COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
1LIFE HEALTHCARE INC | COM | 68269G107 | 4,538 | 250,000 | SH | | DFND | 2 | 250,000 | 0 | 0 |
10X GENOMICS INC | CL A COM | 88025U109 | 5,849 | 93,847 | SH | | DFND | 2 | 93,847 | 0 | 0 |
111 INC | ADS | 68247Q102 | 763 | 115,429 | SH | | DFND | 2 | 115,429 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 101,342 | 1,284,272 | SH | | DFND | 2 | 1,284,272 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 1,935 | 25,400 | SH | | DFND | 2 | 25,400 | 0 | 0 |
ABIOMED INC | COM | 003654100 | 15,688 | 108,072 | SH | | DFND | 2 | 108,072 | 0 | 0 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 1,775 | 42,000 | SH | | DFND | 2 | 42,000 | 0 | 0 |
ACCELERON PHARMA INC | COM | 00434H108 | 1,950 | 21,700 | SH | | DFND | 2 | 21,700 | 0 | 0 |
ADOBE INC | COM | 00724F101 | 477 | 1,500 | SH | | DFND | 2 | 1,500 | 0 | 0 |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 444 | 6,200 | SH | | DFND | 2 | 6,200 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 2,597 | 73,200 | SH | | DFND | 2 | 73,200 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 135,968 | 3,832,244 | SH | | DFND | 1,2 | 3,832,244 | 0 | 0 |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 10,801 | 755,296 | SH | | DFND | 2 | 755,296 | 0 | 0 |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 35,020 | 2,448,948 | SH | | DFND | 1,2 | 2,448,948 | 0 | 0 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 3,313 | 36,900 | SH | | DFND | 2 | 36,900 | 0 | 0 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 116,227 | 1,294,428 | SH | | DFND | 1,2 | 1,294,428 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 35,325 | 203,076 | SH | | DFND | 2 | 203,076 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 34,316 | 315,264 | SH | | DFND | 2 | 315,264 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 158,921 | 1,460,000 | SH | | DFND | 1,2 | 1,460,000 | 0 | 0 |
AMEDISYS INC | COM | 023436108 | 11,222 | 61,143 | SH | | DFND | 2 | 61,143 | 0 | 0 |
AMERICAN EXPRESS CO | COM | 025816109 | 308 | 3,600 | SH | | DFND | 2 | 3,600 | 0 | 0 |
AMGEN INC | COM | 031162100 | 26,674 | 131,573 | SH | | DFND | 2 | 131,573 | 0 | 0 |
ANALOG DEVICES INC | COM | 032654105 | 368 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
ANSYS INC | COM | 03662Q105 | 419 | 1,802 | SH | | DFND | 2 | 1,802 | 0 | 0 |
ANTHEM INC | COM | 036752103 | 83,007 | 365,603 | SH | | DFND | 2 | 365,603 | 0 | 0 |
APELLIS PHARMACUETICALS INC | COM | 03753U106 | 801 | 29,900 | SH | | DFND | 2 | 29,900 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 3,921 | 29,765 | SH | | DFND | 2 | 29,765 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 124,450 | 944,739 | SH | | DFND | 1,2 | 944,739 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 1,104 | 27,400 | SH | | DFND | 2 | 27,400 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 50,049 | 1,241,903 | SH | | DFND | 1,2 | 1,241,903 | 0 | 0 |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 1,340 | 11,900 | SH | | DFND | 2 | 11,900 | 0 | 0 |
ASPEN TECHNOLOGY INC | COM | 045327103 | 285 | 3,000 | SH | | DFND | 2 | 3,000 | 0 | 0 |
AUTOLIV INC | COM | 052800109 | 313 | 6,800 | SH | | DFND | 2 | 6,800 | 0 | 0 |
AVANTOR INC | COM | 05352A100 | 3,929 | 314,566 | SH | | DFND | 2 | 314,566 | 0 | 0 |
AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 4,557 | 179,333 | SH | | DFND | 2 | 179,333 | 0 | 0 |
BAXTER INTL INC | COM | 071813109 | 48,058 | 591,921 | SH | | DFND | 2 | 591,921 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 56,768 | 247,064 | SH | | DFND | 2 | 247,064 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 7,202 | 58,500 | SH | | DFND | 2 | 58,500 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 2,689 | 8,500 | SH | | DFND | 2 | 8,500 | 0 | 0 |
BIOGEN INC | COM | 09062X103 | 7 | 160 | SH | Call | DFND | 2 | 160 | 0 | 0 |
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 844 | 24,800 | SH | | DFND | 2 | 24,800 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 6,092 | 72,100 | SH | | DFND | 2 | 72,100 | 0 | 0 |
BIO RAD LABS INC | CL A | 090572207 | 21,865 | 62,373 | SH | | DFND | 2 | 62,373 | 0 | 0 |
BLACKBAUD INC | COM | 09227Q100 | 228 | 4,107 | SH | | DFND | 2 | 4,107 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 33,184 | 1,330,000 | SH | | DFND | 1,2 | 1,330,000 | 0 | 0 |
BLUEBIRD BIO INC | COM | 09609G100 | 910 | 19,800 | SH | | DFND | 2 | 19,800 | 0 | 0 |
BOOKING HLDGS INC | COM | 09857L108 | 269 | 200 | SH | | DFND | 2 | 200 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 50,290 | 1,541,225 | SH | | DFND | 2 | 1,541,225 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 67,193 | 1,205,472 | SH | | DFND | 2 | 1,205,472 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | RIGHT 99/99/9999 | 110122157 | 63 | 16,600 | SH | | DFND | 2 | 16,600 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | RIGHT 99/99/9999 | 110122157 | 3,040 | 800,000 | SH | | DFND | 1,2 | 800,000 | 0 | 0 |
BROADRIDGE FINL SOLUTIONS IN | COM | 11133T103 | 322 | 3,400 | SH | | DFND | 2 | 3,400 | 0 | 0 |
BROWN FORMAN CORP | CL B | 115637209 | 422 | 7,600 | SH | | DFND | 2 | 7,600 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 27,878 | 1,277,051 | SH | | DFND | 2 | 1,277,051 | 0 | 0 |
CATALENT INC | COM | 148806102 | 2,447 | 47,100 | SH | | DFND | 2 | 47,100 | 0 | 0 |
CELLECTIS S A | SPONSORED ADS | 15117K103 | 693 | 75,300 | SH | | DFND | 2 | 75,300 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 48,138 | 810,270 | SH | | DFND | 2 | 810,270 | 0 | 0 |
CHANGE HEALTHCARE INC | COM | 15912K100 | 10,765 | 1,077,575 | SH | | DFND | 2 | 1,077,575 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 41,854 | 331,623 | SH | | DFND | 2 | 331,623 | 0 | 0 |
CHINA BIOLOGIC PRODS HLDGS I | COM | G21515104 | 486 | 4,500 | SH | | DFND | 2 | 4,500 | 0 | 0 |
CIDARA THERAPEUTICS INC | COM | 171757107 | 7,000 | 2,822,495 | SH | | DFND | 1,2 | 2,822,495 | 0 | 0 |
CIGNA CORP NEW | COM | 125523100 | 61,887 | 349,289 | SH | | DFND | 2 | 349,289 | 0 | 0 |
CLOROX CO DEL | COM | 189054109 | 485 | 2,800 | SH | | DFND | 2 | 2,800 | 0 | 0 |
CLOVIS ONCOLOGY INC | COM | 189464100 | 453 | 71,200 | SH | | DFND | 2 | 71,200 | 0 | 0 |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 787 | 48,500 | SH | | DFND | 2 | 48,500 | 0 | 0 |
COLGATE PALMOLIVE CO | COM | 194162103 | 405 | 6,100 | SH | | DFND | 2 | 6,100 | 0 | 0 |
CONSTELLATION BRANDS INC | CL A | 21036P108 | 295 | 2,059 | SH | | DFND | 2 | 2,059 | 0 | 0 |
