Exhibit 99.1
Immuron CEO, Steven Lydeamore webinar on MarketOpen
Direct Connect
Melbourne, Australia, August 8, 2024: Immuron Limited (ASX: IMC; NASDAQ: IMRN) is pleased to advise our Chief Executive Officer, Steven Lydeamore will be hosting a webinar on MarketOpen Direct Connect on Thursday 8th August 2024, 11:00am AEST (9:00am AWST).
This webinar can be viewed live via zoom & you register for FREE via the link below.
https://us06web.zoom.us/webinar/register/WN_QV-yMVvGRQuYq698XMTQxA
A recorded copy of the webinar will be made available following the event. A copy of the presentation being made is included below.
This release has been authorised by the directors of Immuron Limited.
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COMPANY CONTACT:
Steven Lydeamore
Chief Executive Officer
steve@immuron.com
About Immuron
Immuron Limited (ASX: IMC, NASDAQ: IMRN), is an Australian biopharmaceutical company focused on developing and commercializing orally delivered targeted polyclonal antibodies for the treatment of infectious diseases.
About Travelan®
Travelan® is an orally administered passive immunotherapy that prophylactically reduces the likelihood of contracting travelers’ diarrhea, a digestive tract disorder that is commonly caused by pathogenic bacteria and the toxins they produce. Travelan® is a highly purified tabletized preparation of hyper immune bovine antibodies and other factors, which when taken with meals bind to diarrhea-causing bacteria and prevent colonization and the pathology associated with travelers’ diarrhea. In Australia, Travelan® is a listed medicine on the Australian Register for Therapeutic Goods (AUST L 106709) and is indicated to reduce the risk of Travelers’ Diarrhea, reduce the risk of minor gastro-intestinal disorders and is antimicrobial. In Canada, Travelan® is a licensed natural health product (NPN 80046016) and is indicated to reduce the risk of Travelers’ Diarrhea. In the U.S., Travelan® is sold as a dietary supplement for digestive tract protection.
Travelers’ diarrhea (TD)
TD is generally defined as the passage of ≥ 3 unformed stools per 24 hours plus at least one additional symptom (such as nausea, vomiting, abdominal cramps, fever, blood/mucus in the stools, or fecal urgency) that develop while abroad or within 10 days of returning from any resource-limited destinations (Leung et al., 2006). Diarrhea continues to be the most frequent health problem among travelers to destinations in lower- and middle-income regions (Steffen, 2017). Deployed US military personnel, essentially representing a long-term traveller population, are particularly affected given their population dynamics and the context in which they seek care and treatment (Connor et al., 2012). Diarrhea is the leading infectious disease threat to the overall health and preparedness of deployed US armed forces, with diarrheagenic E. coli, Campylobacter spp., and Shigella spp. among the most commonly reported etiologies (Riddle et al., 2006).
Immuron Platform Technology
Immuron’s proprietary technology is based on polyclonal immunoglobulins (IgG) derived from engineered hyper-immune bovine colostrum. Immuron has the capability of producing highly specific immunoglobulins to any enteric pathogen and our products are orally active. Bovine IgG can withstand the acidic environment of the stomach and is resistant to proteolysis by the digestive enzymes found in the Gastrointestinal (GI) tract. Bovine IgG also possesses this unique ability to remain active in the human GI tract delivering its full benefits directly to the bacteria found there. The underlying nature of Immuron’s platform technology enables the development of medicines across a large range of infectious diseases. The platform can be used to block viruses or bacteria at mucosal surfaces such as the Gastrointestinal tract and neutralize the toxins they produce.
IMM-124E (Travelan®)
IMM-124E was developed using Immuron’s platform technology. IMM-124E is produced from the colostrum of birthing cattle that have been immunised during pregnancy with a vaccine containing the outer antigens of multiple human derived ETEC. A total of 13 ETEC strains are used in the vaccine to produce high levels of antibodies against selected surface antigens from the most common strains of ETEC.
The resultant hyperimmune colostrum IMM-124E from ETEC vaccinated cows contains significant levels of polyclonal antibodies specific for ETEC antigens LPS, CFA-I and Flagellin (Sears et al., 2017).
