COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
1LIFE HEALTHCARE INC | COM | 68269G107 | 16,228 | 446,807 | SH | | DFND | 2 | 446,807 | 0 | 0 |
10X GENOMICS INC | CL A COM | 88025U109 | 10,992 | 123,077 | SH | | DFND | 2 | 123,077 | 0 | 0 |
111 INC | ADS | 68247Q102 | 1,083 | 170,525 | SH | | DFND | 2 | 170,525 | 0 | 0 |
ABBOTT LABS | COM | 002824100 | 117,421 | 1,284,272 | SH | | DFND | 2 | 1,284,272 | 0 | 0 |
ABBVIE INC | COM | 00287Y109 | 3,633 | 37,000 | SH | | DFND | 2 | 37,000 | 0 | 0 |
ABIOMED INC | COM | 003654100 | 23,359 | 96,699 | SH | | DFND | 2 | 96,699 | 0 | 0 |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 2,176 | 44,900 | SH | | DFND | 2 | 44,900 | 0 | 0 |
ADOBE INC | COM | 00724F101 | 479 | 1,100 | SH | | DFND | 2 | 1,100 | 0 | 0 |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 548 | 6,200 | SH | | DFND | 2 | 6,200 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 2,252 | 42,100 | SH | | DFND | 2 | 42,100 | 0 | 0 |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 212,929 | 3,981,473 | SH | | DFND | 1,2 | 3,981,473 | 0 | 0 |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 11,813 | 862,296 | SH | | DFND | 2 | 862,296 | 0 | 0 |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 8,220 | 600,000 | SH | | DFND | 1,2 | 600,000 | 0 | 0 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 13,289 | 118,400 | SH | | DFND | 2 | 118,400 | 0 | 0 |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 145,287 | 1,294,428 | SH | | DFND | 1,2 | 1,294,428 | 0 | 0 |
ALIGN TECHNOLOGY INC | COM | 016255101 | 27,134 | 98,869 | SH | | DFND | 2 | 98,869 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 50,367 | 340,065 | SH | | DFND | 2 | 340,065 | 0 | 0 |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 188,100 | 1,270,000 | SH | | DFND | 1,2 | 1,270,000 | 0 | 0 |
AMEDISYS INC | COM | 023436108 | 12,139 | 61,143 | SH | | DFND | 2 | 61,143 | 0 | 0 |
AMERICAN EXPRESS CO | COM | 025816109 | 343 | 3,600 | SH | | DFND | 2 | 3,600 | 0 | 0 |
AMGEN INC | COM | 031162100 | 39,616 | 167,963 | SH | | DFND | 2 | 167,963 | 0 | 0 |
ANALOG DEVICES INC | COM | 032654105 | 503 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
ANSYS INC | COM | 03662Q105 | 526 | 1,802 | SH | | DFND | 2 | 1,802 | 0 | 0 |
ANTHEM INC | COM | 036752103 | 81,530 | 310,025 | SH | | DFND | 2 | 310,025 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 5,409 | 24,016 | SH | | DFND | 2 | 24,016 | 0 | 0 |
ARGENX SE | SPONSORED ADR | 04016X101 | 209,464 | 930,000 | SH | | DFND | 1,2 | 930,000 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 1,503 | 44,800 | SH | | DFND | 2 | 44,800 | 0 | 0 |
ARVINAS INC | COM | 04335A105 | 51,548 | 1,536,903 | SH | | DFND | 1,2 | 1,536,903 | 0 | 0 |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 1,967 | 13,300 | SH | | DFND | 2 | 13,300 | 0 | 0 |