COOPER COS INC | COM NEW | 216648402 | 6,987 | 25,345 | SH | | DFND | 2 | 25,345 | 0 | 0 |
COSTAR GROUP INC | COM | 22160N109 | 411 | 700 | SH | | DFND | 2 | 700 | 0 | 0 |
COVETRUS INC | COM | 22304C100 | 12 | 1,520 | SH | | DFND | 2 | 1,520 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 33,948 | 800,462 | SH | | DFND | 1,2 | 800,462 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 12,636 | 212,981 | SH | | DFND | 2 | 212,981 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 47,818 | 345,481 | SH | | DFND | 2 | 345,481 | 0 | 0 |
DENTSPLY SIRONA INC | COM | 24906P109 | 4,972 | 128,038 | SH | | DFND | 2 | 128,038 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 27,285 | 101,328 | SH | | DFND | 2 | 101,328 | 0 | 0 |
DIREXION SHS ETF TR | SP BIOTECH BL NEW | 25490K323 | 338 | 15,000 | SH | | DFND | 2 | 15,000 | 0 | 0 |
DOMINOS PIZZA INC | COM | 25754A201 | 616 | 1,900 | SH | | DFND | 2 | 1,900 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 44,130 | 233,965 | SH | | DFND | 2 | 233,965 | 0 | 0 |
ELECTRONIC ARTS INC | COM | 285512109 | 481 | 4,800 | SH | | DFND | 2 | 4,800 | 0 | 0 |
ENTEGRIS INC | COM | 29362U104 | 461 | 10,300 | SH | | DFND | 2 | 10,300 | 0 | 0 |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 40,671 | 1,289,926 | SH | | DFND | 2 | 1,289,926 | 0 | 0 |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 118,173 | 3,747,964 | SH | | DFND | 1,2 | 3,747,964 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 24,872 | 4,580,458 | SH | | DFND | 2 | 4,580,458 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 19,638 | 1,140,400 | SH | | DFND | 2 | 1,140,400 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 48,819 | 2,835,000 | SH | | DFND | 1,2 | 2,835,000 | 0 | 0 |
FACTSET RESH SYS INC | COM | 303075105 | 443 | 1,700 | SH | | DFND | 2 | 1,700 | 0 | 0 |
FASTENAL CO | COM | 311900104 | 603 | 19,299 | SH | | DFND | 2 | 19,299 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 1,950 | 87,800 | SH | | DFND | 2 | 87,800 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 32,769 | 1,475,400 | SH | | DFND | 1,2 | 1,475,400 | 0 | 0 |
FIBROGEN INC | COM | 31572Q808 | 1,307 | 37,600 | SH | | DFND | 2 | 37,600 | 0 | 0 |
G1 THERAPEUTICS INC | COM | 3621LQ109 | 7,956 | 721,925 | SH | | DFND | 1,2 | 721,925 | 0 | 0 |
GENMARK DIAGNOSTICS INC | COM | 372309104 | 9,937 | 2,411,926 | SH | | DFND | 2 | 2,411,926 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 10,803 | 144,500 | SH | | DFND | 2 | 144,500 | 0 | 0 |
GLAUKOS CORP | COM | 377322102 | 12,734 | 412,623 | SH | | DFND | 2 | 412,623 | 0 | 0 |
GLOBUS MED INC | CL A | 379577208 | 14,378 | 338,067 | SH | | DFND | 2 | 338,067 | 0 | 0 |
GRACO INC | COM | 384109104 | 473 | 9,700 | SH | | DFND | 2 | 9,700 | 0 | 0 |
GUARDANT HEALTH INC | COM | 40131M109 | 7,328 | 105,294 | SH | | DFND | 2 | 105,294 | 0 | 0 |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 21,977 | 250,966 | SH | | DFND | 2 | 250,966 | 0 | 0 |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 1,725 | 95,900 | SH | | DFND | 2 | 95,900 | 0 | 0 |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 136,149 | 7,568,056 | SH | | DFND | 1,2 | 7,568,056 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 24,526 | 272,966 | SH | | DFND | 2 | 272,966 | 0 | 0 |
