The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
1LIFE HEALTHCARE INC | COM | 68269G107 | 13,288 | 468,564 | SH | DFND | 2 | 468,564 | 0 | 0 | |
10X GENOMICS INC | CL A COM | 88025U109 | 19,199 | 153,989 | SH | DFND | 2 | 153,989 | 0 | 0 | |
ABBOTT LABS | COM | 002824100 | 140,204 | 1,288,285 | SH | DFND | 2 | 1,288,285 | 0 | 0 | |
ABBVIE INC | COM | 00287Y109 | 3,241 | 37,000 | SH | DFND | 2 | 37,000 | 0 | 0 | |
ABIOMED INC | COM | 003654100 | 28,093 | 101,398 | SH | DFND | 2 | 101,398 | 0 | 0 | |
ACADIA PHARMACEUTICALS INC | COM | 004225108 | 1,852 | 44,900 | SH | DFND | 2 | 44,900 | 0 | 0 | |
ACCOLADE INC | COM | 00437E102 | 8,137 | 209,327 | SH | DFND | 2 | 209,327 | 0 | 0 | |
ADOBE SYSTEMS INCORPORATED | COM | 00724F101 | 539 | 1,100 | SH | DFND | 2 | 1,100 | 0 | 0 | |
AGILENT TECHNOLOGIES INC | COM | 00846U101 | 626 | 6,200 | SH | DFND | 2 | 6,200 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 1,474 | 42,100 | SH | DFND | 2 | 42,100 | 0 | 0 | |
AGIOS PHARMACEUTICALS INC | COM | 00847X104 | 143,812 | 4,108,902 | SH | DFND | 1,2 | 4,108,902 | 0 | 0 | |
AKCEA THERAPEUTICS INC | COM | 00972L107 | 6,172 | 340,264 | SH | DFND | 3 | 340,264 | 0 | 0 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 14,498 | 126,700 | SH | DFND | 2 | 126,700 | 0 | 0 | |
ALEXION PHARMACEUTICALS INC | COM | 015351109 | 148,121 | 1,294,428 | SH | DFND | 1,2 | 1,294,428 | 0 | 0 | |
ALIGN TECHNOLOGY INC | COM | 016255101 | 27,706 | 84,635 | SH | DFND | 2 | 84,635 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 8,256 | 56,700 | SH | DFND | 2 | 56,700 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 174,720 | 1,200,000 | SH | DFND | 1,2 | 1,200,000 | 0 | 0 | |
ALNYLAM PHARMACEUTICALS INC | COM | 02043Q107 | 44,132 | 303,105 | SH | DFND | 3 | 303,105 | 0 | 0 | |
AMEDISYS INC | COM | 023436108 | 14,623 | 61,851 | SH | DFND | 2 | 61,851 | 0 | 0 | |
AMERICAN EXPRESS CO | COM | 025816109 | 361 | 3,600 | SH | DFND | 2 | 3,600 | 0 | 0 | |
AMERICAN WELL CORP | CL A | 03044L105 | 11,259 | 379,854 | SH | DFND | 2 | 379,854 | 0 | 0 | |
AMGEN INC | COM | 031162100 | 14,195 | 55,850 | SH | DFND | 2 | 55,850 | 0 | 0 | |
AMGEN INC | COM | 031162100 | 31,456 | 123,763 | SH | DFND | 3 | 123,763 | 0 | 0 | |
ANALOG DEVICES INC | COM | 032654105 | 479 | 4,100 | SH | DFND | 2 | 4,100 | 0 | 0 | |
ANSYS INC | COM | 03662Q105 | 590 | 1,802 | SH | DFND | 2 | 1,802 | 0 | 0 | |
ANTHEM INC | COM | 036752103 | 25,956 | 96,638 | SH | DFND | 2 | 96,638 | 0 | 0 | |
ANTHEM INC | COM | 036752103 | 67,815 | 252,485 | SH | DFND | 3 | 252,485 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 6,305 | 24,016 | SH | DFND | 2 | 24,016 | 0 | 0 | |
ARGENX SE | SPONSORED ADR | 04016X101 | 245,456 | 935,000 | SH | DFND | 1,2 | 935,000 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 345 | 14,600 | SH | DFND | 2 | 14,600 | 0 | 0 | |
ARVINAS INC | COM | 04335A105 | 38,411 | 1,626,903 | SH | DFND | 1,2 | 1,626,903 | 0 | 0 | |
ASCENDIS PHARMA A S | SPONSORED ADR | 04351P101 | 2,392 | 15,500 | SH | DFND | 2 | 15,500 | 0 | 0 | |
