity Method Investments, Policy [Policy Text Block]	Annual Equity Fee Under the Founder’s Agreement with Checkpoint dated March 17, 2015, and amended and restated on July 11, 2016, Fortress is entitled to an annual equity fee on each anniversary of the Agreement equal to 2.5 The Company records the Annual Equity Fee in connection with the Founders Agreement with Fortress as contingent consideration. Contingent consideration is recorded when probable and reasonably estimable. The Company’s future share prices and shares outstanding cannot be estimated prior to the issuance of the Annual Equity Fee due to the nature of its assets and the Company’s stage of development. Due to these uncertainties, the Company has concluded that it is unable to reasonably estimate the contingent consideration until shares are actually issued on March 17 of each year. Because the issuance of shares on March 17, 2017 occurred prior to the issuance of the December 31, 2016 financial statements, the Company recorded approximately $ 3.9 In October 2017, the Founder’s Agreement was amended to change the issuance date of the Annual Equity Fee from the anniversary date of the Agreement to January 1 of each year beginning in 2018. The Annual Equity Fee payable on January 1, 2018 will be prorated such that it will only be payable for the portion of 2017 between March 17, 2017 and December 31, 2017. Because the issuance of shares on January 1, 2018 under the amended Founder’s Agreement occurred prior to the issuance of the December 31, 2017 financial statements, the Company recorded approximately $ 2.3
Share-based Compensation, Option and Incentive Plans Policy [Policy Text Block]	Stock-Based Compensation Expenses The Company expenses stock-based compensation to employees over the requisite service period based on the estimated grant-date fair value of the awards and forfeiture rates. The Company accounts for forfeitures as they occur. For stock-based compensation awards to non-employees, the Company re-measures the fair value of the non-employee awards at each reporting period prior to vesting and finally at the vesting date of the award. Changes in the estimated fair value of these non-employee awards are recognized as stock-based compensation expense in the period of change. The Company estimates the fair value of stock option grants using the Black-Scholes option pricing model. The assumptions used in calculating the fair value of stock-based awards represent management’s best estimates and involve inherent uncertainties and the application of management’s judgment. All stock-based compensation costs are recorded in general and administrative or research and development costs in the statements of operations based upon the underlying individual’s role at the Company.
Fair Value Measurement, Policy [Policy Text Block]	Fair Value Measurement The Company follows the accounting guidance in ASC 820 for its fair value measurements of financial assets and liabilities measured at fair value on a recurring basis. Under this accounting guidance, fair value is defined as an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or a liability. The accounting guidance requires fair value measurements be classified and disclosed in one of the following three categories: Level 1: Quoted prices in active markets for identical assets or liabilities. Level 2: Observable inputs other than Level 1 prices, for similar assets or liabilities that are directly or indirectly observable in the marketplace. Level 3: Unobservable inputs which are supported by little or no market activity and that are financial instruments whose values are determined using pricing models, discounted cash flow methodologies, or similar techniques, as well as instruments for which the determination of fair value requires significant judgment or estimation. The fair value hierarchy also requires an entity to maximize the use of observable inputs and minimize the use of unobservable inputs when measuring fair value. Assets and liabilities measured at fair value are classified in their entirety based on the lowest level of input that is significant to the fair value measurement. The carrying amount of the Company’s financial instruments, including cash and cash equivalents and accounts payable approximate their fair values.
Revenue Recognition, Policy [Policy Text Block]	Revenue Recognition Collaborative Arrangements The Company is paid by TGTX, a related party, a share of the cost of the license, development and future milestone payments that are payable under the agreements as described in Note 3. The gross amount of these payments are reported as revenue in the accompanying Statements of Operations. The Company acts as a principal, bears credit risk, obtains subcontractors and may perform part of the services required in the transactions. Consistent with ASC 605-45-15 these payments are treated as revenue to the Company. The actual expenses creating the payments by TGTX are reflected as research and development expenses. The Company recognizes revenue for the performance of services or the shipment of products when each of the following four criteria is met: (i) persuasive evidence of an arrangement exists; (ii) products are delivered or as services are rendered; (iii) the sales price is fixed or determinable; and (iv) collectability is reasonably assured. The Company follows ASC 605-25, Revenue Recognition - Multiple-Element Arrangements