HEALTH CATALYST INC | COM | 42225T107 | 6,616 | 253,000 | SH | | DFND | 2 | 253,000 | 0 | 0 |
HILL ROM HLDGS INC | COM | 431475102 | 29,725 | 295,479 | SH | | DFND | 2 | 295,479 | 0 | 0 |
HMS HLDGS CORP | COM | 40425J101 | 14,535 | 575,177 | SH | | DFND | 2 | 575,177 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 19,929 | 567,779 | SH | | DFND | 2 | 567,779 | 0 | 0 |
HOMOLOGY MEDICINES INC | COM | 438083107 | 25,052 | 1,612,122 | SH | | DFND | 1,2 | 1,612,122 | 0 | 0 |
HORIZON THERAPEUTICS PUB LTD | SHS | G46188101 | 4,917 | 166,000 | SH | | DFND | 2 | 166,000 | 0 | 0 |
HUAZHU GROUP LTD | SPONSORED ADS | 44332N106 | 388 | 13,500 | SH | | DFND | 2 | 13,500 | 0 | 0 |
HUMANA INC | COM | 444859102 | 62,213 | 198,118 | SH | | DFND | 2 | 198,118 | 0 | 0 |
HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 15,208 | 851,994 | SH | | DFND | 2 | 851,994 | 0 | 0 |
IDEXX LABS INC | COM | 45168D104 | 10,153 | 41,911 | SH | | DFND | 2 | 41,911 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 54,348 | 198,988 | SH | | DFND | 2 | 198,988 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 11,277 | 154,000 | SH | | DFND | 2 | 154,000 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 232,139 | 3,170,000 | SH | | DFND | 1,2 | 3,170,000 | 0 | 0 |
INOGEN INC | COM | 45780L104 | 6,375 | 123,395 | SH | | DFND | 2 | 123,395 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 25,864 | 1,613,470 | SH | | DFND | 2 | 1,613,470 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 8,272 | 137,225 | SH | | DFND | 2 | 137,225 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 16,957 | 102,350 | SH | | DFND | 2 | 102,350 | 0 | 0 |
INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 8,819 | 197,420 | SH | | DFND | 2 | 197,420 | 0 | 0 |
INTERACTIVE BROKERS GROUP IN | COM CL A | 45841N107 | 406 | 9,400 | SH | | DFND | 2 | 9,400 | 0 | 0 |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 756 | 12,000 | SH | | DFND | 2 | 12,000 | 0 | 0 |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 43,882 | 696,976 | SH | | DFND | 1,2 | 696,976 | 0 | 0 |
INTERCONTINENTAL EXCHANGE IN | COM | 45866F104 | 388 | 4,800 | SH | | DFND | 2 | 4,800 | 0 | 0 |
INTERSECT ENT INC | COM | 46071F103 | 6,459 | 545,022 | SH | | DFND | 2 | 545,022 | 0 | 0 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 1,128 | 73,400 | SH | | DFND | 2 | 73,400 | 0 | 0 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 56,230 | 3,658,419 | SH | | DFND | 1,2 | 3,658,419 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 109,130 | 220,371 | SH | | DFND | 2 | 220,371 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 22,334 | 472,387 | SH | | DFND | 2 | 472,387 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 373,855 | 7,907,255 | SH | | DFND | 1,2 | 7,907,255 | 0 | 0 |
IPG PHOTONICS CORP | COM | 44980X109 | 386 | 3,500 | SH | | DFND | 2 | 3,500 | 0 | 0 |
IQVIA HLDGS INC | COM | 46266C105 | 205 | 1,900 | SH | | DFND | 2 | 1,900 | 0 | 0 |
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 10,841 | 133,259 | SH | | DFND | 2 | 133,259 | 0 | 0 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 37,037 | 371,337 | SH | | DFND | 2 | 371,337 | 0 | 0 |
JD COM INC | SPON ADR CL A | 47215P106 | 595 | 14,700 | SH | | DFND | 2 | 14,700 | 0 | 0 |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 15,342 | 3,518,889 | SH | | DFND | 1,2 | 3,518,889 | 0 | 0 |