ASPEN TECHNOLOGY INC | COM | 045327103 | 380 | 3,000 | SH | DFND | 2 | 3,000 | 0 | 0 | |
AUTOLIV INC | COM | 052800109 | 496 | 6,800 | SH | DFND | 2 | 6,800 | 0 | 0 | |
AVANTOR INC | COM | 05352A100 | 6,906 | 307,089 | SH | DFND | 2 | 307,089 | 0 | 0 | |
AVIENT CORPORATION | COM | 05368V106 | 360 | 13,600 | SH | DFND | 2 | 13,600 | 0 | 0 | |
AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 21,356 | 418,408 | SH | DFND | 2 | 418,408 | 0 | 0 | |
AXONICS MODULATION TECHNOLOG | COM | 05465P101 | 11,562 | 226,536 | SH | DFND | 3 | 226,536 | 0 | 0 | |
BAXTER INTL INC | COM | 071813109 | 38,169 | 474,623 | SH | DFND | 2 | 474,623 | 0 | 0 | |
BECTON DICKINSON & CO | COM | 075887109 | 60,694 | 260,846 | SH | DFND | 2 | 260,846 | 0 | 0 | |
BEIGENE LTD | SPONSORED ADR | 07725L102 | 11,286 | 39,400 | SH | DFND | 2 | 39,400 | 0 | 0 | |
BERKELEY LTS INC | COM | 084310101 | 8,209 | 107,510 | SH | DFND | 2 | 107,510 | 0 | 0 | |
BIOGEN INC | COM | 09062X103 | 2,440 | 8,600 | SH | DFND | 2 | 8,600 | 0 | 0 | |
BIOHAVEN PHARMACTL HLDG CO L | COM | G11196105 | 1,593 | 24,500 | SH | DFND | 2 | 24,500 | 0 | 0 | |
BIONTECH SE | SPONSORED ADS | 09075V102 | 3,427 | 49,500 | SH | DFND | 2 | 49,500 | 0 | 0 | |
BIO RAD LABS INC | CL A | 090572207 | 40,302 | 78,186 | SH | DFND | 3 | 78,186 | 0 | 0 | |
BLACKBAUD INC | COM | 09227Q100 | 229 | 4,107 | SH | DFND | 2 | 4,107 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 393 | 13,000 | SH | DFND | 2 | 13,000 | 0 | 0 | |
BLACK DIAMOND THERAPEUTICS I | COM | 09203E105 | 42,020 | 1,390,000 | SH | DFND | 1,2 | 1,390,000 | 0 | 0 | |
BOOKING HOLDINGS INC | COM | 09857L108 | 342 | 200 | SH | DFND | 2 | 200 | 0 | 0 | |
BOSTON SCIENTIFIC CORP | COM | 101137107 | 72,075 | 1,886,297 | SH | DFND | 2 | 1,886,297 | 0 | 0 | |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 28,541 | 473,400 | SH | DFND | 2 | 473,400 | 0 | 0 | |
BRISTOL MYERS SQUIBB CO | COM | 110122108 | 70,691 | 1,172,512 | SH | DFND | 3 | 1,172,512 | 0 | 0 | |
BRISTOL MYERS SQUIBB CO | RIGHT 99/99/9999 | 110122157 | 1,800 | 800,000 | SH | DFND | 1,2 | 800,000 | 0 | 0 | |
BROADRIDGE FINL SOLUTIONS IN | COM | 11133T103 | 449 | 3,400 | SH | DFND | 2 | 3,400 | 0 | 0 | |
BROWN FORMAN CORP | CL B | 115637209 | 572 | 7,600 | SH | DFND | 2 | 7,600 | 0 | 0 | |
BURNING ROCK BIOTECH LTD | SPONSORED ADR | 12233L107 | 3,681 | 146,761 | SH | DFND | 2 | 146,761 | 0 | 0 | |
CAREDX INC | COM | 14167L103 | 42,337 | 1,115,903 | SH | DFND | 3 | 1,115,903 | 0 | 0 | |
CATALENT INC | COM | 148806102 | 488 | 5,700 | SH | DFND | 2 | 5,700 | 0 | 0 | |
CELLECTIS S A | SPON ADS | 15117K103 | 1,545 | 83,500 | SH | DFND | 2 | 83,500 | 0 | 0 | |
CENTENE CORP DEL | COM | 15135B101 | 60,293 | 1,033,647 | SH | DFND | 2 | 1,033,647 | 0 | 0 | |
CHANGE HEALTHCARE INC | COM | 15912K100 | 24,637 | 1,697,939 | SH | DFND | 2 | 1,697,939 | 0 | 0 | |
CHARLES RIV LABS INTL INC | COM | 159864107 | 32,133 | 141,900 | SH | DFND | 2 | 141,900 | 0 | 0 | |
CHARLES RIV LABS INTL INC | COM | 159864107 | 47,369 | 209,183 | SH | DFND | 3 | 209,183 | 0 | 0 | |