The antibodies produced in IMM-124E have been found to have a stronger binding and neutralizing activity (than the antibodies of unvaccinated cattle) against a wide range of LPS antigens including both the variable O-polysaccharide region and the preserved oligosaccharide core ‘R’ region of LPS from the 13 serotypes used in the ETEC vaccine.
IMM-124E is manufactured into a tablet form referred to as Travelan®.
IMM-529
Immuron is developing IMM-529 as an adjunctive therapy in combination with standard of care antibiotics for the prevention and/or treatment of recurrent Clostridioides difficile infection (CDI). IMM-529 antibodies targeting Clostridioides difficile (C. diff) may help to clear CDI infection and promote a quicker re-establishment of normal gut flora, providing an attractive oral preventative for recurrent CDI.
Immuron is collaborating with Dr. Dena Lyras and her team at Monash University, Australia to develop vaccines to produce bovine colostrum-derived antibodies. Dairy cows were immunised to generate hyperimmune bovine colostrum (HBC) that contains antibodies targeting three essential C. diff virulence components. IMM-529 targets Toxin B (TcB), the spores and the surface layer proteins of the vegetative cells.
This unique 3-target approach has yielded promising results in pre-clinical infection and relapse models, including (1) Prevention of primary disease (80% P =0.0052); (2) Protection of disease recurrence (67%, P <0.01) and (3) Treatment of primary disease (78.6%, P<0.0001; TcB HBC). Importantly IMM-529 antibodies cross-react with whole cell lysates of many different human strains of C. diff including hypervirulent strains.
To our knowledge, IMM-529 is, to date, the only investigational drug that has shown therapeutic potential in all three phases of the disease (Hutton et al., 2017).
References
Connor P, Porter CK, Swierczewski B and Riddle MS. Diarrhea during military deployment: current concepts and future directions. Curr Opin Infect Dis. 25(5): 546-54; 2012.
Hutton, M.L., Cunningham, B.A., Mackin, K.E. et al. Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative. Sci Rep 7, 3665 (2017). https://doi.org/10.1038/s41598-017-03982-5
Leung AK, Robson WL, Davies HD. Travelers’ diarrhea. Adv Ther. Jul-Aug; 23(4): 519-27; 2006
Otto W, Najnigier B, Stelmasiak T and Robins-Browne RM. Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers Scandinavian Journal of Gastroenterology 46: 862– 868; 2011.
Riddle MS, Sanders JW, Putnam SD, and Tribble DR. Incidence, etiology, and impact of diarrhea among long-term travelers’ (US military and similar populations): A systematic review. American Journal of Tropical Medicine and Hygiene. 74(5): 891-900; 2006.
Sears KT, Tennant SM, Reymann MK, Simon R, Konstantopolos N, Blackwelder WC, Barry EM and Pasetti MF. Bioactive Immune Components of Anti-Diarrheagenic Enterotoxigenic Escherichia coli Hyperimmune Bovine Colostrum products. Clinical and Vaccine Immunology. 24 (8) 1-14; 2017.
Steffen R. Epidemiology of travelers’ diarrhea. J Travel Med. 24(suppl_1): S2-S5; 2017.
For more information visit: https://www.immuron.com.au/ and https://www.travelan.com
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FORWARD-LOOKING STATEMENTS:
This press release may contain “forward-looking statements” within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, each as amended. Such statements include, but are not limited to, any statements relating to our growth strategy and product development programs and any other statements that are not historical facts. Forward-looking statements are based on management’s current expectations and are subject to risks and uncertainties that could negatively affect our business, operating results, financial condition, and stock value. Factors that could cause actual results to differ materially from those currently anticipated include: risks relating to our growth strategy; our ability to obtain, perform under and maintain financing and strategic agreements and relationships; risks relating to the results of research and development activities; risks relating to the timing of starting and completing clinical trials; uncertainties relating to preclinical and clinical testing; our dependence on third-party suppliers; our ability to attract, integrate and retain key personnel; the early stage of products under development; our need for substantial additional funds; government regulation; patent and intellectual property matters; competition; as well as other risks described in our SEC filings. We expressly disclaim any obligation or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in our expectations or any changes in events, conditions, or circumstances on which any such statement is based, except as required by law.