KOSMOS ENERGY LTD | COM | 500688106 | 54 | 60,000 | SH | | DFND | 2 | 60,000 | 0 | 0 |
KURA ONCOLOGY INC | COM | 50127T109 | 568 | 57,100 | SH | | DFND | 2 | 57,100 | 0 | 0 |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 2,257 | 17,861 | SH | | DFND | 2 | 17,861 | 0 | 0 |
LAUDER ESTEE COS INC | CL A | 518439104 | 358 | 2,248 | SH | | DFND | 2 | 2,248 | 0 | 0 |
LIVE NATION ENTERTAINMENT IN | COM | 538034109 | 282 | 6,200 | SH | | DFND | 2 | 6,200 | 0 | 0 |
LIVONGO HEALTH INC | COM | 539183103 | 7,738 | 271,232 | SH | | DFND | 2 | 271,232 | 0 | 0 |
M & T BK CORP | COM | 55261F104 | 310 | 3,000 | SH | | DFND | 2 | 3,000 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 8,090 | 1,389,991 | SH | | DFND | 2 | 1,389,991 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 27,524 | 4,729,159 | SH | | DFND | 1,2 | 4,729,159 | 0 | 0 |
MARKEL CORP | COM | 570535104 | 371 | 400 | SH | | DFND | 2 | 400 | 0 | 0 |
MARKETAXESS HLDGS INC | COM | 57060D108 | 440 | 1,322 | SH | | DFND | 2 | 1,322 | 0 | 0 |
MASIMO CORP | COM | 574795100 | 16,338 | 92,245 | SH | | DFND | 2 | 92,245 | 0 | 0 |
MATCH GROUP INC | COM | 57665R106 | 350 | 5,300 | SH | | DFND | 2 | 5,300 | 0 | 0 |
MCCORMICK & CO INC | COM NON VTG | 579780206 | 395 | 2,800 | SH | | DFND | 2 | 2,800 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 526 | 3,892 | SH | | DFND | 2 | 3,892 | 0 | 0 |
MEDTRONIC PLC | SHS | G5960L103 | 85,249 | 945,316 | SH | | DFND | 2 | 945,316 | 0 | 0 |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 483 | 700 | SH | | DFND | 2 | 700 | 0 | 0 |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 1,222 | 15,900 | SH | | DFND | 2 | 15,900 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 3,965 | 132,400 | SH | | DFND | 2 | 132,400 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 114,343 | 3,817,781 | SH | | DFND | 1,2 | 3,817,781 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM | 608550109 | 38,682 | 2,910,640 | SH | | DFND | 1,2 | 2,910,640 | 0 | 0 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 17,912 | 128,206 | SH | | DFND | 2 | 128,206 | 0 | 0 |
MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 1,833 | 67,400 | SH | | DFND | 2 | 67,400 | 0 | 0 |
MOODYS CORP | COM | 615369105 | 423 | 2,000 | SH | | DFND | 2 | 2,000 | 0 | 0 |
MSCI INC | COM | 55354G100 | 516 | 1,786 | SH | | DFND | 2 | 1,786 | 0 | 0 |
MYOKARDIA INC | COM | 62857M105 | 2,194 | 46,800 | SH | | DFND | 2 | 46,800 | 0 | 0 |
MYOKARDIA INC | COM | 62857M105 | 59,299 | 1,264,913 | SH | | DFND | 1,2 | 1,264,913 | 0 | 0 |
MYOVANT SCIENCES LTD | COM | G637AM102 | 36,354 | 4,815,109 | SH | | DFND | 1,2 | 4,815,109 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 15,423 | 864,037 | SH | | DFND | 2 | 864,037 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 46,779 | 2,620,676 | SH | | DFND | 1,2 | 2,620,676 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 7,045 | 81,400 | SH | | DFND | 2 | 81,400 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 275,062 | 3,178,074 | SH | | DFND | 1,2 | 3,178,074 | 0 | 0 |
NEURONETICS INC | COM | 64131A105 | 616 | 325,961 | SH | | DFND | 2 | 325,961 | 0 | 0 |
NEVRO CORP | COM | 64157F103 | 7,989 | 79,906 | SH | | DFND | 2 | 79,906 | 0 | 0 |
