The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 5,040 | 100,000 | SH | DFND | 2 | 100,000 | 0 | 0 | |
ABBOTT LABS | COM | 002824100 | 91,879 | 1,098,114 | SH | DFND | 2 | 1,098,114 | 0 | 0 | |
ABIOMED INC | COM | 003654100 | 23,665 | 133,031 | SH | DFND | 2 | 133,031 | 0 | 0 | |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 3,253 | 90,400 | SH | DFND | 2 | 90,400 | 0 | 0 | |
ACCELERON PHARMA INC | COM | 00434H108 | 1,019 | 25,800 | SH | DFND | 2 | 25,800 | 0 | 0 | |
ADAMAS PHARMACEUTICALS INC | COM | 00548A106 | 593 | 116,000 | SH | DFND | 2 | 116,000 | 0 | 0 | |
ADOBE INC | COM | 00724F101 | 414 | 1,500 | SH | DFND | 2 | 1,500 | 0 | 0 | |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 2,284 | 29,800 | SH | DFND | 2 | 29,800 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 797 | 24,600 | SH | DFND | 2 | 24,600 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 114,921 | 3,546,954 | SH | DFND | 1,2 | 3,546,954 | 0 | 0 | |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 10,172 | 660,963 | SH | DFND | 2 | 660,963 | 0 | 0 | |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 37,689 | 2,448,948 | SH | DFND | 1,2 | 2,448,948 | 0 | 0 | |
ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 32,561 | 1,726,458 | SH | DFND | 2 | 1,726,458 | 0 | 0 | |
ALDER BIOPHARMACEUTICALS INC | COM | 014339105 | 52,167 | 2,766,008 | SH | DFND | 1,2 | 2,766,008 | 0 | 0 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 5,103 | 52,100 | SH | DFND | 2 | 52,100 | 0 | 0 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 128,735 | 1,314,428 | SH | DFND | 1,2 | 1,314,428 | 0 | 0 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 113 | 150 | SH | Call | DFND | 2 | 150 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 61,238 | 338,483 | SH | DFND | 2 | 338,483 | 0 | 0 | |
ALLERGAN PLC | SHS | G0177J108 | 5,183 | 30,800 | SH | DFND | 2 | 30,800 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 22,838 | 283,983 | SH | DFND | 2 | 283,983 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 135,193 | 1,681,089 | SH | DFND | 1,2 | 1,681,089 | 0 | 0 | |
AMEDISYS INC | COM | 023436108 | 23,013 | 175,658 | SH | DFND | 2 | 175,658 | 0 | 0 | |
AMERICAN EXPRESS CO | COM | 025816109 | 426 | 3,600 | SH | DFND | 2 | 3,600 | 0 | 0 | |
AMGEN INC | COM | 031162100 | 11,166 | 57,700 | SH | DFND | 2 | 57,700 | 0 | 0 | |
ANALOG DEVICES INC | COM | 032654105 | 458 | 4,100 | SH | DFND | 2 | 4,100 | 0 | 0 | |
ANSYS INC | COM | 03662Q105 | 399 | 1,802 | SH | DFND | 2 | 1,802 | 0 | 0 | |
ANTHEM INC | COM | 036752103 | 73,496 | 306,106 | SH | DFND | 2 | 306,106 | 0 | 0 | |
ARENA PHARMACEUTICALS INC | COM NEW | 040047607 | 1,076 | 23,517 | SH | DFND | 2 | 23,517 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 2,098 | 18,500 | SH | DFND | 2 | 18,500 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 108,262 | 954,739 | SH | DFND | 1,2 | 954,739 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 17,378 | 806,403 | SH | DFND | 1,2 | 806,403 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 1,310 | 13,600 | SH | DFND | 2 | 13,600 | 0 | 0 | |
ASPEN TECHNOLOGY INC | COM | 045327103 | 369 | 3,000 | SH | DFND | 2 | 3,000 | 0 | 0 | |
