Bellevue (BLVGF) 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ABBOTT LABS	COM	002824100	80,534	957,595	SH		DFND	6	957,595	0	0
ABIOMED INC	COM	003654100	35,083	134,682	SH		DFND	6	134,682	0	0
ACADIA PHARMACEUTICALS INC	COM	004225108	2,775	103,800	SH		DFND	6	103,800	0	0
ADOBE INC	COM	00724F101	352	1,193	SH		DFND	6	1,193	0	0
AFFIMED N V	COM	N01045108	481	167,500	SH		DFND	6	167,500	0	0
AGILENT TECHNOLOGIES INC	COM	00846U101	3,792	50,782	SH		DFND	6	50,782	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	156,031	3,128,134	SH		DFND	1,4,6	3,128,134	0	0
AKCEA THERAPEUTICS INC	COM	00972L107	15,285	651,820	SH		DFND	6	651,820	0	0
AKCEA THERAPEUTICS INC	COM	00972L107	57,428	2,448,948	SH		DFND	1,4,6	2,448,948	0	0
ALDER BIOPHARMACEUTICALS INC	COM	014339105	15,922	1,352,798	SH		DFND	6	1,352,798	0	0
ALDER BIOPHARMACEUTICALS INC	COM	014339105	32,556	2,766,008	SH		DFND	1,4,6	2,766,008	0	0
ALEXION PHARMACEUTICALS INC	COM	015351109	3,536	27,000	SH		DFND	6	27,000	0	0
ALEXION PHARMACEUTICALS INC	COM	015351109	172,164	1,314,428	SH		DFND	1,3,6	1,314,428	0	0
ALIGN TECHNOLOGY INC	COM	016255101	83,915	306,595	SH		DFND	6	306,595	0	0
ALLERGAN PLC	SHS	G0177J108	5,375	32,100	SH		DFND	6	32,100	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	17,872	246,305	SH		DFND	6	246,305	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	121,980	1,681,089	SH		DFND	1.4,6	1,681,089	0	0
AMEDISYS INC	COM	023436108	21,163	174,310	SH		DFND	6	174,310	0	0
AMERICAN EXPRESS CO	COM	025816109	370	3,000	SH		DFND	6	3,000	0	0
AMGEN INC	COM	031162100	8,587	46,600	SH		DFND	6	46,600	0	0
AMICUS THERAPEUTICS INC	COM	03152W109	1,872	150,000	SH		DFND	6	150,000	0	0
ANALOG DEVICES INC	COM	032654105	336	2,973	SH		DFND	6	2,973	0	0
ANAPTYSBIO INC	COM	032724106	959	17,000	SH		DFND	6	17,000	0	0
ANSYS INC	COM	03662Q105	369	1,802	SH		DFND	6	1,802	0	0
ANTHEM INC	COM	036752103	101,804	360,739	SH		DFND	6	360,739	0	0
ARENA PHARMACEUTICALS INC	COM NEW	040047607	2,751	46,917	SH		DFND	6	46,917	0	0
ARGENX SE	SPONSORED ADR	04016X101	2,817	19,900	SH		DFND	6	19,900	0	0
ARGENX SE	SPONSORED ADR	04016X101	130,925	924,739	SH		DFND	1,4,6	924,739	0	0
ASCENDIS PHARMA A S	SPONSORED ADR	04351P101	2,096	18,200	SH		DFND	6	18,200	0	0
ASPEN TECHNOLOGY INC	COM	045327103	373	3,000	SH		DFND	6	3,000	0	0
AUDENTES THERAPEUTICS INC	COM	05070R104	51,853	1,369,604	SH		DFND	1,4,6	1,369,604	0	0
AUTOLIV INC	COM	052800109	253	3,582	SH		DFND	6	3,582	0	0
AUTOLUS THERAPEUTICS PLC	SPON ADS	05280R100	547	34,000	SH		DFND	6	34,000	0	0
AVANTOR INC	COM	05352A100	3,574	187,231	SH		DFND	6	187,231	0	0
AVEDRO INC	COM	05355N109	15,798	804,379	SH		DFND	6	804,379	0	0