8 AUGUST 2024 Steven Lydeamore Chief Executive Officer Direct Connect Webinar NASDAQ: IMRN ASX: IMC
Certain statements made in this presentation are forward - looking statements and are based on Immuron’s current expectations, estimates and projections. Words such as “anticipates,” “expects,” ” intends,” ” plans,” ” believes,” ” seeks,” “estimates,” “guidance” and s imilar expressions are intended to identify forward - looking statements. Although Immuron believes the forward - looking statements are based on reasonable assumptions, they are subject to certain r i sks and uncertainties, some of which are beyond Immuron’s control, including those r i sks or uncertainties inherent in the process of both developing and commercializing technology. As a result, actual results could materially differ f rom those expressed or forecasted in the forward - looking statements. The forward - looking statements made in this presentation relate only to events as of the date on which the statements are made. Immuron will not undertake any obligation to release publicly any revisions or updates to these forward - looking statements to reflect events, c i rcumstances or unanticipated events occurring after the date of this presentation except as required by law or by any appropriate regulatory authority. YTD FY 2024 results in this presentation are subject to audit review. SAFE HARBOR STATEMENT
3 Executive summary Immuron Ltd (NASDAQ:IMRN) (ASX:IMC) is a globally integrated biopharmaceutical company focused on developing, and commercialising, oral immunotherapeutics for the treatment of gut mediated diseases 3 as of 6 August 2024 recruited ~77% of target 866 CampETEC Phase 2 clinical trial completed inpatient phase IMM - 529 pre - IND filed with FDA Major Shareholders Financial Snapshot 227,998,346 Shares on Issue 15,078,839 Total Options IMC: A$0.098 Last Traded Price IMC: A$0.17/0.065 IMRN: $5.96/1.48 52 week High/Low IMC: A$22.3m Market Cap A$15.2m Cash & Cash Equivalents (as at 31 Dec 23) % of CSO Units Holder 34.2 % 78,066,184 BNY Mellon Asset Management 2.4 % 5,500,000 Authentics Australia Pty. Ltd. 1.7 % 3,846,712 Grandlodge 0.9 % 1,954,070 Management & Board Company Overview Two commercially available oral immunotherapeutic products – Travelan® and Protectyn® 4 clinical programs: Travelan®(IMC: Phase 2 CHIM trial), Travelan®(USU: Phase 4 field study), CampETEC (NMRC: Phase 2 CHIM trial), IMM - 529 (IMC: Protocol development phase, Phase 2 trial) Business Update Flagship product Travelan® growing strongly as overseas travel rebounds Travelan® (IMM - 124E) Phase 2 CHIM trial topline results Travelan® (IMM - 124E) Travelan® Uniformed Services University (USU) P2TD IMM - 124E field clinical trial Results & Outlook Sales 1 Jul 23 to 30 June 24 of A$4.9 million up 174% on pcp (unaudited) Evaluating options to enter international markets Evaluating options to add to marketed products portfolio
4 Chief Commercial Officer has 20+ year’s experience with local and global (Asia, UK) commercial leadership roles with GSK and P&G Addressable market & industry overview * IMC Company Report - Travelan Market Analysis 2019 ** Centers for Disease Control and Prevention Yellow Book USA Market FY24: launch on amazon.com and Walmart.com Planning for increased market penetration in FY25 $83m Based on US annual travel numbers and a penetration rate of 15%, the market potential is estimated at $83m* $50m Based on EU travel numbers and a penetration rate of 15%, the market potential is estimated at $50m* $1.7b Clostridioides difficile infections (CDIs) to grow to almost $1.7 billion by 2026, according to GlobalData to add marketed products to portfolio in FY25 Evaluating options for entry into international markets Billion Dollar Market Traveller’s diarrhoea treatment market is large and growing at a CAGR of ~7% Industry tailwinds Travel picking up significantly following COVID lockdowns Frequent Symptom 30% - 70% of travelers experience traveller’s diarrhoea**
5 + Reduce occurrence and reduce/relieve diarrhoea + Reduce/relieve abdominal cramping + Reduce/relieve gastrointestinal pain + Assists repair of gastrointestinal/gut wall lining + Enhance/promote immune defence + Enhance/promote health liver function Australian Permitted indications; these statements have not been evaluated by the Food and Drug Administration (FDA) * Gomes et. al., NFS Journal, Volume 25, November 2021, pages 1 - 11, https://doi.org/10.1016/j.nfs.2021.10.001 Step 1 Development of Highly Specific Vaccines Step 2 Isolation of Hyperimmune antibody - rich bovine colostrum Step 3 Oral Antimicrobial therapeutic without drawbacks of antibiotics Final Product Toxin Neutralization + Clearance of targeted gut pathogens Technology platform Immuron’s proprietary technology platform combines the natural human nutrition & health benefits of bovine colostrum with a novel class of specifically targeted oral polyclonal antibodies that offer delivery within the gastrointestinal (“GI”) tract and can be used to target viruses or bacteria and neutralize the toxins they produce at mucosal surfaces. Bovine colostrum is the first milk of cows after calving. It is rich in immunoglobulins, lactoferrin, lysozyme, lactoperoxidase, growth factors and bioactive peptides. Colostrum has higher levels of protein, fat, vitamins, and minerals when compared to milk. This enables full development of the newborn calf in addition to immunity against several pathogens.*
