Bellevue (BLVGF) 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
1LIFE HEALTHCARE INC	COM	68269G107	16,933	836,190	SH		DFND	2	836,190	0	0
10X GENOMICS INC	CL A COM	88025U109	33,872	232,672	SH		DFND	2	232,672	0	0
ABBOTT LABS	COM	002824100	163,905	1,387,499	SH		DFND	2	1,387,499	0	0
ABBVIE INC	COM	00287Y109	30,516	282,900	SH		DFND	2	282,900	0	0
ABIOMED INC	COM	003654100	49,211	151,178	SH		DFND	2	151,178	0	0
AC IMMUNE SA	SHS	H00263105	933	139,000	SH		DFND	2	139,000	0	0
ACCOLADE INC	COM	00437E102	29,033	688,479	SH		DFND	2	688,479	0	0
ACCOLADE INC	COM	00437E102	49,412	1,171,724	SH		DFND	3	1,171,724	0	0
ADAPTIVE BIOTECHNOLOGIES COR	COM	00650F109	45,411	1,336,023	SH		DFND	3	1,336,023	0	0
AGILENT TECHNOLOGIES INC	COM	00846U101	425	2,700	SH		DFND	2	2,700	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	1,708	37,000	SH		DFND	2	37,000	0	0
AGIOS PHARMACEUTICALS INC	COM	00847X104	198,675	4,304,992	SH		DFND	1,2	4,304,992	0	0
ALIGN TECHNOLOGY INC	COM	016255101	104,493	157,031	SH		DFND	2	157,031	0	0
ALLAKOS INC	COM	01671P100	1,959	18,500	SH		DFND	2	18,500	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	8,610	45,600	SH		DFND	2	45,600	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	209,579	1,110,000	SH		DFND	1,2	1,110,000	0	0
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	47,735	252,818	SH		DFND	3	252,818	0	0
AMEDISYS INC	COM	023436108	9,019	60,487	SH		DFND	2	60,487	0	0
AMEDISYS INC	COM	023436108	36,129	242,311	SH		DFND	3	242,311	0	0
AMERICAN EXPRESS CO	COM	025816109	436	2,600	SH		DFND	2	2,600	0	0
AMERICAN WELL CORP	CL A	03044L105	19,385	2,127,838	SH		DFND	2	2,127,838	0	0
AMGEN INC	COM	031162100	7,219	33,950	SH		DFND	2	33,950	0	0
ANSYS INC	COM	03662Q105	306	900	SH		DFND	2	900	0	0
ANTHEM INC	COM	036752103	101,649	272,664	SH		DFND	2	272,664	0	0
ANTHEM INC	COM	036752103	75,509	202,546	SH		DFND	3	202,546	0	0
APELLIS PHARMACEUTICALS INC	COM	03753U106	1,582	48,000	SH		DFND	2	48,000	0	0
ARCTURUS THERAPEUTICS HLDGS	COM	03969T109	1,648	34,500	SH		DFND	2	34,500	0	0
ARCUS BIOSCIENCES INC	COM	03969F109	3,302	94,700	SH		DFND	2	94,700	0	0
ARGENX SE	SPONSORED ADR	04016X101	8,577	28,400	SH		DFND	2	28,400	0	0
ARGENX SE	SPONSORED ADR	04016X101	288,572	955,538	SH		DFND	1,2	955,538	0	0
ARVINAS INC	COM	04335A105	5,301	64,500	SH		DFND	2	64,500	0	0
ARVINAS INC	COM	04335A105	178,898	2,176,903	SH		DFND	1,2	2,176,903	0	0
ASPEN TECHNOLOGY INC	COM	045327103	295	2,400	SH		DFND	2	2,400	0	0
ATRICURE INC	COM	04963C209	29,073	418,016	SH		DFND	3	418,016	0	0
AVALARA INC	COM	05338G106	402	2,300	SH		DFND	2	2,300	0	0
AVANTOR INC	COM	05352A100	20,950	512,216	SH		DFND	2	512,216	0	0
AXONICS INC	COM	05465P101	64,973	998,204	SH		DFND	2	998,204	0	0
