| Document and Entity Information | May 19, 2022 |
| Cover [Abstract] | |
| Amendment Flag | false |
| Entity Central Index Key | 0001662774 |
| Document Type | 8-K |
| Document Period End Date | May 19, 2022 |
| Entity Registrant Name | CORTEXYME, INC. |
| Entity Incorporation State Country Code | DE |
| Entity File Number | 001-38890 |
| Entity Tax Identification Number | 90-1024039 |
| Entity Address, Address Line One | 269 East Grand Ave. |
| Entity Address, City or Town | South San Francisco |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 94080 |
| City Area Code | (415) |
| Local Phone Number | 910-5717 |
| Written Communications | false |
| Soliciting Material | false |
| Pre Commencement Tender Offer | false |
| Pre Commencement Issuer Tender Offer | false |
| Security 12b Title | Common Stock, $0.001 par value per share |
| Trading Symbol | CRTX |
| Security Exchange Name | NASDAQ |
| Entity Emerging Growth Company | false |