ASPEN TECHNOLOGY INC | COM | 045327103 | 311 | 3,000 | SH | | DFND | 2 | 3,000 | 0 | 0 |
AUTOLIV INC | COM | 052800109 | 439 | 6,800 | SH | | DFND | 2 | 6,800 | 0 | 0 |
AVANTOR INC | COM | 05352A100 | 6,203 | 364,877 | SH | | DFND | 2 | 364,877 | 0 | 0 |
AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 18,132 | 516,428 | SH | | DFND | 2 | 516,428 | 0 | 0 |
BAXTER INTL INC | COM | 071813109 | 53,855 | 625,495 | SH | | DFND | 2 | 625,495 | 0 | 0 |
BECTON DICKINSON & CO | COM | 075887109 | 58,846 | 245,940 | SH | | DFND | 2 | 245,940 | 0 | 0 |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 10,927 | 58,000 | SH | | DFND | 2 | 58,000 | 0 | 0 |
BIOMARIN PHARMACEUTICAL INC | COM | 09061G101 | 9,485 | 76,900 | SH | | DFND | 2 | 76,900 | 0 | 0 |
BIONTECH SE | SPONSORED ADS | 09075V102 | 3,337 | 50,000 | SH | | DFND | 2 | 50,000 | 0 | 0 |
BIO RAD LABS INC | CL A | 090572207 | 36,061 | 79,871 | SH | | DFND | 2 | 79,871 | 0 | 0 |
BLACKBAUD INC | COM | 09227Q100 | 234 | 4,107 | SH | | DFND | 2 | 4,107 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 548 | 13,000 | SH | | DFND | 2 | 13,000 | 0 | 0 |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 58,602 | 1,390,000 | SH | | DFND | 1,2 | 1,390,000 | 0 | 0 |
BOOKING HLDGS INC | COM | 09857L108 | 318 | 200 | SH | | DFND | 2 | 200 | 0 | 0 |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 60,762 | 1,730,620 | SH | | DFND | 2 | 1,730,620 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 94,792 | 1,612,112 | SH | | DFND | 2 | 1,612,112 | 0 | 0 |
BRISTOL MYERS SQUIBB CO | RIGHT 99/99/9999 | 110122157 | 2,864 | 800,000 | SH | | DFND | 1,2 | 800,000 | 0 | 0 |
BROADRIDGE FINL SOLUTIONS IN | COM | 11133T103 | 429 | 3,400 | SH | | DFND | 2 | 3,400 | 0 | 0 |
BROWN FORMAN CORP | CL B | 115637209 | 484 | 7,600 | SH | | DFND | 2 | 7,600 | 0 | 0 |
BURNING ROCK BIOTECH LTD | SPONSORED ADR | 12233L107 | 1,215 | 45,000 | SH | | DFND | 2 | 45,000 | 0 | 0 |
CAREDX INC | COM | 14167L103 | 41,341 | 1,166,839 | SH | | DFND | 2 | 1,166,839 | 0 | 0 |
CATALENT INC | COM | 148806102 | 418 | 5,700 | SH | | DFND | 2 | 5,700 | 0 | 0 |
CELLECTIS S A | SPON ADS | 15117K103 | 1,486 | 83,500 | SH | | DFND | 2 | 83,500 | 0 | 0 |
CENTENE CORP DEL | COM | 15135B101 | 66,267 | 1,042,747 | SH | | DFND | 2 | 1,042,747 | 0 | 0 |
CHANGE HEALTHCARE INC | COM | 15912K100 | 16,299 | 1,455,240 | SH | | DFND | 2 | 1,455,240 | 0 | 0 |
CHARLES RIV LABS INTL INC | COM | 159864107 | 63,783 | 365,833 | SH | | DFND | 2 | 365,833 | 0 | 0 |
CIDARA THERAPEUTICS INC | COM | 171757107 | 10,415 | 2,822,495 | SH | | DFND | 1,2 | 2,822,495 | 0 | 0 |
CIGNA CORP NEW | COM | 125523100 | 63,187 | 336,726 | SH | | DFND | 2 | 336,726 | 0 | 0 |
