COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
10X GENOMICS INC | CL A COM | 88025U109 | 9,846 | 129,127 | SH | | DFND | 2 | 129,127 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 115,126 | 1,325,420 | SH | | DFND | 2 | 1,325,420 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 3,763 | 42,500 | SH | | DFND | 2 | 42,500 | 0 | 0 |
ABIOMED INC | COM | 003654100 | 14,984 | 87,839 | SH | | DFND | 2 | 87,839 | 0 | 0 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 1,711 | 40,000 | SH | | DFND | 2 | 40,000 | 0 | 0 |
ACCELERON PHARMA INC | COM | 00434H108 | 1,283 | 24,200 | SH | | DFND | 2 | 24,200 | 0 | 0 |
ADOBE INC | COM | 00724F101 | 495 | 1,500 | SH | | DFND | 2 | 1,500 | 0 | 0 |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 1,536 | 18,000 | SH | | DFND | 2 | 18,000 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 1,337 | 28,000 | SH | | DFND | 2 | 28,000 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 186,080 | 3,896,954 | SH | | DFND | 1,2 | 3,896,954 | 0 | 0 |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 12,090 | 713,695 | SH | | DFND | 2 | 713,695 | 0 | 0 |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 41,485 | 2,448,948 | SH | | DFND | 1,2 | 2,448,948 | 0 | 0 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 8,057 | 74,500 | SH | | DFND | 2 | 74,500 | 0 | 0 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 142,155 | 1,314,428 | SH | | DFND | 1,2 | 1,314,428 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 77,769 | 278,703 | SH | | DFND | 2 | 278,703 | 0 | 0 |
ALKERMES PLC | SHS | G01767105 | 3,435 | 168,400 | SH | | DFND | 2 | 168,400 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 30,495 | 264,783 | SH | | DFND | 2 | 264,783 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 184,272 | 1,600,000 | SH | | DFND | 1,2 | 1,600,000 | 0 | 0 |
AMEDISYS INC | COM | 023436108 | 8,908 | 53,365 | SH | | DFND | 2 | 53,365 | 0 | 0 |
AMERICAN EXPRESS CO | COM | 025816109 | 448 | 3,600 | SH | | DFND | 2 | 3,600 | 0 | 0 |
AMGEN INC | COM | 031162100 | 9,727 | 40,350 | SH | | DFND | 2 | 40,350 | 0 | 0 |
AMNEAL PHARMACEUTICALS INC | COM STK CL A | 03168L105 | 1,446 | 300,000 | SH | | DFND | 2 | 300,000 | 0 | 0 |
ANALOG DEVICES INC | COM | 032654105 | 487 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
ANSYS INC | COM | 03662Q105 | 464 | 1,802 | SH | | DFND | 2 | 1,802 | 0 | 0 |
ANTHEM INC | COM | 036752103 | 98,212 | 325,174 | SH | | DFND | 2 | 325,174 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 3,732 | 23,250 | SH | | DFND | 2 | 23,250 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 152,338 | 944,739 | SH | | DFND | 1,2 | 944,739 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 51,030 | 1,241,903 | SH | | DFND | 1,2 | 1,241,903 | 0 | 0 |
ASPEN TECHNOLOGY INC | COM | 045327103 | 363 | 3,000 | SH | | DFND | 2 | 3,000 | 0 | 0 |
AUDENTES THERAPEUTICS INC | COM | 05070R104 | 736 | 12,300 | SH | | DFND | 2 | 12,300 | 0 | 0 |
AUTOLIV INC | COM | 052800109 | 574 | 6,800 | SH | | DFND | 2 | 6,800 | 0 | 0 |
AUTOLUS THERAPEUTICS PLC | SPON ADS | 05280R100 | 821 | 62,200 | SH | | DFND | 2 | 62,200 | 0 | 0 |
AVANTOR INC | COM | 05352A100 | 5,709 | 314,566 | SH | | DFND | 2 | 314,566 | 0 | 0 |