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 281 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | |
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 39,877 | 1,419,604 | SH | DFND | 1,2 | 1,419,604 | 0 | 0 | |
AUTOLIV INC | COM | 052800109 | 536 | 6,800 | SH | DFND | 2 | 6,800 | 0 | 0 | |
AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 430 | 34,600 | SH | DFND | 2 | 34,600 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 2,895 | 196,951 | SH | DFND | 2 | 196,951 | 0 | 0 | |
BAXTER INTL INC | COM | 071813109 | 31,102 | 355,568 | SH | DFND | 2 | 355,568 | 0 | 0 | |
BECTON DICKINSON & CO | COM | 075887109 | 50,801 | 200,827 | SH | DFND | 2 | 200,827 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 8,979 | 72,100 | SH | DFND | 2 | 72,100 | 0 | 0 | |
BENEFITFOCUS INC | COM | 08180D106 | 2,154 | 90,463 | SH | DFND | 2 | 90,463 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 7,532 | 32,350 | SH | DFND | 2 | 32,350 | 0 | 0 | |
BIO RAD LABS INC | CL A | 090572207 | 2,246 | 6,750 | SH | DFND | 2 | 6,750 | 0 | 0 | |
BLACKBAUD INC | COM | 09227Q100 | 371 | 4,107 | SH | DFND | 2 | 4,107 | 0 | 0 | |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 1,161 | 15,800 | SH | DFND | 2 | 15,800 | 0 | 0 | |
BOOKING HLDGS INC | COM | 09857L108 | 393 | 200 | SH | DFND | 2 | 200 | 0 | 0 | |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 57,779 | 1,419,988 | SH | DFND | 2 | 1,419,988 | 0 | 0 | |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 47,516 | 937,009 | SH | DFND | 2 | 937,009 | 0 | 0 | |
BROADRIDGE FINL SOLUTIONS IN | COM | 11133T103 | 423 | 3,400 | SH | DFND | 2 | 3,400 | 0 | 0 | |
BROWN FORMAN CORP | CL B | 115637209 | 477 | 7,600 | SH | DFND | 2 | 7,600 | 0 | 0 | |
CAREDX INC | COM | 14167L103 | 16,339 | 722,655 | SH | DFND | 2 | 722,655 | 0 | 0 | |
CATALENT INC | COM | 148806102 | 1,787 | 37,500 | SH | DFND | 2 | 37,500 | 0 | 0 | |
CELGENE CORP | COM | 151020104 | 1,053 | 10,600 | SH | DFND | 2 | 10,600 | 0 | 0 | |
CELGENE CORP | COM | 151020104 | 106,748 | 1,075,000 | SH | DFND | 1,2 | 1,075,000 | 0 | 0 | |
CENTENE CORP DEL | COM | 15135B101 | 29,975 | 692,914 | SH | DFND | 2 | 692,914 | 0 | 0 | |
CERNER CORP | COM | 156782104 | 423 | 6,200 | SH | DFND | 2 | 6,200 | 0 | 0 | |
CHANGE HEALTHCARE INC | COM | 15912K100 | 10,436 | 863,922 | SH | DFND | 2 | 863,922 | 0 | 0 | |
CHARLES RIV LABS INTL INC | COM | 159864107 | 1,099 | 8,300 | SH | DFND | 2 | 8,300 | 0 | 0 | |
CHINA BIOLOGIC PRODS HLDGS I | COM | G21515104 | 515 | 4,500 | SH | DFND | 2 | 4,500 | 0 | 0 | |
CIDARA THERAPEUTICS INC | COM | 171757107 | 4,579 | 2,295,272 | SH | DFND | 1,2 | 2,295,272 | 0 | 0 | |
CIGNA CORP NEW | COM | 125523100 | 36,322 | 239,294 | SH | DFND | 2 | 239,294 | 0 | 0 | |
CLOROX CO DEL | COM | 189054109 | 425 | 2,800 | SH | DFND | 2 | 2,800 | 0 | 0 | |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 4,081 | 201,435 | SH | DFND | 2 | 201,435 | 0 | 0 | |
COLGATE PALMOLIVE CO | COM | 194162103 | 448 | 6,100 | SH | DFND | 2 | 6,100 | 0 | 0 | |
COOPER COS INC | COM NEW | 216648402 | 9,495 | 31,969 | SH | DFND | 2 | 31,969 | 0 | 0 | |