CLOROX CO DEL | COM | 189054109 | 439 | 2,000 | SH | | DFND | 2 | 2,000 | 0 | 0 |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 20,671 | 1,157,400 | SH | | DFND | 2 | 1,157,400 | 0 | 0 |
CONSTELLATION BRANDS INC | CL A | 21036P108 | 360 | 2,059 | SH | | DFND | 2 | 2,059 | 0 | 0 |
COOPER COS INC | COM NEW | 216648402 | 7,189 | 25,345 | SH | | DFND | 2 | 25,345 | 0 | 0 |
COSTAR GROUP INC | COM | 22160N109 | 497 | 700 | SH | | DFND | 2 | 700 | 0 | 0 |
COVETRUS INC | COM | 22304C100 | 27 | 1,520 | SH | | DFND | 2 | 1,520 | 0 | 0 |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 58,826 | 800,462 | SH | | DFND | 1,2 | 800,462 | 0 | 0 |
CVS HEALTH CORP | COM | 126650100 | 15,052 | 231,681 | SH | | DFND | 2 | 231,681 | 0 | 0 |
DANAHER CORPORATION | COM | 235851102 | 79,862 | 451,633 | SH | | DFND | 2 | 451,633 | 0 | 0 |
DAVITA INC | COM | 23918K108 | 23,758 | 300,200 | SH | | DFND | 2 | 300,200 | 0 | 0 |
DENTSPLY SIRONA INC | COM | 24906P109 | 7,011 | 159,129 | SH | | DFND | 2 | 159,129 | 0 | 0 |
DEXCOM INC | COM | 252131107 | 41,637 | 102,705 | SH | | DFND | 2 | 102,705 | 0 | 0 |
DOMINOS PIZZA INC | COM | 25754A201 | 369 | 1,000 | SH | | DFND | 2 | 1,000 | 0 | 0 |
DR REDDYS LABS LTD | ADR | 256135203 | 1,961 | 37,000 | SH | | DFND | 2 | 37,000 | 0 | 0 |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 54,713 | 791,682 | SH | | DFND | 2 | 791,682 | 0 | 0 |
ELECTRONIC ARTS INC | COM | 285512109 | 617 | 4,670 | SH | | DFND | 2 | 4,670 | 0 | 0 |
ENTEGRIS INC | COM | 29362U104 | 431 | 7,300 | SH | | DFND | 2 | 7,300 | 0 | 0 |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 79,796 | 1,555,171 | SH | | DFND | 2 | 1,555,171 | 0 | 0 |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 192,308 | 3,747,964 | SH | | DFND | 1,2 | 3,747,964 | 0 | 0 |
EVOLENT HEALTH INC | CL A | 30050B101 | 35,802 | 5,028,363 | SH | | DFND | 2 | 5,028,363 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 5,045 | 212,500 | SH | | DFND | 2 | 212,500 | 0 | 0 |
EXELIXIS INC | COM | 30161Q104 | 67,303 | 2,835,000 | SH | | DFND | 1,2 | 2,835,000 | 0 | 0 |
FACTSET RESH SYS INC | COM | 303075105 | 558 | 1,700 | SH | | DFND | 2 | 1,700 | 0 | 0 |
FASTENAL CO | COM | 311900104 | 428 | 10,000 | SH | | DFND | 2 | 10,000 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 3,122 | 91,000 | SH | | DFND | 2 | 91,000 | 0 | 0 |
FATE THERAPEUTICS INC | COM | 31189P102 | 64,173 | 1,870,400 | SH | | DFND | 1,2 | 1,870,400 | 0 | 0 |
FORTINET INC | COM | 34959E109 | 398 | 2,900 | SH | | DFND | 2 | 2,900 | 0 | 0 |
G1 THERAPEUTICS INC | COM | 3621LQ109 | 17,514 | 721,925 | SH | | DFND | 1,2 | 721,925 | 0 | 0 |
GENERATION BIO CO | COM | 37148K100 | 30,240 | 1,440,000 | SH | | DFND | 1,2 | 1,440,000 | 0 | 0 |
GENETRON HLDGS LTD | ADS | 37186H100 | 1,207 | 100,000 | SH | | DFND | 2 | 100,000 | 0 | 0 |
GENMARK DIAGNOSTICS INC | COM | 372309104 | 21,907 | 1,489,284 | SH | | DFND | 2 | 1,489,284 | 0 | 0 |