BAXTER INTL INC | COM | 071813109 | 45,128 | 539,675 | SH | | DFND | 2 | 539,675 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 68,540 | 252,012 | SH | | DFND | 2 | 252,012 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 7,767 | 46,856 | SH | | DFND | 2 | 46,856 | 0 | 0 |
BENEFITFOCUS INC | COM | 08180D106 | 1,985 | 90,463 | SH | | DFND | 2 | 90,463 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 148 | 500 | SH | | DFND | 2 | 500 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 8 | 160 | SH | Call | DFND | 2 | 160 | 0 | 0 |
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 1,236 | 22,700 | SH | | DFND | 2 | 22,700 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 5,682 | 67,200 | SH | | DFND | 2 | 67,200 | 0 | 0 |
BIO RAD LABS INC | CL A | 090572207 | 17,312 | 46,785 | SH | | DFND | 2 | 46,785 | 0 | 0 |
BLACKBAUD INC | COM | 09227Q100 | 327 | 4,107 | SH | | DFND | 2 | 4,107 | 0 | 0 |
BLUEBIRD BIO INC | COM | 09609G100 | 1,606 | 18,300 | SH | | DFND | 2 | 18,300 | 0 | 0 |
BLUEPRINT MEDICINES CORP | COM | 09627Y109 | 1,618 | 20,200 | SH | | DFND | 2 | 20,200 | 0 | 0 |
BOOKING HLDGS INC | COM | 09857L108 | 411 | 200 | SH | | DFND | 2 | 200 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 71,385 | 1,578,621 | SH | | DFND | 2 | 1,578,621 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 82,756 | 1,289,242 | SH | | DFND | 2 | 1,289,242 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 51,352 | 800,000 | SH | | DFND | 1,2 | 800,000 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | RIGHT 99/99/9999 | 110122157 | 50 | 16,600 | SH | | DFND | 2 | 16,600 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | RIGHT 99/99/9999 | 110122157 | 2,408 | 800,000 | SH | | DFND | 1,2 | 800,000 | 0 | 0 |
BROADRIDGE FINL SOLUTIONS IN | COM | 11133T103 | 420 | 3,400 | SH | | DFND | 2 | 3,400 | 0 | 0 |
BROWN FORMAN CORP | CL B | 115637209 | 514 | 7,600 | SH | | DFND | 2 | 7,600 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 25,382 | 1,176,730 | SH | | DFND | 2 | 1,176,730 | 0 | 0 |
CATALENT INC | COM | 148806102 | 1,931 | 34,300 | SH | | DFND | 2 | 34,300 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 46,562 | 740,611 | SH | | DFND | 2 | 740,611 | 0 | 0 |
CERNER CORP | COM | 156782104 | 455 | 6,200 | SH | | DFND | 2 | 6,200 | 0 | 0 |
CHANGE HEALTHCARE INC | COM | 15912K100 | 14,160 | 863,922 | SH | | DFND | 2 | 863,922 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 43,246 | 283,098 | SH | | DFND | 2 | 283,098 | 0 | 0 |
CHINA BIOLOGIC PRODS HLDGS I | COM | G21515104 | 524 | 4,500 | SH | | DFND | 2 | 4,500 | 0 | 0 |
CIDARA THERAPEUTICS INC | COM | 171757107 | 8,814 | 2,295,272 | SH | | DFND | 1,2 | 2,295,272 | 0 | 0 |
CIGNA CORP NEW | COM | 125523100 | 65,262 | 319,146 | SH | | DFND | 2 | 319,146 | 0 | 0 |
CLOROX CO DEL | COM | 189054109 | 430 | 2,800 | SH | | DFND | 2 | 2,800 | 0 | 0 |
CLOVIS ONCOLOGY INC | COM | 189464100 | 760 | 72,900 | SH | | DFND | 2 | 72,900 | 0 | 0 |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 2,674 | 148,500 | SH | | DFND | 2 | 148,500 | 0 | 0 |
COLGATE PALMOLIVE CO | COM | 194162103 | 420 | 6,100 | SH | | DFND | 2 | 6,100 | 0 | 0 |
CONSTELLATION BRANDS INC | CL A | 21036P108 | 391 | 2,059 | SH | | DFND | 2 | 2,059 | 0 | 0 |