COVETRUS INC | COM | 22304C100 | 18 | 1,520 | SH | DFND | 2 | 1,520 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 1,094 | 26,700 | SH | DFND | 2 | 26,700 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 33,221 | 810,462 | SH | DFND | 1,2 | 810,462 | 0 | 0 | |
CTRIP COM INTL LTD | SPONSORED ADS | 22943F100 | 384 | 13,100 | SH | DFND | 2 | 13,100 | 0 | 0 | |
CVS HEALTH CORP | COM | 126650100 | 6,666 | 105,688 | SH | DFND | 2 | 105,688 | 0 | 0 | |
DANAHER CORPORATION | COM | 235851102 | 53,694 | 371,763 | SH | DFND | 2 | 371,763 | 0 | 0 | |
DENTSPLY SIRONA INC | COM | 24906P109 | 7,027 | 131,818 | SH | DFND | 2 | 131,818 | 0 | 0 | |
DEXCOM INC | COM | 252131107 | 25,205 | 168,887 | SH | DFND | 2 | 168,887 | 0 | 0 | |
DIREXION SHS ETF TR | DAILY S&P BIOTEC | 25460E539 | 1,393 | 55,000 | SH | DFND | 2 | 55,000 | 0 | 0 | |
DOMINOS PIZZA INC | COM | 25754A201 | 465 | 1,900 | SH | DFND | 2 | 1,900 | 0 | 0 | |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 42,758 | 194,432 | SH | DFND | 2 | 194,432 | 0 | 0 | |
ELECTRONIC ARTS INC | COM | 285512109 | 470 | 4,800 | SH | DFND | 2 | 4,800 | 0 | 0 | |
ENTEGRIS INC | COM | 29362U104 | 485 | 10,300 | SH | DFND | 2 | 10,300 | 0 | 0 | |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 21,574 | 588,497 | SH | DFND | 2 | 588,497 | 0 | 0 | |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 133,918 | 3,652,964 | SH | DFND | 1,2 | 3,652,964 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 21,750 | 3,025,022 | SH | DFND | 2 | 3,025,022 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 18,104 | 1,023,700 | SH | DFND | 2 | 1,023,700 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 50,137 | 2,835,000 | SH | DFND | 1,2 | 2,835,000 | 0 | 0 | |
FASTENAL CO | COM | 311900104 | 630 | 19,299 | SH | DFND | 2 | 19,299 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 933 | 60,100 | SH | DFND | 2 | 60,100 | 0 | 0 | |
FITBIT INC | CL A | 33812L102 | 10,134 | 2,659,944 | SH | DFND | 2 | 2,659,944 | 0 | 0 | |
G1 THERAPEUTICS INC | COM | 3621LQ109 | 16,445 | 721,925 | SH | DFND | 1,2 | 721,925 | 0 | 0 | |
GENMARK DIAGNOSTICS INC | COM | 372309104 | 13,740 | 2,267,252 | SH | DFND | 2 | 2,267,252 | 0 | 0 | |
GILEAD SCIENCES INC | COM | 375558103 | 7,073 | 111,600 | SH | DFND | 2 | 111,600 | 0 | 0 | |
GILEAD SCIENCES INC | COM | 375558103 | 27,887 | 440,000 | SH | DFND | 1,2 | 440,000 | 0 | 0 | |
GLAUKOS CORP | COM | 377322102 | 25,138 | 402,148 | SH | DFND | 2 | 402,148 | 0 | 0 | |
GLOBUS MED INC | CL A | 379577208 | 15,217 | 297,666 | SH | DFND | 2 | 297,666 | 0 | 0 | |
GRACO INC | COM | 384109104 | 447 | 9,700 | SH | DFND | 2 | 9,700 | 0 | 0 | |
GUARDANT HEALTH INC | COM | 40131M109 | 6,049 | 94,761 | SH | DFND | 2 | 94,761 | 0 | 0 | |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 1,202 | 10,453 | SH | DFND | 2 | 10,453 | 0 | 0 | |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 796 | 51,300 | SH | DFND | 2 | 51,300 | 0 | 0 | |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 123,507 | 7,963,056 | SH | DFND | 1,2 | 7,963,056 | 0 | 0 | |
HCA HEALTHCARE INC | COM | 40412C101 | 25,455 | 211,382 | SH | DFND | 2 | 211,382 | 0 | 0 | |
HEALTH CATALYST INC | COM | 42225T107 | 5,069 | 160,216 | SH | DFND | 2 | 160,216 | 0 | 0 | |