BAXTER INTL INC	COM	071813109	25,736	314,237	SH		DFND	6	314,237	0	0
BECTON DICKINSON & CO	COM	075887109	37,724	149,692	SH		DFND	6	149,692	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	11,527	93,000	SH		DFND	6	93,000	0	0
BENEFITFOCUS INC	COM	08180D106	2,394	88,163	SH		DFND	6	88,163	0	0
BIOGEN INC	COM	09062X103	6,911	29,550	SH		DFND	6	29,550	0	0
BLACKBAUD INC	COM	09227Q100	343	4,107	SH		DFND	6	4,107	0	0
BLUEBIRD BIO INC	COM	09609G100	2,315	18,200	SH		DFND	6	18,200	0	0
BLUEPRINT MEDICINES CORP	COM	09627Y109	1,462	15,500	SH		DFND	6	15,500	0	0
BOOKING HLDGS INC	COM	09857L108	304	162	SH		DFND	6	162	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	59,346	1,380,782	SH		DFND	6	1,380,782	0	0
BRISTOL MYERS SQUIBB CO	COM	110122108	38,802	855,609	SH		DFND	6	855,609	0	0
BROADRIDGE FINL SOLUTIONS IN	COM	11133T103	365	2,862	SH		DFND	6	2,862	0	0
BROWN FORMAN CORP	CL B	115637209	356	6,417	SH		DFND	6	6,417	0	0
CAREDX INC	COM	14167L103	17,707	492,008	SH		DFND	6	492,008	0	0
CASTLIGHT HEALTH INC	CL B	14862Q100	2,584	800,000	SH		DFND	6	800,000	0	0
CATALENT INC	COM	148806102	2,033	37,500	SH		DFND	6	37,500	0	0
CELGENE CORP	COM	151020104	171,014	1,850,000	SH		DFND	1,3,6	1,850,000	0	0
CENTENE CORP DEL	COM	15135B101	35,372	674,525	SH		DFND	6	674,525	0	0
CERNER CORP	COM	156782104	388	5,298	SH		DFND	6	5,298	0	0
CHANGE HEALTHCARE INC	COM	15912K100	14,600	1,000,000	SH		DFND	6	1,000,000	0	0
CHINA BIOLOGIC PRODS HLDGS I	COM	G21515104	344	3,609	SH		DFND	6	3,609	0	0
CIDARA THERAPEUTICS INC	COM	171757107	3,856	2,295,272	SH		DFND	1,4,6	2,295,272	0	0
CIGNA CORP NEW	COM	125523100	33,204	210,754	SH		DFND	6	210,754	0	0
COHERUS BIOSCIENCES INC	COM	19249H103	3,683	166,635	SH		DFND	6	166,635	0	0
COLGATE PALMOLIVE CO	COM	194162103	333	4,651	SH		DFND	6	4,651	0	0
COOPER COS INC	COM NEW	216648402	10,770	31,969	SH		DFND	6	31,969	0	0
COVETRUS INC	COM	22304C100	37	1,520	SH		DFND	6	1,520	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	38,173	810,462	SH		DFND	1,4,6	810,462	0	0
CTRIP COM INTL LTD	SPONSORED ADS	22943F100	333	9,032	SH		DFND	6	9,032	0	0
CVS HEALTH CORP	COM	126650100	3,233	59,326	SH		DFND	6	59,326	0	0
DANAHER CORPORATION	COM	235851102	50,122	350,698	SH		DFND	6	350,698	0	0
DENTSPLY SIRONA INC	COM	24906P109	7,313	125,313	SH		DFND	6	125,313	0	0
DEXCOM INC	COM	252131107	24,744	165,136	SH		DFND	6	165,136	0	0
DIREXION SHS ETF TR	DAILY S&P BIOTEC	25460E539	2,018	112,000	SH		DFND	6	112,000	0	0
DOMINOS PIZZA INC	COM	25754A201	362	1,300	SH		DFND	6	1,300	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	32,138	173,966	SH		DFND	6	173,966	0	0
ELECTRONIC ARTS INC	COM	285512109	314	3,100	SH		DFND	6	3,100	0	0
ENTEGRIS INC	COM	29362U104	325	8,706	SH		DFND	6	8,706	0	0
