Merrill Lynch, Pierce, Fenner & Smith
Incorporated
One Bryant Park
New York, New York 10036
Credit Suisse Securities (USA) LLC
Eleven Madison Avenue
New York, New York 10010
May 6, 2019
VIA EDGAR
| Securities and Exchange Commission | ||
| Division of Corporation Finance | ||
| 100 F Street, N.E. | ||
| Washington, D.C. 20549 | ||
| Attn: | Suzanne Hayes | |
| Jeffrey Gabor | ||
| Joseph McCann | ||
Re: Cortexyme, Inc. Acceleration Request
Acceleration Request
Requested Date: May 8, 2019
Requested Time: 3:30 p.m. Eastern Time
Ladies and Gentlemen:
In accordance with Rule 461 under the Securities Act of 1933, as amended (the “Act”), we, as representatives of the several underwriters, hereby join in the request of Cortexyme, Inc. (the “Company”) for acceleration of the effective date of the Registration Statement on FormS-1 (FileNo. 333-230853), as amended, requesting effectiveness as of 3:30 p.m., Eastern Time, on May 8, 2019, or at such later time as the Company or its outside counsel, Orrick, Herrington & Sutcliffe LLP, may request via telephone call to the staff of the Division of Corporation Finance of the Securities and Exchange Commission.
Pursuant to Rule 460 under the Act, we, as representatives of the several underwriters, wish to advise you that between April 29, 2019 through the date hereof we have distributed approximately 1,280 copies of the Company’s preliminary prospectus dated April 29, 2019 to prospective underwriters, dealers, institutional investors and others.
We, the undersigned, as representatives of the several underwriters, have complied and will comply, and we have been informed by the participating underwriters that they have complied and will comply, with the requirements of Rule15c2-8 under the Securities Exchange Act of 1934, as amended.
[Signature page follows]
| Very truly yours, | ||
| MERRILL LYNCH, PIERCE, FENNER & SMITH INCORPORATED | ||
| By: | /s/ Charles Newton | |
| Authorized Signatory | ||
| CREDIT SUISSE SECURITIES (USA) LLC | ||
| By: | /s/ John Hoffman | |
| Authorized Signatory | ||
[Signature Page to Underwriters’ Acceleration Request]
