(4) | Pursuant to Rule 415(a)(6) under the Securities Act, the securities registered pursuant to this registration statement include $111,712,902 of unsold securities (the “Unsold Securities”) previously registered pursuant to the Registration Statement on Form S-3 (File No. 333-249848), which was declared effective on November 16, 2020 (the “Prior Registration Statement”), which include $85,717,806 of unsold common stock pursuant to the sales agreement prospectus included in the Prior Registration Statement. In connection with the filing of the Prior Registration Statement, the registrant paid a filing fee of $14,500 associated with the offering of the Unsold Securities (based on the filing fee rate in effect at the time of the filing of the Prior Registration Statement). The filing fee associated with the offering of the Unsold Securities is hereby carried forward to be applied to the Unsold Securities registered hereunder, and no additional filing fee is due with respect to the Unsold Securities in connection with the filing of this Registration Statement. The registrant is also registering new securities on this registration statement with an aggregate initial offering price of $338,287,098 (the “New Securities”), which aggregate offering price is not specified as to each class of securities. A filing fee of $37,280 with respect to the New Securities is being paid in connection with the filing of this registration statement. To the extent that, after the filing date hereof and prior to the effectiveness of this registration statement, the registrant sells any Unsold Securities pursuant to the Prior Registration Statement, the registrant will identify in a pre-effective amendment to this registration statement the updated number of Unsold Securities from the Prior Registration Statement to be included in this registration statement pursuant to Rule 415(a)(6) and the updated amount of new securities to be registered on this registration statement. Pursuant to Rule 415(a)(6), the offering of securities under the Prior Registration Statement will be deemed terminated as of the date of effectiveness of this registration statement. |