COOPER COS INC | COM NEW | 216648402 | 13,345 | 41,535 | SH | | DFND | 2 | 41,535 | 0 | 0 |
COVETRUS INC | COM | 22304C100 | 20 | 1,520 | SH | | DFND | 2 | 1,520 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 44,489 | 730,462 | SH | | DFND | 1,2 | 730,462 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 15,399 | 207,279 | SH | | DFND | 2 | 207,279 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 56,265 | 366,593 | SH | | DFND | 2 | 366,593 | 0 | 0 |
DENTSPLY SIRONA INC | COM | 24906P109 | 9,396 | 166,039 | SH | | DFND | 2 | 166,039 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 17,166 | 78,475 | SH | | DFND | 2 | 78,475 | 0 | 0 |
DOMINOS PIZZA INC | COM | 25754A201 | 558 | 1,900 | SH | | DFND | 2 | 1,900 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 47,298 | 202,743 | SH | | DFND | 2 | 202,743 | 0 | 0 |
ELECTRONIC ARTS INC | COM | 285512109 | 516 | 4,800 | SH | | DFND | 2 | 4,800 | 0 | 0 |
ENTEGRIS INC | COM | 29362U104 | 516 | 10,300 | SH | | DFND | 2 | 10,300 | 0 | 0 |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 47,528 | 797,046 | SH | | DFND | 2 | 797,046 | 0 | 0 |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 222,298 | 3,727,964 | SH | | DFND | 1,2 | 3,727,964 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 32,115 | 3,548,613 | SH | | DFND | 2 | 3,548,613 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 19,306 | 1,095,700 | SH | | DFND | 2 | 1,095,700 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 49,953 | 2,835,000 | SH | | DFND | 1,2 | 2,835,000 | 0 | 0 |
FACTSET RESH SYS INC | COM | 303075105 | 456 | 1,700 | SH | | DFND | 2 | 1,700 | 0 | 0 |
FASTENAL CO | COM | 311900104 | 713 | 19,299 | SH | | DFND | 2 | 19,299 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 1,620 | 82,800 | SH | | DFND | 2 | 82,800 | 0 | 0 |
FIBROGEN INC | COM | 31572Q808 | 1,651 | 38,500 | SH | | DFND | 2 | 38,500 | 0 | 0 |
FITBIT INC | CL A | 33812L102 | 3,751 | 570,959 | SH | | DFND | 2 | 570,959 | 0 | 0 |
G1 THERAPEUTICS INC | COM | 3621LQ109 | 19,080 | 721,925 | SH | | DFND | 1,2 | 721,925 | 0 | 0 |
GENMARK DIAGNOSTICS INC | COM | 372309104 | 11,742 | 2,441,241 | SH | | DFND | 2 | 2,441,241 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 552 | 8,500 | SH | | DFND | 2 | 8,500 | 0 | 0 |
GLAUKOS CORP | COM | 377322102 | 21,905 | 402,148 | SH | | DFND | 2 | 402,148 | 0 | 0 |
GLOBUS MED INC | CL A | 379577208 | 19,892 | 337,837 | SH | | DFND | 2 | 337,837 | 0 | 0 |
GRACO INC | COM | 384109104 | 504 | 9,700 | SH | | DFND | 2 | 9,700 | 0 | 0 |
GUARDANT HEALTH INC | COM | 40131M109 | 8,606 | 110,136 | SH | | DFND | 2 | 110,136 | 0 | 0 |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 1,171 | 11,200 | SH | | DFND | 2 | 11,200 | 0 | 0 |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 1,308 | 73,800 | SH | | DFND | 2 | 73,800 | 0 | 0 |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 141,185 | 7,963,056 | SH | | DFND | 1,2 | 7,963,056 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 37,341 | 252,628 | SH | | DFND | 2 | 252,628 | 0 | 0 |
HEALTH CATALYST INC | COM | 42225T107 | 7,790 | 224,508 | SH | | DFND | 2 | 224,508 | 0 | 0 |
HENRY SCHEIN INC | COM | 806407102 | 397 | 5,948 | SH | | DFND | 2 | 5,948 | 0 | 0 |
HILL ROM HLDGS INC | COM | 431475102 | 26,939 | 237,286 | SH | | DFND | 2 | 237,286 | 0 | 0 |
