Pay vs Performance Disclosure - USD ($) | 12 Months Ended |
Dec. 31, 2022 | Dec. 31, 2021 |
Pay vs Performance Disclosure [Table] | | |
Pay vs Performance [Table Text Block] | PAY VERSUS PERFORMANCE As required by Section 953(a) of the Dodd-Frank Wall Street Reform and Consumer Protection Act, and Item 402(v) of Regulation S-K, Year (1) Summary Compensation Table Total (2) Compensation Actually Paid to PEO (3) Average Non-PEO (4) Average Non-PEO (5) Value of Initial Fixed $100 Net (Millions) (7) Thye (2) Lowe (2) Lynch (2) Thye (3) Lowe (3) Lynch (3) (b) Total (6) Peer Group (a) (b) (b) (b) (c) (c) (d) (e) (f) (g) (h) 2022 $ 4,968,477 $ 3,400,870 $ 5,167,258 $ 1,790,159 ($ 742,796 ) ($ 1,870,802 ) $ 2,746,696 $ 230,797 $ 2.29 N/A ($ 51,660 ) 2021 — — $ 887,344 — — ($ 2,845,137 ) $ 990,776 ($ 1,811,740 ) $ 45.43 N/A ($ 89,945 ) (1) We are a smaller reporting company pursuant to Rule 405 of the Securities Act, and as such, are only required to include information for the past two fiscal years in this table. (2) The dollar amounts reported in column (b) are the amounts of total compensation reported for Dr. Thye, Mr. Lowe and Ms. Lynch (each of whom served as Chief Executive Officer during fiscal year 2022) for each corresponding year in the “Total” column of the Summary Compensation Table. Refer to “Executive Compensation Tables—Summary Compensation Table.” Ms. Lynch served as our Chief Executive Officer from 2014 until her departure from the Company effective January 28, 2022, upon which the Company appointed Mr. Lowe to serve as Interim Chief Executive Officer of the Company. Mr. Lowe served as Interim Chief Executive Officer until the Company appointed Dr. Thye to serve as the Chief Executive Officer of the Company effective May 19, 2022. (3) The dollar amounts reported in column (c) represent the amount of “compensation actually paid” to Dr. Thye, Mr. Lowe and Ms. Lynch, respectively, as computed in accordance with Item 402(v) of Regulation S-K. S-K, Year Reported Summary Reported Value of Equity Awards (a) Equity Award Adjustments (b) Compensation Actually Paid to Dirk Thye, M.D. 2022 $ 4,968,477 $ 4,483,313 $1,304,995 $1,790,159 Christopher Lowe 2022 $ 3,400,870 $ 1,989,888 ($1,401,278 ) ($742,796 ) Casey C. Lynch 2022 $ 5,167,258 $ 4,355,604 ($2,682,456 ) ($1,870,802 ) 2021 $ 887,344 — ($3,732,481 ) ($2,845,137 ) (a) The grant date fair value of equity awards represents the total of the amounts reported in the “Stock Awards” and “Option Awards” columns in the Summary Compensation Table for the applicable year. (b) The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior fiscal year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. The amounts deducted or added in calculating the equity award adjustments are as follow s: Year Year End Year over Year Fair Value as Year over Fair Value at Value of Total Equity Award Adjustments Dirk Thye, M.D. 2022 $ 1,239,525 — $ 65,470 — — — $ 1,304,995 Christopher Lowe 2022 — — $ 578,618 ($ 306,149 ) ($ 1,673,748 ) — ($ 1,401,278 ) Casey C. Lynch 2022 — — $ 39,763 ($ 646 ) ($ 2,721,573 ) — ($ 2,682,456 ) 2021 — ($ 7,494,039 ) — $ 3,761,558 — — ($ 3,732,481 ) (4) The dollar amounts reported in column (d) represent the average of the amounts reported for the Company’s named executive officers (“NEOs”) as a group (excluding, in the case of 2022, Dr. Thye, Mr. Lowe and Ms. Lynch, and in the case of 2021, Ms. Lynch) in the “Total” column of the Summary Compensation Table in each applicable year. The names of each of the non-PEO (5) The dollar amounts reported in column (e) represent the average amount of “compensation actually paid” to the NEOs as a group (excluding, in the case of 2022, Dr. Thye, Mr. Lowe and Ms. Lynch, and in the case of 2021, Ms. Lynch), as computed in accordance with Item 402(v) of Regulation S-K. non-PEO non-PEO Year Average Reported Summary Compensation Table Total for Non-PEO Average Reported Value of Equity Awards (a) Average Equity (b) Average Compensation Actually Paid to Non-PEO 2022 $ 2,746,696 $ 1,909,671 ($ 288,565 ) $ 230,797 2021 $ 990,776 $ 369,500 ($ 2,433,016 ) ($ 1,811,740 ) (a) The amounts deducted or added in calculating the total average equity award adjustments are as follows: Year Average Year Average Year Average Fair Average Year Average Fair Average Value Average Equity Award Adjustments 2022 $ 291,917 — $ 147,463 ($ 117,791 ) ($ 610,155 ) — ($ 288,565 ) 2021 $ 69,390 ($ 4,280,801 ) $ 82,269 $ 1,696,127 — — ($ 2,433,016 ) (6) Cumulative total shareholder return (“TSR”) is calculated by dividing the sum of the cumulative amount of dividends for the measurement period, assuming dividend reinvestment, and the difference between the Company’s share price at the end and the beginning of the measurement period by the Company’s share price at the beginning of the measurement period. (7) The dollar amounts reported represent the amount of net income (loss) reflected in the Company’s audited financial statements for the applicable year. | |