OMNICELL INC | COM | 68213N109 | 12,863 | 196,136 | SH | | DFND | 2 | 196,136 | 0 | 0 |
OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 6,133 | 662,315 | SH | | DFND | 2 | 662,315 | 0 | 0 |
PACIFIC BIOSIENCES CALIF IN | COM | 69404D108 | 22,579 | 7,378,791 | SH | | DFND | 2 | 7,378,791 | 0 | 0 |
PALO ALTO NETWORKS INC | COM | 697435105 | 2,787 | 17,000 | SH | | DFND | 2 | 17,000 | 0 | 0 |
PAYCHEX INC | COM | 704326107 | 340 | 5,400 | SH | | DFND | 2 | 5,400 | 0 | 0 |
PENUMBRA INC | COM | 70975L107 | 13,251 | 82,139 | SH | | DFND | 2 | 82,139 | 0 | 0 |
PERKINELMER INC | COM | 714046109 | 361 | 4,800 | SH | | DFND | 2 | 4,800 | 0 | 0 |
PERRIGO CO PLC | SHS | G97822103 | 981 | 20,400 | SH | | DFND | 2 | 20,400 | 0 | 0 |
PFIZER INC | COM | 717081103 | 2,938 | 90,000 | SH | | DFND | 2 | 90,000 | 0 | 0 |
PHREESIA INC | COM | 71944F106 | 7,592 | 360,998 | SH | | DFND | 2 | 360,998 | 0 | 0 |
POLYONE CORP | COM | 73179P106 | 258 | 13,600 | SH | | DFND | 2 | 13,600 | 0 | 0 |
POOL CORPORATION | COM | 73278L105 | 433 | 2,200 | SH | | DFND | 2 | 2,200 | 0 | 0 |
PTC THERAPEUTICS INC | COM | 69366J200 | 2,909 | 65,200 | SH | | DFND | 2 | 65,200 | 0 | 0 |
QIAGEN NV | SHS NEW | N72482123 | 3,852 | 92,600 | SH | | DFND | 2 | 92,600 | 0 | 0 |
QUANTERIX CORP | COM | 74766Q101 | 8,187 | 445,673 | SH | | DFND | 2 | 445,673 | 0 | 0 |
QUIDEL CORP | COM | 74838J101 | 11,146 | 113,955 | SH | | DFND | 2 | 113,955 | 0 | 0 |
QUOTIENT LTD | SHS | G73268107 | 1,406 | 355,899 | SH | | DFND | 2 | 355,899 | 0 | 0 |
RADIUS HEALTH INC | COM NEW | 750469207 | 1,322 | 101,700 | SH | | DFND | 2 | 101,700 | 0 | 0 |
RADIUS HEALTH INC | COM NEW | 750469207 | 89,462 | 6,881,685 | SH | | DFND | 1,2 | 6,881,685 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 9,326 | 19,100 | SH | | DFND | 2 | 19,100 | 0 | 0 |
REGENXBIO INC | COM | 75901B107 | 1,195 | 36,900 | SH | | DFND | 2 | 36,900 | 0 | 0 |
REPLIGEN CORP | COM | 759916109 | 1,313 | 13,600 | SH | | DFND | 2 | 13,600 | 0 | 0 |
RESMED INC | COM | 761152107 | 11,563 | 78,505 | SH | | DFND | 2 | 78,505 | 0 | 0 |
S&P GLOBAL INC | COM | 78409V104 | 417 | 1,700 | SH | | DFND | 2 | 1,700 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 517 | 18,000 | SH | | DFND | 2 | 18,000 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 40,211 | 1,400,104 | SH | | DFND | 1,2 | 1,400,104 | 0 | 0 |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 24,525 | 3,850,000 | SH | | DFND | 1,2 | 3,850,000 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 1,956 | 20,000 | SH | | DFND | 2 | 20,000 | 0 | 0 |
SCHOLAR ROCK HOLDING CORP | COM | 80706P103 | 32,880 | 2,715,106 | SH | | DFND | 1,2 | 2,715,106 | 0 | 0 |
SEATTLE GENETICS INC | COM | 812578102 | 4,777 | 41,400 | SH | | DFND | 2 | 41,400 | 0 | 0 |
SENSATA TECHNOLOGIES HLDNG P | SHS | G8060N102 | 286 | 9,900 | SH | | DFND | 2 | 9,900 | 0 | 0 |
SERVICE CORP INTL | COM | 817565104 | 332 | 8,500 | SH | | DFND | 2 | 8,500 | 0 | 0 |
SHOCKWAVE MED INC | COM | 82489T104 | 10,772 | 324,661 | SH | | DFND | 2 | 324,661 | 0 | 0 |
SILK RD MED INC | COM | 82710M100 | 6,125 | 194,583 | SH | | DFND | 2 | 194,583 | 0 | 0 |
SKYWORKS SOLUTIONS INC | COM | 83088M102 | 509 | 5,700 | SH | | DFND | 2 | 5,700 | 0 | 0 |
