COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBOTT LABS | COM | 002824100 | 56,246 | 766,710 | SH | | DFND | 1 | 0 | 0 | 766,710 |
ABIOMED INC | COM | 003654100 | 14,902 | 33,135 | SH | | DFND | 1 | 0 | 0 | 33,135 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 1,183 | 57,000 | SH | | DFND | 1 | 0 | 0 | 57,000 |
ACCELERON PHARMA INC | COM | 00434H108 | 927 | 16,200 | SH | | DFND | 1 | 0 | 0 | 16,200 |
ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 794 | 58,535 | SH | | DFND | 1 | 0 | 0 | 58,535 |
AETNA INC NEW | COM | 00817Y108 | 1,440 | 7,100 | SH | | DFND | 1 | 0 | 0 | 7,100 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 1,532 | 19,861 | SH | | DFND | 1 | 0 | 0 | 19,861 |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 14,656 | 418,496 | SH | | DFND | 1 | 0 | 0 | 418,496 |
ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 15,072 | 905,254 | SH | | DFND | 1 | 0 | 0 | 905,254 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 25,450 | 183,080 | SH | | DFND | 1 | 0 | 0 | 183,080 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 57,239 | 146,310 | SH | | DFND | 1 | 0 | 0 | 146,310 |
ALLERGAN PLC | SHS | G0177J108 | 2,476 | 13,000 | SH | | DFND | 1 | 0 | 0 | 13,000 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 19,245 | 219,891 | SH | | DFND | 1 | 0 | 0 | 219,891 |
AMEDISYS INC | COM | 023436108 | 3,149 | 25,204 | SH | | DFND | 1 | 0 | 0 | 25,204 |
AMERISOURCEBERGEN CORP | COM | 03073E105 | 22,027 | 238,853 | SH | | DFND | 1 | 0 | 0 | 238,853 |
AMGEN INC | COM | 031162100 | 7,659 | 36,950 | SH | | DFND | 1 | 0 | 0 | 36,950 |
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 2,108 | 95,000 | SH | | DFND | 1 | 0 | 0 | 95,000 |
ANGIODYNAMICS INC | COM | 03475V101 | 1,646 | 75,700 | SH | | DFND | 1 | 0 | 0 | 75,700 |
ANTHEM INC | COM | 036752103 | 61,439 | 224,188 | SH | | DFND | 1 | 0 | 0 | 224,188 |
ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 1,418 | 30,817 | SH | | DFND | 1 | 0 | 0 | 30,817 |
BAXTER INTL INC | COM | 071813109 | 20,301 | 263,348 | SH | | DFND | 1 | 0 | 0 | 263,348 |
BECTON DICKINSON & CO | COM | 075887109 | 27,513 | 105,413 | SH | | DFND | 1 | 0 | 0 | 105,413 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 2,001 | 11,620 | SH | | DFND | 1 | 0 | 0 | 11,620 |
BIOGEN INC | COM | 09062X103 | 13,866 | 39,245 | SH | | DFND | 1 | 0 | 0 | 39,245 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 4,642 | 47,869 | SH | | DFND | 1 | 0 | 0 | 47,869 |
BLUEBIRD BIO INC | COM | 09609G100 | 1,664 | 11,400 | SH | | DFND | 1 | 0 | 0 | 11,400 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 37,689 | 978,929 | SH | | DFND | 1 | 0 | 0 | 978,929 |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 21,215 | 341,729 | SH | | DFND | 1 | 0 | 0 | 341,729 |
CAREDX INC | COM | 14167l103 | 9,724 | 337,049 | SH | | DFND | 1 | 0 | 0 | 337,049 |
CASTLIGHT HEALTH INC | CL B | 14862Q100 | 2,400 | 888,842 | SH | | DFND | 1 | 0 | 0 | 888,842 |
CELGENE CORP | COM | 151020104 | 54,231 | 606,000 | SH | | DFND | 1 | 0 | 0 | 606,000 |
CELLECTIS S A | SPONSORED ADS | 15117K103 | 1,400 | 49,600 | SH | | DFND | 1 | 0 | 0 | 49,600 |
CENTENE CORP DEL | COM | 15135B101 | 31,565 | 218,021 | SH | | DFND | 1 | 0 | 0 | 218,021 |
CERNER CORP | COM | 156782104 | 3,810 | 59,146 | SH | | DFND | 1 | 0 | 0 | 59,146 |