AXONICS INC	COM	05465P101	39,743	610,590	SH		DFND	3	610,590	0	0
AXSOME THERAPEUTICS INC	COM	05464T104	24,817	752,945	SH		DFND	3	752,945	0	0
BAXTER INTL INC	COM	071813109	74,255	923,223	SH		DFND	2	923,223	0	0
BEAM THERAPEUTICS INC	COM	07373V105	522	6,000	SH		DFND	2	6,000	0	0
BEAM THERAPEUTICS INC	COM	07373V105	52,799	606,821	SH		DFND	1,2	606,821	0	0
BECTON DICKINSON & CO	COM	075887109	111,989	455,572	SH		DFND	2	455,572	0	0
BEIGENE LTD	SPONSORED ADR	07725L102	8,349	23,000	SH		DFND	2	23,000	0	0
BERKELEY LTS INC	COM	084310101	7,531	385,014	SH		DFND	2	385,014	0	0
BICYCLE THERAPEUTICS PLC	SPONSORED ADS	088786108	2,732	65,700	SH		DFND	2	65,700	0	0
BIOGEN INC	COM	09062X103	7,641	27,000	SH		DFND	2	27,000	0	0
BIOGEN INC	COM	09062X103	141,495	500,000	SH		DFND	1,2	500,000	0	0
BIOHAVEN PHARMACTL HLDG CO L	COM	G11196105	2,431	17,500	SH		DFND	2	17,500	0	0
BIONTECH SE	SPONSORED ADS	09075V102	3,467	12,700	SH		DFND	2	12,700	0	0
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	3,996	51,700	SH		DFND	2	51,700	0	0
BIO RAD LABS INC	CL A	090572207	34,325	46,015	SH		DFND	3	46,015	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	195	23,000	SH		DFND	2	23,000	0	0
BLACK DIAMOND THERAPEUTICS I	COM	09203E105	29,102	3,440,000	SH		DFND	1,2	3,440,000	0	0
BOOKING HOLDINGS INC	COM	09857L108	380	160	SH		DFND	2	160	0	0
BOSTON SCIENTIFIC CORP	COM	101137107	128,744	2,967,127	SH		DFND	2	2,967,127	0	0
BRIGHT HEALTH GROUP INC	COM	10920V107	12,240	1,500,000	SH		DFND	2	1,500,000	0	0
BRISTOL-MYERS SQUIBB CO	COM	110122108	1,923	32,500	SH		DFND	2	32,500	0	0
BRISTOL-MYERS SQUIBB CO	COM	110122108	75,172	1,270,434	SH		DFND	3	1,270,434	0	0
BROWN FORMAN CORP	CL B	115637209	308	4,600	SH		DFND	2	4,600	0	0
BURNING ROCK BIOTECH LTD	SPONSORED ADS	12233L107	8,759	489,890	SH		DFND	2	489,890	0	0
C4 THERAPEUTICS INC	COM STK	12529R107	2,109	47,200	SH		DFND	2	47,200	0	0
CAREDX INC	COM	14167L103	1,961	30,943	SH		DFND	3	30,943	0	0
CARMAX INC	COM	143130102	365	2,850	SH		DFND	2	2,850	0	0
CATALENT INC	COM	148806102	4,791	36,000	SH		DFND	2	36,000	0	0
CELLECTIS S A	SPON ADS	15117K103	1,040	82,500	SH		DFND	2	82,500	0	0
CENTENE CORP DEL	COM	15135B101	71,940	1,154,545	SH		DFND	2	1,154,545	0	0
CHARLES RIV LABS INTL INC	COM	159864107	26,134	63,329	SH		DFND	3	63,329	0	0
CIGNA CORP NEW	COM	125523100	43,597	217,812	SH		DFND	2	217,812	0	0
CLOROX CO DEL	COM	189054109	331	2,000	SH		DFND	2	2,000	0	0
CONSTELLATION BRANDS INC	CL A	21036P108	307	1,459	SH		DFND	2	1,459	0	0
COOPER COS INC	COM NEW	216648402	30,695	74,266	SH		DFND	2	74,266	0	0
COSTAR GROUP INC	COM	22160N109	301	3,500	SH		DFND	2	3,500	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	2,809	25,100	SH		DFND	2	25,100	0	0
CRISPR THERAPEUTICS AG	NAMEN AKT	H17182108	106,287	949,584	SH		DFND	1,2	949,584	0	0