CIDARA THERAPEUTICS INC | COM | 171757107 | 8,044 | 2,822,495 | SH | DFND | 1,2 | 2,822,495 | 0 | 0 | |
CIGNA CORP NEW | COM | 125523100 | 56,877 | 335,737 | SH | DFND | 2 | 335,737 | 0 | 0 | |
CLOROX CO DEL | COM | 189054109 | 420 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | |
COHERUS BIOSCIENCES INC | COM | 19249H103 | 25,738 | 1,403,400 | SH | DFND | 2 | 1,403,400 | 0 | 0 | |
CONSTELLATION BRANDS INC | CL A | 21036P108 | 390 | 2,059 | SH | DFND | 2 | 2,059 | 0 | 0 | |
COOPER COS INC | COM NEW | 216648402 | 8,544 | 25,345 | SH | DFND | 2 | 25,345 | 0 | 0 | |
COSTAR GROUP INC | COM | 22160N109 | 594 | 700 | SH | DFND | 2 | 700 | 0 | 0 | |
COVETRUS INC | COM | 22304C100 | 37 | 1,520 | SH | DFND | 2 | 1,520 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 736 | 8,800 | SH | DFND | 2 | 8,800 | 0 | 0 | |
CRISPR THERAPEUTICS AG | NAMEN AKT | H17182108 | 78,660 | 940,462 | SH | DFND | 1,2 | 940,462 | 0 | 0 | |
CUREVAC NV | COM | N2451R105 | 2,351 | 50,500 | SH | DFND | 2 | 50,500 | 0 | 0 | |
CVS HEALTH CORP | COM | 126650100 | 10,920 | 186,981 | SH | DFND | 2 | 186,981 | 0 | 0 | |
CYBERARK SOFTWARE LTD | SHS | M2682V108 | 445 | 4,300 | SH | DFND | 2 | 4,300 | 0 | 0 | |
DANAHER CORPORATION | COM | 235851102 | 97,627 | 453,384 | SH | DFND | 2 | 453,384 | 0 | 0 | |
DAVITA INC | COM | 23918K108 | 27,956 | 326,400 | SH | DFND | 2 | 326,400 | 0 | 0 | |
DENTSPLY SIRONA INC | COM | 24906P109 | 6,959 | 159,129 | SH | DFND | 2 | 159,129 | 0 | 0 | |
DEXCOM INC | COM | 252131107 | 50,170 | 121,705 | SH | DFND | 2 | 121,705 | 0 | 0 | |
DOMINOS PIZZA INC | COM | 25754A201 | 425 | 1,000 | SH | DFND | 2 | 1,000 | 0 | 0 | |
DR REDDYS LABS LTD | ADR | 256135203 | 591 | 8,500 | SH | DFND | 2 | 8,500 | 0 | 0 | |
EDWARDS LIFESCIENCES CORP | COM | 28176E108 | 66,076 | 827,818 | SH | DFND | 2 | 827,818 | 0 | 0 | |
ELECTRONIC ARTS INC | COM | 285512109 | 609 | 4,670 | SH | DFND | 2 | 4,670 | 0 | 0 | |
ENTEGRIS INC | COM | 29362U104 | 543 | 7,300 | SH | DFND | 2 | 7,300 | 0 | 0 | |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 1,531 | 41,200 | SH | DFND | 2 | 41,200 | 0 | 0 | |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 139,312 | 3,747,964 | SH | DFND | 1,2 | 3,747,964 | 0 | 0 | |
ESPERION THERAPEUTICS INC NEW | COM | 29664W105 | 62,317 | 1,676,551 | SH | DFND | 3 | 1,676,551 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 14,629 | 1,178,839 | SH | DFND | 2 | 1,178,839 | 0 | 0 | |
EVOLENT HEALTH INC | CL A | 30050B101 | 25,993 | 2,094,486 | SH | DFND | 3 | 2,094,486 | 0 | 0 | |
EXACT SCIENCES CORP | COM | 30063P105 | 31,043 | 304,490 | SH | DFND | 3 | 304,490 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 5,831 | 238,500 | SH | DFND | 2 | 238,500 | 0 | 0 | |
EXELIXIS INC | COM | 30161Q104 | 69,316 | 2,835,000 | SH | DFND | 1,2 | 2,835,000 | 0 | 0 | |
FACTSET RESH SYS INC | COM | 303075105 | 569 | 1,700 | SH | DFND | 2 | 1,700 | 0 | 0 | |
FASTENAL CO | COM | 311900104 | 451 | 10,000 | SH | DFND | 2 | 10,000 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 3,098 | 77,500 | SH | DFND | 2 | 77,500 | 0 | 0 | |
