COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
ABBOTT LABS | COM | 002824100 | 70,627 | 976,451 | SH | | DFND | 1 | 0 | 0 | 976,451 |
ABIOMED INC | COM | 003654100 | 12,619 | 38,822 | SH | | DFND | 1 | 0 | 0 | 38,822 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 1,549 | 95,800 | SH | | DFND | 1 | 0 | 0 | 95,800 |
ACCELERON PHARMA INC | COM | 00434H108 | 623 | 14,300 | SH | | DFND | 1 | 0 | 0 | 14,300 |
ADAPTIMMUNE THERAPEUTICS PLC | SPONDS ADR | 00653A107 | 754 | 131,135 | SH | | DFND | 1 | 0 | 0 | 131,135 |
AFFIMED N V | COM | N01045108 | 529 | 170,000 | SH | | DFND | 1 | 0 | 0 | 170,000 |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 13,813 | 458,296 | SH | | DFND | 1 | 0 | 0 | 458,296 |
ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 11,519 | 1,123,813 | SH | | DFND | 1 | 0 | 0 | 1,123,813 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 15,157 | 155,680 | SH | | DFND | 1 | 0 | 0 | 155,680 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 65,090 | 310,795 | SH | | DFND | 1 | 0 | 0 | 310,795 |
ALLERGAN PLC | SHS | G0177J108 | 2,139 | 16,000 | SH | | DFND | 1 | 0 | 0 | 16,000 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 16,360 | 224,385 | SH | | DFND | 1 | 0 | 0 | 224,385 |
AMEDISYS INC | COM | 023436108 | 2,952 | 25,204 | SH | | DFND | 1 | 0 | 0 | 25,204 |
AMERISOURCEBERGEN CORP | COM | 03073E105 | 18,359 | 246,762 | SH | | DFND | 1 | 0 | 0 | 246,762 |
AMGEN INC | COM | 031162100 | 8,750 | 44,950 | SH | | DFND | 1 | 0 | 0 | 44,950 |
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 1,285 | 95,000 | SH | | DFND | 1 | 0 | 0 | 95,000 |
ANGIODYNAMICS INC | COM | 03475V101 | 1,524 | 75,700 | SH | | DFND | 1 | 0 | 0 | 75,700 |
ANTHEM INC | COM | 036752103 | 61,103 | 232,660 | SH | | DFND | 1 | 0 | 0 | 232,660 |
ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 1,181 | 30,317 | SH | | DFND | 1 | 0 | 0 | 30,317 |
ARGENX SE | SPONSORED ADR | 04016X101 | 1,210 | 12,600 | SH | | DFND | 1 | 0 | 0 | 12,600 |
BAXTER INTL INC | COM | 071813109 | 16,754 | 254,543 | SH | | DFND | 1 | 0 | 0 | 254,543 |
BECTON DICKINSON & CO | COM | 075887109 | 27,460 | 121,872 | SH | | DFND | 1 | 0 | 0 | 121,872 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 11,726 | 83,600 | SH | | DFND | 1 | 0 | 0 | 83,600 |
BIOGEN INC | COM | 09062X103 | 7,598 | 25,250 | SH | | DFND | 1 | 0 | 0 | 25,250 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 3,914 | 45,969 | SH | | DFND | 1 | 0 | 0 | 45,969 |
BLUEBIRD BIO INC | COM | 09609G100 | 1,280 | 12,900 | SH | | DFND | 1 | 0 | 0 | 12,900 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 37,350 | 1,056,889 | SH | | DFND | 1 | 0 | 0 | 1,056,889 |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 25,305 | 486,824 | SH | | DFND | 1 | 0 | 0 | 486,824 |
CAREDX INC | COM | 14167L103 | 13,487 | 536,488 | SH | | DFND | 1 | 0 | 0 | 536,488 |
CASTLIGHT HEALTH INC | CL B | 14862Q100 | 2,299 | 1,059,515 | SH | | DFND | 1 | 0 | 0 | 1,059,515 |
CELGENE CORP | COM | 151020104 | 42,146 | 657,601 | SH | | DFND | 1 | 0 | 0 | 657,601 |
CELLECTIS S A | SPONSORED ADS | 15117K103 | 778 | 46,750 | SH | | DFND | 1 | 0 | 0 | 46,750 |
CENTENE CORP DEL | COM | 15135B101 | 10,389 | 90,101 | SH | | DFND | 1 | 0 | 0 | 90,101 |
CERNER CORP | COM | 156782104 | 3,102 | 59,146 | SH | | DFND | 1 | 0 | 0 | 59,146 |