GILEAD SCIENCES INC | COM | 375558103 | 10,348 | 134,500 | SH | | DFND | 2 | 134,500 | 0 | 0 |
GLAUKOS CORP | COM | 377322102 | 18,972 | 493,811 | SH | | DFND | 2 | 493,811 | 0 | 0 |
GLOBUS MED INC | CL A | 379577208 | 16,590 | 347,729 | SH | | DFND | 2 | 347,729 | 0 | 0 |
GRACO INC | COM | 384109104 | 466 | 9,700 | SH | | DFND | 2 | 9,700 | 0 | 0 |
GUARDANT HEALTH INC | COM | 40131M109 | 10,268 | 126,561 | SH | | DFND | 2 | 126,561 | 0 | 0 |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 42,899 | 349,566 | SH | | DFND | 2 | 349,566 | 0 | 0 |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 2,279 | 85,000 | SH | | DFND | 2 | 85,000 | 0 | 0 |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 178,167 | 6,645,552 | SH | | DFND | 1,2 | 6,645,552 | 0 | 0 |
HCA HEALTHCARE INC | COM | 40412C101 | 33,308 | 343,166 | SH | | DFND | 2 | 343,166 | 0 | 0 |
HEALTH CATALYST INC | COM | 42225T107 | 10,185 | 349,169 | SH | | DFND | 2 | 349,169 | 0 | 0 |
HILL ROM HLDGS INC | COM | 431475102 | 46,250 | 421,294 | SH | | DFND | 2 | 421,294 | 0 | 0 |
HMS HLDGS CORP | COM | 40425J101 | 26,374 | 814,264 | SH | | DFND | 2 | 814,264 | 0 | 0 |
HOLOGIC INC | COM | 436440101 | 30,272 | 531,089 | SH | | DFND | 2 | 531,089 | 0 | 0 |
HOMOLOGY MEDICINES INC | COM | 438083107 | 26,387 | 1,737,122 | SH | | DFND | 1,2 | 1,737,122 | 0 | 0 |
HORIZON THERAPEUTICS PUB LTD | SHS | G46188101 | 8,793 | 158,200 | SH | | DFND | 2 | 158,200 | 0 | 0 |
HUAZHU GROUP LTD | SPONSORED ADS | 44332N106 | 473 | 13,500 | SH | | DFND | 2 | 13,500 | 0 | 0 |
HUMANA INC | COM | 444859102 | 91,369 | 235,640 | SH | | DFND | 2 | 235,640 | 0 | 0 |
HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 26,137 | 947,674 | SH | | DFND | 2 | 947,674 | 0 | 0 |
IDEXX LABS INC | COM | 45168D104 | 24,302 | 73,607 | SH | | DFND | 2 | 73,607 | 0 | 0 |
ILLUMINA INC | COM | 452327109 | 35,571 | 96,047 | SH | | DFND | 2 | 96,047 | 0 | 0 |
INARI MED INC | COM | 45332Y109 | 727 | 15,000 | SH | | DFND | 2 | 15,000 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 38,739 | 372,600 | SH | | DFND | 2 | 372,600 | 0 | 0 |
INCYTE CORP | COM | 45337C102 | 303,592 | 2,920,000 | SH | | DFND | 1,2 | 2,920,000 | 0 | 0 |
INOGEN INC | COM | 45780L104 | 5,289 | 148,912 | SH | | DFND | 2 | 148,912 | 0 | 0 |
INSMED INC | COM PAR $.01 | 457669307 | 40,103 | 1,456,174 | SH | | DFND | 2 | 1,456,174 | 0 | 0 |
INSPIRE MED SYS INC | COM | 457730109 | 21,255 | 244,250 | SH | | DFND | 2 | 244,250 | 0 | 0 |
INSULET CORP | COM | 45784P101 | 45,020 | 231,749 | SH | | DFND | 2 | 231,749 | 0 | 0 |
INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 9,440 | 200,897 | SH | | DFND | 2 | 200,897 | 0 | 0 |