FATE THERAPEUTICS INC | COM | 31189P102 | 85,536 | 2,140,000 | SH | DFND | 1,2 | 2,140,000 | 0 | 0 | |
FIBROGEN INC | COM | 31572Q808 | 2,179 | 53,000 | SH | DFND | 2 | 53,000 | 0 | 0 | |
FORTINET INC | COM | 34959E109 | 342 | 2,900 | SH | DFND | 2 | 2,900 | 0 | 0 | |
G1 THERAPEUTICS INC | COM | 3621LQ109 | 8,338 | 721,925 | SH | DFND | 1,2 | 721,925 | 0 | 0 | |
GARTNER INC | COM | 366651107 | 425 | 3,400 | SH | DFND | 2 | 3,400 | 0 | 0 | |
GENERATION BIO CO | COM | 37148K100 | 58,111 | 1,880,000 | SH | DFND | 1,2 | 1,880,000 | 0 | 0 | |
GENETRON HLDGS LTD | ADS | 37186H100 | 1,915 | 160,410 | SH | DFND | 2 | 160,410 | 0 | 0 | |
GENMARK DIAGNOSTICS INC | COM | 372309104 | 17,946 | 1,263,811 | SH | DFND | 3 | 1,263,811 | 0 | 0 | |
GILEAD SCIENCES INC | COM | 375558103 | 7,817 | 123,700 | SH | DFND | 2 | 123,700 | 0 | 0 | |
GLAUKOS CORP | COM | 377322102 | 25,540 | 515,754 | SH | DFND | 2 | 515,754 | 0 | 0 | |
GLOBUS MED INC | CL A | 379577208 | 20,290 | 409,735 | SH | DFND | 2 | 409,735 | 0 | 0 | |
GOHEALTH INC | COM CL A | 38046W105 | 4,099 | 314,672 | SH | DFND | 2 | 314,672 | 0 | 0 | |
GRACO INC | COM | 384109104 | 595 | 9,700 | SH | DFND | 2 | 9,700 | 0 | 0 | |
GUARDANT HEALTH INC | COM | 40131M109 | 18,151 | 162,383 | SH | DFND | 2 | 162,383 | 0 | 0 | |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 1,947 | 20,000 | SH | DFND | 2 | 20,000 | 0 | 0 | |
GW PHARMACEUTICALS PLC | ADS | 36197T103 | 52,856 | 542,943 | SH | DFND | 3 | 542,943 | 0 | 0 | |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 1,971 | 75,000 | SH | DFND | 2 | 75,000 | 0 | 0 | |
HALOZYME THERAPEUTICS INC | COM | 40637H109 | 141,758 | 5,394,131 | SH | DFND | 1,2 | 5,394,131 | 0 | 0 | |
HCA HEALTHCARE INC | COM | 40412C101 | 43,025 | 345,085 | SH | DFND | 2 | 345,085 | 0 | 0 | |
HEALTH CATALYST INC | COM | 42225T107 | 19,101 | 521,896 | SH | DFND | 2 | 521,896 | 0 | 0 | |
HILL ROM HLDGS INC | COM | 431475102 | 47,690 | 571,069 | SH | DFND | 3 | 571,069 | 0 | 0 | |
HMS HLDGS CORP | COM | 40425J101 | 21,962 | 916,984 | SH | DFND | 2 | 916,984 | 0 | 0 | |
HOLOGIC INC | COM | 436440101 | 21,689 | 326,305 | SH | DFND | 2 | 326,305 | 0 | 0 | |
HOLOGIC INC | COM | 436440101 | 24,639 | 370,675 | SH | DFND | 3 | 370,675 | 0 | 0 | |
HOMOLOGY MEDICINES INC | COM | 438083107 | 18,587 | 1,737,122 | SH | DFND | 1,2 | 1,737,122 | 0 | 0 | |
HORIZON THERAPEUTICS PUB LTD | SHS | G46188101 | 6,012 | 77,400 | SH | DFND | 2 | 77,400 | 0 | 0 | |
HUAZHU GROUP LTD | SPONSORED ADS | 44332N106 | 584 | 13,500 | SH | DFND | 2 | 13,500 | 0 | 0 | |
HUMANA INC | COM | 444859102 | 54,609 | 131,941 | SH | DFND | 2 | 131,941 | 0 | 0 | |
HUMANA INC | COM | 444859102 | 46,378 | 112,055 | SH | DFND | 3 | 112,055 | 0 | 0 | |
HUTCHISON CHINA MEDITECH LTD | SPONSORED ADR | 44842L103 | 30,610 | 947,674 | SH | DFND | 3 | 947,674 | 0 | 0 | |
IDEXX LABS INC | COM | 45168D104 | 30,819 | 78,398 | SH | DFND | 2 | 78,398 | 0 | 0 | |
ILLUMINA INC | COM | 452327109 | 18,096 | 58,547 | SH | DFND | 2 | 58,547 | 0 | 0 | |
I MAB | SPONSORED ADS | 44975P103 | 3,057 | 65,000 | SH | DFND | 2 | 65,000 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 34,052 | 379,450 | SH | DFND | 2 | 379,450 | 0 | 0 | |