Collaborative Arrangements ASC 605-25 provides guidance relating to the separability of deliverables included in an arrangement into different units of accounting and the allocation of arrangement consideration to the units of accounting. The evaluation of multiple-element arrangements requires management to make judgments about (i) the identification of deliverables, (ii) whether such deliverables are separable from the other aspects of the contractual relationship, (iii) the estimated selling price of each deliverable, and (iv) the expected period of performance for each deliverable. To determine the units of accounting under a multiple-element arrangement, management evaluates certain separation criteria, including whether the deliverables have stand-alone value, based on the relevant facts and circumstances for each arrangement. Management then estimates the selling price for each unit of accounting and allocates the arrangement consideration to each unit utilizing the relative selling price method. The allocated consideration for each unit of accounting is recognized over the related obligation period in accordance with the applicable revenue recognition criteria. If there are deliverables in an arrangement that are not separable from other aspects of the contractual relationship, they are treated as a combined unit of accounting, with the allocated revenue for the combined unit recognized in a manner consistent with the revenue recognition applicable to the final deliverable in the combined unit. Payments received prior to satisfying the relevant revenue recognition criteria are recorded as deferred revenue in the Balance Sheet and recognized as revenue in the Statements of Operations when the related revenue recognition criteria are met. See Note 3 for a description of the collaborative arrangement. Revenue Recognition - Milestone Method The Company follows ASC 605-28, Revenue Recognition-Milestone Method
Income Tax, Policy [Policy Text Block]	Income Taxes The Company records income taxes using the asset and liability method. Deferred income tax assets and liabilities are recognized for the future tax effects attributable to temporary differences between the financial statement carrying amounts of existing assets and liabilities and their respective income tax bases, and operating loss and tax credit carryforwards. The Company establishes a valuation allowance if management believes it is more likely than not that the deferred tax assets will not be recovered based on an evaluation of objective verifiable evidence. For tax positions that are more likely than not of being sustained upon audit, the Company recognizes the largest amount of the benefit that is greater than 50% likely of being realized. For tax positions that are not more likely than not of being sustained upon audit, the Company does not recognize any portion of the benefit. The Company files a separate tax return under Subchapter C of the Internal Revenue Code. Prior to October 1, 2015, the Company was a subsidiary included in the consolidated tax return of Fortress. As a result of issuances of its common stock, the Company exited the consolidated tax group for federal and state income tax purposes. For financial reporting purposes, the Company calculated income tax provision and deferred income tax balances for the year ended December 31, 2015 as if it was a separate entity and had filed its own separate tax return under Subchapter C of the Internal Revenue Code.
Earnings Per Share, Policy [Policy Text Block]	Net Loss per Share Net loss per share is computed by dividing net loss by the weighted average number of common shares outstanding during the period. Since dividends are declared, paid and set aside among the holders of shares of common stock and Class A common stock pro-rata on an as-if-converted basis, the two-class method of computing net loss per share is not required. Diluted net loss per share does not reflect the effect of shares of common stock to be issued upon the exercise of stock options and warrants, as their inclusion would be anti-dilutive. December 31, 2017 2016 2015 Warrants (Note 7) 4,326,555 4,331,106 4,286,782 Stock options (Note 7) 60,000 60,000 - Unvested restricted stock (Note 7) 2,611,116 2,533,063 2,500,000 Total 6,997,671 6,924,169 6,786,782
New Accounting Pronouncements, Policy [Policy Text Block]	Recently Adopted Accounting Pronouncements In August 2014, the FASB issued ASU No. 2014-15, Disclosure of Uncertainties about an Entity’s Ability to Continue as a Going Concern In March 2016, the FASB issued ASU No. 2016-09 Compensation-Stock Compensation (Topic 718), Improvements to Employee Share-Based Payment Accounting (“ASU 2016-09”) In May 2014, the FASB issued ASU 2014-09, Revenue from Contracts with Customers (Topic 606), Revenue from Contracts with Customers (Topic 606): Deferral of the Effective Date Revenue from Contracts with Customers (Topic 606): Principal versus Agent Considerations (Reporting Revenue Gross versus Net), Revenue from Contracts with Customers (Topic 606): Identifying Performance Obligations and Licensing, Revenue from Contracts with Customers (Topic 606): Narrow-Scope Improvements and Practical Expedients. In January 2017, the issued an 2017-01, “ Business Combinations (Topic 805) Clarifying the Definition of a Business In May 2017, the issued an ASU”) 2017-09, Compensation-Stock Compensation (Topic 718): Scope of Modification Accounting