CUREVAC N V	COM	N2451R105	1	120	SH	Call	DFND	2	120	0	0
CUREVAC N V	COM	N2451R105	1,923	35,200	SH		DFND	2	35,200	0	0
CVS HEALTH CORP	COM	126650100	13,454	158,548	SH		DFND	2	158,548	0	0
CYBERARK SOFTWARE LTD	SHS	M2682V108	331	2,100	SH		DFND	2	2,100	0	0
DANAHER CORPORATION	COM	235851102	139,031	456,679	SH		DFND	2	456,679	0	0
DENTSPLY SIRONA INC	COM	24906P109	9,237	159,129	SH		DFND	2	159,129	0	0
DEXCOM INC	COM	252131107	144,283	263,839	SH		DFND	2	263,839	0	0
DOLBY LABORATORIES INC	COM CL A	25659T107	317	3,600	SH		DFND	2	3,600	0	0
DOMINOS PIZZA INC	COM	25754A201	477	1,000	SH		DFND	2	1,000	0	0
DR REDDYS LABS LTD	ADR	256135203	554	8,500	SH		DFND	2	8,500	0	0
EDWARDS LIFESCIENCES CORP	COM	28176E108	98,487	869,951	SH		DFND	2	869,951	0	0
ELECTRONIC ARTS INC	COM	285512109	323	2,270	SH		DFND	2	2,270	0	0
ENTEGRIS INC	COM	29362U104	378	3,000	SH		DFND	2	3,000	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	496	41,200	SH		DFND	2	41,200	0	0
ESPERION THERAPEUTICS INC NE	COM	29664W105	53,959	4,477,964	SH		DFND	1,2	4,477,964	0	0
ESSA PHARMA INC	COM NEW	29668H708	152	19,000	SH		DFND	2	19,000	0	0
ESSA PHARMA INC	COM NEW	29668H708	40,127	5,015,814	SH		DFND	1,2	5,015,814	0	0
EVOLENT HEALTH INC	CL A	30050B101	51,267	1,653,761	SH		DFND	2	1,653,761	0	0
EVOLENT HEALTH INC	CL A	30050B101	42,746	1,378,917	SH		DFND	3	1,378,917	0	0
EXACT SCIENCES CORP	COM	30063P105	40,974	429,273	SH		DFND	3	429,273	0	0
EXELIXIS INC	COM	30161Q104	507	24,000	SH		DFND	2	24,000	0	0
EXELIXIS INC	COM	30161Q104	59,932	2,835,000	SH		DFND	1,2	2,835,000	0	0
FACTSET RESH SYS INC	COM	303075105	415	1,050	SH		DFND	2	1,050	0	0
FASTENAL CO	COM	311900104	361	7,000	SH		DFND	2	7,000	0	0
FATE THERAPEUTICS INC	COM	31189P102	3,064	51,700	SH		DFND	2	51,700	0	0
FATE THERAPEUTICS INC	COM	31189P102	188,854	3,186,336	SH		DFND	1,2	3,186,336	0	0
FORTINET INC	COM	34959E109	642	2,200	SH		DFND	2	2,200	0	0
GARTNER INC	COM	366651107	638	2,100	SH		DFND	2	2,100	0	0
GENERATION BIO CO	COM	37148K100	476	19,000	SH		DFND	2	19,000	0	0
GENERATION BIO CO	COM	37148K100	61,501	2,453,180	SH		DFND	1,2	2,453,180	0	0
GENETRON HLDGS LTD	ADS	37186H100	10,015	723,137	SH		DFND	2	723,137	0	0
GILEAD SCIENCES INC	COM	375558103	10,966	157,000	SH		DFND	2	157,000	0	0
GLAUKOS CORP	COM	377322102	6,930	143,870	SH		DFND	2	143,870	0	0
GLOBUS MED INC	CL A	379577208	55,888	729,420	SH		DFND	2	729,420	0	0
GRACO INC	COM	384109104	315	4,500	SH		DFND	2	4,500	0	0
GUARDANT HEALTH INC	COM	40131M109	42,490	339,894	SH		DFND	2	339,894	0	0
HALOZYME THERAPEUTICS INC	COM	40637H109	37,487	921,500	SH		DFND	2	921,500	0	0
HARMONY BIOSCIENCES HLDGS IN	COM	413197104	4,956	129,289	SH		DFND	2	129,289	0	0
HCA HEALTHCARE INC	COM	40412C101	82,882	341,473	SH		DFND	2	341,473	0	0