HMS HLDGS CORP | COM | 40425J101 | 15,314 | 517,377 | SH | | DFND | 2 | 517,377 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 13,667 | 261,779 | SH | | DFND | 2 | 261,779 | 0 | 0 |
HOMOLOGY MEDICINES INC | COM | 438083107 | 33,371 | 1,612,122 | SH | | DFND | 1,2 | 1,612,122 | 0 | 0 |
HORIZON THERAPEUTICS PUB LTD | SHS | G46188101 | 11,428 | 315,700 | SH | | DFND | 2 | 315,700 | 0 | 0 |
HUAZHU GROUP LTD | SPONSORED ADS | 44332N106 | 541 | 13,500 | SH | | DFND | 2 | 13,500 | 0 | 0 |
HUMANA INC | COM | 444859102 | 83,364 | 227,447 | SH | | DFND | 2 | 227,447 | 0 | 0 |
HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 20,503 | 817,817 | SH | | DFND | 2 | 817,817 | 0 | 0 |
IDEXX LABS INC | COM | 45168D104 | 12,393 | 47,461 | SH | | DFND | 2 | 47,461 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 73,536 | 221,667 | SH | | DFND | 2 | 221,667 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 10,216 | 117,000 | SH | | DFND | 2 | 117,000 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 296,888 | 3,400,000 | SH | | DFND | 1,2 | 3,400,000 | 0 | 0 |
INOGEN INC | COM | 45780L104 | 9,415 | 137,787 | SH | | DFND | 2 | 137,787 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 37,815 | 1,583,560 | SH | | DFND | 2 | 1,583,560 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 19,533 | 263,217 | SH | | DFND | 2 | 263,217 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 17,365 | 101,430 | SH | | DFND | 2 | 101,430 | 0 | 0 |
INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 15,023 | 257,772 | SH | | DFND | 2 | 257,772 | 0 | 0 |
INTERACTIVE BROKERS GROUP IN | COM CL A | 45841N107 | 438 | 9,400 | SH | | DFND | 2 | 9,400 | 0 | 0 |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 2,255 | 18,200 | SH | | DFND | 2 | 18,200 | 0 | 0 |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 86,369 | 696,976 | SH | | DFND | 1,2 | 696,976 | 0 | 0 |
INTERCONTINENTAL EXCHANGE IN | COM | 45866F104 | 444 | 4,800 | SH | | DFND | 2 | 4,800 | 0 | 0 |
INTERSECT ENT INC | COM | 46071F103 | 14,215 | 570,902 | SH | | DFND | 2 | 570,902 | 0 | 0 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 2,264 | 66,000 | SH | | DFND | 2 | 66,000 | 0 | 0 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 78,913 | 2,300,000 | SH | | DFND | 1,2 | 2,300,000 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 104,206 | 176,276 | SH | | DFND | 2 | 176,276 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 26,391 | 436,865 | SH | | DFND | 2 | 436,865 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 482,975 | 7,994,955 | SH | | DFND | 1,2 | 7,994,955 | 0 | 0 |
IPG PHOTONICS CORP | COM | 44980X109 | 507 | 3,500 | SH | | DFND | 2 | 3,500 | 0 | 0 |
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 9,299 | 136,563 | SH | | DFND | 2 | 136,563 | 0 | 0 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 56,921 | 381,303 | SH | | DFND | 2 | 381,303 | 0 | 0 |
JD COM INC | SPON ADR CL A | 47215P106 | 518 | 14,700 | SH | | DFND | 2 | 14,700 | 0 | 0 |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 6,218 | 1,550,669 | SH | | DFND | 1,2 | 1,550,669 | 0 | 0 |
KOSMOS ENERGY LTD | COM | 500688106 | 342 | 60,000 | SH | | DFND | 2 | 60,000 | 0 | 0 |