INTERACTIVE BROKERS GROUP IN | COM CL A | 45841N107 | 393 | 9,400 | SH | | DFND | 2 | 9,400 | 0 | 0 |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 383 | 8,000 | SH | | DFND | 2 | 8,000 | 0 | 0 |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 33,392 | 696,976 | SH | | DFND | 1,2 | 696,976 | 0 | 0 |
INTERCONTINENTAL EXCHANGE IN | COM | 45866F104 | 440 | 4,800 | SH | | DFND | 2 | 4,800 | 0 | 0 |
INTERSECT ENT INC | COM | 46071F103 | 7,624 | 563,090 | SH | | DFND | 2 | 563,090 | 0 | 0 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 3,119 | 121,500 | SH | | DFND | 2 | 121,500 | 0 | 0 |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 93,912 | 3,658,419 | SH | | DFND | 1,2 | 3,658,419 | 0 | 0 |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 89,026 | 156,233 | SH | | DFND | 2 | 156,233 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 26,832 | 455,087 | SH | | DFND | 2 | 455,087 | 0 | 0 |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 459,581 | 7,794,786 | SH | | DFND | 1,2 | 7,794,786 | 0 | 0 |
IPG PHOTONICS CORP | COM | 44980X109 | 433 | 2,700 | SH | | DFND | 2 | 2,700 | 0 | 0 |
IQVIA HLDGS INC | COM | 46266C105 | 411 | 2,900 | SH | | DFND | 2 | 2,900 | 0 | 0 |
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 10,794 | 93,140 | SH | | DFND | 2 | 93,140 | 0 | 0 |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 32,124 | 291,136 | SH | | DFND | 2 | 291,136 | 0 | 0 |
JD.COM INC | SPON ADR CL A | 47215P106 | 524 | 8,700 | SH | | DFND | 2 | 8,700 | 0 | 0 |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 21,973 | 4,241,940 | SH | | DFND | 1,2 | 4,241,940 | 0 | 0 |
KOSMOS ENERGY LTD | COM | 500688106 | 100 | 60,000 | SH | | DFND | 2 | 60,000 | 0 | 0 |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 9,009 | 54,234 | SH | | DFND | 2 | 54,234 | 0 | 0 |
LAUDER ESTEE COS INC | CL A | 518439104 | 424 | 2,248 | SH | | DFND | 2 | 2,248 | 0 | 0 |
LEGEND BIOTECH CORP | SPONSORED ADS | 52490G102 | 5,714 | 134,261 | SH | | DFND | 2 | 134,261 | 0 | 0 |
LIVE NATION ENTERTAINMENT IN | COM | 538034109 | 275 | 6,200 | SH | | DFND | 2 | 6,200 | 0 | 0 |
LIVONGO HEALTH INC | COM | 539183103 | 19,343 | 257,258 | SH | | DFND | 2 | 257,258 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 16,253 | 582,116 | SH | | DFND | 2 | 582,116 | 0 | 0 |
MACROGENICS INC | COM | 556099109 | 123,406 | 4,420,000 | SH | | DFND | 1,2 | 4,420,000 | 0 | 0 |
MARKEL CORP | COM | 570535104 | 369 | 400 | SH | | DFND | 2 | 400 | 0 | 0 |
MARKETAXESS HLDGS INC | COM | 57060D108 | 412 | 822 | SH | | DFND | 2 | 822 | 0 | 0 |
MASIMO CORP | COM | 574795100 | 22,238 | 97,541 | SH | | DFND | 2 | 97,541 | 0 | 0 |
MATCH GROUP INC | COM | 57665R106 | 567 | 5,300 | SH | | DFND | 2 | 5,300 | 0 | 0 |
MCCORMICK & CO INC | COM NON VTG | 579780206 | 502 | 2,800 | SH | | DFND | 2 | 2,800 | 0 | 0 |
MCKESSON CORP | COM | 58155Q103 | 597 | 3,892 | SH | | DFND | 2 | 3,892 | 0 | 0 |