ESPERION THERAPEUTICS INC NEW	COM	29664W105	24,862	534,447	SH		DFND	6	534,447	0	0
ESPERION THERAPEUTICS INC NEW	COM	29664W105	163,888	3,522,964	SH		DFND	1,4,6	3,522,964	0	0
EVOLENT HEALTH INC	CL A	30050B101	18,675	2,349,000	SH		DFND	6	2,349,000	0	0
EXELIXIS INC	COM	30161Q104	22,306	1,043,800	SH		DFND	6	1,043,800	0	0
EXELIXIS INC	COM	30161Q104	60,584	2,835,000	SH		DFND	1,4,6	2,835,000	0	0
FASTENAL CO	COM	311900104	319	9,798	SH		DFND	6	9,798	0	0
FATE THERAPEUTICS INC	COM	31189P102	1,198	59,000	SH		DFND	6	59,000	0	0
FITBIT INC	CL A	33812L102	16,265	3,696,530	SH		DFND	6	3,696,530	0	0
G1 THERAPEUTICS INC	COM	3621LQ109	20,601	671,925	SH		DFND	1,4,6	671,925	0	0
GENMARK DIAGNOSTICS INC	COM	372309104	15,271	2,353,067	SH		DFND	6	2,353,067	0	0
GILEAD SCIENCES INC	COM	375558103	8,053	119,200	SH		DFND	6	119,200	0	0
GILEAD SCIENCES INC	COM	375558103	64,182	950,000	SH		DFND	1,2,6	950,000	0	0
GLAUKOS CORP	COM	377322102	8,086	107,235	SH		DFND	6	107,235	0	0
GLOBUS MED INC	CL A	379577208	11,568	273,482	SH		DFND	6	273,482	0	0
GRACO INC	COM	384109104	346	6,903	SH		DFND	6	6,903	0	0
GUARDANT HEALTH INC	COM	40131M109	10,346	119,848	SH		DFND	6	119,848	0	0
GW PHARMACEUTICALS PLC	ADS	36197T103	2,130	12,353	SH		DFND	6	12,353	0	0
HALOZYME THERAPEUTICS INC	COM	40637H109	141,698	8,247,860	SH		DFND	1,4,6	8,247,860	0	0
HCA HEALTHCARE INC	COM	40412C101	25,242	186,745	SH		DFND	6	186,745	0	0
HENRY SCHEIN INC	COM	806407102	4,048	57,917	SH		DFND	6	57,917	0	0
HILL ROM HLDGS INC	COM	431475102	24,397	233,198	SH		DFND	6	233,198	0	0
HMS HLDGS CORP	COM	40425J101	12,906	398,442	SH		DFND	6	398,442	0	0
HOLOGIC INC	COM	436440101	7,085	147,548	SH		DFND	6	147,548	0	0
HOMOLOGY MEDICINES INC	COM	438083107	27,440	1,402,122	SH		DFND	1,4,6	1,402,122	0	0
HORIZON THERAPEUTICS PUB LTD	SHS	G46188101	6,460	268,500	SH		DFND	6	268,500	0	0
HUAZHU GROUP LTD	SPONSORED ADS	44332N106	339	9,344	SH		DFND	6	9,344	0	0
HUMANA INC	COM	444859102	63,994	241,212	SH		DFND	6	241,212	0	0
HUTCHISON CHINA MEDITECH LTD	SPONSORED ADR	44842L103	13,163	598,310	SH		DFND	6	598,310	0	0
IDEXX LABS INC	COM	45168D104	8,934	32,449	SH		DFND	6	32,449	0	0
ILLUMINA INC	COM	452327109	84,009	228,191	SH		DFND	6	228,191	0	0
INCYTE CORP	COM	45337C102	9,996	117,650	SH		DFND	6	117,650	0	0
INCYTE CORP	COM	45337C102	304,157	3,580,000	SH		DFND	1,4,6	3,580,000	0	0
INOGEN INC	COM	45780L104	6,465	96,843	SH		DFND	6	96,843	0	0
INSMED INC	COM PAR $.01	457669307	15,884	620,459	SH		DFND	6	620,459	0	0
INSPIRE MED SYS INC	COM	457730109	11,787	194,340	SH		DFND	6	194,340	0	0
INSULET CORP	COM	45784P101	9,938	83,246	SH		DFND	6	83,246	0	0