CIGNA CORPORATION | COM | 125509109 | 35,291 | 169,463 | SH | | DFND | 1 | 0 | 0 | 169,463 |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 3,563 | 215,935 | SH | | DFND | 1 | 0 | 0 | 215,935 |
COOPER COS INC | COM NEW | 216648402 | 6,322 | 22,811 | SH | | DFND | 1 | 0 | 0 | 22,811 |
CVS HEALTH CORP | COM | 126650100 | 630 | 8,000 | SH | | DFND | 1 | 0 | 0 | 8,000 |
DANAHER CORP DEL | COM | 235851102 | 27,493 | 253,016 | SH | | DFND | 1 | 0 | 0 | 253,016 |
DENTSPLY SIRONA INC | COM | 24906P109 | 4,185 | 110,878 | SH | | DFND | 1 | 0 | 0 | 110,878 |
DEXCOM INC | COM | 252131107 | 10,248 | 71,647 | SH | | DFND | 1 | 0 | 0 | 71,647 |
EAGLE PHARMACEUTICALS INC | COM | 269796108 | 1,248 | 18,000 | SH | | DFND | 1 | 0 | 0 | 18,000 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 44,105 | 253,333 | SH | | DFND | 1 | 0 | 0 | 253,333 |
ENDO INTL PLC | SHS | G30401106 | 3,659 | 217,392 | SH | | DFND | 1 | 0 | 0 | 217,392 |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 17,386 | 391,852 | SH | | DFND | 1 | 0 | 0 | 391,852 |
EXPRESS SCRIPTS HLDG CO | COM | 30219G108 | 4,228 | 44,500 | SH | | DFND | 1 | 0 | 0 | 44,500 |
FITBIT INC | CL A | 33812L102 | 13,449 | 2,513,900 | SH | | DFND | 1 | 0 | 0 | 2,513,900 |
GENMARK DIAGNOSTICS INC | COM | 372309104 | 9,845 | 1,339,502 | SH | | DFND | 1 | 0 | 0 | 1,339,502 |
GILEAD SCIENCES INC | COM | 375558103 | 10,616 | 137,500 | SH | | DFND | 1 | 0 | 0 | 137,500 |
GLOBUS MED INC | CL A | 379577208 | 8,585 | 151,251 | SH | | DFND | 1 | 0 | 0 | 151,251 |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 1,145 | 6,629 | SH | | DFND | 1 | 0 | 0 | 6,629 |
HCA HEALTHCARE INC | COM | 40412C101 | 5,132 | 36,888 | SH | | DFND | 1 | 0 | 0 | 36,888 |
HEALTHCARE SVCS GRP INC | COM | 421906108 | 609 | 15,000 | SH | | DFND | 1 | 0 | 0 | 15,000 |
SCHEIN HENRY INC | COM | 806407102 | 4,368 | 51,368 | SH | | DFND | 1 | 0 | 0 | 51,368 |
HILL ROM HLDGS INC | COM | 431475102 | 17,529 | 185,689 | SH | | DFND | 1 | 0 | 0 | 185,689 |
HMS HLDGS CORP | COM | 40425J101 | 7,449 | 227,020 | SH | | DFND | 1 | 0 | 0 | 227,020 |
HOLOGIC INC | COM | 436440101 | 14,830 | 361,894 | SH | | DFND | 1 | 0 | 0 | 361,894 |
HORIZON PHARMA PLC | SHS | G4617B105 | 4,340 | 221,678 | SH | | DFND | 1 | 0 | 0 | 221,678 |
HUMANA INC | COM | 444859102 | 33,348 | 98,510 | SH | | DFND | 1 | 0 | 0 | 98,510 |
HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 12,877 | 400,029 | SH | | DFND | 1 | 0 | 0 | 400,029 |
IDEXX LABS INC | COM | 45168D104 | 6,068 | 24,307 | SH | | DFND | 1 | 0 | 0 | 24,307 |
ILLUMINA INC | COM | 452327109 | 54,217 | 147,707 | SH | | DFND | 1 | 0 | 0 | 147,707 |
INCYTE CORP | COM | 45337C102 | 3,616 | 52,350 | SH | | DFND | 1 | 0 | 0 | 52,350 |
INOGEN INC | COM | 45780L104 | 5,678 | 23,261 | SH | | DFND | 1 | 0 | 0 | 23,261 |
INSMED INC | COM PAR $.01 | 457669307 | 11,451 | 566,301 | SH | | DFND | 1 | 0 | 0 | 566,301 |
INSPIRE MED SYS INC | COM | 457730109 | 3,816 | 90,696 | SH | | DFND | 1 | 0 | 0 | 90,696 |
INSULET CORP | COM | 45784P101 | 1,907 | 18,000 | SH | | DFND | 1 | 0 | 0 | 18,000 |
INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 9,329 | 141,620 | SH | | DFND | 1 | 0 | 0 | 141,620 |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 470 | 16,434 | SH | | DFND | 1 | 0 | 0 | 16,434 |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 3,051 | 24,148 | SH | | DFND | 1 | 0 | 0 | 24,148 |