MEDTRONIC PLC | SHS | G5960L103 | 89,639 | 977,523 | SH | | DFND | 2 | 977,523 | 0 | 0 |
MERCADOLIBRE INC | COM | 58733R102 | 493 | 500 | SH | | DFND | 2 | 500 | 0 | 0 |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 564 | 700 | SH | | DFND | 2 | 700 | 0 | 0 |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 2,032 | 17,800 | SH | | DFND | 2 | 17,800 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 7,702 | 119,950 | SH | | DFND | 2 | 119,950 | 0 | 0 |
MODERNA INC | COM | 60770K107 | 207,077 | 3,225,000 | SH | | DFND | 1,2 | 3,225,000 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM | 608550109 | 441 | 32,000 | SH | | DFND | 2 | 32,000 | 0 | 0 |
MOLECULAR TEMPLATES INC | COM | 608550109 | 47,510 | 3,445,240 | SH | | DFND | 1,2 | 3,445,240 | 0 | 0 |
MOLINA HEALTHCARE INC | COM | 60855R100 | 29,291 | 164,572 | SH | | DFND | 2 | 164,572 | 0 | 0 |
MOMENTA PHARMACEUTICALS INC | COM | 60877T100 | 2,475 | 74,400 | SH | | DFND | 2 | 74,400 | 0 | 0 |
MOODYS CORP | COM | 615369105 | 549 | 2,000 | SH | | DFND | 2 | 2,000 | 0 | 0 |
MSCI INC | COM | 55354G100 | 396 | 1,186 | SH | | DFND | 2 | 1,186 | 0 | 0 |
MYOKARDIA INC | COM | 62857M105 | 2,744 | 28,400 | SH | | DFND | 2 | 28,400 | 0 | 0 |
MYOKARDIA INC | COM | 62857M105 | 114,003 | 1,179,913 | SH | | DFND | 1,2 | 1,179,913 | 0 | 0 |
MYOVANT SCIENCES LTD | COM | G637AM102 | 969 | 47,000 | SH | | DFND | 2 | 47,000 | 0 | 0 |
MYOVANT SCIENCES LTD | COM | G637AM102 | 94,852 | 4,600,000 | SH | | DFND | 1,2 | 4,600,000 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 21,176 | 914,337 | SH | | DFND | 2 | 914,337 | 0 | 0 |
NEKTAR THERAPEUTICS | COM | 640268108 | 60,695 | 2,620,676 | SH | | DFND | 1,2 | 2,620,676 | 0 | 0 |
NEOGENOMICS INC | COM NEW | 64049M209 | 15,040 | 485,470 | SH | | DFND | 2 | 485,470 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 35,490 | 290,900 | SH | | DFND | 2 | 290,900 | 0 | 0 |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 356,240 | 2,920,000 | SH | | DFND | 1,2 | 2,920,000 | 0 | 0 |
NEURONETICS INC | COM | 64131A105 | 483 | 250,000 | SH | | DFND | 2 | 250,000 | 0 | 0 |
NEVRO CORP | COM | 64157F103 | 13,352 | 111,762 | SH | | DFND | 2 | 111,762 | 0 | 0 |
NUVASIVE INC | COM | 670704105 | 3,701 | 66,500 | SH | | DFND | 2 | 66,500 | 0 | 0 |
OMNICELL INC | COM | 68213N109 | 14,274 | 202,131 | SH | | DFND | 2 | 202,131 | 0 | 0 |
OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 8,889 | 683,795 | SH | | DFND | 2 | 683,795 | 0 | 0 |
PACIFIC BIOSIENCES CALIF IN | COM | 69404D108 | 28,855 | 8,363,741 | SH | | DFND | 2 | 8,363,741 | 0 | 0 |
PAYCHEX INC | COM | 704326107 | 409 | 5,400 | SH | | DFND | 2 | 5,400 | 0 | 0 |
PENUMBRA INC | COM | 70975L107 | 17,552 | 98,152 | SH | | DFND | 2 | 98,152 | 0 | 0 |