CIGNA CORPORATION | COM | 125509109 | 31,456 | 165,625 | SH | | DFND | 1 | 0 | 0 | 165,625 |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 3,248 | 358,935 | SH | | DFND | 1 | 0 | 0 | 358,935 |
COOPER COS INC | COM NEW | 216648402 | 7,538 | 29,619 | SH | | DFND | 1 | 0 | 0 | 29,619 |
CVS HEALTH CORP | COM | 126650100 | 1,692 | 25,825 | SH | | DFND | 1 | 0 | 0 | 25,825 |
DANAHER CORP DEL | COM | 235851102 | 34,328 | 332,896 | SH | | DFND | 1 | 0 | 0 | 332,896 |
DENTSPLY SIRONA INC | COM | 24906P109 | 4,126 | 110,878 | SH | | DFND | 1 | 0 | 0 | 110,878 |
DEXCOM INC | COM | 252131107 | 9,321 | 77,808 | SH | | DFND | 1 | 0 | 0 | 77,808 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 24,170 | 157,797 | SH | | DFND | 1 | 0 | 0 | 157,797 |
ENDO INTL PLC | SHS | G30401106 | 1,244 | 170,392 | SH | | DFND | 1 | 0 | 0 | 170,392 |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 20,791 | 451,972 | SH | | DFND | 1 | 0 | 0 | 451,972 |
EVOLENT HEALTH INC | CL A | 30050B101 | 903 | 45,270 | SH | | DFND | 1 | 0 | 0 | 45,270 |
EXELIXIS INC | COM | 30161Q104 | 1,849 | 94,000 | SH | | DFND | 1 | 0 | 0 | 94,000 |
FIBROGEN INC | COM | 31572Q808 | 1,481 | 32,000 | SH | | DFND | 1 | 0 | 0 | 32,000 |
FITBIT INC | CL A | 33812L102 | 15,998 | 3,218,884 | SH | | DFND | 1 | 0 | 0 | 3,218,884 |
GENMARK DIAGNOSTICS INC | COM | 372309104 | 9,718 | 1,999,540 | SH | | DFND | 1 | 0 | 0 | 1,999,540 |
GILEAD SCIENCES INC | COM | 375558103 | 7,694 | 123,000 | SH | | DFND | 1 | 0 | 0 | 123,000 |
GLOBUS MED INC | CL A | 379577208 | 6,623 | 153,031 | SH | | DFND | 1 | 0 | 0 | 153,031 |
GUARDANT HEALTH INC | COM | 40131M109 | 4,102 | 109,117 | SH | | DFND | 1 | 0 | 0 | 109,117 |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 626 | 6,429 | SH | | DFND | 1 | 0 | 0 | 6,429 |
HCA HEALTHCARE INC | COM | 40412C101 | 5,853 | 47,034 | SH | | DFND | 1 | 0 | 0 | 47,034 |
HEALTHCARE SVCS GRP INC | COM | 421906108 | 603 | 15,000 | SH | | DFND | 1 | 0 | 0 | 15,000 |
SCHEIN HENRY INC | COM | 806407102 | 4,033 | 51,368 | SH | | DFND | 1 | 0 | 0 | 51,368 |
HILL ROM HLDGS INC | COM | 431475102 | 18,153 | 205,008 | SH | | DFND | 1 | 0 | 0 | 205,008 |
HMS HLDGS CORP | COM | 40425J101 | 6,099 | 216,817 | SH | | DFND | 1 | 0 | 0 | 216,817 |
HOLOGIC INC | COM | 436440101 | 3,699 | 90,000 | SH | | DFND | 1 | 0 | 0 | 90,000 |
HORIZON PHARMA PLC | SHS | G4617B105 | 3,292 | 168,500 | SH | | DFND | 1 | 0 | 0 | 168,500 |
HUMANA INC | COM | 444859102 | 22,535 | 78,660 | SH | | DFND | 1 | 0 | 0 | 78,660 |
HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 10,164 | 440,169 | SH | | DFND | 1 | 0 | 0 | 440,169 |
IDEXX LABS INC | COM | 45168D104 | 4,522 | 24,307 | SH | | DFND | 1 | 0 | 0 | 24,307 |
ILLUMINA INC | COM | 452327109 | 75,550 | 251,893 | SH | | DFND | 1 | 0 | 0 | 251,893 |
INCYTE CORP | COM | 45337C102 | 3,730 | 58,650 | SH | | DFND | 1 | 0 | 0 | 58,650 |
INOGEN INC | COM | 45780L104 | 4,134 | 33,292 | SH | | DFND | 1 | 0 | 0 | 33,292 |
INSMED INC | COM PAR $.01 | 457669307 | 10,616 | 809,146 | SH | | DFND | 1 | 0 | 0 | 809,146 |
INSPIRE MED SYS INC | COM | 457730109 | 3,913 | 92,616 | SH | | DFND | 1 | 0 | 0 | 92,616 |
INSULET CORP | COM | 45784P101 | 1,428 | 18,000 | SH | | DFND | 1 | 0 | 0 | 18,000 |
INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 6,575 | 145,779 | SH | | DFND | 1 | 0 | 0 | 145,779 |