INCYTE CORP | COM | 45337C102 | 260,246 | 2,900,000 | SH | DFND | 1,2 | 2,900,000 | 0 | 0 | |
INOGEN INC | COM | 45780L104 | 4,318 | 148,912 | SH | DFND | 2 | 148,912 | 0 | 0 | |
INSMED INC | COM PAR $.01 | 457669307 | 39,216 | 1,220,169 | SH | DFND | 3 | 1,220,169 | 0 | 0 | |
INSPIRE MED SYS INC | COM | 457730109 | 35,228 | 272,983 | SH | DFND | 2 | 272,983 | 0 | 0 | |
INSULET CORP | COM | 45784P101 | 63,850 | 269,875 | SH | DFND | 2 | 269,875 | 0 | 0 | |
INTEGRA LIFESCIENCES HLDGS C | COM NEW | 457985208 | 5,781 | 122,426 | SH | DFND | 2 | 122,426 | 0 | 0 | |
INTERACTIVE BROKERS GROUP IN | COM CL A | 45841N107 | 454 | 9,400 | SH | DFND | 2 | 9,400 | 0 | 0 | |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 332 | 8,000 | SH | DFND | 2 | 8,000 | 0 | 0 | |
INTERCEPT PHARMACEUTICALS IN | COM | 45845P108 | 28,897 | 696,976 | SH | DFND | 1,2 | 696,976 | 0 | 0 | |
INTERCONTINENTAL EXCHANGE IN | COM | 45866F104 | 480 | 4,800 | SH | DFND | 2 | 4,800 | 0 | 0 | |
INTERSECT ENT INC | COM | 46071F103 | 7,721 | 473,382 | SH | DFND | 2 | 473,382 | 0 | 0 | |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 3,118 | 121,500 | SH | DFND | 2 | 121,500 | 0 | 0 | |
INTRA CELLULAR THERAPIES INC | COM | 46116X101 | 88,743 | 3,458,419 | SH | DFND | 1,2 | 3,458,419 | 0 | 0 | |
INTUITIVE SURGICAL INC | COM NEW | 46120E602 | 108,690 | 153,184 | SH | DFND | 2 | 153,184 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 8,876 | 187,050 | SH | DFND | 2 | 187,050 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 389,086 | 8,199,913 | SH | DFND | 1,2 | 8,199,913 | 0 | 0 | |
IONIS PHARMACEUTICALS INC | COM | 462222100 | 15,626 | 329,307 | SH | DFND | 3 | 329,307 | 0 | 0 | |
IPG PHOTONICS CORP | COM | 44980X109 | 459 | 2,700 | SH | DFND | 2 | 2,700 | 0 | 0 | |
IQVIA HLDGS INC | COM | 46266C105 | 457 | 2,900 | SH | DFND | 2 | 2,900 | 0 | 0 | |
IRHYTHM TECHNOLOGIES INC | COM | 450056106 | 21,553 | 90,518 | SH | DFND | 2 | 90,518 | 0 | 0 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 5,675 | 39,800 | SH | DFND | 2 | 39,800 | 0 | 0 | |
JAZZ PHARMACEUTICALS PLC | SHS USD | G50871105 | 45,137 | 316,550 | SH | DFND | 3 | 316,550 | 0 | 0 | |
JD.COM INC | SPON ADR CL A | 47215P106 | 675 | 8,700 | SH | DFND | 2 | 8,700 | 0 | 0 | |
KEZAR LIFE SCIENCES INC | COM | 49372L100 | 21,940 | 4,533,148 | SH | DFND | 1,2 | 4,533,148 | 0 | 0 | |
KOSMOS ENERGY LTD | COM | 500688106 | 417 | 425,000 | SH | DFND | 2 | 425,000 | 0 | 0 | |
KURA ONCOLOGY INC | COM | 50127T109 | 1,471 | 48,000 | SH | DFND | 2 | 48,000 | 0 | 0 | |
LABORATORY CORP AMER HLDGS | COM NEW | 50540R409 | 10,211 | 54,234 | SH | DFND | 2 | 54,234 | 0 | 0 | |
LAUDER ESTEE COS INC | CL A | 518439104 | 491 | 2,248 | SH | DFND | 2 | 2,248 | 0 | 0 | |
LIVE NATION ENTERTAINMENT IN | COM | 538034109 | 334 | 6,200 | SH | DFND | 2 | 6,200 | 0 | 0 | |
LIVONGO HEALTH INC | COM | 539183103 | 28,476 | 203,329 | SH | DFND | 2 | 203,329 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 2,757 | 109,450 | SH | DFND | 2 | 109,450 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 118,463 | 4,702,761 | SH | DFND | 1,2 | 4,702,761 | 0 | 0 | |