Significant Accounting Polici20

Significant Accounting Policies (Tables)	12 Months Ended
	Dec. 31, 2017
Earnings Per Share [Abstract]
Schedule of Antidilutive Securities Excluded from Computation of Earnings Per Share [Table Text Block]	The following table summarizes potentially dilutive securities outstanding at December 31, 2017, 2016, and 2015 that were excluded from the computation of diluted net loss per share, as they would be anti-dilutive: December 31, 2017 2016 2015 Warrants (Note 7) 4,326,555 4,331,106 4,286,782 Stock options (Note 7) 60,000 60,000 - Unvested restricted stock (Note 7) 2,611,116 2,533,063 2,500,000 Total 6,997,671 6,924,169 6,786,782

Notes Payable (Tables)

Notes Payable (Tables)	12 Months Ended
	Dec. 31, 2017
Debt Disclosure [Abstract]
Schedule of Debt [Table Text Block]	The following table summarizes the Company’s Amended NSC Note activities as of December 31, 2016 ($ in thousands). NSC Note Payable Discount NSC Note Payable, December 31, 2015 balance $ 2,792 $ (324) 2,468 Payment of NSC debt (2,792) - (2,792) Amortization of debt discount - 324 324 December 31, 2016 balance $ - $ - $ -

Stockholders' Equity (Tables)

Stockholders' Equity (Tables)	12 Months Ended
	Dec. 31, 2017
Stockholders' Equity Note [Abstract]
Nonvested Restricted Stock Shares Activity [Table Text Block]	The following table summarizes restricted stock award activity for the year ended December 31, 2017: Weighted Average Grant Date Fair Number of Units Value Nonvested at December 31, 2016 2,533,063 $ 2.93 Granted 359,303 7.69 Vested (281,250) 0.07 Nonvested at December 31, 2017 2,611,116 $ 3.89
Schedule of Share-based Compensation, Stock Options, Activity [Table Text Block]	The following table summarizes stock option award activity for the year ended December 31, 2017. Stock Options Weighted Average Weighted Average Outstanding as of December 31, 2016 60,000 $ 5.43 9.96 Granted - - Outstanding as of December 31, 2017 60,000 $ 5.43 9.09
Schedule of Stockholders' Equity Note, Warrants or Rights [Table Text Block]	A summary of warrant activities for year ended December 31, 2017 is presented below: Warrants Weighted Average Weighted Average Outstanding as of December 31, 2016 4,331,106 $ 6.62 4.67 Granted - - Exercised (4,551) - Outstanding as of December 31, 2017 4,326,555 $ 6.62 3.67
Schedule of Share-based Compensation, Activity [Table Text Block]	The following table summarizes stock-based compensation expense for the years ended December 31, 2017 and 2016 ($ in thousands). For the year ended December 31, 2017 2016 2015 Research and development $ 1,180 $ 2,557 $ 2,987 General and administrative 1,937 1,310 265 Total stock-based compensation expense $ 3,117 $ 3,867 $ 3,252

Income Taxes (Tables)

Income Taxes (Tables)	12 Months Ended
	Dec. 31, 2017
Income Tax Disclosure [Abstract]
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block]	A reconciliation of the statutory U.S. federal rate to the Company’s effective tax rate is as follows: For the years ended December 31, 2017 2016 Statutory federal income tax rate 35 % 35 % State taxes, net of federal tax benefit 11 % 1 % Credits 2 % 3 % Change in federal tax rate (27) % - Change in state tax rate 8 % (2) % Provision to return 5 % 5 % Stock based compensation shortfall (4) % (4) % Other - (2) % Change in valuation allowance (30) % (36) % Income taxes provision (benefit) - -
Schedule of Deferred Tax Assets and Liabilities [Table Text Block]	The components of the net deferred tax asset as of December 31, 2017 and 2016 are the following (in thousands): As of December 31, 2017 2016 Deferred tax assets: Net operating loss carryovers $ 10,662 $ 5,148 Stock compensation and other 1,839 1,624 Change in fair value of warrant liabilities 149 157 Amortization of license 5,410 4,656 Accruals and reserves 11 25 Tax credits 905 733 Start Up Costs 46 54 Total deferred tax assets 19,022 12,397 Less valuation allowance (19,022) (12,397) Deferred tax asset, net of valuation allowance $ - $ -