INTERSECT ENT INC | COM | 46071F103 | 6,734 | 234,227 | SH | | DFND | 1 | 0 | 0 | 234,227 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 1,185 | 54,600 | SH | | DFND | 1 | 0 | 0 | 54,600 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 50,436 | 87,868 | SH | | DFND | 1 | 0 | 0 | 87,868 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 16,017 | 310,536 | SH | | DFND | 1 | 0 | 0 | 310,536 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 281 | 25,000 | SH | | DFND | 1 | 0 | 0 | 25,000 |
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 6,594 | 69,661 | SH | | DFND | 1 | 0 | 0 | 69,661 |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 1,466 | 79,400 | SH | | DFND | 1 | 0 | 0 | 79,400 |
ISHARES TR | NASDAQ BIOTECH | 464287556 | 3,414 | 28,000 | SH | | DFND | 1 | 0 | 0 | 28,000 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 35,939 | 213,758 | SH | | DFND | 1 | 0 | 0 | 213,758 |
JOHNSON & JOHNSON | COM | 478160104 | 2,763 | 20,000 | SH | | DFND | 1 | 0 | 0 | 20,000 |
K2M GROUP HLDGS INC | COM | 48273J107 | 15,110 | 552,054 | SH | | DFND | 1 | 0 | 0 | 552,054 |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 16,333 | 94,040 | SH | | DFND | 1 | 0 | 0 | 94,040 |
LIGAND PHARMACEUTICALS INC | COM NEW | 53220K504 | 3,094 | 11,270 | SH | | DFND | 1 | 0 | 0 | 11,270 |
LIVANOVA PLC | SHS | G5509L101 | 14,435 | 116,443 | SH | | DFND | 1 | 0 | 0 | 116,443 |
MACROGENICS INC | COM | 556099109 | 15,529 | 724,302 | SH | | DFND | 1 | 0 | 0 | 724,302 |
MASIMO CORP | COM | 574795100 | 2,426 | 19,476 | SH | | DFND | 1 | 0 | 0 | 19,476 |
MATERIALISE NV | SPONSORED ADS | 57667T100 | 2,908 | 210,731 | SH | | DFND | 1 | 0 | 0 | 210,731 |
MCKESSON CORP | COM | 58155Q103 | 1,128 | 8,503 | SH | | DFND | 1 | 0 | 0 | 8,503 |
MEDIDATA SOLUTIONS INC | COM | 58471A105 | 2,706 | 36,907 | SH | | DFND | 1 | 0 | 0 | 36,907 |
MEDTRONIC PLC | SHS | G5960L103 | 48,835 | 496,446 | SH | | DFND | 1 | 0 | 0 | 496,446 |
MERCK & CO INC | COM | 58933Y105 | 887 | 12,500 | SH | | DFND | 1 | 0 | 0 | 12,500 |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 1,178 | 25,000 | SH | | DFND | 1 | 0 | 0 | 25,000 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 7,506 | 50,478 | SH | | DFND | 1 | 0 | 0 | 50,478 |
MYLAN N V | SHS EURO | N59465109 | 20,692 | 565,350 | SH | | DFND | 1 | 0 | 0 | 565,350 |
NEKTAR THERAPEUTICS | COM | 640268108 | 3,384 | 55,520 | SH | | DFND | 1 | 0 | 0 | 55,520 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 5,109 | 41,550 | SH | | DFND | 1 | 0 | 0 | 41,550 |
NEURONETICS INC | COM | 64131A105 | 3,588 | 111,907 | SH | | DFND | 1 | 0 | 0 | 111,907 |
NEVRO CORP | COM | 64157F103 | 4,584 | 80,415 | SH | | DFND | 1 | 0 | 0 | 80,415 |
OMNICELL INC | COM | 68213N109 | 7,524 | 104,650 | SH | | DFND | 1 | 0 | 0 | 104,650 |
OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 3,600 | 221,837 | SH | | DFND | 1 | 0 | 0 | 221,837 |
PACIFIC BIOSCIENCES OF CALIF INC | COM | 69404D108 | 13,931 | 2,575,000 | SH | | DFND | 1 | 0 | 0 | 2,575,000 |
PENUMBRA INC | COM | 70975L107 | 2,866 | 19,142 | SH | | DFND | 1 | 0 | 0 | 19,142 |
PFIZER INC | COM | 717081103 | 1,287 | 29,200 | SH | | DFND | 1 | 0 | 0 | 29,200 |
PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 710 | 26,650 | SH | | DFND | 1 | 0 | 0 | 26,650 |