MACROGENICS INC | COM | 556099109 | 11,839 | 469,977 | SH | DFND | 3 | 469,977 | 0 | 0 | |
MARKEL CORP | COM | 570535104 | 389 | 400 | SH | DFND | 2 | 400 | 0 | 0 | |
MARKETAXESS HLDGS INC | COM | 57060D108 | 396 | 822 | SH | DFND | 2 | 822 | 0 | 0 | |
MASIMO CORP | COM | 574795100 | 24,114 | 102,153 | SH | DFND | 2 | 102,153 | 0 | 0 | |
MATCH GROUP INC NEW | COM | 57667L107 | 606 | 5,478 | SH | DFND | 2 | 5,478 | 0 | 0 | |
MCCORMICK & CO INC | COM NON VTG | 579780206 | 543 | 2,800 | SH | DFND | 2 | 2,800 | 0 | 0 | |
MCKESSON CORP | COM | 58155Q103 | 580 | 3,892 | SH | DFND | 2 | 3,892 | 0 | 0 | |
MEDTRONIC PLC | SHS | G5960L103 | 86,404 | 831,450 | SH | DFND | 2 | 831,450 | 0 | 0 | |
MERCADOLIBRE INC | COM | 58733R102 | 541 | 500 | SH | DFND | 2 | 500 | 0 | 0 | |
METTLER TOLEDO INTERNATIONAL | COM | 592688105 | 676 | 700 | SH | DFND | 2 | 700 | 0 | 0 | |
MIRATI THERAPEUTICS INC | COM | 60468T105 | 2,956 | 17,800 | SH | DFND | 2 | 17,800 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 6,505 | 91,950 | SH | DFND | 2 | 91,950 | 0 | 0 | |
MODERNA INC | COM | 60770K107 | 229,938 | 3,250,000 | SH | DFND | 1,2 | 3,250,000 | 0 | 0 | |
MOLECULAR TEMPLATES INC | COM | 608550109 | 349 | 32,000 | SH | DFND | 2 | 32,000 | 0 | 0 | |
MOLECULAR TEMPLATES INC | COM | 608550109 | 54,491 | 4,989,996 | SH | DFND | 1,2 | 4,989,996 | 0 | 0 | |
MOLINA HEALTHCARE INC | COM | 60855R100 | 30,123 | 164,572 | SH | DFND | 2 | 164,572 | 0 | 0 | |
MOODYS CORP | COM | 615369105 | 580 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | |
MSCI INC | COM | 55354G100 | 423 | 1,186 | SH | DFND | 2 | 1,186 | 0 | 0 | |
MYOKARDIA INC | COM | 62857M105 | 3,872 | 28,400 | SH | DFND | 2 | 28,400 | 0 | 0 | |
MYOKARDIA INC | COM | 62857M105 | 149,963 | 1,100,000 | SH | DFND | 1,2 | 1,100,000 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 660 | 47,000 | SH | DFND | 2 | 47,000 | 0 | 0 | |
MYOVANT SCIENCES LTD | COM | G637AM102 | 70,882 | 5,045,000 | SH | DFND | 1,2 | 5,045,000 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 478 | 28,800 | SH | DFND | 2 | 28,800 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 43,477 | 2,620,676 | SH | DFND | 1,2 | 2,620,676 | 0 | 0 | |
NEKTAR THERAPEUTICS | COM | 640268108 | 16,306 | 982,882 | SH | DFND | 3 | 982,882 | 0 | 0 | |
NEOGENOMICS INC | COM NEW | 64049M209 | 15,748 | 426,892 | SH | DFND | 3 | 426,892 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 29,084 | 302,451 | SH | DFND | 2 | 302,451 | 0 | 0 | |
NEUROCRINE BIOSCIENCES INC | COM | 64125C109 | 287,999 | 2,995,000 | SH | DFND | 1,2 | 2,995,000 | 0 | 0 | |
NEVRO CORP | COM | 64157F103 | 16,795 | 120,569 | SH | DFND | 2 | 120,569 | 0 | 0 | |
NUVASIVE INC | COM | 670704105 | 3,988 | 82,100 | SH | DFND | 2 | 82,100 | 0 | 0 | |
OMNICELL INC | COM | 68213N109 | 20,787 | 278,421 | SH | DFND | 2 | 278,421 | 0 | 0 | |
OUTSET MED INC | COM | 690145107 | 3,996 | 79,921 | SH | DFND | 2 | 79,921 | 0 | 0 | |
