Column Group Iii SC 13D Tenaya Therapeutics / COLUMN GROUP III ownership change

Exhibit 1

JOINT FILING AGREEMENT

The undersigned hereby agree that the foregoing statement on Schedule 13D is filed on behalf of each of the undersigned, and any amendments thereto executed by the undersigned shall be filed on behalf of each of the undersigned without the necessity of filing any additional joint filing agreement. The undersigned acknowledge that each is responsible for the timely filing of such statement on Schedule 13D and any amendments thereto, and for the completeness and accuracy of the information concerning him, her or it contained therein, but shall not be responsible for the completeness or accuracy of the information concerning the others of the undersigned, except to the extent that he, she or it knows or has reason to believe that such information is inaccurate or incomplete. This Joint Filing Agreement may be executed in any number of counterparts, all of which taken together shall constitute one and the same instrument.

Dated: December 1, 2022

THE COLUMN GROUP III, LP		THE COLUMN GROUP III GP, LP
By:	The Column Group III GP, LP
By:	/s/ James Evangelista, Attorney in Fact	By:	/s/ James Evangelista, Attorney in Fact
Name:	James Evangelista	Name:	James Evangelista
Title:	Attorney in Fact	Title:	Attorney in Fact
THE COLUMN GROUP III-A, LP		THE COLUMN GROUP OPPORTUNITY III, LP
By:	The Column Group III GP, LP	By: By:	The Column Group Opportunity III GP, LP TCG Opportunity III GP, LLC
By:	/s/ James Evangelista, Attorney in Fact	By:	/s/ James Evangelista, Attorney in Fact
Name:	James Evangelista	Name:	James Evangelista
Title:	Attorney in Fact	Title:	Attorney in Fact
THE COLUMN GROUP OPPORTUNITY III GP, LP		TCG OPPORTUNITY III GP, LLC
By:	TCG Opportunity III GP, LLC
By:	/s/ James Evangelista, Attorney in Fact	By:	/s/ James Evangelista, Attorney in Fact
Name:	James Evangelista	Name:	James Evangelista
Title:	Attorney in Fact	Title:	Attorney in Fact