PERKINELMER INC | COM | 714046109 | 471 | 4,800 | SH | | DFND | 2 | 4,800 | 0 | 0 |
PHREESIA INC | COM | 71944F106 | 10,666 | 377,169 | SH | | DFND | 2 | 377,169 | 0 | 0 |
POLYONE CORP | COM | 73179P106 | 357 | 13,600 | SH | | DFND | 2 | 13,600 | 0 | 0 |
POOL CORPORATION | COM | 73278L105 | 598 | 2,200 | SH | | DFND | 2 | 2,200 | 0 | 0 |
PTC THERAPEUTICS INC | COM | 69366J200 | 2,882 | 56,800 | SH | | DFND | 2 | 56,800 | 0 | 0 |
QUANTERIX CORP | COM | 74766Q101 | 13,079 | 477,515 | SH | | DFND | 2 | 477,515 | 0 | 0 |
QUEST DIAGNOSTICS INC | COM | 74834L100 | 6,838 | 60,005 | SH | | DFND | 2 | 60,005 | 0 | 0 |
QUOTIENT LTD | SHS | G73268107 | 4,434 | 599,154 | SH | | DFND | 2 | 599,154 | 0 | 0 |
RADIUS HEALTH INC | COM NEW | 750469207 | 1,032 | 75,700 | SH | | DFND | 2 | 75,700 | 0 | 0 |
RADIUS HEALTH INC | COM NEW | 750469207 | 94,479 | 6,931,685 | SH | | DFND | 1,2 | 6,931,685 | 0 | 0 |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 14,406 | 23,100 | SH | | DFND | 2 | 23,100 | 0 | 0 |
REGENXBIO INC | COM | 75901B107 | 1,510 | 41,000 | SH | | DFND | 2 | 41,000 | 0 | 0 |
RESMED INC | COM | 761152107 | 14,939 | 77,805 | SH | | DFND | 2 | 77,805 | 0 | 0 |
S&P GLOBAL INC | COM | 78409V104 | 560 | 1,700 | SH | | DFND | 2 | 1,700 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 640 | 15,400 | SH | | DFND | 2 | 15,400 | 0 | 0 |
SAGE THERAPEUTICS INC | COM | 78667J108 | 58,216 | 1,400,104 | SH | | DFND | 1,2 | 1,400,104 | 0 | 0 |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 34,496 | 3,850,000 | SH | | DFND | 1,2 | 3,850,000 | 0 | 0 |
SANOFI | SPONSORED ADR | 80105N105 | 2,910 | 57,000 | SH | | DFND | 2 | 57,000 | 0 | 0 |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 3,255 | 20,300 | SH | | DFND | 2 | 20,300 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 565 | 31,000 | SH | | DFND | 2 | 31,000 | 0 | 0 |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 49,442 | 2,715,106 | SH | | DFND | 1,2 | 2,715,106 | 0 | 0 |
SEATTLE GENETICS INC | COM | 812578102 | 9,329 | 54,900 | SH | | DFND | 2 | 54,900 | 0 | 0 |
SENSATA TECHNOLOGIES HLDNG P | SHS | G8060N102 | 369 | 9,900 | SH | | DFND | 2 | 9,900 | 0 | 0 |
SERVICE CORP INTL | COM | 817565104 | 331 | 8,500 | SH | | DFND | 2 | 8,500 | 0 | 0 |
SHOCKWAVE MED INC | COM | 82489T104 | 19,805 | 418,089 | SH | | DFND | 2 | 418,089 | 0 | 0 |
SILK RD MED INC | COM | 82710M100 | 10,277 | 245,338 | SH | | DFND | 2 | 245,338 | 0 | 0 |
SKYWORKS SOLUTIONS INC | COM | 83088M102 | 473 | 3,700 | SH | | DFND | 2 | 3,700 | 0 | 0 |
SOCIEDAD QUIMICA MINERA DE C | SPON ADR SER B | 833635105 | 474 | 18,200 | SH | | DFND | 2 | 18,200 | 0 | 0 |
STARBUCKS CORP | COM | 855244109 | 319 | 4,334 | SH | | DFND | 2 | 4,334 | 0 | 0 |
STRYKER CORP | COM | 863667101 | 58,371 | 323,942 | SH | | DFND | 2 | 323,942 | 0 | 0 |