KURA ONCOLOGY INC | COM | 50127T109 | 2,170 | 157,800 | SH | | DFND | 2 | 157,800 | 0 | 0 |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 935 | 5,526 | SH | | DFND | 2 | 5,526 | 0 | 0 |
LAUDER ESTEE COS INC | CL A | 518439104 | 464 | 2,248 | SH | | DFND | 2 | 2,248 | 0 | 0 |
LIGAND PHARMACEUTICALS INC | COM NEW | 53220K504 | 1,616 | 15,500 | SH | | DFND | 2 | 15,500 | 0 | 0 |
LIVANOVA PLC | SHS | G5509L101 | 9,552 | 126,639 | SH | | DFND | 2 | 126,639 | 0 | 0 |
LIVE NATION ENTERTAINMENT IN | COM | 538034109 | 443 | 6,200 | SH | | DFND | 2 | 6,200 | 0 | 0 |
LIVONGO HEALTH INC | COM | 539183103 | 4,575 | 182,574 | SH | | DFND | 2 | 182,574 | 0 | 0 |
M & T BK CORP | COM | 55261F104 | 509 | 3,000 | SH | | DFND | 2 | 3,000 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 14,734 | 1,354,197 | SH | | DFND | 2 | 1,354,197 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 49,168 | 4,519,159 | SH | | DFND | 1,2 | 4,519,159 | 0 | 0 |
MARKEL CORP | COM | 570535104 | 457 | 400 | SH | | DFND | 2 | 400 | 0 | 0 |
MARKETAXESS HLDGS INC | COM | 57060D108 | 501 | 1,322 | SH | | DFND | 2 | 1,322 | 0 | 0 |
MASIMO CORP | COM | 574795100 | 12,494 | 79,049 | SH | | DFND | 2 | 79,049 | 0 | 0 |
MCCORMICK & CO INC | COM NON VTG | 579780206 | 475 | 2,800 | SH | | DFND | 2 | 2,800 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 812 | 5,874 | SH | | DFND | 2 | 5,874 | 0 | 0 |
MEDTRONIC PLC | SHS | G5960L103 | 96,243 | 848,330 | SH | | DFND | 2 | 848,330 | 0 | 0 |
MERCK & CO INC | COM | 58933Y105 | 2,729 | 30,000 | SH | | DFND | 2 | 30,000 | 0 | 0 |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 555 | 700 | SH | | DFND | 2 | 700 | 0 | 0 |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 2,100 | 16,300 | SH | | DFND | 2 | 16,300 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 2,294 | 117,300 | SH | | DFND | 2 | 117,300 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 94,236 | 4,817,781 | SH | | DFND | 1,2 | 4,817,781 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM | 608550109 | 18,120 | 1,295,687 | SH | | DFND | 1,2 | 1,295,687 | 0 | 0 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 17,724 | 130,619 | SH | | DFND | 2 | 130,619 | 0 | 0 |
MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 3,204 | 162,400 | SH | | DFND | 2 | 162,400 | 0 | 0 |
MOODYS CORP | COM | 615369105 | 475 | 2,000 | SH | | DFND | 2 | 2,000 | 0 | 0 |
MSCI INC | COM | 55354G100 | 461 | 1,786 | SH | | DFND | 2 | 1,786 | 0 | 0 |
MYLAN N V | SHS EURO | N59465109 | 1,608 | 80,000 | SH | | DFND | 2 | 80,000 | 0 | 0 |
MYOKARDIA INC | COM | 62857M105 | 3,017 | 41,400 | SH | | DFND | 2 | 41,400 | 0 | 0 |
MYOKARDIA INC | COM | 62857M105 | 92,193 | 1,264,913 | SH | | DFND | 1,2 | 1,264,913 | 0 | 0 |
MYOVANT SCIENCES LTD | COM | G637AM102 | 74,730 | 4,815,109 | SH | | DFND | 1,2 | 4,815,109 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 17,189 | 796,322 | SH | | DFND | 2 | 796,322 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 56,567 | 2,620,676 | SH | | DFND | 1,2 | 2,620,676 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 9,706 | 90,300 | SH | | DFND | 2 | 90,300 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 346,986 | 3,228,074 | SH | | DFND | 1,2 | 3,228,074 | 0 | 0 |
NEURONETICS INC | COM | 64131A105 | 1,464 | 325,961 | SH | | DFND | 2 | 325,961 | 0 | 0 |