HEALTH CATALYST INC	COM	42225T107	36,369	727,233	SH		DFND	2	727,233	0	0
HILL-ROM HLDGS INC	COM	431475102	63,107	420,716	SH		DFND	3	420,716	0	0
HOLOGIC INC	COM	436440101	28,770	389,779	SH		DFND	2	389,779	0	0
HOLOGIC INC	COM	436440101	35,494	480,883	SH		DFND	3	480,883	0	0
HOMOLOGY MEDICINES INC	COM	438083107	13,671	1,737,122	SH		DFND	1,2	1,737,122	0	0
HORIZON THERAPEUTICS PUB L	SHS	G46188101	45,591	416,200	SH		DFND	2	416,200	0	0
HUMANA INC	COM	444859102	53,407	137,239	SH		DFND	2	137,239	0	0
HUMANA INC	COM	444859102	68,305	175,523	SH		DFND	3	175,523	0	0
HUTCHMED CHINA LTD	SPONSORED ADS	44842L103	36,835	1,006,147	SH		DFND	3	1,006,147	0	0
IDEXX LABS INC	COM	45168D104	73,459	118,120	SH		DFND	2	118,120	0	0
ILLUMINA INC	COM	452327109	28,445	70,130	SH		DFND	2	70,130	0	0
I MAB	SPONSORED ADS	44975P103	11,813	162,957	SH		DFND	2	162,957	0	0
INCYTE CORP	COM	45337C102	4,127	60,000	SH		DFND	2	60,000	0	0
INCYTE CORP	COM	45337C102	199,256	2,897,000	SH		DFND	1,2	2,897,000	0	0
INOGEN INC	COM	45780L104	10,435	242,174	SH		DFND	2	242,174	0	0
INSMED INC	COM PAR $.01	457669307	93,241	3,385,645	SH		DFND	3	3,385,645	0	0
INSPIRE MED SYS INC	COM	457730109	98,056	421,058	SH		DFND	2	421,058	0	0
INSULET CORP	COM	45784P101	108,858	382,994	SH		DFND	2	382,994	0	0
INTELLIA THERAPEUTICS INC	COM	45826J105	2,226	16,594	SH		DFND	2	16,594	0	0
INTERCONTINENTAL EXCHANGE IN	COM	45866F104	344	3,000	SH		DFND	2	3,000	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	4,119	110,500	SH		DFND	2	110,500	0	0
INTRA-CELLULAR THERAPIES INC	COM	46116X101	136,572	3,663,419	SH		DFND	1,2	3,663,419	0	0
INTUIT	COM	461202103	486	900	SH		DFND	2	900	0	0
INTUITIVE SURGICAL INC	COM NEW	46120E602	202,404	203,595	SH		DFND	2	203,595	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	4,097	122,150	SH		DFND	2	122,150	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	305,649	9,112,973	SH		DFND	1,2	9,112,973	0	0
IONIS PHARMACEUTICALS INC	COM	462222100	3,783	112,803	SH		DFND	3	112,803	0	0
IPG PHOTONICS CORP	COM	44980X109	214	1,350	SH		DFND	2	1,350	0	0
IQVIA HLDGS INC	COM	46266C105	45,661	190,620	SH		DFND	2	190,620	0	0
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	100,162	769,238	SH		DFND	3	769,238	0	0
JD.COM INC	SPON ADR CL A	47215P106	260	3,600	SH		DFND	2	3,600	0	0
JOHNSON & JOHNSON	COM	478160104	4,926	30,500	SH		DFND	2	30,500	0	0
JUMIA TECHNOLOGIES AG	SPONSORED ADS	48138M105	335	18,000	SH		DFND	2	18,000	0	0
KEZAR LIFE SCIENCES INC	COM	49372L100	39,166	4,533,148	SH		DFND	1,2	4,533,148	0	0
KOSMOS ENERGY LTD	COM	500688106	864	292,000	SH		DFND	2	292,000	0	0
KURA ONCOLOGY INC	COM	50127T109	1,077	57,500	SH		DFND	2	57,500	0	0
KYMERA THERAPEUTICS INC	COM	501575104	2,085	35,500	SH		DFND	2	35,500	0	0