6 Pre - Clinical Studies Broad spectrum antimicrobial Travelan® | Mechanism of action With Travelan ® Bacteria neutralized by Travelan ® antibodies Without Travelan® Bacteria attach to gut wall and infect Protects against bacterial adhesion to host cell intestinal epithelia Binds to surface layer proteins preventing bacterial colonization and motility Toxin neutralization and clearance of targeted gut pathogens
7 Further analysis of the Phase 2 Study found that some subjects did not experience any diarrhoea until after antibiotics were administered Diarrhoea could be related to antibiotic administration Protective Efficacy was calculated for the 5 - day period post challenge There were 4 subjects in the Travelan® group that did not experience any diarrhoea until antibiotics were administered There was a 43.8% reduction in diarrhoea in the Travelan® group which is approaching statistical significance (p=0.066) IMM - 124E (Travelan®) Phase 2 Study Additional data analysis Protective Efficacy
8 SUBJECTS WITH DIARRHEA OF ANY SEVERITY Placebo (N=30) Travelan® (N=30) Intent - to - treat Analysis Set 16 (53.3%) 13 (43.3%) Number of subjects with ETEC - induced diarrhoea of any severity [1] 0.438 P - value ( - 15.2%, 35.2%) 95% 2 - sided Confidence Interval Placebo (N=30) Travelan® (N=30) PE for a 5 - Day Period Post Challenge 16 (53.3%) 9 (30.0%) Number of subjects with ETEC - induced diarrhoea of any severity [2] 0.066 P - value ( - 0.9%, 47.6%) 95% 2 - sided Confidence Interval 43.8% Reduction in number of subjects with diarrhoea of any severity in Travelan® group In a 5 - day period post challenge 1 Number of subjects with any grade 3 - 5 stools post challenge 2 Includes time period subjects received daily dosing of Travelan/placebo, inclusive of subjects who received early antibiotics. After day 5 dosing of Travelan®/placebo stopped, Comments: Data not included in interim analysis 18 subjects met the primary endpoint a further 11 subjects had milder diarrhoea 4 subjects in the Travelan® group did not experience any diarrhoea until the Travelan® dosing was complete and antibiotics were administered and all subjects received antibiotics (Days 6 - 9)
9 Objective : To compare the time to diarrhoea onset between patients receiving a therapeutic treatment and those receiving a placebo. Data Collection : o Patients are monitored over a specified period. o The time to the onset of diarrhoea is recorded for each patient. o Patients are divided into two groups: those receiving the therapeutic treatment and those receiving the placebo. Kaplan - Meier Estimation : o Survival Function : Plots the probability of not having diarrhoea as a function of time for both groups. o Censoring : Accounts for patients who do not develop diarrhoea during the study period or drop out of the study. IMM - 124E (Travelan®): Kaplan - Meier Plot Plot Interpretation : Statistical Tests : o X - Axis : Time to onset of diarrhoea (e.g., days). o Y - Axis : Probability of remaining diarrhoea - free (survival probability). o Curves : Two separate curves represent the therapeutic group and the placebo group. o Stepwise Decline : Each step represents an event (onset of diarrhoea) or a censored observation. o Comparison : The therapeutic curve is compared to the placebo curve to assess the effectiveness of the treatment. o Log - Rank Test : Commonly used to compare the survival distributions of the two groups. o Hazard Ratios : Can be calculated to quantify the difference in risk between the groups. Interpretation of Results: Therapeutic Effectiveness : If the curve for the therapeutic group remains higher (indicating a higher probability of being diarrhoea - free for a longer time) compared to the placebo group, the therapeutic treatment can be considered effective. Statistical Significance : A significant p - value from the log - rank test suggests a statistically significant difference between the two groups. Clinical Implications : Helps in deciding whether the therapeutic treatment should be recommended over the placebo. Conclusion: In the clinical trial, the Kaplan - Meier plot shows that the Travelan® therapeutic treatment group has a higher survival probability over time compared to the placebo group, it suggests that the therapeutic treatment is effective in delaying the onset of diarrhoea.
