Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
Cortexyme, Inc.
South San Francisco, California
We hereby consent to the incorporation by reference in this Registration Statement of our report dated March 4, 2019 (except for the “Reverse Stock Split” paragraph of Note 2, as to which the date is April 29, 2019), relating to the financial statements of Cortexyme, Inc. included in the Company’s Registration Statement on FormS-1(333-230853), as amended.
/s/ BDO USA, LLP
San Jose, California
May 9, 2019