LABORATORY CORP AMER HLDGS	COM NEW	50540R409	12,412	44,100	SH		DFND	2	44,100	0	0
LAUDER ESTEE COS INC	CL A	518439104	404	1,348	SH		DFND	2	1,348	0	0
LEGEND BIOTECH CORP	SPONSORED ADS	52490G102	14,488	286,556	SH		DFND	2	286,556	0	0
LIVE NATION ENTERTAINMENT IN	COM	538034109	428	4,700	SH		DFND	2	4,700	0	0
MACROGENICS INC	COM	556099109	1,046	49,950	SH		DFND	2	49,950	0	0
MACROGENICS INC	COM	556099109	148,162	7,075,564	SH		DFND	1,2	7,075,564	0	0
MACROGENICS INC	COM	556099109	29,716	1,419,083	SH		DFND	3	1,419,083	0	0
MARKEL CORP	COM	570535104	359	300	SH		DFND	2	300	0	0
MARKETAXESS HLDGS INC	COM	57060D108	278	662	SH		DFND	2	662	0	0
MASIMO CORP	COM	574795100	34,573	127,713	SH		DFND	2	127,713	0	0
MATCH GROUP INC NEW	COM	57667L107	373	2,378	SH		DFND	2	2,378	0	0
MCCORMICK & CO INC	COM NON VTG	579780206	324	4,000	SH		DFND	2	4,000	0	0
MCKESSON CORP	COM	58155Q103	484	2,430	SH		DFND	2	2,430	0	0
MEDTRONIC PLC	SHS	G5960L103	42,509	339,125	SH		DFND	2	339,125	0	0
MERCADOLIBRE INC	COM	58733R102	285	170	SH		DFND	2	170	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	1,188	126,000	SH		DFND	2	126,000	0	0
MERSANA THERAPEUTICS INC	COM	59045L106	38,993	4,135,000	SH		DFND	1,2	4,135,000	0	0
METTLER TOLEDO INTERNATIONAL	COM	592688105	372	270	SH		DFND	2	270	0	0
MIRATI THERAPEUTICS INC	COM	60468T105	3,344	18,900	SH		DFND	2	18,900	0	0
MODERNA INC	COM	60770K107	18,858	49,000	SH		DFND	2	49,000	0	0
MODERNA INC	COM	60770K107	645,929	1,678,349	SH		DFND	1,2	1,678,349	0	0
MOLECULAR TEMPLATES INC	COM	608550109	577	86,000	SH		DFND	2	86,000	0	0
MOLECULAR TEMPLATES INC	COM	608550109	72,414	10,792,003	SH		DFND	1,2	10,792,003	0	0
MOLINA HEALTHCARE INC	COM	60855R100	45,649	168,255	SH		DFND	2	168,255	0	0
MOODYS CORP	COM	615369105	444	1,250	SH		DFND	2	1,250	0	0
MSCI INC	COM	55354G100	496	816	SH		DFND	2	816	0	0
MYOVANT SCIENCES LTD	COM	G637AM102	1,055	47,000	SH		DFND	2	47,000	0	0
MYOVANT SCIENCES LTD	COM	G637AM102	128,403	5,722,039	SH		DFND	1,2	5,722,039	0	0
NEKTAR THERAPEUTICS	COM	640268108	517	28,800	SH		DFND	2	28,800	0	0
NEKTAR THERAPEUTICS	COM	640268108	47,067	2,620,676	SH		DFND	1,2	2,620,676	0	0
NEKTAR THERAPEUTICS	COM	640268108	34,935	1,945,180	SH		DFND	3	1,945,180	0	0
NEOGENOMICS INC	COM NEW	64049M209	27,096	561,683	SH		DFND	3	561,683	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	8,503	88,651	SH		DFND	2	88,651	0	0
NEUROCRINE BIOSCIENCES INC	COM	64125C109	279,616	2,915,400	SH		DFND	1,2	2,915,400	0	0
NEUROPACE INC	COM	641288105	8,051	507,930	SH		DFND	2	507,930	0	0
NEVRO CORP	COM	64157F103	25,017	214,956	SH		DFND	2	214,956	0	0
NEW YORK TIMES CO	CL A	650111107	370	7,500	SH		DFND	2	7,500	0	0
NOVAVAX INC	COM NEW	670002401	3,317	16,000	SH		DFND	2	16,000	0	0