NEVRO CORP | COM | 64157F103 | 12,895 | 109,705 | SH | | DFND | 2 | 109,705 | 0 | 0 |
OMNICELL INC | COM | 68213N109 | 16,045 | 196,339 | SH | | DFND | 2 | 196,339 | 0 | 0 |
OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 10,590 | 637,972 | SH | | DFND | 2 | 637,972 | 0 | 0 |
PACIFIC BIOSIENCES CALIF IN | COM | 69404D108 | 29,474 | 5,734,309 | SH | | DFND | 2 | 5,734,309 | 0 | 0 |
PAYCHEX INC | COM | 704326107 | 459 | 5,400 | SH | | DFND | 2 | 5,400 | 0 | 0 |
PENUMBRA INC | COM | 70975L107 | 11,311 | 68,855 | SH | | DFND | 2 | 68,855 | 0 | 0 |
PERKINELMER INC | COM | 714046109 | 466 | 4,800 | SH | | DFND | 2 | 4,800 | 0 | 0 |
PFIZER INC | COM | 717081103 | 2,351 | 60,000 | SH | | DFND | 2 | 60,000 | 0 | 0 |
PHREESIA INC | COM | 71944F106 | 7,221 | 271,045 | SH | | DFND | 2 | 271,045 | 0 | 0 |
POLYONE CORP | COM | 73179P106 | 500 | 13,600 | SH | | DFND | 2 | 13,600 | 0 | 0 |
POOL CORPORATION | COM | 73278L105 | 467 | 2,200 | SH | | DFND | 2 | 2,200 | 0 | 0 |
PROSHARES TR | PSHS ULT NASB | 74347R214 | 1,544 | 25,000 | SH | | DFND | 2 | 25,000 | 0 | 0 |
PTC THERAPEUTICS INC | COM | 69366J200 | 2,694 | 56,100 | SH | | DFND | 2 | 56,100 | 0 | 0 |
QIAGEN NV | SHS NEW | N72482123 | 5,437 | 160,846 | SH | | DFND | 2 | 160,846 | 0 | 0 |
QUANTERIX CORP | COM | 74766Q101 | 10,284 | 435,217 | SH | | DFND | 2 | 435,217 | 0 | 0 |
QUIDEL CORP | COM | 74838J101 | 25,325 | 337,528 | SH | | DFND | 2 | 337,528 | 0 | 0 |
QUOTIENT LTD | SHS | G73268107 | 3,385 | 355,899 | SH | | DFND | 2 | 355,899 | 0 | 0 |
RADIUS HEALTH INC | COM NEW | 750469207 | 1,224 | 60,700 | SH | | DFND | 2 | 60,700 | 0 | 0 |
RADIUS HEALTH INC | COM NEW | 750469207 | 138,735 | 6,881,685 | SH | | DFND | 1,2 | 6,881,685 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 8,261 | 22,000 | SH | | DFND | 2 | 22,000 | 0 | 0 |
REGENXBIO INC | COM | 75901B107 | 856 | 20,900 | SH | | DFND | 2 | 20,900 | 0 | 0 |
REPLIGEN CORP | COM | 759916109 | 1,258 | 13,600 | SH | | DFND | 2 | 13,600 | 0 | 0 |
RESMED INC | COM | 761152107 | 11,748 | 75,810 | SH | | DFND | 2 | 75,810 | 0 | 0 |
S&P GLOBAL INC | COM | 78409V104 | 464 | 1,700 | SH | | DFND | 2 | 1,700 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 2,075 | 28,750 | SH | | DFND | 2 | 28,750 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 92,411 | 1,280,104 | SH | | DFND | 1,2 | 1,280,104 | 0 | 0 |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 32,225 | 3,850,000 | SH | | DFND | 1,2 | 3,850,000 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 2,000 | 15,500 | SH | | DFND | 2 | 15,500 | 0 | 0 |
SCHOLAR ROCK HOLDING CORP | COM | 80706P103 | 34,722 | 2,634,466 | SH | | DFND | 1,2 | 2,634,466 | 0 | 0 |
SEATTLE GENETICS INC | COM | 812578102 | 4,273 | 37,400 | SH | | DFND | 2 | 37,400 | 0 | 0 |
SENSATA TECHNOLOGIES HLDNG P | SHS | G8060N102 | 533 | 9,900 | SH | | DFND | 2 | 9,900 | 0 | 0 |
SERVICE CORP INTL | COM | 817565104 | 391 | 8,500 | SH | | DFND | 2 | 8,500 | 0 | 0 |
SHOCKWAVE MED INC | COM | 82489T104 | 9,256 | 210,758 | SH | | DFND | 2 | 210,758 | 0 | 0 |
SILK RAOD MEDICAL INC | COM | 82710M100 | 7,426 | 183,896 | SH | | DFND | 2 | 183,896 | 0 | 0 |
SKYWORKS SOLUTIONS INC | COM | 83088M102 | 689 | 5,700 | SH | | DFND | 2 | 5,700 | 0 | 0 |