OXFORD IMMUNOTEC GLOBAL PLC | ORD SHS | G6855A103 | 9,362 | 800,157 | SH | DFND | 2 | 800,157 | 0 | 0 | |
PACIFIC BIOSIENCES CALIF IN | COM | 69404D108 | 21,004 | 2,128,100 | SH | DFND | 2 | 2,128,100 | 0 | 0 | |
PACIFIC BIOSIENCES CALIF IN | COM | 69404D108 | 17,533 | 1,776,367 | SH | DFND | 3 | 1,776,367 | 0 | 0 | |
PAYCHEX INC | COM | 704326107 | 431 | 5,400 | SH | DFND | 2 | 5,400 | 0 | 0 | |
PENUMBRA INC | COM | 70975L107 | 23,558 | 121,194 | SH | DFND | 2 | 121,194 | 0 | 0 | |
PERKINELMER INC | COM | 714046109 | 602 | 4,800 | SH | DFND | 2 | 4,800 | 0 | 0 | |
PFIZER INC | COM | 717081103 | 2,712 | 73,900 | SH | DFND | 2 | 73,900 | 0 | 0 | |
PHREESIA INC | COM | 71944F106 | 13,718 | 426,956 | SH | DFND | 2 | 426,956 | 0 | 0 | |
POOL CORP | COM | 73278L105 | 736 | 2,200 | SH | DFND | 2 | 2,200 | 0 | 0 | |
QUANTERIX CORP | COM | 74766Q101 | 24,417 | 723,674 | SH | DFND | 2 | 723,674 | 0 | 0 | |
QUEST DIAGNOSTICS INC | COM | 74834L100 | 6,870 | 60,005 | SH | DFND | 2 | 60,005 | 0 | 0 | |
QUOTIENT LTD | SHS | G73268107 | 4,714 | 917,074 | SH | DFND | 2 | 917,074 | 0 | 0 | |
RADIUS HEALTH INC | COM NEW | 750469207 | 858 | 75,700 | SH | DFND | 2 | 75,700 | 0 | 0 | |
RADIUS HEALTH INC | COM NEW | 750469207 | 83,414 | 7,355,714 | SH | DFND | 1,2 | 7,355,714 | 0 | 0 | |
REGENERON PHARMACEUTICALS | COM | 75886F107 | 11,196 | 20,000 | SH | DFND | 2 | 20,000 | 0 | 0 | |
RELAY THERAPEUTICS INC | COM | 75943R102 | 55,367 | 1,300,000 | SH | DFND | 1,2 | 1,300,000 | 0 | 0 | |
RESMED INC | COM | 761152107 | 13,338 | 77,805 | SH | DFND | 2 | 77,805 | 0 | 0 | |
S&P GLOBAL INC | COM | 78409V104 | 613 | 1,700 | SH | DFND | 2 | 1,700 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 2,408 | 39,400 | SH | DFND | 2 | 39,400 | 0 | 0 | |
SAGE THERAPEUTICS INC | COM | 78667J108 | 94,131 | 1,540,104 | SH | DFND | 1,2 | 1,540,104 | 0 | 0 | |
SANGAMO THERAPEUTICS INC | COM | 800677106 | 36,383 | 3,850,000 | SH | DFND | 1,2 | 3,850,000 | 0 | 0 | |
SANOFI | SPONSORED ADR | 80105N105 | 2,860 | 57,000 | SH | DFND | 2 | 57,000 | 0 | 0 | |
SAREPTA THERAPEUTICS INC | COM | 803607100 | 2,851 | 20,300 | SH | DFND | 2 | 20,300 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 548 | 31,000 | SH | DFND | 2 | 31,000 | 0 | 0 | |
SCHOLAR ROCK HLDG CORP | COM | 80706P103 | 49,736 | 2,811,515 | SH | DFND | 1,2 | 2,811,515 | 0 | 0 | |
SEATTLE GENETICS INC | COM | 812578102 | 9,119 | 46,600 | SH | DFND | 2 | 46,600 | 0 | 0 | |
SENSATA TECHNOLOGIES HLDNG P | SHS | G8060N102 | 427 | 9,900 | SH | DFND | 2 | 9,900 | 0 | 0 | |
SERVICE CORP INTL | COM | 817565104 | 359 | 8,500 | SH | DFND | 2 | 8,500 | 0 | 0 | |
SHOCKWAVE MED INC | COM | 82489T104 | 34,963 | 461,253 | SH | DFND | 2 | 461,253 | 0 | 0 | |
SILK RD MED INC | COM | 82710M100 | 20,205 | 300,619 | SH | DFND | 2 | 300,619 | 0 | 0 | |
SKYWORKS SOLUTIONS INC | COM | 83088M102 | 538 | 3,700 | SH | DFND | 2 | 3,700 | 0 | 0 | |
SOCIEDAD QUIMICA Y MINERA DE | SPON ADR SER B | 833635105 | 590 | 18,200 | SH | DFND | 2 | 18,200 | 0 | 0 | |
STARBUCKS CORP | COM | 855244109 | 372 | 4,334 | SH | DFND | 2 | 4,334 | 0 | 0 | |
