Leerink Partners LLC
1301 Avenue of the Americas, 12th Floor
New York, NY 10019
RBC Capital Markets, LLC
200 Vesey Street, 8th Floor
New York, NY 10281
May 22, 2018
United States Securities and Exchange Commission
Division of Corporation Finance
Mail Stop 4720
100 F Street, N.E.
Washington, D.C. 20549
| Attn: | Ms. Christine Westbrook |
Ms. Suzanne Hayes
| Re: | Iterum Therapeutics plc |
Registration Statement on Form S-1
Registration File No. 333- 224582
Ladies and Gentlemen:
In accordance with Rule 461 under the Securities Act of 1933, as amended (the “Act”), we, as representatives of the several underwriters, hereby join in the request of Iterum Therapeutics plc (the “Company”) for acceleration of the effective date of the above-named Registration Statement so that it becomes effective at 3:00 PM, Eastern Time, on May 24, 2018 or as soon thereafter as practicable, or at such other time as the Company or its outside counsel, Cooley LLP, request by telephone that such Registration Statement be declared effective.
Pursuant to Rule 460 under the Act, we, as representatives of the several underwriters, wish to advise you that we have effected the following distribution of the Company’s Preliminary Prospectus dated May 16, 2018:
| (i) | Dates of distribution: May 16, 2018 through the date hereof |
| (ii) | Number of prospective underwriters to which the preliminary prospectus was furnished: 4 |
| (iii) | Number of prospectuses furnished to investors: approximately 1,400 |
| (iv) | Number of prospectuses distributed to others, including the Company, the Company’s counsel, independent accountants, and underwriters’ counsel: approximately 300 |
We, the undersigned, as representatives of the several underwriters, have complied and will comply, and we have been informed by the participating underwriters that they have complied and will comply, with the requirements of Rule 15c2-8 under the Securities Exchange Act of 1934, as amended.
| Very truly yours, | ||
| LEERINK PARTNERS LLC | ||
Acting on behalf of itself and the several underwriters | ||
| By: | LEERINK PARTNERS LLC | |
| By: | /s/ Stuart R. Nayman | |
Name: Stuart R. Nayman | ||
Title: Managing Director, Senior Legal Counsel | ||
| Very truly yours, | ||
| RBC CAPITAL MARKETS, LLC | ||
Acting on behalf of itself and the several underwriters | ||
| By: | RBC CAPITAL MARKETS, LLC | |
| By: | /s/ Jennifer Caruso | |
Name: Jennifer Caruso | ||
Title: Managing Director | ||