SMILEDIRECTCLUB INC | CL A COM | 83192H106 | 4,634 | 530,230 | SH | | DFND | 2 | 530,230 | 0 | 0 |
SOCIEDAD QUIMICA MINERA DE C | SPON ADR SER B | 833635105 | 486 | 18,200 | SH | | DFND | 2 | 18,200 | 0 | 0 |
STARBUCKS CORP | COM | 855244109 | 381 | 4,334 | SH | | DFND | 2 | 4,334 | 0 | 0 |
STRYKER CORP | COM | 863667101 | 33,854 | 161,255 | SH | | DFND | 2 | 161,255 | 0 | 0 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 13,653 | 575,600 | SH | | DFND | 2 | 575,600 | 0 | 0 |
SYNEOS HEALTH INC | CL A | 87166B102 | 2,712 | 45,600 | SH | | DFND | 2 | 45,600 | 0 | 0 |
TABULA RASA HEALTHCARE INC | COM | 873379101 | 9,816 | 201,635 | SH | | DFND | 2 | 201,635 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 11,931 | 200,147 | SH | | DFND | 2 | 200,147 | 0 | 0 |
TELADOC HEALTH INC | COM | 87918A105 | 62,794 | 750,045 | SH | | DFND | 2 | 750,045 | 0 | 0 |
TELEFLEX INC | COM | 879369106 | 28,127 | 74,719 | SH | | DFND | 2 | 74,719 | 0 | 0 |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 2,607 | 266,000 | SH | | DFND | 2 | 266,000 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 21,051 | 64,797 | SH | | DFND | 2 | 64,797 | 0 | 0 |
TRANSUNION | COM | 89400J107 | 436 | 5,096 | SH | | DFND | 2 | 5,096 | 0 | 0 |
TRIMBLE INC | COM | 896239100 | 488 | 11,700 | SH | | DFND | 2 | 11,700 | 0 | 0 |
TRIP COM GROUP LTD | ADS | 89677Q107 | 439 | 13,100 | SH | | DFND | 2 | 13,100 | 0 | 0 |
TYLER TECHNOLOGIES INC | COM | 902252105 | 458 | 1,525 | SH | | DFND | 2 | 1,525 | 0 | 0 |
UNIQURE NV | SHS | N90064101 | 2,071 | 28,900 | SH | | DFND | 2 | 28,900 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 80,906 | 275,210 | SH | | DFND | 2 | 275,210 | 0 | 0 |
VARIAN MED SYS INC | COM | 92220P105 | 582 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
VEEVA SYS INC | CL A COM | 922475108 | 7,157 | 50,884 | SH | | DFND | 2 | 50,884 | 0 | 0 |
VERISIGN INC | COM | 92343E102 | 405 | 2,100 | SH | | DFND | 2 | 2,100 | 0 | 0 |
VERISK ANALYTICS INC | COM | 92345Y106 | 372 | 2,489 | SH | | DFND | 2 | 2,489 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 32,687 | 149,289 | SH | | DFND | 2 | 149,289 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 271,498 | 1,240,000 | SH | | DFND | 1,2 | 1,240,000 | 0 | 0 |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 6,314 | 304,143 | SH | | DFND | 2 | 304,143 | 0 | 0 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 335 | 24,000 | SH | | DFND | 2 | 24,000 | 0 | 0 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 37,390 | 2,680,283 | SH | | DFND | 1,2 | 2,680,283 | 0 | 0 |
WABTEC CORP | COM | 929740108 | 498 | 6,400 | SH | | DFND | 2 | 6,400 | 0 | 0 |
WATSCO INC | COM | 942622200 | 504 | 2,800 | SH | | DFND | 2 | 2,800 | 0 | 0 |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 19,259 | 2,402,858 | SH | | DFND | 1,2 | 2,402,858 | 0 | 0 |
WRIGHT MED GROUP NV | ORD SHS | N96617118 | 17,078 | 560,311 | SH | | DFND | 2 | 560,311 | 0 | 0 |
XILINX INC | COM | 983919101 | 411 | 4,200 | SH | | DFND | 2 | 4,200 | 0 | 0 |
ZAI LAB LTD | ADR | 98887Q104 | 5,023 | 120,782 | SH | | DFND | 2 | 120,782 | 0 | 0 |
ZIMMER BIOMET HLDGS INC | COM | 98956P102 | 32,186 | 215,032 | SH | | DFND | 2 | 215,032 | 0 | 0 |
ZOGENIX INC | COM NEW | 98978L204 | 1,361 | 26,100 | SH | | DFND | 2 | 26,100 | 0 | 0 |