Accounts Payable and Accrued 24

Accounts Payable and Accrued Expenses (Tables)	12 Months Ended
	Dec. 31, 2017
Payables and Accruals [Abstract]
Schedule of Accounts Payable and Accrued Liabilities [Table Text Block]	At December 31, 2017 and 2016, accounts payable and accrued expenses consisted of the following: For the year ended December 31, 2017 2016 Accounts payable $ 3,645 $ 2,473 Accrued compensation 405 291 Research and development 1,466 378 Other 246 213 Accounts payable and accrued expenses - related party 610 318 Total accounts payable and accrued expenses $ 6,372 $ 3,673

Quarterly Financial Data (Una25

Quarterly Financial Data (Unaudited) (Tables)	12 Months Ended
	Dec. 31, 2017
Quarterly Financial Information Disclosure [Abstract]
Quarterly Financial Information [Table Text Block]	(in thousands, except per share data) First Quarter Second Quarter Third Quarter Fourth Quarter 2017 Total Revenue $ 693 $ 351 $ 349 $ 332 Operating expenses $ 5,107 $ 6,823 $ 6,299 $ 6,271 Other income $ 31 $ 24 $ 22 $ 21 Net loss $ (4,383) $ (6,448) $ (5,928) $ (5,918) Basic and diluted net loss per common share $ (0.20) $ (0.28) $ (0.26) $ (0.26) 2016 Total Revenue $ 277 $ 1,249 $ 546 $ 498 Operating expenses $ 3,549 $ 6,667 $ 5,685 $ 8,833 Other income/(expense) $ (333) $ 13 $ 11 $ 12 Net loss $ (3,605) $ (5,405) $ (5,128) $ (8,323) Basic and diluted net loss per common share $ (0.17) $ (0.25) $ (0.24) $ (0.38)

Organization and Description 26

Organization and Description of Business Operations (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	Mar. 08, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Retained Earnings (Accumulated Deficit)		$ (59,030)	$ (36,353)
Payments of Stock Issuance Costs		$ 0	$ 0	$ 6,321
Underwritten Public Offering [Member] | Subsequent Event [Member]
Stock Issued During Period, Shares, New Issues	4,600,000
Shares Issued, Price Per Share	$ 4.35
Stock Issued During Period, Value, New Issues	$ 23,000
Proceeds from Issuance Underwritten Public Offering	20,900
Payments of Stock Issuance Costs	$ 2,100
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period	690,000

Significant Accounting Polici27

Significant Accounting Policies (Details) - shares	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	6,997,671	6,924,169	6,786,782
Warrants (Note 7)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	4,326,555	4,331,106	4,286,782
Stock options (Note 7)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	60,000	60,000	0
Unvested restricted stock (Note 7)
Antidilutive Securities Excluded from Computation of Earnings Per Share, Amount	2,611,116	2,533,063	2,500,000

Significant Accounting Polici28

Significant Accounting Policies (Details Textual) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Mar. 17, 2015
Equity Method Investment, Annual Equity Fee, Percentage			2.50%
Research and Development Expense [Member]
Stock Issued During Period, Value, Issued for Services	$ 2.3	$ 3.9