HENRY SCHEIN INC | COM | 806407102 | 4,037 | 63,575 | SH | DFND | 2 | 63,575 | 0 | 0 | |
HILL ROM HLDGS INC | COM | 431475102 | 20,916 | 198,762 | SH | DFND | 2 | 198,762 | 0 | 0 | |
HMS HLDGS CORP | COM | 40425J101 | 14,199 | 411,972 | SH | DFND | 2 | 411,972 | 0 | 0 | |
HOLOGIC INC | COM | 436440101 | 7,836 | 155,208 | SH | DFND | 2 | 155,208 | 0 | 0 | |
HOMOLOGY MEDICINES INC | COM | 438083107 | 29,179 | 1,612,122 | SH | DFND | 1,2 | 1,612,122 | 0 | 0 | |
HORIZON THERAPEUTICS PUB LTD | SHS | G46188101 | 8,803 | 323,300 | SH | DFND | 2 | 323,300 | 0 | 0 | |
HUAZHU GROUP LTD | SPONSORED ADS | 44332N106 | 446 | 13,500 | SH | DFND | 2 | 13,500 | 0 | 0 | |
HUMANA INC | COM | 444859102 | 62,044 | 242,673 | SH | DFND | 2 | 242,673 | 0 | 0 | |
HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 13,788 | 788,198 | SH | DFND | 2 | 788,198 | 0 | 0 | |
IDEXX LABS INC | COM | 45168D104 | 9,282 | 34,134 | SH | DFND | 2 | 34,134 | 0 | 0 | |
ILLUMINA INC | COM | 452327109 | 63,075 | 207,332 | SH | DFND | 2 | 207,332 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 8,626 | 116,200 | SH | DFND | 2 | 116,200 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 265,743 | 3,580,000 | SH | DFND | 1,2 | 3,580,000 | 0 | 0 | |
INOGEN INC | COM | 45780L104 | 5,429 | 113,323 | SH | DFND | 2 | 113,323 | 0 | 0 | |
INSMED INC | COM PAR $.01 | 457669307 | 21,018 | 1,191,480 | SH | DFND | 2 | 1,191,480 | 0 | 0 | |
INSPIRE MED SYS INC | COM | 457730109 | 14,856 | 243,457 | SH | DFND | 2 | 243,457 | 0 | 0 | |
INSULET CORP | COM | 45784P101 | 14,719 | 89,245 | SH | DFND | 2 | 89,245 | 0 | 0 | |
INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 12,828 | 213,557 | SH | DFND | 2 | 213,557 | 0 | 0 | |
INTERACTIVE BROKERS GROUP IN | COM CL A | 45841N107 | 506 | 9,400 | SH | DFND | 2 | 9,400 | 0 | 0 | |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 345 | 5,200 | SH | DFND | 2 | 5,200 | 0 | 0 | |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 46,251 | 696,976 | SH | DFND | 1,2 | 696,976 | 0 | 0 | |
INTERCONTINENTAL EXCHANGE IN | COM | 45866F104 | 443 | 4,800 | SH | DFND | 2 | 4,800 | 0 | 0 | |
INTERSECT ENT INC | COM | 46071F103 | 7,801 | 458,588 | SH | DFND | 2 | 458,588 | 0 | 0 | |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 19,340 | 2,588,990 | SH | DFND | 1,2 | 2,588,990 | 0 | 0 | |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 94,836 | 175,645 | SH | DFND | 2 | 175,645 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 19,588 | 326,959 | SH | DFND | 2 | 326,959 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 478,978 | 7,994,955 | SH | DFND | 1,2 | 7,994,955 | 0 | 0 | |
IPG PHOTONICS CORP | COM | 44980X109 | 475 | 3,500 | SH | DFND | 2 | 3,500 | 0 | 0 | |
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 13,667 | 184,419 | SH | DFND | 2 | 184,419 | 0 | 0 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 42,315 | 330,227 | SH | DFND | 2 | 330,227 | 0 | 0 | |
JD COM INC | SPON ADR CL A | 47215P106 | 415 | 14,700 | SH | DFND | 2 | 14,700 | 0 | 0 | |
JOHNSON & JOHNSON | COM | 478160104 | 1,294 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 4,036 | 1,230,523 | SH | DFND | 1,2 | 1,230,523 | 0 | 0 | |