OLINK HLDG AB	SPONSORED ADS	680710100	4,790	197,527	SH		DFND	2	197,527	0	0
OMNICELL INC	COM	68213N109	58,420	393,583	SH		DFND	2	393,583	0	0
OPTHEA LTD	SPONSORED ADS	68386J208	392	49,000	SH		DFND	2	49,000	0	0
OPTION CARE HEALTH INC	COM NEW	68404L201	62,974	2,595,814	SH		DFND	3	2,595,814	0	0
OSCAR HEALTH INC	CL A	687793109	11,824	679,952	SH		DFND	2	679,952	0	0
OUTSET MED INC	COM	690145107	22,597	457,060	SH		DFND	2	457,060	0	0
PACIFIC BIOSIENCES CALIF IN	COM	69404D108	41,983	1,643,159	SH		DFND	2	1,643,159	0	0
PENUMBRA INC	COM	70975L107	54,817	205,692	SH		DFND	2	205,692	0	0
PERKINELMER INC	COM	714046109	381	2,200	SH		DFND	2	2,200	0	0
PFIZER INC	COM	717081103	4,284	99,600	SH		DFND	2	99,600	0	0
PHREESIA INC	COM	71944F106	38,411	622,542	SH		DFND	2	622,542	0	0
POOL CORP	COM	73278L105	391	900	SH		DFND	2	900	0	0
PRIVIA HEALTH GROUP INC	COM	74276R102	12,369	525,000	SH		DFND	2	525,000	0	0
PROCEPT BIOROBOTICS CORP	COM	74276L105	5,723	150,000	SH		DFND	2	150,000	0	0
PULMONX CORP	COM	745848101	6,351	176,510	SH		DFND	2	176,510	0	0
QUANTERIX CORP	COM	74766Q101	29,566	593,819	SH		DFND	2	593,819	0	0
QUEST DIAGNOSTICS INC	COM	74834L100	1,889	13,000	SH		DFND	2	13,000	0	0
RADIUS HEALTH INC	COM NEW	750469207	782	63,000	SH		DFND	2	63,000	0	0
RADIUS HEALTH INC	COM NEW	750469207	95,628	7,705,714	SH		DFND	1,2	7,705,714	0	0
REGENERON PHARMACEUTICALS	COM	75886F107	64,397	106,410	SH		DFND	2	106,410	0	0
RELAY THERAPEUTICS INC	COM	75943R102	631	20,000	SH		DFND	2	20,000	0	0
RELAY THERAPEUTICS INC	COM	75943R102	117,795	3,735,962	SH		DFND	1,2	3,735,962	0	0
RESMED INC	COM	761152107	23,231	88,145	SH		DFND	2	88,145	0	0
REVOLUTION MEDICINES INC	COM	76155X100	1,340	48,700	SH		DFND	2	48,700	0	0
REVOLUTION MEDICINES INC	COM	76155X100	93,812	3,410,105	SH		DFND	1,2	3,410,105	0	0
S&P GLOBAL INC	COM	78409V104	510	1,200	SH		DFND	2	1,200	0	0
SAGE THERAPEUTICS INC	COM	78667J108	1,724	38,900	SH		DFND	2	38,900	0	0
SAGE THERAPEUTICS INC	COM	78667J108	140,467	3,170,104	SH		DFND	1,2	3,170,104	0	0
SANOFI	SPONSORED ADR	80105N105	3,230	67,000	SH		DFND	2	67,000	0	0
SAREPTA THERAPEUTICS INC	COM	803607100	52,637	569,168	SH		DFND	3	569,168	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	637	19,300	SH		DFND	2	19,300	0	0
SCHOLAR ROCK HLDG CORP	COM	80706P103	75,125	2,275,125	SH		DFND	1,2	2,275,125	0	0
SEAGEN INC	COM	81181C104	9,067	53,400	SH		DFND	2	53,400	0	0
SEER INC	COM CL A	81578P106	4,701	136,133	SH		DFND	2	136,133	0	0
SENSATA TECHNOLOGIES HLDNG PL	SHS	G8060N102	323	5,900	SH		DFND	2	5,900	0	0
SERVICE CORP INTL	COM	817565104	392	6,500	SH		DFND	2	6,500	0	0
SHOCKWAVE MED INC	COM	82489T104	95,579	464,247	SH		DFND	2	464,247	0	0
SIGHT SCIENCES INC	COM	82657M105	6,810	300,000	SH		DFND	2	300,000	0	0