PRA HEALTH SCIENCES INC | COM | 69354M108 | 18,336 | 166,400 | SH | | DFND | 1 | 0 | 0 | 166,400 |
PREMIER INC | CL A | 74051N102 | 691 | 15,100 | SH | | DFND | 1 | 0 | 0 | 15,100 |
PTC THERAPEUTICS INC | COM | 69366J200 | 1,058 | 22,500 | SH | | DFND | 1 | 0 | 0 | 22,500 |
QIAGEN NV | SHS NEW | N72482123 | 5,083 | 134,189 | SH | | DFND | 1 | 0 | 0 | 134,189 |
QUANTERIX CORP | COM | 74766Q101 | 6,709 | 313,230 | SH | | DFND | 1 | 0 | 0 | 313,230 |
QUOTIENT LTD | SHS | G73268107 | 5,450 | 721,858 | SH | | DFND | 1 | 0 | 0 | 721,858 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 10,295 | 25,480 | SH | | DFND | 1 | 0 | 0 | 25,480 |
REGENXBIO INC | COM | 75901B107 | 1,759 | 23,300 | SH | | DFND | 1 | 0 | 0 | 23,300 |
RESMED INC | COM | 761152107 | 10,749 | 93,192 | SH | | DFND | 1 | 0 | 0 | 93,192 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 1,582 | 11,200 | SH | | DFND | 1 | 0 | 0 | 11,200 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 2,116 | 13,100 | SH | | DFND | 1 | 0 | 0 | 13,100 |
SEATTLE GENETICS INC | COM | 812578102 | 3,621 | 46,950 | SH | | DFND | 1 | 0 | 0 | 46,950 |
SHIRE PLC | SPONSORED ADR | 82481R106 | 11,635 | 64,185 | SH | | DFND | 1 | 0 | 0 | 64,185 |
STRYKER CORP | COM | 863667101 | 25,120 | 141,380 | SH | | DFND | 1 | 0 | 0 | 141,380 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 19,460 | 386,500 | SH | | DFND | 1 | 0 | 0 | 386,500 |
SYNEOS HEALTH INC | CL A | 87166B102 | 1,348 | 26,156 | SH | | DFND | 1 | 0 | 0 | 26,156 |
TABULA RASA HEALTHCARE INC | COM | 873379101 | 7,054 | 86,884 | SH | | DFND | 1 | 0 | 0 | 86,884 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 4,164 | 97,195 | SH | | DFND | 1 | 0 | 0 | 97,195 |
TELADOC HEALTH INC | COM | 87918A105 | 50,646 | 586,520 | SH | | DFND | 1 | 0 | 0 | 586,520 |
TELEFLEX INC | COM | 879369106 | 4,734 | 17,792 | SH | | DFND | 1 | 0 | 0 | 17,792 |
TESARO INC | COM | 881569107 | 1,504 | 38,550 | SH | | DFND | 1 | 0 | 0 | 38,550 |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADR | 881624209 | 1,292 | 60,000 | SH | | DFND | 1 | 0 | 0 | 60,000 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 8,414 | 34,471 | SH | | DFND | 1 | 0 | 0 | 34,471 |
ULTRAGENYX PHARMACEUTICAL INC | COM | 90400D108 | 2,431 | 31,850 | SH | | DFND | 1 | 0 | 0 | 31,850 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 32,949 | 123,848 | SH | | DFND | 1 | 0 | 0 | 123,848 |
UNIQURE NV | SHS | N90064101 | 724 | 19,900 | SH | | DFND | 1 | 0 | 0 | 19,900 |
VARIAN MED SYS INC | COM | 92220P105 | 705 | 6,300 | SH | | DFND | 1 | 0 | 0 | 6,300 |
VEEVA SYS INC | CL A COM | 922475108 | 3,559 | 32,691 | SH | | DFND | 1 | 0 | 0 | 32,691 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 7,805 | 40,494 | SH | | DFND | 1 | 0 | 0 | 40,494 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 822 | 43,422 | SH | | DFND | 1 | 0 | 0 | 43,422 |
WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 16,477 | 226,018 | SH | | DFND | 1 | 0 | 0 | 226,018 |
WELLCARE HEALTH PLANS INC | COM | 94946T106 | 9,060 | 28,269 | SH | | DFND | 1 | 0 | 0 | 28,269 |
WRIGHT MED GROUP NV | ORD SHS 0.03 PAR | N96617118 | 18,071 | 622,692 | SH | | DFND | 1 | 0 | 0 | 622,692 |
ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 12,109 | 92,104 | SH | | DFND | 1 | 0 | 0 | 92,104 |