KIRBY CORP | COM | 497266106 | 485 | 5,900 | SH | DFND | 2 | 5,900 | 0 | 0 | |
KOSMOS ENERGY LTD | COM | 500688106 | 374 | 60,000 | SH | DFND | 2 | 60,000 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 2,523 | 166,300 | SH | DFND | 2 | 166,300 | 0 | 0 | |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 936 | 5,573 | SH | DFND | 2 | 5,573 | 0 | 0 | |
LAUDER ESTEE COS INC | CL A | 518439104 | 447 | 2,248 | SH | DFND | 2 | 2,248 | 0 | 0 | |
LINDE PLC | SHS | G5494J103 | 358 | 1,848 | SH | DFND | 2 | 1,848 | 0 | 0 | |
LIVANOVA PLC | SHS | G5509L101 | 20,020 | 271,314 | SH | DFND | 2 | 271,314 | 0 | 0 | |
LIVE NATION ENTERTAINMENT IN | COM | 538034109 | 411 | 6,200 | SH | DFND | 2 | 6,200 | 0 | 0 | |
LIVONGO HEALTH INC | COM | 539183103 | 754 | 43,220 | SH | DFND | 2 | 43,220 | 0 | 0 | |
M & T BK CORP | COM | 55261F104 | 474 | 3,000 | SH | DFND | 2 | 3,000 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 13,161 | 1,031,405 | SH | DFND | 2 | 1,031,405 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 52,241 | 4,094,159 | SH | DFND | 1,2 | 4,094,159 | 0 | 0 | |
MARKEL CORP | COM | 570535104 | 473 | 400 | SH | DFND | 2 | 400 | 0 | 0 | |
MARKETAXESS HLDGS INC | COM | 57060D108 | 433 | 1,322 | SH | DFND | 2 | 1,322 | 0 | 0 | |
MASIMO CORP | COM | 574795100 | 10,176 | 68,392 | SH | DFND | 2 | 68,392 | 0 | 0 | |
MATERIALISE NV | SPONSORED ADS | 57667T100 | 4,449 | 240,770 | SH | DFND | 2 | 240,770 | 0 | 0 | |
MCCORMICK & CO INC | COM NON VTG | 579780206 | 438 | 2,800 | SH | DFND | 2 | 2,800 | 0 | 0 | |
MCKESSON CORP | COM | 58155Q103 | 810 | 5,924 | SH | DFND | 2 | 5,924 | 0 | 0 | |
MEDICINES CO | COM | 584688105 | 1,445 | 28,900 | SH | DFND | 2 | 28,900 | 0 | 0 | |
MEDTRONIC PLC | SHS | G5960L103 | 87,726 | 807,638 | SH | DFND | 2 | 807,638 | 0 | 0 | |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 493 | 700 | SH | DFND | 2 | 700 | 0 | 0 | |
MICROCHIP TECHNOLOGY INC | COM | 595017104 | 465 | 5,000 | SH | DFND | 2 | 5,000 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 1,239 | 15,900 | SH | DFND | 2 | 15,900 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 419 | 26,300 | SH | DFND | 2 | 26,300 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 76,699 | 4,817,781 | SH | DFND | 1,2 | 4,817,781 | 0 | 0 | |
MOLINA HEALTHCARE INC | COM | 60855R100 | 9,352 | 85,239 | SH | DFND | 2 | 85,239 | 0 | 0 | |
MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 648 | 50,000 | SH | DFND | 2 | 50,000 | 0 | 0 | |
MOODYS CORP | COM | 615369105 | 410 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | |
MSCI INC | COM | 55354G100 | 389 | 1,786 | SH | DFND | 2 | 1,786 | 0 | 0 | |
MYLAN N V | SHS EURO | N59465109 | 5,799 | 293,200 | SH | DFND | 2 | 293,200 | 0 | 0 | |
MYOKARDIA INC | COM | 62857M105 | 1,439 | 27,600 | SH | DFND | 2 | 27,600 | 0 | 0 | |
MYOKARDIA INC | COM | 62857M105 | 65,965 | 1,264,913 | SH | DFND | 1,2 | 1,264,913 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 25,039 | 4,815,109 | SH | DFND | 1,2 | 4,815,109 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 11,880 | 652,210 | SH | DFND | 2 | 652,210 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 45,914 | 2,520,676 | SH | DFND | 1,2 | 2,520,676 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 7,695 | 85,400 | SH | DFND | 2 | 85,400 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 289,530 | 3,213,074 | SH | DFND | 1,2 | 3,213,074 | 0 | 0 | |