License Agreements (Details Tex

License Agreements (Details Textual) - USD ($)	1 Months Ended				12 Months Ended
	May 31, 2016	Sep. 30, 2015	May 31, 2015	Mar. 31, 2015	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Clinical Development Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue Recognition Milestone Method, Payments Due					$ 87,200,000
Neupharma [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment Of Upfront Fees				$ 1,000,000
Reimbursement Of Cost Recognized As Revenue					600,000	$ 1,000,000
Payment For Non refundable Milestone payments						1,000,000
Neupharma [Member] | Additional Sales Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum Potential Milestone Payments					22,500,000
Neupharma [Member] | Clinical Development Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum Potential Milestone Payments					40,000,000
Neupharma [Member] | Regulatory Approvals To Commercialize The Products [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum Potential Milestone Payments					40,000,000
Dana-Farber [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Shares Issued, Price Per Share			$ 0.065
Stock Issued During Period, Shares, Issued for Services		136,830	500,000
Stock Issued During Period, Value, Issued for Services		$ 600,000	$ 32,500
Payment Of Upfront Fees				$ 1,000,000
Noncontrolling Interest, Ownership Percentage by Noncontrolling Owners			5.00%
Proceeds from Issuance of Common Stock		$ 10,000,000
Dana-Farber [Member] | First Commercial Sale Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue Recognition Milestone Method, Payments Due					21,500,000
Maximum Potential Milestone Payments					21,500,000
Dana-Farber [Member] | Additional Sales Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue Recognition Milestone Method, Payments Due					60,000,000
Maximum Potential Milestone Payments					60,000,000
Teva Pharmaceutical Industries Ltd [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment Of Upfront Fees					500,000
Teva Pharmaceutical Industries Ltd [Member] | Clinical Development Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum Potential Milestone Payments					220,000,000
Teva Pharmaceutical Industries Ltd [Member] | Regulatory Approvals To Commercialize The Products [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum Potential Milestone Payments					206,500,000
Jubilant Biosys Ltd [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment Of Upfront Fees	$ 2,000,000
Revenue Recognition, Milestone Method, Revenue Recognized					1,000,000	1,500,000
Research and Development Cost, Shared Percentage	50.00%
Jubilant Biosys Ltd [Member] | Clinical Development Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue Recognition Milestone Method, Payments Due					89,000,000
Maximum Potential Milestone Payments					89,000,000
Jubilant Biosys Ltd [Member] | Regulatory Approvals To Commercialize The Products [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum Potential Milestone Payments					59,500,000
Jubilant Biosys Ltd [Member] | Successful Achievement Of One Preclinical Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue Recognition Milestone Method, Payments Due					25,500,000
Jubilant Biosys Ltd [Member] | Five Regulatory Approvals And First Commercial Sales [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum Potential Milestone Payments					61,700,000
Jubilant Biosys Ltd [Member] | Sale Millstone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Maximum Potential Milestone Payments					89,000,000
Collaboration Agreement With TGTX [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Payment Of Upfront Fees	$ 1,000,000
Revenue Recognition, Milestone Method, Revenue Recognized					84,000	$ 42,000	$ 590,000
Payment Of Upfront Licensing Fee					500,000
Collaboration Agreement With TGTX [Member] | Clinical Development Milestone [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue Recognition Milestone Method, Payments Due					7,000,000
Collaboration Agreement With TGTX [Member] | Commercial Sales In Specified Territories [Member]
Research and Development Arrangement, Contract to Perform for Others [Line Items]
Revenue Recognition Milestone Method, Payments Due					$ 14,500,000