Named Executive Officers, Footnote [Text Block] | The dollar amounts reported in column (d) represent the average of the amounts reported for the Company’s named executive officers (“NEOs”) as a group (excluding, in the case of 2022, Dr. Thye, Mr. Lowe and Ms. Lynch, and in the case of 2021, Ms. Lynch) in the “Total” column of the Summary Compensation Table in each applicable year. The names of each of the non-PEO | |
Adjustment To PEO Compensation, Footnote [Text Block] | (3) The dollar amounts reported in column (c) represent the amount of “compensation actually paid” to Dr. Thye, Mr. Lowe and Ms. Lynch, respectively, as computed in accordance with Item 402(v) of Regulation S-K. S-K, Year Reported Summary Reported Value of Equity Awards (a) Equity Award Adjustments (b) Compensation Actually Paid to Dirk Thye, M.D. 2022 $ 4,968,477 $ 4,483,313 $1,304,995 $1,790,159 Christopher Lowe 2022 $ 3,400,870 $ 1,989,888 ($1,401,278 ) ($742,796 ) Casey C. Lynch 2022 $ 5,167,258 $ 4,355,604 ($2,682,456 ) ($1,870,802 ) 2021 $ 887,344 — ($3,732,481 ) ($2,845,137 ) (a) The grant date fair value of equity awards represents the total of the amounts reported in the “Stock Awards” and “Option Awards” columns in the Summary Compensation Table for the applicable year. (b) The equity award adjustments for each applicable year include the addition (or subtraction, as applicable) of the following: (i) the year-end the applicable year, the amount equal to the change as of the vesting date (from the end of the prior fiscal year) in fair value; (v) for awards granted in prior years that are determined to fail to meet the applicable vesting conditions during the applicable year, a deduction for the amount equal to the fair value at the end of the prior fiscal year; and (vi) the dollar value of any dividends or other earnings paid on stock or option awards in the applicable year prior to the vesting date that are not otherwise reflected in the fair value of such award or included in any other component of total compensation for the applicable year. The amounts deducted or added in calculating the equity award adjustments are as follow s: Year Year End Year over Year Fair Value as Year over Fair Value at Value of Total Equity Award Adjustments Dirk Thye, M.D. 2022 $ 1,239,525 — $ 65,470 — — — $ 1,304,995 Christopher Lowe 2022 — — $ 578,618 ($ 306,149 ) ($ 1,673,748 ) — ($ 1,401,278 ) Casey C. Lynch 2022 — — $ 39,763 ($ 646 ) ($ 2,721,573 ) — ($ 2,682,456 ) 2021 — ($ 7,494,039 ) — $ 3,761,558 — — ($ 3,732,481 ) | |
Non-PEO NEO Average Total Compensation Amount | $ 2,746,696 | $ 990,776 |
Non-PEO NEO Average Compensation Actually Paid Amount | $ 230,797 | (1,811,740) |
Adjustment to Non-PEO NEO Compensation Footnote [Text Block] | (5) The dollar amounts reported in column (e) represent the average amount of “compensation actually paid” to the NEOs as a group (excluding, in the case of 2022, Dr. Thye, Mr. Lowe and Ms. Lynch, and in the case of 2021, Ms. Lynch), as computed in accordance with Item 402(v) of Regulation S-K. non-PEO non-PEO Year Average Reported Summary Compensation Table Total for Non-PEO Average Reported Value of Equity Awards (a) Average Equity (b) Average Compensation Actually Paid to Non-PEO 2022 $ 2,746,696 $ 1,909,671 ($ 288,565 ) $ 230,797 2021 $ 990,776 $ 369,500 ($ 2,433,016 ) ($ 1,811,740 ) (a) The amounts deducted or added in calculating the total average equity award adjustments are as follows: Year Average Year Average Year Average Fair Average Year Average Fair Average Value Average Equity Award Adjustments 2022 $ 291,917 — $ 147,463 ($ 117,791 ) ($ 610,155 ) — ($ 288,565 ) 2021 $ 69,390 ($ 4,280,801 ) $ 82,269 $ 1,696,127 — — ($ 2,433,016 ) | |
Compensation Actually Paid vs. Total Shareholder Return [Text Block] | Compensation Actually Paid and Cumulative TSR The following graph sets forth the relationship between Compensation Actually Paid to our PEOs, the average of Compensation Actually Paid to our other NEOs, and the Company’s cumulative TSR over the two most recently completed fiscal years. | |
Compensation Actually Paid vs. Net Income [Text Block] | Compensation Actually Paid and Net Income (Loss) The following graph sets forth the relationship between Compensation Actually Paid to our PEOs, the average of Compensation Actually Paid to our other NEOs, and the Company’s net income (loss) over the two most recently completed fiscal years. | |
Total Shareholder Return Amount | $ 2.29 | 45.43 |
Net Income (Loss) | (51,660,000,000) | (89,945,000,000) |
Dirk Thye, M.D. [Member] | | |
Pay vs Performance Disclosure [Table] | | |
PEO Total Compensation Amount | 4,968,477 | 0 |
PEO Actually Paid Compensation Amount | $ 1,790,159 | 0 |
PEO Name | Dirk Thye, M.D. | |
Christopher Lowe [Member] | | |
Pay vs Performance Disclosure [Table] | | |
PEO Total Compensation Amount | $ 3,400,870 | 0 |
PEO Actually Paid Compensation Amount | $ (742,796) | 0 |