NEURONETICS INC | COM | 64131A105 | 2,709 | 325,961 | SH | DFND | 2 | 325,961 | 0 | 0 | |
NEVRO CORP | COM | 64157F103 | 12,475 | 145,111 | SH | DFND | 2 | 145,111 | 0 | 0 | |
OMNICELL INC | COM | 68213N109 | 12,405 | 171,646 | SH | DFND | 2 | 171,646 | 0 | 0 | |
OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 10,609 | 637,972 | SH | DFND | 2 | 637,972 | 0 | 0 | |
PACIFIC BIOSIENCES CALIF IN | COM | 69404D108 | 12,249 | 2,373,787 | SH | DFND | 2 | 2,373,787 | 0 | 0 | |
PAYCHEX INC | COM | 704326107 | 447 | 5,400 | SH | DFND | 2 | 5,400 | 0 | 0 | |
PENUMBRA INC | COM | 70975L107 | 3,369 | 25,048 | SH | DFND | 2 | 25,048 | 0 | 0 | |
PFIZER INC | COM | 717081103 | 1,437 | 40,000 | SH | DFND | 2 | 40,000 | 0 | 0 | |
PHREESIA INC | COM | 71944F106 | 5,350 | 220,690 | SH | DFND | 2 | 220,690 | 0 | 0 | |
POLYONE CORP | COM | 73179P106 | 444 | 13,600 | SH | DFND | 2 | 13,600 | 0 | 0 | |
POOL CORPORATION | COM | 73278L105 | 444 | 2,200 | SH | DFND | 2 | 2,200 | 0 | 0 | |
PORTOLA PHARMACEUTICALS INC | COM | 737010108 | 1,172 | 43,700 | SH | DFND | 2 | 43,700 | 0 | 0 | |
PTC THERAPEUTICS INC | COM | 69366J200 | 2,746 | 81,200 | SH | DFND | 2 | 81,200 | 0 | 0 | |
QIAGEN NV | SHS NEW | N72482123 | 21,066 | 638,943 | SH | DFND | 2 | 638,943 | 0 | 0 | |
QUANTERIX CORP | COM | 74766Q101 | 8,918 | 406,101 | SH | DFND | 2 | 406,101 | 0 | 0 | |
QUIDEL CORP | COM | 74838J101 | 9,817 | 160,016 | SH | DFND | 2 | 160,016 | 0 | 0 | |
QUOTIENT LTD | SHS | G73268107 | 5,811 | 747,894 | SH | DFND | 2 | 747,894 | 0 | 0 | |
RADIUS HEALTH INC | COM NEW | 750469207 | 2,451 | 95,200 | SH | DFND | 2 | 95,200 | 0 | 0 | |
RADIUS HEALTH INC | COM NEW | 750469207 | 174,628 | 6,781,685 | SH | DFND | 1,2 | 6,781,685 | 0 | 0 | |
REGENXBIO INC | COM | 75901B107 | 1,200 | 33,700 | SH | DFND | 2 | 33,700 | 0 | 0 | |
RESMED INC | COM | 761152107 | 7,381 | 54,630 | SH | DFND | 2 | 54,630 | 0 | 0 | |
S&P GLOBAL INC | COM | 78409V104 | 416 | 1,700 | SH | DFND | 2 | 1,700 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 3,283 | 23,400 | SH | DFND | 2 | 23,400 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 179,586 | 1,280,104 | SH | DFND | 1,2 | 1,280,104 | 0 | 0 | |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 33,033 | 3,650,000 | SH | DFND | 1,2 | 3,650,000 | 0 | 0 | |
SCHOLAR ROCK HOLDING CORP | COM | 80706P103 | 19,664 | 2,197,100 | SH | DFND | 1,2 | 2,197,100 | 0 | 0 | |
SEATTLE GENETICS INC | COM | 812578102 | 6,943 | 81,300 | SH | DFND | 2 | 81,300 | 0 | 0 | |
SENSATA TECHNOLOGIES HLDNG P | SHS | G8060N102 | 496 | 9,900 | SH | DFND | 2 | 9,900 | 0 | 0 | |
SHOCKWAVE MED INC | COM | 82489T104 | 3,034 | 101,358 | SH | DFND | 2 | 101,358 | 0 | 0 | |
SILK RAOD MEDICAL INC | COM | 82710M100 | 4,292 | 131,954 | SH | DFND | 2 | 131,954 | 0 | 0 | |
SKYWORKS SOLUTIONS INC | COM | 83088M102 | 452 | 5,700 | SH | DFND | 2 | 5,700 | 0 | 0 | |
SMILEDIRECTCLUB INC | CL A COM | 83192H106 | 4,858 | 350,000 | SH | DFND | 2 | 350,000 | 0 | 0 | |