10 TIME TO DIARRHOEA ONSET Time to Diarrhea onset • The Kaplan - Meier estimator is useful for determining the time of the onset of diarrhoea between patients receiving Travelan® or placebo treatment • Y - Axis : Probability of remaining diarrhoea - free • X - Axis : Time to onset of diarrhoea • The Red Travelan® curve remains higher than the Blue Placebo curve indicating the Therapeutic Effectiveness of treatment with Travelan® • Travelan® patients have a higher probability of being diarrhoea free compared to Placebo • Censoring = Patients who did not develop diarrhoea or who dropped out of the study • Each step is a diarrhoea event (diarrhoea of any severity) • 50% chance of diarrhoea up to day 6 in the Travelan® group • 66.7% chance in the Placebo group Antibiotic treatment after day 6
11 Includes all safety data set (63 subjects) and additional 3 subjects who were not challenged Considers all Adverse Events and number of events over the whole study period pre and post challenge Number of events is reduced in the Travelan® treated group for all organ classes IMM - 124E (Travelan®) Phase 2 Study – additional data analysis Adverse Events
12 SUMMARY OF ADVERSE EVENTS Reduction in number of Events % Placebo (N=31) Travelan (N=32) Subjects with at least 1 AE per System organ class Includes all safety data set (63 subjects) Events (m) Subjects n Events (m) Subjects n 46.8% 109 28 (90.3%) 58 24 (75%) Total 34.9% 66 28 43 23 Gastrointestinal disorders (diarrhea, abdominal pain & distension nausea, vomiting, constipation) 46.2% 13 10 7 7 Nervous system disorders (headache, dizziness, hyper anaesthesia) 85.7% 7 7 1 1 Musculoskeletal and connective tissue (back pain, myalgia, arthralgia) 25% 4 2 3 3 General disorders (chills, pyrexia, muscle weakness) 75% 4 4 1 1 Nutrition disorders (decreased appetite) 66.7% 3 2 1 1 Skin and tissue (rash, itch, redness) 100% 3 3 0 0 Cardiac disorders (tachycardia) 50% 2 2 1 1 Infections (viral, upper respiratory)
13 IMM - 124E (Travelan®) Phase 2 Study – additional data analysis Summary of Enrolled Participants and Demographics
14 ALL ENROLLED SUBJECTS Total (N=63) Placebo (N=31) Travelan® (N=32) 63 31 32 Randomization Included in 63 31 32 Safety Analysis Set 60 30 30 Intent - to - Treat Analysis Set 54 27 27 Completed Study 9 4 5 Discontinued Study 6 3 3 Subject Withdrew Consent 2 0 2 Investigator Discretion 1 1 0 Lost to Follow Up Note: Intent - to - treat analysis set defined as randomized subjects who received study medication and were challenged .