PEO Name | Christopher Lowe | |
Casey C. Lynch [Member] | | |
Pay vs Performance Disclosure [Table] | | |
PEO Total Compensation Amount | $ 5,167,258 | 887,344 |
PEO Actually Paid Compensation Amount | $ (1,870,802) | $ (2,845,137) |
PEO Name | Casey C. Lynch | Casey C. Lynch |
PEO [Member] | Dirk Thye, M.D. [Member] | Reported Value of Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | $ 4,483,313 | |
PEO [Member] | Dirk Thye, M.D. [Member] | Equity Award Adjustments [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 1,304,995 | |
PEO [Member] | Dirk Thye, M.D. [Member] | Year End Fair Value of Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 1,239,525 | |
PEO [Member] | Dirk Thye, M.D. [Member] | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | |
PEO [Member] | Dirk Thye, M.D. [Member] | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 65,470 | |
PEO [Member] | Dirk Thye, M.D. [Member] | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | |
PEO [Member] | Dirk Thye, M.D. [Member] | Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | |
PEO [Member] | Dirk Thye, M.D. [Member] | Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | |
PEO [Member] | Dirk Thye, M.D. [Member] | Total Equity Award Adjustments [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 1,304,995 | |
PEO [Member] | Christopher Lowe [Member] | Reported Value of Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 1,989,888 | |
PEO [Member] | Christopher Lowe [Member] | Equity Award Adjustments [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (1,401,278) | |
PEO [Member] | Christopher Lowe [Member] | Year End Fair Value of Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | |
PEO [Member] | Christopher Lowe [Member] | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | |
PEO [Member] | Christopher Lowe [Member] | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 578,618 | |
PEO [Member] | Christopher Lowe [Member] | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (306,149) | |
PEO [Member] | Christopher Lowe [Member] | Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (1,673,748) | |
PEO [Member] | Christopher Lowe [Member] | Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | |
PEO [Member] | Christopher Lowe [Member] | Total Equity Award Adjustments [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (1,401,278) | |
PEO [Member] | Casey C. Lynch [Member] | Reported Value of Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 4,355,604 | $ 0 |
PEO [Member] | Casey C. Lynch [Member] | Equity Award Adjustments [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (2,682,456) | (3,732,481) |
PEO [Member] | Casey C. Lynch [Member] | Year End Fair Value of Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | 0 |
PEO [Member] | Casey C. Lynch [Member] | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | (7,494,039) |
PEO [Member] | Casey C. Lynch [Member] | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 39,763 | 0 |
PEO [Member] | Casey C. Lynch [Member] | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (646) | 3,761,558 |
PEO [Member] | Casey C. Lynch [Member] | Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (2,721,573) | 0 |
PEO [Member] | Casey C. Lynch [Member] | Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | 0 |
PEO [Member] | Casey C. Lynch [Member] | Total Equity Award Adjustments [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (2,682,456) | (3,732,481) |
Non-PEO NEO [Member] | Reported Value of Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 1,909,671 | 369,500 |
Non-PEO NEO [Member] | Equity Award Adjustments [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (288,565) | (2,433,016) |
Non-PEO NEO [Member] | Year End Fair Value of Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 291,917 | 69,390 |
Non-PEO NEO [Member] | Year over Year Change in Fair Value of Outstanding and Unvested Equity Awards [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | (4,280,801) |
Non-PEO NEO [Member] | Fair Value as of Vesting Date of Equity Awards Granted and Vested in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 147,463 | 82,269 |
Non-PEO NEO [Member] | Year over Year Change in Fair Value of Equity Awards Granted in Prior Years that Vested in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (117,791) | 1,696,127 |
Non-PEO NEO [Member] | Fair Value at the End of the Prior Year of Equity Awards that Failed to Meet Vesting Conditions in the Year [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | (610,155) | 0 |
Non-PEO NEO [Member] | Value of Dividends or other Earnings Paid on Stock or Option Awards not Otherwise Reflected in Fair Value or Total Compensation [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | 0 | 0 |
Non-PEO NEO [Member] | Total Equity Award Adjustments [Member] | | |
Pay vs Performance Disclosure [Table] | | |
Adjustment to Compensation Amount | $ (288,565) | $ (2,433,016) |