INTELLIA THERAPEUTICS INC | COM | 45826J105 | 216 | 15,834 | SH | | DFND | 1 | 0 | 0 | 15,834 |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 2,333 | 23,148 | SH | | DFND | 1 | 0 | 0 | 23,148 |
INTERSECT ENT INC | COM | 46071F103 | 6,691 | 237,444 | SH | | DFND | 1 | 0 | 0 | 237,444 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 599 | 52,600 | SH | | DFND | 1 | 0 | 0 | 52,600 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 66,473 | 138,797 | SH | | DFND | 1 | 0 | 0 | 138,797 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 20,683 | 382,588 | SH | | DFND | 1 | 0 | 0 | 382,588 |
IOVANCE BIOTHERAPEUTICS INC | COM | 462260100 | 142 | 16,000 | SH | | DFND | 1 | 0 | 0 | 16,000 |
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 5,822 | 83,792 | SH | | DFND | 1 | 0 | 0 | 83,792 |
IRONWOOD PHARMACEUTICALS INC | COM CL A | 46333X108 | 793 | 76,500 | SH | | DFND | 1 | 0 | 0 | 76,500 |
ISHARES TR NASDAQ BIOTECH | CALL | 464287906 | 70,000 | 200 | SH | | DFND | 1 | 0 | 0 | 200 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 32,310 | 260,648 | SH | | DFND | 1 | 0 | 0 | 260,648 |
JOHNSON & JOHNSON | COM | 478160104 | 2,581 | 20,000 | SH | | DFND | 1 | 0 | 0 | 20,000 |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 821 | 6,500 | SH | | DFND | 1 | 0 | 0 | 6,500 |
LIGAND PHARMACEUTICALS INC | COM NEW | 53220K504 | 3,239 | 23,870 | SH | | DFND | 1 | 0 | 0 | 23,870 |
LIVANOVA PLC | SHS | G5509L101 | 11,663 | 127,510 | SH | | DFND | 1 | 0 | 0 | 127,510 |
LOXO ONCOLOGY INC | COM | 548862101 | 1,205 | 8,600 | SH | | DFND | 1 | 0 | 0 | 8,600 |
MACROGENICS INC | COM | 556099109 | 13,551 | 1,066,993 | SH | | DFND | 1 | 0 | 0 | 1,066,993 |
MASIMO CORP | COM | 574795100 | 2,446 | 22,780 | SH | | DFND | 1 | 0 | 0 | 22,780 |
MATERIALISE NV | SPONSORED ADS | 57667T100 | 4,310 | 215,192 | SH | | DFND | 1 | 0 | 0 | 215,192 |
MCKESSON CORP | COM | 58155Q103 | 760 | 6,879 | SH | | DFND | 1 | 0 | 0 | 6,879 |
MEDIDATA SOLUTIONS INC | COM | 58471A105 | 3,318 | 49,211 | SH | | DFND | 1 | 0 | 0 | 49,211 |
MEDTRONIC PLC | SHS | G5960L103 | 45,157 | 496,446 | SH | | DFND | 1 | 0 | 0 | 496,446 |
MERCK & CO INC | COM | 58933Y105 | 1,146 | 15,000 | SH | | DFND | 1 | 0 | 0 | 15,000 |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 1,018 | 24,000 | SH | | DFND | 1 | 0 | 0 | 24,000 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 6,437 | 55,384 | SH | | DFND | 1 | 0 | 0 | 55,384 |
MYLAN N V | SHS EURO | N59465109 | 5,396 | 196,950 | SH | | DFND | 1 | 0 | 0 | 196,950 |
MYRIAD GENETICS INC | COM | 62855J104 | 927 | 31,900 | SH | | DFND | 1 | 0 | 0 | 31,900 |
NEKTAR THERAPEUTICS | COM | 640268108 | 8,586 | 261,210 | SH | | DFND | 1 | 0 | 0 | 261,210 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 2,860 | 40,050 | SH | | DFND | 1 | 0 | 0 | 40,050 |
NEURONETICS INC | COM | 64131A105 | 3,200 | 165,400 | SH | | DFND | 1 | 0 | 0 | 165,400 |
NEVRO CORP | COM | 64157F103 | 3,167 | 81,438 | SH | | DFND | 1 | 0 | 0 | 81,438 |
OMNICELL INC | COM | 68213N109 | 6,616 | 108,042 | SH | | DFND | 1 | 0 | 0 | 108,042 |
OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 3,918 | 306,606 | SH | | DFND | 1 | 0 | 0 | 306,606 |
PENUMBRA INC | COM | 70975L107 | 2,939 | 24,050 | SH | | DFND | 1 | 0 | 0 | 24,050 |
PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 501 | 25,650 | SH | | DFND | 1 | 0 | 0 | 25,650 |
PRA HEALTH SCIENCES INC | COM | 69354M108 | 13,086 | 142,300 | SH | | DFND | 1 | 0 | 0 | 142,300 |
PREMIER INC | CL A | 74051N102 | 500 | 13,400 | SH | | DFND | 1 | 0 | 0 | 13,400 |
PTC THERAPEUTICS INC | COM | 69366J200 | 745 | 21,700 | SH | | DFND | 1 | 0 | 0 | 21,700 |
QIAGEN NV | SHS NEW | N72482123 | 14,996 | 435,299 | SH | | DFND | 1 | 0 | 0 | 435,299 |
QUANTERIX CORP | COM | 74766Q101 | 5,235 | 285,907 | SH | | DFND | 1 | 0 | 0 | 285,907 |
QUIDEL CORP | COM | 74838J101 | 6,103 | 125,000 | SH | | DFND | 1 | 0 | 0 | 125,000 |
QUOTIENT LTD | SHS | G73268107 | 5,102 | 833,619 | SH | | DFND | 1 | 0 | 0 | 833,619 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 5,677 | 15,200 | SH | | DFND | 1 | 0 | 0 | 15,200 |
REGENXBIO INC | COM | 75901B107 | 977 | 23,300 | SH | | DFND | 1 | 0 | 0 | 23,300 |
RESMED INC | COM | 761152107 | 6,307 | 55,392 | SH | | DFND | 1 | 0 | 0 | 55,392 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 1,015 | 10,600 | SH | | DFND | 1 | 0 | 0 | 10,600 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,386 | 12,700 | SH | | DFND | 1 | 0 | 0 | 12,700 |
SEATTLE GENETICS INC | COM | 812578102 | 1,983 | 35,000 | SH | | DFND | 1 | 0 | 0 | 35,000 |
STRYKER CORP | COM | 863667101 | 23,643 | 150,834 | SH | | DFND | 1 | 0 | 0 | 150,834 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 11,464 | 345,100 | SH | | DFND | 1 | 0 | 0 | 345,100 |
TABULA RASA HEALTHCARE INC | COM | 873379101 | 5,602 | 87,857 | SH | | DFND | 1 | 0 | 0 | 87,857 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 3,769 | 99,253 | SH | | DFND | 1 | 0 | 0 | 99,253 |
TELADOC HEALTH INC | COM | 87918A105 | 53,230 | 1,073,839 | SH | | DFND | 1 | 0 | 0 | 1,073,839 |
TELEFLEX INC | COM | 879369106 | 5,104 | 19,748 | SH | | DFND | 1 | 0 | 0 | 19,748 |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADR | 881624209 | 925 | 60,000 | SH | | DFND | 1 | 0 | 0 | 60,000 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 8,211 | 36,692 | SH | | DFND | 1 | 0 | 0 | 36,692 |
ULTRAGENYX PHARMACEUTICAL INC | COM | 90400D108 | 965 | 22,200 | SH | | DFND | 1 | 0 | 0 | 22,200 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 33,092 | 132,836 | SH | | DFND | 1 | 0 | 0 | 132,836 |
UNIQURE NV | SHS | N90064101 | 288 | 10,000 | SH | | DFND | 1 | 0 | 0 | 10,000 |
VARIAN MED SYS INC | COM | 92220P105 | 354 | 3,122 | SH | | DFND | 1 | 0 | 0 | 3,122 |
VEEVA SYS INC | CL A COM | 922475108 | 3,402 | 38,092 | SH | | DFND | 1 | 0 | 0 | 38,092 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 19,007 | 114,700 | SH | | DFND | 1 | 0 | 0 | 114,700 |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 1,297 | 32,950 | SH | | DFND | 1 | 0 | 0 | 32,950 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 262 | 27,900 | SH | | DFND | 1 | 0 | 0 | 27,900 |
WALGREENS BOOTS ALLIANCE INC | COM | 931427108 | 15,224 | 222,802 | SH | | DFND | 1 | 0 | 0 | 222,802 |
WELLCARE HEALTH PLANS INC | COM | 94946T106 | 19,644 | 83,204 | SH | | DFND | 1 | 0 | 0 | 83,204 |
WRIGHT MED GROUP NV | ORD SHS 0.03 PAR | N96617118 | 18,458 | 678,114 | SH | | DFND | 1 | 0 | 0 | 678,114 |
ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 9,553 | 92,104 | SH | | DFND | 1 | 0 | 0 | 92,104 |