Related Party Agreements (Detai

Related Party Agreements (Details Textual) - USD ($)	1 Months Ended			12 Months Ended
	Mar. 17, 2017	Dec. 31, 2016	Mar. 17, 2015	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Related Party Transaction [Line Items]
Agreement Description Terms	(i) issue annually to Fortress, on the anniversary date of the Founders Agreement, shares of common stock equal to two and one-half percent (2.5%) of the fully-diluted outstanding equity of Checkpoint at the time of issuance; (ii) pay an equity fee in shares of common stock, payable within five (5) business days of the closing of any equity or debt financing for Checkpoint or any of its respective subsidiaries that occurs after the effective date of the Founders Agreement and ending on the date when Fortress no longer has majority voting control in Checkpoint’s voting equity, equal to two and one-half percent (2.5%) of the gross amount of any such equity or debt financing; and (iii) pay a cash fee equal to four and one half percent (4.5%) of Checkpoint’s annual net sales, payable on an annual basis, within ninety (90) days of the end of each calendar year. In the event of a change in control (as it is defined in the Founders Agreement), Checkpoint will pay a one-time change in control fee equal to five times (5x) the product of (i) monthly net sales for the twelve (12) months immediately preceding the change in control and (ii) four and one-half percent (4.5%).
Management Services Agreement [Member]
Related Party Transaction [Line Items]
Annual Consulting Fee			$ 500,000
Increase In Annual Consulting Fee			1,000,000
Excess In Net Assets Value			100,000,000
Costs and Expenses, Related Party				$ 500,000	$ 500,000	$ 400,000
Fortress Biotech, Inc [Member] | Founders Agreement [Member]
Related Party Transaction [Line Items]
Long-term Debt, Gross			$ 2,800,000
Caribe Boiadvisors LLC [Member]
Related Party Transaction [Line Items]
Costs and Expenses, Related Party				70,000
Advisory Service Fee		$ 60,000
Caribe Boiadvisors LLC [Member] | Equity Incentive Grant [Member]
Related Party Transaction [Line Items]
Costs and Expenses, Related Party				$ 10,000

Notes Payable (Details)

Notes Payable (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Feb. 29, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Debt [Line Items]
Discount, Beginning		$ 0	$ 324
Amortization of debt discount		0	324	$ 89
Discount, Ending			0	324
Payment of NSC debt, Net		0	(2,792)	0
NSC Note [Member]
Debt [Line Items]
Notes Payable, Beginning		0	2,792
Payment of NSC debt	$ (2,800)		(2,792)
Notes Payable, Ending			0	2,792
Discount, Beginning		0	(324)
Amortization of debt discount			324	89
Discount, Ending			0	(324)
NSC Note Payable, Net, Beginning		$ 0	2,468
Payment of NSC debt, Net			(2,792)
Amortization of debt discount, Net			324
NSC Note Payable, Net, Ending			$ 0	$ 2,468

Notes Payable (Details Textual)

Notes Payable (Details Textual) - USD ($)	1 Months Ended		12 Months Ended
	Feb. 29, 2016	Mar. 31, 2015	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Debt [Line Items]
Debt Instrument, Unamortized Discount (Premium), Net				$ 0	$ 324,000
Amortization of Debt Discount (Premium)			$ 0	324,000	89,000
NSC Note [Member]
Debt [Line Items]
Class of Warrant or Right, Number of Securities Called by Warrants or Rights		139,592
Class Of Warrant or Right ,Value Of Warrant On Proceeds On Note Payable, Percentage		25.00%
Class Of warrant Or Right ,Warrant Term		10 years
Repayments of Debt	$ 2,800,000			2,792,000
Debt Instrument, Unamortized Discount (Premium), Net				0	(324,000)
Amortization of Debt Discount (Premium)				324,000	89,000
Interest Expense, Debt				$ 20,000	146,000
Debt Instrument, Interest Rate, Stated Percentage				8.00%
Long-term Debt, Gross		$ 2,800,000		$ 0	$ 2,792,000
NSC Note [Member] | Fortress Biotech, Inc [Member]
Debt [Line Items]
Notes Payable		$ 10,000,000

Stockholders' Equity (Details)

Stockholders' Equity (Details) - Restricted Stock [Member]	12 Months Ended
	Dec. 31, 2017$ / sharesshares
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Nonvested at December 31, 2016 | shares	2,533,063
Number of Units, Granted | shares	359,303
Number of Units, Vested | shares	(281,250)
Nonvested at December 31, 2017 | shares	2,611,116
Nonvested at December 31, 2016 | $ / shares	$ 2.93
Weighted Average Grant Date Fair Value, Granted | $ / shares	7.69
Weighted Average Grant Date Fair Value, Vested | $ / shares	0.07
Nonvested at December 31, 2017 | $ / shares	$ 3.89

Stockholders' Equity (Details 1

Stockholders' Equity (Details 1) - $ / shares	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number Of Stock Options , Outstanding (Begining)	60,000
Number Of Stock Options , Granted	0
Number Of Stock Options , Outstanding (Endining)	60,000	60,000
Weighted Average Exercise Price , Outstanding (Begining)	$ 5.43
Weighted Average Exercise Price , Granted	0
Weighted Average Exercise Price , Outstanding (Endining)	$ 5.43	$ 5.43
Weighted Average Remaining Contractual Life, Granted (in years)	9 years 1 month 2 days	9 years 11 months 16 days