STONECO LTD | COM CL A | G85158106 | 566 | 10,700 | SH | DFND | 2 | 10,700 | 0 | 0 | |
STRYKER CORPORATION | COM | 863667101 | 67,256 | 322,771 | SH | DFND | 2 | 322,771 | 0 | 0 | |
TABULA RASA HEALTHCARE INC | COM | 873379101 | 9,967 | 244,469 | SH | DFND | 2 | 244,469 | 0 | 0 | |
TANDEM DIABETES CARE INC | COM NEW | 875372203 | 35,576 | 313,444 | SH | DFND | 2 | 313,444 | 0 | 0 | |
TELADOC HEALTH INC | COM | 87918A105 | 26,606 | 121,354 | SH | DFND | 2 | 121,354 | 0 | 0 | |
TELEFLEX INCORPORATED | COM | 879369106 | 26,772 | 78,644 | SH | DFND | 2 | 78,644 | 0 | 0 | |
THERMO FISHER SCIENTIFIC INC | COM | 883556102 | 31,288 | 70,865 | SH | DFND | 2 | 70,865 | 0 | 0 | |
TRADEWEB MKTS INC | CL A | 892672106 | 394 | 6,800 | SH | DFND | 2 | 6,800 | 0 | 0 | |
TRANSMEDICS GROUP INC | COM | 89377M109 | 7,953 | 577,147 | SH | DFND | 2 | 577,147 | 0 | 0 | |
TRANSUNION | COM | 89400J107 | 429 | 5,096 | SH | DFND | 2 | 5,096 | 0 | 0 | |
TRIMBLE INC | COM | 896239100 | 570 | 11,700 | SH | DFND | 2 | 11,700 | 0 | 0 | |
TRIP COM GROUP LTD | ADS | 89677Q107 | 408 | 13,100 | SH | DFND | 2 | 13,100 | 0 | 0 | |
TYLER TECHNOLOGIES INC | COM | 902252105 | 532 | 1,525 | SH | DFND | 2 | 1,525 | 0 | 0 | |
ULTA BEAUTY INC | COM | 90384S303 | 448 | 2,000 | SH | DFND | 2 | 2,000 | 0 | 0 | |
ULTRAGENYX PHARMACEUTICAL IN | COM | 90400D108 | 3,370 | 41,000 | SH | DFND | 2 | 41,000 | 0 | 0 | |
UNIQURE NV | SHS | N90064101 | 1,271 | 34,500 | SH | DFND | 2 | 34,500 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 66,787 | 214,218 | SH | DFND | 2 | 214,218 | 0 | 0 | |
UNITEDHEALTH GROUP INC | COM | 91324P102 | 34,243 | 109,835 | SH | DFND | 3 | 109,835 | 0 | 0 | |
VARIAN MED SYS INC | COM | 92220P105 | 705 | 4,100 | SH | DFND | 2 | 4,100 | 0 | 0 | |
VEEVA SYS INC | CL A COM | 922475108 | 26,816 | 95,367 | SH | DFND | 2 | 95,367 | 0 | 0 | |
VERISIGN INC | COM | 92343E102 | 430 | 2,100 | SH | DFND | 2 | 2,100 | 0 | 0 | |
VERISK ANALYTICS INC | COM | 92345Y106 | 461 | 2,489 | SH | DFND | 2 | 2,489 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 16,490 | 60,600 | SH | DFND | 2 | 60,600 | 0 | 0 | |
VERTEX PHARMACEUTICALS INC | COM | 92532F100 | 244,908 | 900,000 | SH | DFND | 1,2 | 900,000 | 0 | 0 | |
VOCERA COMMUNICATONS INC | COM | 92857F107 | 5,856 | 201,390 | SH | DFND | 2 | 201,390 | 0 | 0 | |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 339 | 31,800 | SH | DFND | 2 | 31,800 | 0 | 0 | |
VOYAGER THERAPEUTICS INC | COM | 92915B106 | 28,599 | 2,680,283 | SH | DFND | 1,2 | 2,680,283 | 0 | 0 | |
WABTEC | COM | 929740108 | 396 | 6,400 | SH | DFND | 2 | 6,400 | 0 | 0 | |
WATSCO INC | COM | 942622200 | 652 | 2,800 | SH | DFND | 2 | 2,800 | 0 | 0 | |
WAVE LIFE SCIENCES LTD | SHS | Y95308105 | 22,098 | 2,602,858 | SH | DFND | 1,2 | 2,602,858 | 0 | 0 | |
XILINX INC | COM | 983919101 | 438 | 4,200 | SH | DFND | 2 | 4,200 | 0 | 0 | |
ZAI LAB LTD | ADR | 98887Q104 | 13,407 | 161,200 | SH | DFND | 2 | 161,200 | 0 | 0 | |
ZIMMER BIOMET HOLDINGS INC | COM | 98956P102 | 30,732 | 225,740 | SH | DFND | 2 | 225,740 | 0 | 0 |