15 DEMOGRAPHICS Total (N=63) Placebo (N=31) Travelan® (N=32) 34.1 35.1 33.1 Mean Age at Consent Sex at Birth 34 16 18 Male 29 15 14 Female Ethnicity 15 10 5 Hispanic/Latino 48 21 27 Not Hispanic/Latino Race 13 (20.6%) 5 (16.1%) 8 (25%) White 45 (71.4%) 22 (71%) 23 (71.9%) Black or African American 1 (1.6%) 0 1 (3.1%) Asian 4 (6.3%) 4 (12.9%) 0 Mixed/Other
16 IMM - 124E Phase 3 strategy Phase 1 clinical study (Baltimore, 1996) Phase 2 clinical study (Poland, 2000) FDA 1 IND 2 approval (December 2022) Phase 2 clinical study (Baltimore, 2024) Additional topline data analysis August 2024 Clinical Study Report anticipated September 2024 End of Phase 2 FDA meeting FDA meeting – Phase 3 clinical protocol Initiate Phase 3 Trial duration ~ 2 years End of Phase 3 FDA meeting BLA 3 submission Pre 2H 2024 1H 2025 2H 2025 Post + The pivotal registration studies is anticipated to involve two randomized, double - blind, parallel - group, placebo - controlled Phase 3 clinical studies (drug substance IMM - 124E) to assess the efficacy and safety of Travelan® for prevention of traveler’s diarrhea (TD) + Anticipated enrolment of approximately 1200 healthy adult subjects (600 subjects in two studies) traveling to regions with high TD risk. + Subjects anticipated to be randomized 1:1 to receive Travelan® or placebo. + Dosing anticipated to begin 3 days prior to arrival in country and for at least 14 days in country. + The primary endpoint requested will be traveler’s diarrhea. 1. U.S. Food and Drug Administration; 2. Investigational New Drug; 3. Biologics License Application
EMAIL: STEVE@IMMURON.COM PHONE: AUSTRALIA: +61 438 027 172 STEVEN LYDEAMORE CHIEF EXECUTIVE OFFICER IMMURON LIMITED CONTACT INFORMATION:
18 Scientific references Travelan® (IMM - 124E) Scandinavian Journal of Gastroenterology, 46:7 - 8, 862 - 868, DOI: 10.3109/00365521.2011.574726 Travelan® has been shown to reduce both the incidence and severity of ETEC - induced diarrhea in up to 90% of volunteers Military Health System Research Symposium 14 - 17 Aug 2023_Abstract 1 Clinical Evaluation of Travelan® an Oral Prophylactic for Prevention of Travelers’ Diarrhea in Active Duty Military Service Assigned Abroad. Immuron Limited, 29 April, 2011 Travelan as a broad Spectrum anti - bacterial US Department of Defense, Armed Forces Research Institute of Medical Sciences (AFRIM), 4 September, 2019 Travelan® demonstrates broad reactivity to Vibrio cholera strains from Southeast Asia indicating broad potential for prevention of traveler’s diarrhea US Department of Defense, Armed Forces Research Institute of Medical Sciences (AFRIM), 5 September, 2018 Travelan® prevented clinical shigellosis (bacillary dysentery) in 75% of Travelan® treated animals compared to placebo and demonstrated a significant clinical benefit US Department of Defense, Armed Forces Research Institute of Medical Sciences (AFRIM), 30 January, 2017 Travelan® able to bind and was reactive to 60 clinical isolates of each bacteria, Campylobacter, ETEC, and Shigella Islam D, Ruamsap N, Imerbsin R, Khanijou P, Gonwong S, Wegner MD, et al. (2023) Bioactivity and efficacy of a hyperimmune bovine colostrum product - Travelan, against shigellosis in a non - Human primate model (Macaca mulatta). PLoS ONE 18(12): e0294021. Bioactivity and efficacy of a hyperimmune bovine colostrum product - Travelan, against shigellosis in a non - Human primate model (Macaca mulatta) Clin Vaccine Immunol 24:e00186 - 16. https://doi.org/10.1128/CVI.00186 - 16 Bioactive Immune Components of Travelan® Infect Immun. 2023 Nov; 91(11): e00097 - 23. Hyperimmune bovine colostrum containing lipopolysaccharide antibodies (IMM - 124E) has a non - detrimental effect on gut microbial communities in unchallenged mice Journal of Crohn’s and Colitis, Volume 13, Issue 6, June 2019, Pages 785 – 797, https://doi.org/10.1093/ecco - jcc/jjy213 Administration of the Hyper - immune Bovine Colostrum Extract IMM - 124E Ameliorates Experimental Murine Colitis IMM - 529 Sci Rep 7, 3665 (2017). https://doi.org/10.1038/s41598 - 017 - 03982 - 5 Bovine antibodies targeting primary and recurrent Clostridium difficile disease are a potent antibiotic alternative