Stockholders' Equity (Details 2

Stockholders' Equity (Details 2) - Warrant [Member] - $ / shares	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Number of Warrants, Outstanding	4,331,106
Number of Units, Granted	0
Number of Warrants, Exercised	(4,551)
Number of Warrants, Outstanding	4,326,555	4,331,106
Nonvested at December 31, 2016	$ 6.62
Weighted Average Exercise Price, Granted	0
Weighted Average Grant Date Fair Value, Vested	0
Nonvested at December 31, 2017	$ 6.62	$ 6.62
Weighted Average Remaining Contractual Life, Outstanding (in years)	3 years 8 months 1 day	4 years 8 months 1 day

Stockholders' Equity (Details 3

Stockholders' Equity (Details 3) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Employee Benefits and Share-based Compensation	$ 3,117	$ 3,867	$ 3,252
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Employee Benefits and Share-based Compensation	1,180	2,557	2,987
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Employee Benefits and Share-based Compensation	$ 1,937	$ 1,310	$ 265

Stockholders' Equity (Details T

Stockholders' Equity (Details Textual) - USD ($)	Oct. 04, 2017	Mar. 17, 2017	Feb. 29, 2016	Mar. 31, 2015	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Mar. 12, 2018	Nov. 30, 2017	Mar. 17, 2016	Mar. 17, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common Stock, Shares Authorized					50,000,000	50,000,000
Common Stock, Par or Stated Value Per Share					$ 0.0001	$ 0.0001
Common Stock, Shares, Issued					18,512,429	17,426,876
Share-based Compensation					$ 3,117,000	$ 3,867,000	$ 3,252,000
Equity Method Investment, Annual Equity Fee, Percentage											2.50%
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross					0
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options					$ 2,900,000
Issuance of Stock and Warrants for Services or Claims					$ 0	$ 14,000	1,269,000
Shelf Registration Statement, Maximum Authorized Securities									$ 100,000,000
Agent [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Commission rate					3.00%
Subsequent Event [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Shelf Registration Statement, Remaining Authorized Securities								$ 77,000,000
2015 Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant					2,961,697
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period					10 years
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized					5,000,000
Restricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number					2,611,116	2,533,063
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period					359,303
Non-vested Resricted Stock [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Employee Service Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition					1 year 2 months 12 days
Performance Shares [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number					333,334
Dr. Marasco [Member] | Share-based Compensation Award, Tranche One [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period				48 months
Percentage of award vested on first anniversary date				25.00%
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Gross				1,500,000
Dr. Marasco [Member] | Restricted Stock [Member] | 2015 Incentive Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Grants in Period	139,303
Percentage of shares granted on diluted equity outstanding	0.50%
General and Administrative Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation					$ 1,800,000	$ 1,300,000	300,000
Research and Development Expense [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation					226,000	58,000
Issuance of Stock and Warrants for Services or Claims					2,300,000	3,900,000
Research and Development Expense [Member] | Grant [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation					$ 900,000	2,500,000	$ 3,000,000
Opus Point Healthcare Fund GP, LLC [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Proceeds from Issuance of Private Placement			$ 600,000
Class of Warrant or Right, Number of Securities Called by Each Warrant or Right			3,500
Class of Warrant or Right, Exercise Price of Warrants or Rights			$ 7
Stock Issued During Period, Shares, New Issues			126,640
Number Of Warrant Issued			44,324
Sale of Stock, Number of Shares Issued in Transaction			10,000
Sale of Stock, Consideration Received on Transaction			$ 45,000
Fortress Biotech, Inc [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Stock Issued During Period, Shares, New Issues		721,699	3,166		721,699
Share-based Compensation						$ 14,000
Equity Method Investment, Annual Equity Fee, Percentage			2.50%		2.50%					2.50%
Common Class A [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Common Stock, Shares Authorized					15,000,000
Common Stock, Shares, Issued					7,000,000	7,000,000