SOCIEDAD QUIMICA MINERA DE C | SPON ADR SER B | 833635105 | 410 | 18,200 | SH | | DFND | 2 | 18,200 | 0 | 0 |
STARBUCKS CORP | COM | 855244109 | 285 | 4,334 | SH | | DFND | 2 | 4,334 | 0 | 0 |
STRYKER CORP | COM | 863667101 | 28,755 | 172,713 | SH | | DFND | 2 | 172,713 | 0 | 0 |
SUPERNUS PHARMACEUTICALS INC | COM | 868459108 | 9,945 | 552,800 | SH | | DFND | 2 | 552,800 | 0 | 0 |
SYNEOS HEALTH INC | CL A | 87166B102 | 2,440 | 61,900 | SH | | DFND | 2 | 61,900 | 0 | 0 |
TABULA RASA HEALTHCARE INC | COM | 873379101 | 10,919 | 208,809 | SH | | DFND | 2 | 208,809 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 12,551 | 195,038 | SH | | DFND | 2 | 195,038 | 0 | 0 |
TELADOC HEALTH INC | COM | 87918A105 | 31,193 | 201,235 | SH | | DFND | 2 | 201,235 | 0 | 0 |
TELEFLEX INCORPORATED | COM | 879369106 | 22,941 | 78,333 | SH | | DFND | 2 | 78,333 | 0 | 0 |
TEVA PHARMACEUTICAL INDS LTD | SPONSORED ADS | 881624209 | 2,721 | 303,000 | SH | | DFND | 2 | 303,000 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 11,217 | 39,552 | SH | | DFND | 2 | 39,552 | 0 | 0 |
TRANSUNION | COM | 89400J107 | 337 | 5,096 | SH | | DFND | 2 | 5,096 | 0 | 0 |
TRIMBLE INC | COM | 896239100 | 372 | 11,700 | SH | | DFND | 2 | 11,700 | 0 | 0 |
TRIP COM GROUP LTD | ADS | 89677Q107 | 307 | 13,100 | SH | | DFND | 2 | 13,100 | 0 | 0 |
TYLER TECHNOLOGIES INC | COM | 902252105 | 452 | 1,525 | SH | | DFND | 2 | 1,525 | 0 | 0 |
UBER TECHNOLOGIES INC | COM | 90353T100 | 2,792 | 100,000 | SH | | DFND | 2 | 100,000 | 0 | 0 |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 955 | 21,500 | SH | | DFND | 2 | 21,500 | 0 | 0 |
UNIQURE NV | SHS | N90064101 | 1,495 | 31,500 | SH | | DFND | 2 | 31,500 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 78,856 | 316,208 | SH | | DFND | 2 | 316,208 | 0 | 0 |
VARIAN MED SYS INC | COM | 92220P105 | 421 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
VEEVA SYS INC | CL A COM | 922475108 | 7,957 | 50,884 | SH | | DFND | 2 | 50,884 | 0 | 0 |
VERISIGN INC | COM | 92343E102 | 378 | 2,100 | SH | | DFND | 2 | 2,100 | 0 | 0 |
VERISK ANALYTICS INC | COM | 92345Y106 | 347 | 2,489 | SH | | DFND | 2 | 2,489 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 38,807 | 163,089 | SH | | DFND | 2 | 163,089 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 264,125 | 1,110,000 | SH | | DFND | 1,2 | 1,110,000 | 0 | 0 |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 7,449 | 350,724 | SH | | DFND | 2 | 350,724 | 0 | 0 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 401 | 43,800 | SH | | DFND | 2 | 43,800 | 0 | 0 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 24,525 | 2,680,283 | SH | | DFND | 1,2 | 2,680,283 | 0 | 0 |
WABTEC CORP | COM | 929740108 | 308 | 6,400 | SH | | DFND | 2 | 6,400 | 0 | 0 |
WATSCO INC | COM | 942622200 | 442 | 2,800 | SH | | DFND | 2 | 2,800 | 0 | 0 |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 24,389 | 2,602,858 | SH | | DFND | 1,2 | 2,602,858 | 0 | 0 |
XILINX INC | COM | 983919101 | 327 | 4,200 | SH | | DFND | 2 | 4,200 | 0 | 0 |
ZAI LAB LTD | ADR | 98887Q104 | 7,928 | 154,000 | SH | | DFND | 2 | 154,000 | 0 | 0 |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 10,596 | 104,832 | SH | | DFND | 2 | 104,832 | 0 | 0 |
ZYMEWORKS INC | COM | 98985W102 | 653 | 18,400 | SH | | DFND | 2 | 18,400 | 0 | 0 |