INTEGRA LIFESCIENCES HLDGS C	COM NEW	457985208	10,708	191,733	SH		DFND	6	191,733	0	0
INTERACTIVE BROKERS GROUP IN	COM CL A	45841N107	312	5,757	SH		DFND	6	5,757	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	1,180	14,827	SH		DFND	6	14,827	0	0
INTERCEPT PHARMACEUTICALS IN	COM	45845P108	55,458	696,976	SH		DFND	1,4,6	696,976	0	0
INTERCONTINENTAL EXCHANGE IN	COM	45866F104	330	3,837	SH		DFND	6	3,837	0	0
INTERSECT ENT INC	COM	46071F103	10,258	450,718	SH		DFND	6	450,718	0	0
INTRA CELLULAR THERAPIES INC	COM	46116X101	591	45,500	SH		DFND	6	45,500	0	0
INTRA CELLULAR THERAPIES INC	COM	46116X101	28,556	2,200,000	SH		DFND	1,4,6	2,200,000	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	88,377	168,482	SH		DFND	6	168,482	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	18,166	282,658	SH		DFND	6	282,658	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	493,238	7,674,470	SH		DFND	1,4,6	7,674,470	0	0
IPG PHOTONICS CORP	COM	44980X109	330	2,141	SH		DFND	6	2,141	0	0
IRHYTHM TECHNOLOGIES INC	COM	450056106	14,143	178,848	SH		DFND	6	178,848	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	47,355	332,173	SH		DFND	6	332,173	0	0
JD COM INC	SPON ADR CL A	47215P106	371	12,263	SH		DFND	6	12,263	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	9,487	1,230,523	SH		DFND	1,5,6	1,230,523	0	0
KIRBY CORP	COM	497266106	338	4,274	SH		DFND	6	4,274	0	0
KOSMOS ENERGY LTD	COM	500688106	376	60,000	SH		DFND	6	60,000	0	0
KURA ONCOLOGY INC	COM	50127T109	2,859	145,200	SH		DFND	6	145,200	0	0
LABORATORY CORP AMER HLDGS	COM NEW	50540R409	1,000	5,783	SH		DFND	6	5,783	0	0
LAUDER ESTEE COS INC	CL A	518439104	412	2,248	SH		DFND	6	2,248	0	0
LIVANOVA PLC	SHS	G5509L101	19,117	265,666	SH		DFND	6	265,666	0	0
LIVE NATION ENTERTAINMENT IN	COM	538034109	331	5,000	SH		DFND	6	5,000	0	0
M & T BK CORP	COM	55261F104	294	1,731	SH		DFND	6	1,731	0	0
MACROGENICS INC	COM	556099109	14,839	874,405	SH		DFND	6	874,405	0	0
MACROGENICS INC	COM	556099109	59,749	3,520,859	SH		DFND	1,4,6	3,520,859	0	0
MARKEL CORP	COM	570535104	304	279	SH		DFND	6	279	0	0
MARKETAXESS HLDGS INC	COM	57060D108	425	1,322	SH		DFND	6	1,322	0	0
MASIMO CORP	COM	574795100	9,761	65,592	SH		DFND	6	65,592	0	0
MATERIALISE NV	SPONSORED ADS	57667T100	4,700	240,770	SH		DFND	6	240,770	0	0
MCCORMICK & CO INC	COM NON VTG	579780206	371	2,391	SH		DFND	6	2,391	0	0
MCKESSON CORP	COM	58155Q103	826	6,149	SH		DFND	6	6,149	0	0
MEDICINES CO	COM	584688105	1,586	43,500	SH		DFND	6	43,500	0	0
MEDTRONIC PLC	SHS	G5960L103	75,907	779,411	SH		DFND	6	779,411	0	0
MERCADOLIBRE INC	COM	58733R102	511	835	SH		DFND	6	835	0	0
METTLER TOLEDO INTERNATIONAL	COM	592688105	399	475	SH		DFND	6	475	0	0