SOCIEDAD QUIMICA MINERA DE C | SPON ADR SER B | 833635105 | 501 | 18,200 | SH | DFND | 2 | 18,200 | 0 | 0 | |
STARBUCKS CORP | COM | 855244109 | 383 | 4,334 | SH | DFND | 2 | 4,334 | 0 | 0 | |
STEMLINE THERAPEUTICS INC | COM | 85858C107 | 328 | 31,500 | SH | DFND | 2 | 31,500 | 0 | 0 | |
STRYKER CORP | COM | 863667101 | 40,726 | 188,284 | SH | DFND | 2 | 188,284 | 0 | 0 | |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 11,448 | 416,600 | SH | DFND | 2 | 416,600 | 0 | 0 | |
SYNEOS HEALTH INC | CL A | 87166B102 | 3,299 | 62,000 | SH | DFND | 2 | 62,000 | 0 | 0 | |
TABULA RASA HEALTHCARE INC | COM | 873379101 | 11,081 | 201,693 | SH | DFND | 2 | 201,693 | 0 | 0 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 11,486 | 194,736 | SH | DFND | 2 | 194,736 | 0 | 0 | |
TELADOC HEALTH INC | COM | 87918A105 | 77,137 | 1,139,057 | SH | DFND | 2 | 1,139,057 | 0 | 0 | |
TELEFLEX INC | COM | 879369106 | 20,084 | 59,114 | SH | DFND | 2 | 59,114 | 0 | 0 | |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 1,028 | 150,000 | SH | DFND | 2 | 150,000 | 0 | 0 | |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 16,671 | 57,236 | SH | DFND | 2 | 57,236 | 0 | 0 | |
TRIMBLE INC | COM | 896239100 | 454 | 11,700 | SH | DFND | 2 | 11,700 | 0 | 0 | |
TYLER TECHNOLOGIES INC | COM | 902252105 | 400 | 1,525 | SH | DFND | 2 | 1,525 | 0 | 0 | |
UNIQURE NV | SHS | N90064101 | 1,216 | 30,900 | SH | DFND | 2 | 30,900 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 51,877 | 238,712 | SH | DFND | 2 | 238,712 | 0 | 0 | |
VARIAN MED SYS INC | COM | 92220P105 | 488 | 4,100 | SH | DFND | 2 | 4,100 | 0 | 0 | |
VEEVA SYS INC | CL A COM | 922475108 | 7,769 | 50,884 | SH | DFND | 2 | 50,884 | 0 | 0 | |
VEONEER INCORPORATED | COM | 92336X109 | 445 | 29,700 | SH | DFND | 2 | 29,700 | 0 | 0 | |
VERISIGN INC | COM | 92343E102 | 396 | 2,100 | SH | DFND | 2 | 2,100 | 0 | 0 | |
VERISK ANALYTICS INC | COM | 92345Y106 | 394 | 2,489 | SH | DFND | 2 | 2,489 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 25,267 | 149,139 | SH | DFND | 2 | 149,139 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 216,858 | 1,280,000 | SH | DFND | 1,2 | 1,280,000 | 0 | 0 | |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 6,142 | 249,173 | SH | DFND | 2 | 249,173 | 0 | 0 | |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 420 | 24,400 | SH | DFND | 2 | 24,400 | 0 | 0 | |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 46,128 | 2,680,283 | SH | DFND | 1,2 | 2,680,283 | 0 | 0 | |
WABTEC CORP | COM | 929740108 | 460 | 6,400 | SH | DFND | 2 | 6,400 | 0 | 0 | |
WATSCO INC | COM | 942622200 | 474 | 2,800 | SH | DFND | 2 | 2,800 | 0 | 0 | |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 31,880 | 1,552,858 | SH | DFND | 1,2 | 1,552,858 | 0 | 0 | |
WRIGHT MED GROUP NV | ORD SHS | N96617118 | 16,593 | 804,291 | SH | DFND | 2 | 804,291 | 0 | 0 | |
XILINX INC | COM | 983919101 | 403 | 4,200 | SH | DFND | 2 | 4,200 | 0 | 0 | |
ZAI LAB LTD | ADR | 98887Q104 | 971 | 30,000 | SH | DFND | 2 | 30,000 | 0 | 0 | |
ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 19,818 | 144,373 | SH | DFND | 2 | 144,373 | 0 | 0 | |
ZOGENIX INC | COM NEW | 98978L204 | 921 | 23,000 | SH | DFND | 2 | 23,000 | 0 | 0 |