Income Taxes (Details)

Income Taxes (Details)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Statutory federal income tax rate	35.00%	35.00%
State taxes, net of federal tax benefit	11.00%	1.00%
Credits	2.00%	3.00%
Change in federal tax rate	(27.00%)	0.00%
Change in state tax rate	8.00%	(2.00%)
Provision to return	5.00%	5.00%
Stock based compensation shortfall	(4.00%)	(4.00%)
Other	0.00%	(2.00%)
Change in valuation allowance	(30.00%)	(36.00%)
Income taxes provision (benefit)	0.00%	0.00%

Income Taxes (Details 1)

Income Taxes (Details 1) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Deferred tax assets:
Net operating loss carryovers	$ 10,662	$ 5,148
Stock compensation and other	1,839	1,624
Change in fair value of warrant liabilities	149	157
Amortization of license	5,410	4,656
Accruals and reserves	11	25
Tax credits	905	733
Start Up Costs	46	54
Total deferred tax assets	19,022	12,397
Less valuation allowance	(19,022)	(12,397)
Deferred tax asset, net of valuation allowance	$ 0	$ 0

Income Taxes (Details Textual)

Income Taxes (Details Textual) - USD ($)	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016
Deferred Tax Assets, Valuation Allowance		$ 19,022,000	$ 12,397,000
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent		35.00%	35.00%
Effective Income Tax Rate Reconciliation, Change in Deferred Tax Assets Valuation Allowance, Amount		$ 6,200,000
Deferred Income Tax Expense (Benefit)		0
Scenario, Plan [Member]
Effective Income Tax Rate Reconciliation, at Federal Statutory Income Tax Rate, Percent	21.00%
Domestic Tax Authority [Member]
Operating Loss Carryforwards		$ 31,300,000
Operating Loss Carryforwards, Expiration Period		2,035
State and Local Jurisdiction [Member]
Operating Loss Carryforwards		$ 60,500,000
Operating Loss Carryforwards, Expiration Period		2,035

Accounts Payable and Accrued 41

Accounts Payable and Accrued Expenses (Details) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Accounts payable	$ 3,645	$ 2,473
Accrued compensation	405	291
Research and development	1,466	378
Other	246	213
Accounts payable and accrued expenses - related party	610	318
Total accounts payable and accrued expenses	$ 6,372	$ 3,673

Quarterly Financial Data (Una42

Quarterly Financial Data (Unaudited) (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Total Revenue	$ 332	$ 349	$ 351	$ 693	$ 498	$ 546	$ 1,249	$ 277	$ 1,725	$ 2,570	$ 590
Operating expenses	6,271	6,299	6,823	5,107	8,833	5,685	6,667	3,549	24,500	24,734	13,811
Other income	21	22	24	31
Other income/(expense)					12	11	13	(333)	98	(297)	(671)
Net loss	$ (5,918)	$ (5,928)	$ (6,448)	$ (4,383)	$ (8,323)	$ (5,128)	$ (5,405)	$ (3,605)	$ (22,677)	$ (22,461)	$ (13,892)
Basic and diluted net loss per common share	$ (0.26)	$ (0.26)	$ (0.28)	$ (0.2)	$ (0.38)	$ (0.24)	$ (0.25)	$ (0.17)	$ (1)	$ (1.04)	$ (1.41)

Subsequent Events (Details Text

Subsequent Events (Details Textual) - USD ($) $ / shares in Units, $ in Thousands	Mar. 08, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Subsequent Event [Line Items]
Payments of Stock Issuance Costs		$ 0	$ 0	$ 6,321
Underwritten Public Offering [Member] | Subsequent Event [Member]
Subsequent Event [Line Items]
Stock Issued During Period, Shares, New Issues	4,600,000
Shares Issued, Price Per Share	$ 4.35
Stock Issued During Period, Value, New Issues	$ 23,000
Proceeds from Issuance Underwritten Public Offering	20,900
Payments of Stock Issuance Costs	$ 2,100
Over-Allotment Option [Member] | Subsequent Event [Member]
Subsequent Event [Line Items]
Stock Issued During Period, Shares, Other	690,000