MICROCHIP TECHNOLOGY INC	COM	595017104	314	3,617	SH		DFND	6	3,617	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	2,215	21,500	SH		DFND	6	21,500	0	0
MODERNA INC	COM	60770K107	69,163	4,724,246	SH		DFND	1,5,6	4,724,246	0	0
MOLINA HEALTHCARE INC	COM	60855R100	11,689	81,661	SH		DFND	6	81,661	0	0
MOODYS CORP	COM	615369105	363	1,858	SH		DFND	6	1,858	0	0
MSCI INC	COM	55354G100	426	1,786	SH		DFND	6	1,786	0	0
MYOKARDIA INC	COM	62857M105	63,423	1,264,913	SH		DFND	1,4,6	1,264,913	0	0
MYOVANT SCIENCES LTD	COM	G637AM102	35,386	3,910,109	SH		DFND	1,4,6	3,910,109	0	0
NEKTAR THERAPEUTICS	COM	640268108	18,217	512,010	SH		DFND	6	512,010	0	0
NEKTAR THERAPEUTICS	COM	640268108	75,454	2,120,676	SH		DFND	1,4,6	2,120,676	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	6,944	82,250	SH		DFND	6	82,250	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	292,482	3,464,194	SH		DFND	1,4,6	3,464,194	0	0
NEURONETICS INC	COM	64131A105	4,063	324,779	SH		DFND	6	324,779	0	0
NEVRO CORP	COM	64157F103	9,112	140,548	SH		DFND	6	140,548	0	0
OMNICELL INC	COM	68213N109	14,342	166,715	SH		DFND	6	166,715	0	0
OXFORD IMMUNOTEC GLOBAL PLC	ORD SHS	G6855A103	7,962	578,615	SH		DFND	6	578,615	0	0
PENUMBRA INC	COM	70975L107	4,029	25,180	SH		DFND	6	25,180	0	0
PFIZER INC	COM	717081103	1,733	40,000	SH		DFND	6	40,000	0	0
POLYONE CORP	COM	73179P106	284	9,035	SH		DFND	6	9,035	0	0
POOL CORPORATION	COM	73278L105	367	1,921	SH		DFND	6	1,921	0	0
PROSHARES TR	ULTSH NASD BIOT	74347B789	426	25,000	SH		DFND	6	25,000	0	0
PTC THERAPEUTICS INC	COM	69366J200	3,758	83,500	SH		DFND	6	83,500	0	0
QIAGEN NV	SHS NEW	N72482123	30,190	744,513	SH		DFND	6	744,513	0	0
QUANTERIX CORP	COM	74766Q101	13,434	397,569	SH		DFND	6	397,569	0	0
QUIDEL CORP	COM	74838J101	15,926	268,470	SH		DFND	6	268,470	0	0
QUOTIENT LTD	SHS	G73268107	6,858	733,441	SH		DFND	6	733,441	0	0
RADIUS HEALTH INC	COM NEW	750469207	1,440	59,100	SH		DFND	6	59,100	0	0
RADIUS HEALTH INC	COM NEW	750469207	165,202	6,781,685	SH		DFND	1,5,6	6,781,685	0	0
REGENXBIO INC	COM	75901B107	1,700	33,100	SH		DFND	6	33,100	0	0
RESMED INC	COM	761152107	6,422	52,626	SH		DFND	6	52,626	0	0
S&P GLOBAL INC	COM	78409V104	352	1,544	SH		DFND	6	1,544	0	0
SAGE THERAPEUTICS INC	COM	78667J108	2,984	16,300	SH		DFND	6	16,300	0	0
SAGE THERAPEUTICS INC	COM	78667J108	238,951	1,305,104	SH		DFND	1,4,6	1,305,104	0	0
SALESFORCE COM INC	COM	79466L302	297	1,956	SH		DFND	6	1,956	0	0
SANGAMO THERAPEUTICS INC	COM	800677106	39,311	3,650,000	SH		DFND	1,4,6	3,650,000	0	0
SCHOLAR ROCK HOLDING CORP	COM	80706P103	30,956	1,951,839	SH		DFND	1,4,6	1,951,839	0	0
SEATTLE GENETICS INC	COM	812578102	5,052	73,000	SH		DFND	6	73,000	0	0
SENSATA TECHNOLOGIES HLDNG P	SHS	G8060N102	302	6,162	SH		DFND	6	6,162	0	0
