Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We consent to the incorporation by reference in this Registration Statement onForm S-8 of our report dated February 23, 2018 (March 19, 2018 as to the effects of the reverse stock split and other matters described in Note 17) relating to the financial statements of Homology Medicines, Inc., appearing in Amendment No. 3 to Registration StatementNo. 333-223409 of Homology Medicines, Inc. onForm S-1.
/s/ Deloitte & Touche LLP
Boston, Massachusetts
March 27, 2018