SILK RD MED INC	COM	82710M100	43,015	781,660	SH		DFND	3	781,660	0	0
SKYWORKS SOLUTIONS INC	COM	83088M102	346	2,100	SH		DFND	2	2,100	0	0
SPOTIFY TECHNOLOGY SA	SHS	L8681T102	248	1,100	SH		DFND	2	1,100	0	0
STARBUCKS CORP	COM	855244109	357	3,234	SH		DFND	2	3,234	0	0
STONECO LTD	COM CL A	G85158106	149	4,300	SH		DFND	2	4,300	0	0
STRYKER CORPORATION	COM	863667101	111,377	422,332	SH		DFND	2	422,332	0	0
SYNEOS HEALTH INC	CL A	87166B102	4,986	57,000	SH		DFND	2	57,000	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	66,023	553,053	SH		DFND	2	553,053	0	0
TANDEM DIABETES CARE INC	COM NEW	875372203	57,477	481,466	SH		DFND	3	481,466	0	0
TELADOC HEALTH INC	COM	87918A105	27,379	215,906	SH		DFND	2	215,906	0	0
TELEFLEX INCORPORATED	COM	879369106	36,833	97,818	SH		DFND	2	97,818	0	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	49,637	86,879	SH		DFND	2	86,879	0	0
TRADEWEB MKTS INC	CL A	892672106	420	5,200	SH		DFND	2	5,200	0	0
TRANSMEDICS GROUP INC	COM	89377M109	19,226	581,029	SH		DFND	2	581,029	0	0
TRANSUNION	COM	89400J107	415	3,696	SH		DFND	2	3,696	0	0
TRIMBLE INC	COM	896239100	395	4,800	SH		DFND	2	4,800	0	0
TRIP COM GROUP LTD	ADS	89677Q107	308	10,000	SH		DFND	2	10,000	0	0
TYLER TECHNOLOGIES INC	COM	902252105	367	800	SH		DFND	2	800	0	0
ULTA BEAUTY INC	COM	90384S303	397	1,100	SH		DFND	2	1,100	0	0
ULTRAGENYX PHARMACEUTICAL IN	COM	90400D108	2,516	27,900	SH		DFND	2	27,900	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	79,523	203,518	SH		DFND	2	203,518	0	0
UNITEDHEALTH GROUP INC	COM	91324P102	52,540	134,464	SH		DFND	3	134,464	0	0
UNIVERSAL DISPLAY CORP	COM	91347P105	233	1,365	SH		DFND	2	1,365	0	0
VEEVA SYS INC	CL A COM	922475108	50,300	174,551	SH		DFND	2	174,551	0	0
VERISIGN INC	COM	92343E102	349	1,700	SH		DFND	2	1,700	0	0
VERISK ANALYTICS INC	COM	92345Y106	348	1,739	SH		DFND	2	1,739	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	44,041	242,800	SH		DFND	2	242,800	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	85,039	468,816	SH		DFND	3	468,816	0	0
VERTEX PHARMACEUTICALS INC	COM	92532F100	190,460	1,050,000	SH		DFND	1,2	1,050,000	0	0
VOCERA COMMUNICATONS INC	COM	92857F107	22,876	499,912	SH		DFND	2	499,912	0	0
VOCERA COMMUNICATONS INC	COM	92857F107	29,933	654,129	SH		DFND	3	654,129	0	0
WABTEC	COM	929740108	362	4,200	SH		DFND	2	4,200	0	0
WATSCO INC	COM	942622200	344	1,300	SH		DFND	2	1,300	0	0
WAVE LIFE SCIENCES LTD	SHS	Y95308105	12,754	2,602,858	SH		DFND	1,2	2,602,858	0	0
XENCOR INC	COM	98401F105	1,702	52,100	SH		DFND	2	52,100	0	0
ZAI LAB LTD	ADR	98887Q104	13,174	125,000	SH		DFND	2	125,000	0	0
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	40,993	280,082	SH		DFND	2	280,082	0	0
ZOETIS INC	CL A	98978V103	1,378	7,100	SH		DFND	2	7,100	0	0