SHOCKWAVE MED INC	COM	82489T104	5,569	97,547	SH		DFND	6	97,547	0	0
SILK RAOD MEDICAL INC	COM	82710M100	6,145	126,810	SH		DFND	6	126,810	0	0
SKYWORKS SOLUTIONS INC	COM	83088M102	307	3,978	SH		DFND	6	3,978	0	0
SOCIEDAD QUIMICA MINERA DE C	SPON ADR SER B	833635105	217	6,990	SH		DFND	6	6,990	0	0
STARBUCKS CORP	COM	855244109	363	4,334	SH		DFND	6	4,334	0	0
STRYKER CORP	COM	863667101	32,721	159,163	SH		DFND	6	159,163	0	0
SUPERNUS PHARMACEUTICALS INC	COM	868459108	15,453	467,000	SH		DFND	6	467,000	0	0
SYNEOS HEALTH INC	CL A	87166B102	3,168	62,000	SH		DFND	6	62,000	0	0
TABULA RASA HEALTHCARE INC	COM	873379101	9,545	191,175	SH		DFND	6	191,175	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	10,829	167,847	SH		DFND	6	167,847	0	0
TELADOC HEALTH INC	COM	87918A105	95,299	1,435,012	SH		DFND	6	1,435,012	0	0
TELEFLEX INC	COM	879369106	12,175	36,766	SH		DFND	6	36,766	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	16,747	57,024	SH		DFND	6	57,024	0	0
TRIMBLE INC	COM	896239100	359	7,958	SH		DFND	6	7,958	0	0
TYLER TECHNOLOGIES INC	COM	902252105	329	1,525	SH		DFND	6	1,525	0	0
ULTRAGENYX PHARMACEUTICAL INC	COM	90400D108	1,448	22,800	SH		DFND	6	22,800	0	0
UNIQURE NV	SHS	N90064101	2,157	27,600	SH		DFND	6	27,600	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	47,434	194,394	SH		DFND	6	194,394	0	0
US BANCORP DEL	COM NEW	902973304	297	5,662	SH		DFND	6	5,662	0	0
VARIAN MED SYS INC	COM	92220P105	380	2,791	SH		DFND	6	2,791	0	0
VEEVA SYS INC	CL A COM	922475108	8,039	49,590	SH		DFND	6	49,590	0	0
VEONEER INCORPORATED	COM	92336X109	167	9,658	SH		DFND	6	9,658	0	0
VERISIGN INC	COM	92343E102	365	1,744	SH		DFND	6	1,744	0	0
VERISK ANALYTICS INC	COM	92345Y106	365	2,489	SH		DFND	6	2,489	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	25,763	140,489	SH		DFND	6	140,489	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	234,726	1,280,000	SH		DFND	1,4,6	1,280,000	0	0
VIKING THERAPEUTICS INC	COM	92686J106	797	96,000	SH		DFND	6	96,000	0	0
VOCERA COMMUNICATONS INC	COM	92857F107	6,181	193,634	SH		DFND	6	193,634	0	0
VOYAGER THERAPEUTICS INC	COM	92915B106	72,957	2,680,283	SH		DFND	1,4,6	2,680,283	0	0
WABTEC CORP	COM	929740108	314	4,382	SH		DFND	6	4,382	0	0
WATSCO INC	COM	942622200	326	1,993	SH		DFND	6	1,993	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	39,526	1,515,002	SH		DFND	1,4,6	1,515,002	0	0
WELLCARE HEALTH PLANS INC	COM	94946T106	1,383	4,851	SH		DFND	6	4,851	0	0
WRIGHT MED GROUP NV	ORD SHS	N96617118	14,269	478,495	SH		DFND	6	478,495	0	0
ZAI LAB LTD	ADR	98887Q104	3,487	100,000	SH		DFND	6	100,000	0	0
ZIMMER BIOMET HLDGS INC	COM	98956P102	11,915	101,199	SH		DFND	6	101,199	0	0