TABULA RASA HEALTHCARE INC | COM | 873379101 | 11,853 | 216,581 | SH | | DFND | 2 | 216,581 | 0 | 0 |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 22,934 | 231,839 | SH | | DFND | 2 | 231,839 | 0 | 0 |
TELADOC HEALTH INC | COM | 87918A105 | 28,874 | 151,299 | SH | | DFND | 2 | 151,299 | 0 | 0 |
TELEFLEX INCORPORATED | COM | 879369106 | 28,512 | 78,333 | SH | | DFND | 2 | 78,333 | 0 | 0 |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 25,179 | 69,491 | SH | | DFND | 2 | 69,491 | 0 | 0 |
TRADEWEB MKTS INC | CL A | 892672106 | 395 | 6,800 | SH | | DFND | 2 | 6,800 | 0 | 0 |
TRANSMEDICS GROUP INC | COM | 89377M109 | 7,616 | 425,000 | SH | | DFND | 2 | 425,000 | 0 | 0 |
TRANSUNION | COM | 89400J107 | 444 | 5,096 | SH | | DFND | 2 | 5,096 | 0 | 0 |
TRIMBLE INC | COM | 896239100 | 505 | 11,700 | SH | | DFND | 2 | 11,700 | 0 | 0 |
TRIP COM GROUP LTD | ADS | 89677Q107 | 340 | 13,100 | SH | | DFND | 2 | 13,100 | 0 | 0 |
TYLER TECHNOLOGIES INC | COM | 902252105 | 529 | 1,525 | SH | | DFND | 2 | 1,525 | 0 | 0 |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 1,877 | 24,000 | SH | | DFND | 2 | 24,000 | 0 | 0 |
UNIQURE NV | SHS | N90064101 | 1,555 | 34,500 | SH | | DFND | 2 | 34,500 | 0 | 0 |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 90,442 | 306,636 | SH | | DFND | 2 | 306,636 | 0 | 0 |
VARIAN MED SYS INC | COM | 92220P105 | 502 | 4,100 | SH | | DFND | 2 | 4,100 | 0 | 0 |
VEEVA SYS INC | CL A COM | 922475108 | 14,782 | 63,056 | SH | | DFND | 2 | 63,056 | 0 | 0 |
VERISIGN INC | COM | 92343E102 | 434 | 2,100 | SH | | DFND | 2 | 2,100 | 0 | 0 |
VERISK ANALYTICS INC | COM | 92345Y106 | 424 | 2,489 | SH | | DFND | 2 | 2,489 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 18,173 | 62,600 | SH | | DFND | 2 | 62,600 | 0 | 0 |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 267,085 | 920,000 | SH | | DFND | 1,2 | 920,000 | 0 | 0 |
VIR BIOTECHNOLOGY INC | COM | 92764N102 | 1,741 | 42,500 | SH | | DFND | 2 | 42,500 | 0 | 0 |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 7,295 | 344,081 | SH | | DFND | 2 | 344,081 | 0 | 0 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 401 | 31,800 | SH | | DFND | 2 | 31,800 | 0 | 0 |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 33,825 | 2,680,283 | SH | | DFND | 1,2 | 2,680,283 | 0 | 0 |
WABTEC | COM | 929740108 | 368 | 6,400 | SH | | DFND | 2 | 6,400 | 0 | 0 |
WATSCO INC | COM | 942622200 | 498 | 2,800 | SH | | DFND | 2 | 2,800 | 0 | 0 |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 27,096 | 2,602,858 | SH | | DFND | 1,2 | 2,602,858 | 0 | 0 |
XILINX INC | COM | 983919101 | 413 | 4,200 | SH | | DFND | 2 | 4,200 | 0 | 0 |
ZAI LAB LTD | ADR | 98887Q104 | 14,381 | 175,100 | SH | | DFND | 2 | 175,100 | 0 | 0 |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 27,155 | 227,508 | SH | | DFND | 2 | 227,508 | 0 | 0 |